Cytoskeletal proteins, which are unique to eukaryotic cells, form a three-dimensional niche filling the cytoplasm. It is quite essential for a myriad of cellular processes in higher eukaryotes such as cell movement, stability, and cell to cell interaction. There are primarily three major types of cytoskeletal protein, viz microfilaments/actin filaments, microtubules, and intermediate filaments.
... [Show full abstract] The polymerization dynamics of these three proteins are in turn regulated by several other accessory proteins depending upon the functional requirement of the cells. These polymerization dynamics of the protein are also responsible for cellular signaling processes that control the cytokine release during various immune responses against foreign particles. It has been widely known that any aberration that occurs during the polymerization dynamics of these three proteins may be responsible for several diseases. These diseases range from various types of cancer, polycystic ovary syndrome, neuropathological disorders, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. Many microorganisms that infect specialized cell types have been shown to be highly dependent on host cytoskeletal elements.