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Int.J.Environ.Res.PublicHealth2020,17,1485;doi:10.3390/ijerph17051485www.mdpi.com/journal/ijerph
Article
RoleofPerceivedSocialSupportontheAssociation
betweenPhysicalDisabilityandSymptomsof
DepressioninSeniorCitizensofPakistan
AzamTariq1,TianBeihai1,*,NadeemAbbas2,SajjadAli3,WangYao4andMuhammadImran5
1DepartmentofSociology,CollegeofHumanitiesandSocialSciences,HuazhongAgriculturalUniversity,
Wuhan430070,China;azam_tariq@webmail.hzau.edu.cn
2InstituteofSocial&CulturalStudies,UniversityofthePunjab,Lahore54000,Pakistan;
nadeem544abbas@gmail.com
3CollegeofEconomicsandManagement,HuazhongAgriculturalUniversity,Wuhan430070,China;
sajjad@webmail.hzau.edu.cn
4DepartmentofSocialSecurity,CollegeofHumanitiesandSocialSciences,HuazhongAgricultural
University,Wuhan430070,China;18627064001@163.com
5DepartmentofComputerScienceandEngineering,ShanghaiJiaoTongUniversity,Shanghai200240,
China;Muhammad_imran@sjtu.edu.cn
*Correspondence:tianbeihai@mail.hzau.edu.cn;Tel.:+86‐189‐7156‐9599
Received:12January2020;Accepted:22February2020;Published:25February2020
Abstract:Anemergingbodyofliteraturehasimpliedthatperceivedsocialsupportisknownasan
upstreamelementofcognitivehealth.Variousdimensionsofperceivedsocialsupportmayhave
divergentinfluenceonphysicalandcognitivehealthinlaterlife.Thepresentstudyaimedto
investigatethemediatingroleofperceivedsocialsupportontherelationshipbetweenphysical
disabilityandsymptomsofdepressioninseniorcitizensofPakistan.Thedatawerecollectedfrom
threemetropolitancities(Lahore,Faisalabad,Multan)inthePunjabprovinceofPakistanand100
participantswereapproachedfromeachcitywithatotalsamplesizeof300.Theresults
demonstratedthatfamilysupport,friends’support,andsignificantothers’supportmediatedthe
associationbetweenphysicaldisabilityandsymptomsofdepression,withanindirecteffectof0.024,
0.058,and0.034,respectively.Thetotaldirectandindirecteffectwas0.493.Physicaldisabilitywas
directlyassociatedwithsymptomsofdepressionandgreaterphysicaldisabilitypredictedahigher
levelofsymptomsofdepression.Perceivedsocialsupport,includingfamilysupport,friends’
support,andsignificantothers’support,showedanindirectassociationwithsymptomsof
depression.Furthermore,familysupportandfriends’supportweremoresignificantlyassociated
withsymptomsofdepressionascomparedtosignificantothers’support.Theresearchdiscoveries
havebetterimplicationsforhealthcareprofessionals,hospicecareworkers,andpolicymakers.A
holisticapproachisrequiredtopreventseniorcitizensfromlate‐lifementaldisorders.
Keywords:perceivedsocialsupport;mediator;symptomsofdepression;physicaldisability;senior
citizens
1.Introduction
AccordingtotheUnitedNation,theglobalpopulationover60yearsofagewas962millionin
2017andisexpectedtobedoubleto2.1billionbytheyear2050.Two‐thirdsofthetotalolder
populationliveindevelopingcountries.Therapidprojectionsshowthatbytheyear2050,almost8
of10elderlypeoplewillberesidentsofdevelopingregions[1].Pakistanisadevelopingcountryand
thepopulationaged60oroverwas11.3millionin2017,anditisprojectedtoincreasetomorethan
43.3millionin2050,whichwillaccountfornearly16%oftheoverallpopulation[2].
Int.J.Environ.Res.PublicHealth2020,17,14852of14
Thisrapiddemographictransitionhasledtoincreasedcomplicatedandinterconnected
problems,includingsocioeconomic,physical,social,andcognitivehealthproblemsofelderlypeople,
andpreviousstudiesdiscoveredthatdepressionintheelderlyhasbecomeaglobalpublichealth
problem[3–5].Aresearchrevealed16.52%life‐timeprevalenceofdepressioninelderlypeople.
