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Medicinal Properties of Cucumis melo Linn

Authors:
Muhammad Asif at The Islamia University of Bahawalpur
Muhammad Asif
Saif Rehman
Saif Rehman
Muhammad Akram at Government College University Faisalabad
Muhammad Akram
Akhtar Naveed at The Islamia University of Bahawalpur
Akhtar Naveed
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Medicinal Properties of Cucumis melo Linn. | RADS Journal of Pharmacy and Pharmaceutical Sciences
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Home / Archives / Vol 2 No 1 (2014): Content volume 2 (1) 2014 / Articles
Medicinal Properties of Cucumis melo Linn.
Hafiz Muhammad Asif
The University of Poonch, Rawalakot, AJ& K, Pakistan
Saif Ur Rehman
The University of Poonch, Rawalakot, AJ& K, Pakistan
Muhammad Akram
The University of Poonch, Rawalakot, AJ& K, Pakistan
Naveed Akhtar
The Islamia University of Bahawalpur, Pakistan
Sabira Sultana
The Islamia University of Bahawalpur, Pakistan
Jalil Ur Rehman
The Islamia University of Bahawalpur, Pakistan
Keywords: Cucumis melo, Pharmacological Activites, Chemical Constituents
Abstract
Cucumis melo Linn. fruit popularly known as Muskmelon is a pubescent or trailing herb with edible,
polymorphous fruits. It is used for various ailments in Traditional System of Medicine. Fruit and roots
have medicinal value. Traditionally it is used for the treatment of kidney stones, flatulence, leprosy,Traditionally it is used for the treatment of kidney stones, flatulence, leprosy,
1/16/22, 9:05 PM
Medicinal Properties of Cucumis melo Linn. | RADS Journal of Pharmacy and Pharmaceutical Sciences
https://jpps.juw.edu.pk/index.php/jpps/article/view/40#:~:text=Traditionally it is used for,%2C lentin%2C xanthin and cryptoxanthin.
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fever, jaundice, diabetes, obesity, cough, bronchitis, ascites, anaemia, constipation and otherfever, jaundice, diabetes, obesity, cough, bronchitis, ascites, anaemia, constipation and other
abdominal disorders. C. melo is a rich source of vitamin A, folate, flavonoids such as ß-carotene, lentin,abdominal disorders. C. melo is a rich source of vitamin A, folate, flavonoids such as ß-carotene, lentin,
xanthin and cryptoxanthin. Its various pharmacological activities have been evaluated such asxanthin and cryptoxanthin.
antihyperlipidimic, antidiuretic, gastroprotective, anti-hyperglycemic, anti-inflammatory and
antihypothyroidism. The present review article covers the up to date information on the chemical
constituents and pharmacological activities of C. melo.
Author Biographies
Hafiz Muhammad Asif, The University of Poonch, Rawalakot, AJ& K, Pakistan
Department of Eastern Medicine & Surgery, Faculty of Health & Medical Sciences
Saif Ur Rehman, The University of Poonch, Rawalakot, AJ& K, Pakistan
Department of Eastern Medicine & Surgery, Faculty of Health & Medical Sciences
Muhammad Akram, The University of Poonch, Rawalakot, AJ& K, Pakistan
Department of Eastern Medicine & Surgery, Faculty of Health & Medical Sciences
Naveed Akhtar, The Islamia University of Bahawalpur, Pakistan
Department of Eastern Medicine & Surgery, Faculty of Health & Medical Sciences
Sabira Sultana, The Islamia University of Bahawalpur, Pakistan
University College of Conventional Medicine, Faculty of Pharmacy & Alternative Medicine
Jalil Ur Rehman, The Islamia University of Bahawalpur, Pakistan
University College of Conventional Medicine, Faculty of Pharmacy & Alternative Medicine
1/16/22, 9:05 PM
Medicinal Properties of Cucumis melo Linn. | RADS Journal of Pharmacy and Pharmaceutical Sciences
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Medicinal Properties of Cucumis melo Linn. | RADS Journal of Pharmacy and Pharmaceutical Sciences
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2014-04-18
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... Traditionally, C. melo has been used to treat gastrointestinal disorders (Gill et al., 2010) and exhibit antidiabetic (Chen and Kang, 2013), anti-hypothyroidism (Parmar and Kar, 2009), antiinflammatory, and analgesic activities (Silva et al., 2020) and neurological diseases in Pakistan, India, Iran, and China (Dixit and Kar, 2010;Asif et al., 2014;Patel and Rauf, 2017;Salehi et al., 2019). C. melo is traditionally used to reduce blood pressure, anaemia, and dementia (Lim, 2012;Asif et al., 2014). ...
