How to Avoid Coronavirus (COVID-19) or Relief it is Symptoms by Natural Products

Abstract

The spread of coronaviruses (COVID-19) globally resulted in numerous deaths and hospitalizations. It causes respiratory tract disease and fatal lung disease in humans. Vitamin C can manage a variety of viral infections. Honey was reported to be effective against the respiratory syncytial virus. Moreover, Ginger was effective in blocking viral attachment and internalization. Furthermore, green tea epigallocate-chin-3-gallate shows a vital role in the adaptable microen-vironment of endosomes and lysosomes. Also, Egyptian chicken soup contains many nutritive values, so it should be taken for upper respiratory tract diseases. Moreover, curcumin considers having a wide range of antiviral activity against several distinct viruses. And finally, fenugreek has a wonderful biological activity as protection from cancer, malaria , allergies, bacteria, and viruses. This work is primarily addressed the antiviral potencies of some natural product that will help to overcome or relief bad symptoms of coro-naviruses.

Full text

How to Avoid Coronavirus (COVID-19) or
Relief it is Symptoms by Natural Products
1
MedDocs Publishers
Received: May 20, 2020
Accepted: Jun 19, 2020
Published Online: Jun 23, 2020
Journal: Annals of Epidemiology and Public health
Publisher: MedDocs Publishers LLC
Online edion: hp://meddocsonline.org/
Copyright: © El Barky AR (2020). This Arcle is
distributed under the terms of Creave Commons
Aribuon 4.0 Internaonal License
*Corresponding Author(s): Amira Ragab El Barky
Biochemistry Unit, Chemistry Department, Faculty
of Science, Tanta University, Egypt
Email: amiramaram52@yahoo.com
Cite this arcle: El Barky AR, Abd Elsalam KG, Mohamed TM. How to Avoid Coronavirus (COVID-19) or Relief it is
Symptoms by Natural Products. A Epidemiol Public Health. 2020; 3(1): 1020.
Annals of Epidemiology & Public Health
Open Access | Review Arcle
Abstract
The spread of coronaviruses (COVID-19) globally resulted
in numerous deaths and hospitalizaons. It causes respira-
tory tract disease and fatal lung disease in humans. Vitamin
C can manage a variety of viral infecons. Honey was re-
ported to be eecve against the respiratory syncyal virus.
Moreover, Ginger was eecve in blocking viral aachment
and internalizaon. Furthermore, green tea epigallocate-
chin-3-gallate shows a vital role in the adaptable microen-
vironment of endosomes and lysosomes. Also, Egypan
chicken soup contains many nutrive values, so it should
be taken for upper respiratory tract diseases. Moreover,
curcumin considers having a wide range of anviral acvity
against several disnct viruses. And nally, fenugreek has a
wonderful biological acvity as protecon from cancer, ma-
laria, allergies, bacteria, and viruses. This work is primarily
addressed the anviral potencies of some natural product
that will help to overcome or relief bad symptoms of coro-
naviruses.
ISSN: 2639-4391
Amira Ragab El Barky1*; Khloud Gamal Abd Elsalam2; Tarek M Mohamed1
1Biochemistry Unit, Chemistry Department, Faculty of Science, Tanta University, Egypt
2Biochemistry Unit, Chemistry Department, Faculty of Science, Damanhour University, Egypt
Keywords: Viruses; Coronaviruses; Vitamin C; Curcumin, Green
tea; Honeybees.
Abbreviaons: HCoV-229E: Human Coronavirus 229E; SARS-
CoV: Severe Acute Respiratory Syndrome Coronavirus; ROS: Re-
acve oxygen species.
Highlights
Viral infecons are one of the serious problems globally, •
as it aects health and economic burdens.
A novel coronavirus disease (COVID-19), spread globally, •
aects many people, involved in an acute respiratory and
cause death in some cases.
There is no vaccinaon unl now for this pandemic virus; •
so, natural anviral compounds might overcome this pan-
demic virus.