However,theprevalenceofdepressionvariedamongcountries[6].InPakistan,theprevalenceof
depressioninseniorcitizensisrisingdaybyday,andmanystudieshavereported18%to66%inboth
ruralandurbansettings[7–10].Itisexpectedthatbytheyear2020,depressionwillbetheleading
burdenofdiseaseintheworld[11].Depressionisinterrelatedwithadversesocioeconomicoutcomes,
likeemotionalandcognitivesuffering,poverty,familyconflicts,riseinhealthcareexpenditure,and
deathrate[12].
Physicaldisabilityisdefinedasimpairmentsorlimitationsindailyactivitiesandrestrictedsocial
involvement[13].Theinabilitytoperformdailytasksofself‐careandlimitationsinanindividual’s
capacitytoparticipateinthesocialandphysicalenvironmentisalsoknownasphysicaldisability
[14].Thedeclineinphysicalhealthismostlyassociatedwithagingandactsasabigstressorinlater
life[15,16].Ithasbeenproventhatfailuretocarryoutactivitiesofdailyliving(ADL)and
instrumentalactivitiesofdailyliving(IADL)areassociatedwithdepressioninolderpeople[17,18].
Physicalorfunctionaldisabilityoftenleaveselderlypeoplevulnerabletodepression[19–22].Ithas
beenfoundthatanincreasedlevelofADLpredictsalowerlevelofdepression[23].Across‐sectional
studycarriedoutinChinawithasamplesizeof372elderlypeoplefoundthatlessdependencyin
activitiesofdailylivingwasassociatedwithlowerlevelofdepression[24].Furthermore,some
longitudinalstudiessupporttheargumentthatitleadstohighersymptomsinolderadults[25].The
giveninfluenceofphysicaldisabilityondepressionhighlightstheneedtofinddirectionstodealwith
it.
Socialsupportisoneofthefactorswhichinfluencessymptomsofdepressioninelderlypeople.
Socialsupportreferstotheseriesofaccessiblesupporttoapersonthroughtheirsocialrelationships
withotherpeople[26].Italsoincludesinformationorknowledge,emotionalaid,substantialhelp,
andself‐sufficiencythatindividualsgainthroughmutualrelationships[27].Perceivedsocialsupport,
alsoknownassubjectivesupport,isdefinedasthelevelofsatisfactionofbeingempathized,valued,
andsupportedinthesociety[28].Itrepresentshowmuchapersonfeelssafeandcompanionable[29].
Socialsupporthasreceivedsufficientattentionbecauseofitsfunctionofminimizingstressand
mentalhealthproblemsandpreventingtheharmfuleffectsofphysicaldisabilityonpsychological
well‐being[30].Perceivedsocialsupportplaystheroleofapowerfulstressreducerandhasbeen
foundtobeeffectiveinminimizingormediatingtheassociationbetweenphysicaldisabilityand
symptomsofdepression[31,32].AstudycarriedoutonTurkisholderpeoplewith102respondents
discoveredasignificanteffectofperceivedsocialsupportondepressionandfoundthatlower
perceivedsocialsupportwasassociatedwithgreaterdepression[29].Buildingupthisassociation,a
studyfoundthatsubjectivesupportmediatestherelationshipbetweenADLandsymptomsof
depressioninelderly[24].
Perceivedsocialsupportcanbefurtherdividedintothreedimensions,asfamilysupport,
friends’support,andsignificantothers’support[33].Accordingtothebestofourknowledge,there
havebeennostudiesdonetodiscovertheeffectsoffamilysupport,friends’support,andsignificant
others’supportontherelationshipbetweenphysicaldisabilityanddepressioninseniorcitizens
(peopleaged60orabove).
