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Allen's Compendium of the Neurotropic Fungi Part I: Soma, Amanita and related Species.

Authors:
  • Publishing Ethnomycological Journals: Sacred Mushroom Studies

Abstract

Throughout history, only an elite few scholars possessed the arcane knowledge of the history of Amanita muscaria (Fr.) Hooker, also referred to as ‘SOMA.’ Two such researchers include the late ethnomycologist, R. Gordon Wasson and Sanskrit scholar Wendy Doniger O’Flaherty. Both believed that ‘SOMA, an ancient mysterious drug plant elixir, was made from Amanita muscaria. Amanita muscaria is also known as and/or referred to as the 'fly agaric' mushroom or the 'fly killer' mushroom. Unlike the psilocybine containing mushrooms, Amanita muscaria does not contain the tryptamine alkaloids psilocine and/or psilocybine. However, Amanita muscaria and several related species contain several chemicals which cause inebriations and intoxications when eaten. Active ingredients found in these mushrooms include: ibotenic acid, muscimol, and the sometimes toxic chemical known as muscarine. The earliest reference confirming the existence of this magical entheogenic plant can be found in the ninth and tenth mandala of the Rig Vida, the most holy and oldest of the ancient Vedic hymns. More than two thousand years ago, its use faded into the pages of history and completely disappeared. Today, the knowledge of the cultural importance of Soma is now reemerging into the 21st century of enthogenism. Although this bibliography is far from complete, it should enable those who wish access to this information, a better understanding of the nature of this fungi, it's chemistry and pharmacological actions, and it's relationship with the human element. The Soma Compendium is a bibliography of the known literature on Amanita muscaria and related subject matter that features: 356 references, 189 annotations and more than 695 cross-references, of which more than 75 additional referenced links have been posted in many of these author-date citations featured throughout this bibliography. Also included are numerous related photographs of species, literature (book and magazine covers), including many abstracts describing the contents featured herein.
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Until now no inquiries into the role of fungal hallucinogens in prehistory have ever dealt with the natives of North America. To most it will come as a surprise to learn that natives of this land shared with the Eurasians the fly agaric (Amanita muscaria) practices documented in Mushrooms Russia and History (Wasson & Wasson 1957) and more fully in Soma: Divine Mushroom of Immortality (Wasson 1968). Evidence is available that indicates that Ojibway and some others of Algonkian linguistic stock living in the woodlands of this country and Canada consulted the fly agaric for divine guidance in their shamanic observances. This evidence will help in clarifying the ambiguities and murky passages of Siberian informants.
Article
Log dose-response curves for induction of contralateral rotational behaviour in the rat by unilateral intranigral injections of the GABA agonist muscimol and the GABA analogue baclofen have been compared. Baclofen, 5--1000 ng, produced a maximal rotational response that was only 40% of that produced by 0.25--100 ng muscimol, and log dose-response curves failed to show parallelism. The behavioural effects of both drugs were only weakly antagonised by haloperidol and were not antagonised by 6-hydroxydopamine lesions of ipsilateral dopamine (DA) neurons, indicating that these responses were independent of DAergic mechanisms. The effects of baclofen were weakly antagonised by picrotoxin. Intranigral muscimol and baclofen substantially elevated striatal DA concentrations. While muscimol also substantially elevated striatal dihydroxyphenylacetic acid (DOPAC) but not homovanillic acid (HVA), bactofen did not significantly effect either DOPAC or HVA. Baclofein, GABA and muscimol displaced specific 3H-GABA binding in vitro with IC50's of 40 micron, 400 nM and 40 nM respectively. These results indicate that muscimol and baclofen do not act via a unitary GABAergic mechanism, but suggest that baclofen may be a partial GABA agonist, at least at nigral GABA receptors.
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The Soma of the Rig Vida: What was it
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