Daily eaten honeybees with Vitamin C as lemon may be •
very eecve in relieving the symptoms of the virus and
may kill the host of coronavirus in the individual body.
Curcumin has the ability to cut o virus adhesion to the •
cell, which prevents virus spread.
Dairy milk should be treated very well with sterilizaon •
before consumpon to avoid the spread of virus corona.

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Introducon
Viral infecons are one of the serious problems globally, as
it aects health and economic burdens. Regardless, the avail-
ability of vaccines or anviral drugs, individual hygiene is a very
eecve way against viral infecons [1]. The spread of coronavi-
ruses (COVID-19) globally resulted in numerous deaths and hos-
pitalizaons. There is no vaccinaon unl now for this pandemic
virus and they cause many side eects if exists, so, this review
arcle aimed to illustrate some of natural anviral compounds
that might overcome this pandemic virus.
Viruses are composed of proteins and are enclosed by a lipid
membrane, the diameter of viruses ranged from 16 nm to 300
nm, the small size of the viruses makes them ultra-lterable,
Viruses have developed through long me duraon and could
adapt to denite organisms or their host cells. Viruses contain
only one type of nucleic acid, DNA or RNA. Viruses do not rep-
licate by division method, but they propagate in the living cells
host. They can develop their genomic acvity and reproduce the
components from which they are synthesis. They can’t encode
their ribosomes or energy-generang metabolic pathways. So,
viruses consider intracellular parasites. They can re-route and
adjust cellular processes for their opmal execuon reproduc-
on. The genec reference for any viruses is not dependent on
encoding structural components only but they have many genes
that coded various regulatory acve proteins as transacvators
and enzymes like proteases and polymerases [2].
History
Unl now, there is a diversity of human diseases with obscure
eology. A viral is one of these diseases. There are about four
disnct types of coronaviruses that have been known. Corona-
viruses have been idened in dierent animals like rodents,
poultry, turkeys, pigs, dogs, cats, rabbits, horses, cale, and hu-
mans; they can induce a variety of severe diseases as gastris
and respiratory tract illness [3]. The coronaviruses that have
been studied in detail are, HCoV-229E and HCoV-OC43 were
discovered in the mid-of1960s, and are known to cause the
common cold [4], SARS-CoV causes life-threatening pneumo-
nia, and is the most known pathogenic human coronavirus [15]
and human coronavirus, HCoVNL63 which was isolated from
a 7-month-old child with acute respiratory disease In January
2003 [6]. Both HCoV-HKU1 and HCoV-NL63 are coronaviruses
aects the respiratory tract, they found in both lower and upper
respiratory tract disease, they have spread globally, especially in
the winter [7].
Coronaviruses diseases in animals dierently than humans,
they produce gastris, respiratory tract, and can aect the cen-
tral nervous system in animals, whereas, in humans, the coro-
naviruses are aected the respiratory tract and in some cases
cause lethal lung disease. SARS-CoV is the most known corona-
virus that resulted in Severe Acute Respiratory Syndrome (SARS)
[8]. SARS-CoV probably originated from a wild animal reservoir,
as bats [9], and was transferred to humans by infected cats.
Nowadays by the end of December 2019, people with pneu-
monia of unknown eology causes were reported in Wuhan. On
the rst of January 2020, China CDC reported a new coronavirus
was reported and classied as SARS-CoV clade. The disease as-
sociated with the virus is referred to as novel coronavirus dis-
ease 2019 (COVID-19), this virus was spread globally, that aects
many people and cause death in some cases. a coronavirus that
involved in an acute respiratory disease known by coronavirus
disease 19 (COVID-19) or SARS CoV- 2 is the third spread virus
from animal to humans in the last two decades that resulted in
a major epidemic [10]. A genus of the Coronaviridae family, are
enveloped viruses with a large plus-strand RNA genome. The
genomic range of RNA is 27 to 32 kb in size, coated and poly-
adenylated. Viruses generally known in all groups by host range
and genome sequence.