Accordingtothestress‐bufferinghypothesis,socialsupporthaspositiveeffectsonhealthand
well‐beingbyprotectingindividualsfromtheharmfuleffectsofstressors.Socialsupportisalso
consideredasacoppingsourceandphysicaldisabilityasastressor[34].So,itismandatorytofind
outwhatdimensionsofperceivedsocialsupportarelinkedwithphysicaldisabilityandsymptoms
ofdepression.
Theprimaryobjectiveofthepresentstudyistodiscoverwhetherperceivedsocialsupport
mediatestheassociationbetweenphysicaldisabilityandsymptomsofdepressioninseniorcitizens
livinginurbanareasoftheIslamicRepublicofPakistan.
Int.J.Environ.Res.PublicHealth2020,17,14853of14
Thecurrentstudyfirsthypothesizesthatphysicaldisabilityissignificantlyassociatedwith
greatersymptomsofdepression(H1).Then,threedimensionsofperceivedsocialsupportcould
mediatetheassociationbetweenphysicaldisability(ADL,IADL)andsymptomsofdepression(H2).
Thisstudyfurtherhypothesizesthatfamilysupportisassociatedwithsymptomsofdepressionmore
significantlythanfriends’supportandsignificantothers’support(H3),asmentionedinthe
hypotheticalmodel(Figure1).Thediscoveriesofthisinvestigationwillhighlighttheroleof
perceivedsocialsupportonphysicaldisabilityandsymptomsofdepressionandisexpectedtobe
helpfulindevelopingpoliciestopromoteperceivedsocialsupportforthewell‐beingofsenior
citizens.
Figure1.Hypotheticalmodel.
2.MaterialsandMethods
2.1.StudyParticipants
Across‐sectionaldesignstudywascarriedoutoverfourmonthsin2018withasamplesizeof
300seniorcitizenparticipantsfromthreebigcities,includingprovincialcapitalcityLahore,
Faisalabad(industrialcity),andMultan,whichisthehistoricalcityandalsoknownasacityofsaints
inthePunjabprovinceofPakistan(Figure2).Theparticipantswereapproachedthroughapurposive
samplingtechniquetoperformaninterview‐basedquestionnairewiththehelpofthreeresearch
assistantswitharelevantfieldofstudy.Participantsaged60yearsorover(theagementionedin
PakistangovernmentseniorcitizenactandreferredbyUnitedNationsOrganization),witha
willingnesstoparticipateonavoluntarybasisandabilitytocommunicateinUrdu(nationallanguage
ofPakistan)wereincludedinthestudy.Seniorcitizenswithseverehearingandsightimpairment,
severephysicalinjuries,andterminalillnesswereexcludedfromthestudy.
Int.J.Environ.Res.PublicHealth2020,17,14854of14
Figure2.SurveymapofselectedcitiesinPunjabprovince,Pakistan(source:authors’own).
Allseniorcitizenswhowerewillingtoparticipateinthisinvestigationwereinformedaboutthe
objectivesofconductingresearch.Thepersonalandprivateinformationwasensuredtobekeptsecret
andaggregatedatawereused.
2.2.MeasurementTools
2.2.1.SymptomsofDepression
Theprimarydependentoutcomevariable“symptomsofdepression”inseniorcitizenswas
assessedviatheBeckdepressioninventory(BDI)scale[35].TheBDIscaleisastandardizedandself‐
reportedmeasurementtoolthatconsistsof21itemsrangingonafour‐pointscale,0to3,andahigher
scoreoftotal63scoresindicatesahigherlevelofsymptomsofdepression.Itisawidelyusedscale
forbothclinicalandresearchpurposesandmeasuresthepresenceofcognitive,vegetative,
psychomotor,andmotivationalfeaturesofdepression[7].TheBDIscalemeasuresthemoodof
subjectsfortheprevioustwoweeks[29].ThescalehasbeentranslatedintoUrdulanguage(Pakistan
nationallanguage)andhasbeenusedinpreviousresearchinthesamesetting[7].TheCronbach
alphaforthissamplewas0.86,whichindicatesitsreliability.