... Traditionally, C. melo has been used to treat gastrointestinal disorders (Gill et al., 2010) and exhibit antidiabetic (Chen and Kang, 2013), anti-hypothyroidism (Parmar and Kar, 2009), antiinflammatory, and analgesic activities (Silva et al., 2020) and neurological diseases in Pakistan, India, Iran, and China (Dixit and Kar, 2010;Asif et al., 2014;Patel and Rauf, 2017;Salehi et al., 2019). C. melo is traditionally used to reduce blood pressure, anaemia, and dementia (Lim, 2012;Asif et al., 2014). In the Unani medicines system, C. melo seeds known as tukhm-e-Kharbuza are categorized as "Muqawwi-e-Qalb, Dimagh wa Badan" which means strengthen the heart, brain, and body (Kirtikar and Basu, 1987;Nadkarni, 1989;Prajapati et al., 2003). ...
Cardioprotective and hypotensive mechanistic insights of hydroethanolic extract of Cucumis melo L. kernels in isoprenaline-induced cardiotoxicity based on metabolomics and in silico electrophysiological models
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Background: Cardiovascular diseases (CVD) continue to threaten health worldwide, and account for a significant portion of deaths and illnesses. In both developing and industrialized nations, they challenge their health systems. There are several traditional uses of Cucurbitaceae seeds in Pakistan, India, Iran, and China, including treating cardiovascular, neurological, and urogenital diseases. Methods: In the present work, integrated techniques of metabolomics profiling and computational cardiomyocyte stimulation were used to investigate possible mechanisms of C. melo in isoprenaline (ISO)-induced myocardial infarction. In vitro, vasoconstrictions, paired atria, and in vivo invasive blood pressure measurement models were performed to explore the mechanism of action of C. melo hydroethanolic seed extract (Cm-EtOH). Results: Results showed that Cm-EtOH demonstrates NO-based endothelium-derived relaxing factor (EDRF) vasorelaxant response, negative chronotropic and inotropic response in the atrium, and hypotensive effects in normotensive rats. Results also revealed that Cm-EtOH decreases cardiomyocyte hypertrophy and reverts the altered gene expressions, biochemical, and metabolites in ISO-induced myocardial infarction (MI) rats. The extract additionally reversed ISO-induced MI-induced oxidative stress, energy consumption, and amino acid metabolism. Moreover, C. melo seeds increased EDRF function, energy production, and antioxidant capacity to treat myocardial and vascular disorders. In computational cardiomyocyte simulation, gallic acid reduced action potential duration, upstroke velocity (dV/dtmax), and effective refractory period. Conclusion: This study highlights the therapeutic potential of C. melo seeds to treat cardiovascular diseases and provides mechanistic insight into its antihypertensive and cardioprotective activities.
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... The pulp of C. melo is commonly eaten in the desert, in salads, raw or roasted [6,7]. It has been used in traditional medicine for centuries in Pakistan, Iran, India, and China for gastrointestinal, circulatory, neurological, and urogenital problems [8][9][10][11]. This study aims to determine whether C. melo seeds have antispasmodic properties and identify how calcium-mediated signaling pathways control smooth muscle contraction genes [12,13]. ...
... Physiological responses of tissues were recorded using LabChart Pro 7. Molecular docking was carried out using Maestro v11. 8 ...