Spread of coronaviruses
Coronaviruses can spread through direct or indirect contact;
it can spread via large respiratory droplets and or small parcle
droplet nuclei, but the way of spread unl unclear as inuenza
A viruses [11]. Although no one knows whether it can spread
through the blood or not, people should avoid blood transfu-
sion or come into contact with anyone’s blood because it may
be a reason to transmit this virus.
How to avoid coronaviruses
Closed places should be avoided as possible; people with a
cold should stay indoors and take plenty of rest. Mask should
be put on the face, as well as safety glasses, hand gloves and
change them every me, usage of a good sterilizer Personal hy-
giene is very eecve in overcoming coronavirus, and nally,
people should eat or drink food and drinks that increase their
immunity.
Natural food should be eang daily during coronavirus
L-Ascorbic acid (Vitamin C)•
L-Ascorbic acid is a found in abundant in vegetables, fruit
foods it has an essenal role in a several of cellular processes, it
is an important product that can protect the body from oxidave
damage which resulted from toxic free radicals and other reac-
ve oxygen species (ROS) that are considered the main cause of
several diseases. Vitamin C act as an anoxidant in physiologi-
cal condions and prooxidant under pathologic disease [12].
It can scavenge oxygen free radicals directly and restoring the
tetrahydrobiopterin and α-tocopherol anoxidants to normal
value [13]. Vitamin C may, therefore, ameliorate viral-induced
oxidave injury. Many infecous diseases cause the acvaon
of phagocytes, and hence release reacve oxygen species. ROS
has a role in the deacvaon of the viruses. But, they are harm-
ful to the host cells and can cause the pathogenesis of viral-
induced host damage.
Respiratory syncyal virus respiratory tract disease which oc-
curs in childhood leads, also may aect adults causing deaths
[14], enhance ROS producon and causes inhibion of lung
anoxidant enzymes, this process leads to an imbalance be-
tween oxidant and oxidant balance and hence cause pulmonary
poisoning [15]. The mechanism of Vitamin acon C is dierent
than tradional anviral drugs in the human body; Vitamin C is
thought to be working in a synergic way that combines with the
virus and the body to preserve the body in a balance [16].
Honeybees•
Honeybees’ products are natural products that have been
used in ancient medicine. The importance of the biological
properes of these products is related to the ingredients a-
vonoids they contain. They thought to have an anbacterial,
an-inammatory, anoxidant, anfungal and anviral role.
Propolis is said to have a role in regenerave and anviral in
cold sores which result from herpes simplex virus [17]. Honey
might be a novel anoxidant to relieve many diseases via di-

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rect or indirect way [18]. It can improve immune status [19]. It
can lower the acute respiratory symptoms in individuals who
eat honey daily [20]. Anviral eect of honey is aributed to its
ingredients components, for example, copper can deacvate a
virus. Moreover, vitamin c, avonoids, and H2O2 producon by
honey cause inhibion of viral growth through cut o viral tran-
scripon and translaon [21]. Honey products are said to have
anviral acvity against several types of viruses, for example,
measles, herpes, and zoster viruses [22]. Nitric oxide metabo-
lites, nitrite, and nitrate have been recognized in the salivary
glands [23]. Nitric oxide can produce host defense against vi-
ruses, both DNA and RNA viruses, nitric oxide acts by slowing
down the development of viral lesions also hinder their replica-
on [23]. Nitric oxide represses replicaon by interfering with
viral polymerase, nucleic acid, and/or viral capsid proteins. The
avonoid content of honey has also been reported to inhibit
viral transcripon and replicaon [24]. Moreover, the mecha-
nism of the anviral acvity of royal jelly has been ascribed to
the impact of 10-Hydroxy-2-Decanoic Acid. This fay acid drives
leukocytes, causing the leukocyte cells to aach to viruses, for
example, HSV and hepas, causing their destrucon [22]. Also,
Feás and Estevinho [25] menoned that honeybees provide an-
viral acvity against the respiratory system Dry mucus led to
frequent long-term infecon [26]. In order for viruses to sur-
vive, they need a host cell to spread, so the idea of killing the
virus kills the host cell. Honey has been shown to have anviral
acvity against respiratory syncyal virus and promotes inhibi-
on of viral reproducon [14].