2.2.2.PhysicalDisability
Physicaldisabilitywasassessedthroughactivitiesofdailyliving(ADL),includingitssubscales
[36],andinstrumentalactivitiesofdailyliving(IADL)withsubscales[37].TheADLsubscale
measuressixtypesofabilities,includingtakingbaths,feeding,dressing,toileting,transferring,and
continence.TheIADLsubscaleisusedtomeasureeighttypesofcomplexactivities,liketelephone
use,goingshopping,transportation,financehandling,laundry,takingmedicine,foodpreparation,
andhousekeeping.Thescoresrangefrom1to4andtotalscoresare56.Thehigherobtainedscores
showgreaterphysicaldisability.TheCronbachalphaforthisstudywas0.85.
Int.J.Environ.Res.PublicHealth2020,17,14855of14
2.2.3.PerceivedSocialSupport
Perceivedsocialsupportwasmeasuredbyusingamultidimensionalscaleofperceivedsocial
support(MSPSS)[38].Thisscalemeasurestheoverallscoreofperceivedsocialsupportincluding
threesubscales,Familysupport,Friendssupportandsignificantotherssupport.Thisscalehasbeen
translatedinUrdu.Furthermore,thisscalehasbeenusedinpreviousstudiesshowinggoodreliability
andpsychometricproperties[39,40].TheCronbachalphaforthecurrentsamplewas0.81.
2.3.AnalyticalTechniques
Thedataanalysiswascarriedoutthroughthestatisticalpackageforsocialsciences(IBMSPSS‐
21,IBMCorp.,Armonk,N.Y.,USA).Priortoexecutingkeyanalysis,descriptivestatisticswere
calculatedonsociodemographiccharacteristicstouncoverthedistributionofdifferentvariablesand
todetermineproportionsfortheprevalenceofdepression.Therange,mean(X),andstandard
deviation(SD)werefoundfortheperceivedsocialsupport,includingitssubscales(familysupport,
friends’support,significantothers’support),physicaldisability,andsymptomsofdepression.
Continuousvariableswereevaluatedthroughone‐wayanalysisofvariancewiththeStudent–
Newman–Keulstestforposthocmultiplecomparisons.Thecorrelationsbetweenphysicaldisability,
perceivedsocialsupport,includingitsdimensions(familysupport,friends’support,andsignificant
others’support),andsymptomsofdepressionweredetermined.
Multiplelinearregressionwasthenexecutedtodeterminethecontributionofphysicaldisability
andperceivedsocialsupport(familysupport,friends’support,significantothers’support)on
symptomsofdepression.Thesymptomsofdepressionwerekeptasadependentvariableinthis
analysis.PROCESSmodel‐4[41]wasusedtodiscoverthemediationeffectofthreedimensionsof
perceivedsocialsupportontheassociationbetweenphysicaldisabilityandsymptomsofdepression,
withsymptomsofdepressionasanoutcomevariable.
3.Results
Thesocio‐demographiccharacteristicsandsymptomsofdepressionforthecurrentsampleare
presentedinTable1.Themajorityoftheresearchparticipantsweremale(72%),theageofthe
respondentsrangedfrom60to90years,amongthem,51.6%werebetween60and69,33.6%were
between70and79years,andtheremaining14.6%were≥80yearsofage.Atotalof74.9%ofthe
respondentswereattheeducationlevelofhighschoolorless,whereasalmost25%oftherespondents
hadeducationabovehighschoollevel;55.6%participantsbelongedtoajointfamilysystem,38.6%
respondentshadafamilysizeofonetofourmembers,whereas48.6%hadfive–eight,and12.6%hada
familysizeof≥eightmembers;64.3%weremarried,39.3%werehouseholdhead,47.3%ofthe
respondentshadfamilyasasourceofincome,44%participantsbelongtothefamilywithtwoearning
hands;41.3%hadlessthan30,000PKR(PakistanRupees)andtheremainingrespondentshadmore
than30,000PKRmonthlyincome;27.6%oftherespondentswerelivingatadistancelessthan3Km
fromhospital,however,themajorityoftherespondents(52.6%)werelivingatthedistanceof4–7km
fromthehospital;14.6%oftherespondentswerenotsufferingfromanychronicdisease,whereas64.2%
hadatleastoneortwochronicdiseases,includingasthma,diabetes,andhypertension.Moreover,60%
oftheparticipantswerelivingwithaspouse,21.3%ofthemweredisabledbybirthorbecauseofan
accident,aseparateroomathomewasavailablefor52%oftheelderly,and62.6%oftherespondents
consideredtheirchildrenasfuturesecurity.