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Background: In addition to the nutritional benefits of Cucumis melo L., herbalists in Pakistan and India employ seeds to treat various ailments. This study aimed to determine the regulatory role of C. melo seeds in calcium-mediated smooth muscle contraction. Methods: We identified and quantified the phytochemicals of C. melo with LC ESI-MS/MS and HPLC, then conducted in vitro and in vivo tests to confirm the involvement in smooth muscle relaxation. Then, diarrhea-predominant irritable bowel syndrome gene datasets from NCBI GEO were acquired, DEGs and WGCNA followed by functional enrichment analysis. Next, molecular docking of key genes was performed. Results: The quantification of C. melo seeds revealed concentrations of rutin, kaempferol, and quercetin were 702.38 μg/g, 686.29 μg/g, and 658.41 μg/g, respectively. In vitro experiments revealed that C. melo seeds had a dose-dependent relaxant effect for potassium chloride (80 mM)-induced spastic contraction and exhibited calcium antagonistic response in calcium dose-response curves. In in vivo studies, Cm.EtOH exhibited antidiarrheal, antiperistaltic, and antisecretory effects. The functional enrichment of WGCNA and DEGs IBS-associated pathogenic genes, including those involved in calcium-mediated signaling, MAPK cascade, and inflammatory responses. MAPK1 and PIK3CG were identified as key genes with greater binding affinity with rutin, quercitrin, and kaempferol in molecular docking. Conclusions: The bronchodilator and antidiarrheal effects of C. melo were produced by altering the regulatory genes of calcium-mediated smooth contraction.
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... Fruits being anti-inflammatory, nutritious, shows the antidiabetic and anti-obesity properties. The fruits has the antihyperlipidimic, anti-hyperglycaemic, and anti-hypothyroidism under lifestyle diseases [12] . Delonix regia (Bojer ex Hook.) ...
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Lifestyle diseases are the diseases caused due to our mode of living, unhealthy diets such as junk and fast food, the alcoholism, and other drug habits. Developing habit of late sleeping and late awaking, using fatty food proportionate to physical exercise through nature of working and maximum sitting for work causing blood pressure, cancer, diabetes, hypertension causing cardiac arrest. Regular exercise, pranayama and yogasana plays a vital role for this management. Besides, herbal drugs are also useful the management of the lifestyle diseases. Seeking out this an exploration of herbs related with the formulation of medicines and tradition use of medicines described in different herbal system of medicines have been made in the Gangetic areas in West Bengal from Rajmahal hill to Gangasagar. During the course of exploration, 34 plants were found being used in different herbal medical systems or having the properties and having the chemical alkaloids and pharmacological properties are mentioned in this paper.
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... Its major effects include cytotoxicity as well as nephron protection, anthelmintic also anti-microbial, anti-oxidant as well as antihyperlipidemia, anti-hyperglycemic, anti-hypercalciuric, anti-hypothyroidism, gastroprotective, anti-inflammatory, analgesic, diuretic, thyroid stimulatory and analgesic. Ascites, anemia, constipation, diabetes, obesity, leprosy, fever, jaundice, kidney stones, flatulence, and other stomach diseases are among the conditions it is traditionally used to cure [13] . ...
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One of the most prevalent illnesses in Mutravaha Srōtasa (The bodily channel responsible for urine) is Mutrāshmari. Mutrāshmari is difficult to treat and requires extra care. Āchārya Sushruta listed it as one of the Ashta Mahāgada (eight dreadful disorders). It is related to urolithiasis, or urinary calculi in modern medical science. The prevalence of Mutrāshmari is rising in the modern day for a number of reasons, including altered eating habits, altered lifestyles, stress as well as strain, and environmental pollution. Cucumis melo and Leea indica are the chosen herbs in a traditional formula, and this review's goal is to investigate how well those selected herbs manage to treat Ashmari. Information about Ashmari was acquired from Ayurvedic scriptures, contemporary texts, and earlier research studies (from primary and secondary sources). It was thought that two herbs could help with Ashmari and afterwards a survey of the literature was done on those two herbs. Also these selected herbs were examined for their Pancha Padārtha (5 elements of the herb) and pharmacological qualities. Selected paste shows anti-urolithiatic and anti-hypercalciuric action. According to a literature review and Pancha Padārtha analysis, those selected herbs are useful in the treatment of Ashmari..
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... It occasionally naturally occurs in open scrub forests. [2]  Pacific: Fiji Island, Guam, Tonga, New Britain and Samoa.  USA: California, New-York, Georgia, Arizona, Texas and Colorado. ...