Ginger (• Zingiber ocinale)
Ginger has been reported to show anbacterial, anfun-
gal, and anviral acvies [27]. It is used to warm the body for
promong circulaon and decrease high blood pressure. The
warming eect of ginger makes it a potent anviral for the
treatment of common cold and u [28]. Ginger can suppress
plaque formaon induced by a human respiratory syncyal vi-
rus in the respiratory tract in vitro. Ginger was said to have a
potenal role in blocking viral aachment and internalizaon
[29]. Ginger was supplemented to the paent with the hepas
C virus in Egypt; it resulted in lowering α-fetoprotein level, both
liver enzymac marker aspartate aminotransferase (AST) and
alanine aminotransferase (ALT) [30].
Green Tea •
Infecous viruses have extremely threatened human health
globally. Viruses are responsible for both acute and chronic in-
fecous diseases. Green tea catechins (GTCs) are polyphenolic
compounds extracted from Camellia sinensis leaves. GTCs were
known for their acon against various health benets against
numerous diseases. GTCs, parcularly epigallocatechin-3-gal-
late (EGCG), was said to have a potent anviral eect along-
side numerous viruses [31]. EGCG is the most ingredient of the
catechins as its individual structure and the presence of both
pyrogallol and galloyl moiees [32]. Furthermore, Xu [33] re-
ported that the existence of phenolic hydroxyl and the galloyl
group in GTCs have a signicant dierent acon on the dier-
ent viral. EGCG can be considered a nucleophilic reagent, the
presence of hydroxyl groups in the pyrogallol and galloyl moi-
ees supply extra lone pair electrons as compared to other
catechins, this allows EGCG to combine with various molecules
under suitable condions. GTCs have the ability to work in dif-
ferent stages of nuclear and cytoplasmic RNA viruses. The in-
hibion belongings of EGCG on mulple viruses indicated that
the green tea EGCG is a potenal alternave agent for viral dis-
eases [31]. It has been reported that EGCG binds strongly to
numerous molecules in the cells, parcularly proteins, and then
inuence their original acvies and funcons [34]. EGCG can
suppress the interacon of the virus or receptors and the host.
EGCG provides a principle role in adjusng both of endosomes
and lysosome in the cell, the acidicaon process is crical for
viral invasion. Viral genome replicaon or viral protein expres-
sion can also be repressed because of the inacvaon of viral
replicates or regulaon of host factors. Although some authors
reported the inhibion ability of EGCG on the stages of virus
and genome synthesis, a few results were menon on anviral
eects on viral protein translaon and assembly and budding
[31]. In vitro study, it has been reported that EGCG exhibits an-
viral acvity against a diverse number of viruses as Retroviridae,
Orthomyxoviridae, and Flaviviridae, including important human
infecous pathogens such as human immunodeciency virus,
inuenza A virus, and hepas C virus [35], and inhibion of
inuenza virus replicaon [36], hinders the entry of HCV entry
[37], it can inacvate both Herpes simplex virus 1,2 at neutral
or acidic medium [38], also, it has been used in the prevenon
or curave of infecons resulted by Zikavirus [39]. Besides, it
has the ability to suppress the acvity of enzymac of reversing
HIV-1 [40]. The mechanisms acon of green tea EGCG in viral,
EGCG is oxidized to form EGCG quinone by autoxidaon, thus it
can combine with the nucleophilic thiol group of a cysteine resi-
due to form EGCG-protein complex [41], else, the autoxidaon
of green tea catechins comprise oxygen radicals and molecular
oxygen [42].
Chicken soup anvirus•
Egypan Balady chicken soup was known for its eecve ac-
on against the inuenza cold symptomac upper respiratory
tract; this soup has medical value components and can alleviate
the inammaon of the virus cold [43]. Chicken soup may have
several benecial eects for an individual with inuenza cold.
These could include acons as diverse as improving hydraon
and nutrional status [44] and accelerang mucosal clearance.