A REVIEW ON "CUCUMIS MELO L" -AN IMPORTANT MEDICINAL PLANT
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The Dicotyledonous Plant Cucumis melo L is a member of the Cucurbitaceae family. This plant is Persian (Iran) in origin. In Central Asia, muskmelons are native. The plant is frequently observed flourishing throughout Turkey, China, and India. Cucumis melo composed of many volatile compounds, biosynthetically derived from fatty acid, carotenoids, amino acid and terpenes. The Therapeutic benefits of Muskmelons include Antioxidant, Antimicrobial, Anti-inflammatory, Anti-ulcer, Anti-fertility, Anti-helminthic, Analgesic and Hepatoprotective qualities. Potassium, Calcium, Magnesium and Carotenoids are all present in muskmelons. Muskmelon fruit peel extracts are utilized in Ayurveda for their Anti-hypothyroitic and Anti-diabetic properties. The present review is an effort to give a look on An Important Medicinal Plant Cucumis melo L.
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... Its major effects include cytotoxicity as well as nephron protection, anthelmintic also anti-microbial, anti-oxidant as well as antihyperlipidemia, anti-hyperglycemic, anti-hypercalciuric, anti-hypothyroidism, gastroprotective, anti-inflammatory, analgesic, diuretic, thyroid stimulatory and analgesic. Ascites, anemia, constipation, diabetes, obesity, leprosy, fever, jaundice, kidney stones, flatulence, and other stomach diseases are among the conditions it is traditionally used to cure [13] . ...
Review of a selective Ayurvedic formula in the management of Ashmari (Urinary stones)
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One of the most prevalent illnesses in Mutravaha Srōtasa (The bodily channel responsible for urine) is Mutrāshmari. Mutrāshmari is difficult to treat and requires extra care. Āchārya Sushruta listed it as one of the Ashta Mahāgada (eight dreadful disorders). It is related to urolithiasis, or urinary calculi in modern medical science. The prevalence of Mutrāshmari is rising in the modern day for a number of reasons, including altered eating habits, altered lifestyles, stress as well as strain, and environmental pollution. Cucumis melo and Leea indica are the chosen herbs in a traditional formula, and this review's goal is to investigate how well those selected herbs manage to treat Ashmari. Information about Ashmari was acquired from Ayurvedic scriptures, contemporary texts, and earlier research studies (from primary and secondary sources). It was thought that two herbs could help with Ashmari and afterwards a survey of the literature was done on those two herbs. Also these selected herbs were examined for their Pancha Padārtha (5 elements of the herb) and pharmacological qualities. Selected paste shows anti-urolithiatic and anti-hypercalciuric action. According to a literature review and Pancha Padārtha analysis, those selected herbs are useful in the treatment of Ashmari..
View
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Integrated Mechanisms of Polarity–Based Extracts of Cucumis melo L. Seed Kernels for Airway Smooth Muscle Relaxation via Key Signaling Pathways Based on WGCNA, In Vivo, and In Vitro Analyses
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The present study aimed to determine the mechanisms responsible for calcium–mediated smooth muscle contractions in C. melo seeds. The phytochemicals of C. melo were identified and quantified with the aid of Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometric (LC/ESI–MS/MS) and high–performance liquid chromatography (HPLC), and then tested in–vitro and in vivo to confirm involvement in smooth muscle relaxation. Allergic asthma gene datasets were acquired from the NCBI gene expression omnibus (GEO) and differentially expressed gene (DEG) analysis, weighted gene co–expression network analysis (WGCNA), and functional enrichment analysis were conducted. Additionally, molecular docking of key genes was carried out. Kaempferol, rutin, and quercetin are identified as phytochemical constituents of C. melo seeds. Results indicated that C. melo seeds exhibit a dose–dependent relaxant effect for potassium chloride (80 mM)– induced spastic contraction and calcium antagonistic response in calcium dose–response curves. The functional enrichment of WGCNA and DEG asthma–associated pathogenic genes showed cytokine–mediated pathways and inflammatory responses. Furthermore, CACNA1A, IL2RB, and NOS2 were identified as key genes with greater binding affinity with rutin, quercitrin, and kaempferol in molecular docking. These results show that the bronchodilator and antidiarrheal effects of C. melo were produced by altering the regulatory genes of calcium–mediated smooth muscle contraction.
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