Olive oil•
Olive oil contains numerous polyphenolic compounds that
consider bioacve compounds against the virus [45]. Polyphe-
nols are characterisc by their anbacterial, anoxidants, an-
inammatory, anviral, and anallergic acon [46]. Oleuropein,
tyrosol, hydroxytyrosol, verboscoside, ligustroide, demethyleu-
ropein were all considered a potent anmicrobial and anviral
agent [47]. Oleuropein has a potent anviral against many dif-
ferent viruses, for example, herpes, hepas, rota, bovine rhino,
canine parvo, and feline leukemia virus [48]. Also, it can manage
respiratory syncyal and inuenza type 3 viruses [49]. The olive
leaf extracts were eecve in control infecon or replicaon in
many diverse viruses as in viral hemorrhagic sepcemia, salmo-
nid rhabdovirus, and HIV-1[50]. Oleuropein olive extract targets
the acon of HIV-1 gp41, which is a way of HIV login into the
normal host [51].
Curcumin (diferuloylmethane)•
Curcumin is a natural polyphenol extracted from turmeric; it
is used in a wide range as food addives [52,53]. Curcumin has
the ability to cut o virus adhesion to the cell, which prevents
virus spread (Chen et al., 2010). It plays a biological role against
several viruses such as inuenza, hepas C and HIV viruses
[54]. Daily eang only a small amount of curcumin per day has
the potenal to suppress the acvity of the monophosphate

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dehydrogenase enzyme [55] and Integrase enzyme (necessary
for HIV-1 recurrence) curcumin may react with the catalyc
core of the enzyme and bind acidic remnant in the integrases
catalyc core and forbid it from binding with its substrates [56].
Curcumin also showed a potenal role against the human respi-
ratory syncyal virus, it hinders the replicaon of the virus and
increased the epithelial barrier role [57]. Moreover, Yang [58]
stated that curcumin nanoparcles present biocompability
and prevent RSV infecon.
Fenugreek (Trigonella foenum-graecum L.)•
Fenugreek possesses pharmacological properes, for exam-
ple, it can ght bacteria, carcinogenic, inammatory and virus
[59]. Moreover, it controls various enzymac acvies, relieves
fever, and reduces body pain. Moreover, Fenugreek contains
many compounds that possess biological acvity in various
diseases as protecon from cancer, malaria, allergies, bacteria,
and viruses [60].
Food should be control before eat•
The spread of rota and coronavirus in Egypt last year had a
great eect on public health and economic loss in animals and
its milk products. Dairy milk may be the main role in infecng a
human with both rota or coronavirus and cause the spread of
these viruses. Manufacture of Kareish white cheese and Balady
yogurt in the home cannot eliminate this rota or coronavirus
when infected milk is used due to decient heat treatment and
poor hygiene [61]. Dairy milk should be treated with steriliza-
on before consumpon [62].
Conclusion
Vitamin C has the ability to relieve the symptoms of coronavi-
rus. Vitamin C acts as an anoxidant in physiological status and
prooxidant in pathologic disease as it can scavenge oxygen free
radicals and restoring tetrahydrobiopterin and α-tocopherol to
normal value. Daily eaten honeybees with Vitamin C as lemon
may be very eecve in relieving the symptoms of the virus and
may kill the host of coronavirus in the individual body. More-
over, ginger was able to prevent plaque forming which results
in respiratory syncyal virus infecon. Also, green tea has the
ability to suppress the acvity of enzymac HIV-1 reverse tran-
scriptase. Furthermore, Egypan chicken soup with lemon as a
source of vitamin C can produce several benecial eects for
individuals with a cold. Their acon is various, they can improve
hydraon and nutrional condion and fasten mucosal rescue.
Finally, Fenugreek possesses more pharmacological acon as
anmicrobial, an-inammatory, anviral. All of the natural
components in this arcle review should be taken daily to over-
come coronavirus and raise the immunity of individuals. On the
other hand, Dairy milk should be treated very well with steriliza-
on before consumpon to avoid the spread of virus corona.
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