Int.J.Environ.Res.PublicHealth2020,17,14856of14
Table1.Comparisonofdifferentsocio‐demographiccharacteristicswithdepressivesymptoms.
Socio‐DemographicVariablesNo.Percentage
(%)
Symptomsof
Depression
𝑿
± SD
Fp
Gender
6.2860.013
Male2167233.14±8.67
Female842830.33±8.82
Age(Years)
25.9280.000
60–6915551.629.58±8.72
70–7910133.633.60±7.70
80yearsorabove4414.639.25±6.85
Education
10.9720.000
Primaryschoolorless5819.337.08±7.03
Middleschool8829.334.30±8.32
Highschool7926.329.07±7.94
Intermediateschool4113.629.14±10.20
Bachelor’sorabove3411.330.73±8.12
FamilyStructure
1.2210.270Joint16755.631.85±8.55
Nuclear13344.332.98±9.07
FamilySize
3.9300.021
1–411638.632.59±8.95
5–814648.633.11±8.75
Above83812.628.71± 7.68
MaritalStatus
Married
Single/Divorced/Widowed
193
107
64.3
35.6
31.31±8.82
34.23±8.45
7.7490.006
Respondent’sStatus
IsHouseholdhead
IsnotHouseholdhead
118
182
39.3
60.6
31.23±8.76
33.08±8.76
3.1750.076
CurrentSourceofIncome
Salary
Pension
Agriculture/Property
Family
6459
35
142
21.3
19.6
11.6
47.3
29.93±8.25
29.67±8.29
33.34±8.40
34.31±8.85
6.2510.000
EarningHands
1
2
3
91
132
77
20.3
44
25.6
31.42±8.99
32.91±8.15
32.49±9.59
0.7830.458
MonthlyIncome
˂30,000
≥30,000
124
176
41.3
58.6
34.16±8.06
31.08±9.07
9.1440.003
DistancefromHospital
˂3km
4–7km
≥8km
83
158
59
27.6
52.6
19.6
31.71±9.03
33.09±8.88
31.28±8.14
1.2180.297
No.ofChronicdiseases
0
1
2
3
44
110
83
63
14.6
36.6
27.6
21
31.09±9.86
33.29±7.69
32.95±9.14
30.82±9.21
1.4890.218
Livingstatus
LivingwithSpouse
Livingwithother’s
(Children/Relatives)
180
120
60
40
29.68±8.96
36.35±6.81
47.9160.000
Physicaldisability(Birth/accidental)
Disabled
Non‐disabled
64
236
21.3
78.6
34.81±8.31
31.69±8.81
6.4610.012
Int.J.Environ.Res.PublicHealth2020,17,14857of14
Smokinghabit
Smoker’s
Nonsmoker’s
130
170
43.3
56.6
32.45±8.68
32.28±8.90
0.0280.867
Childrenasafuturesecurity
Yes
No
188
112
62.6
37.3
30.51±8.75
35.44±7.98
23.7430.000
Separateroomathome
Available
Notavailable
156
144
52
48
31.50± 9.50
33.27±7.87
3.0590.081
Inresults,wecomparedthesocio‐demographicvariables,includinggender,age,levelof
education,familysystem,familysize,maritalstatus,respondentscurrentstatus,currentsourceof
income,totalearninghandsinfamily,monthlyhouseholdincome,distancefromhospital,number
ofchronicdiseases,livingstatus,physicaldisability,smokinghabit,separateroomathome,and
childrenasfuturesecurity,withthecriterionvariablesymptomsofdepression.Itwasfoundthatthe
familysystem,respondent’shouseholdstatus,totalearninghands,distancefromthehospital,
numberofchronicdiseases,smokinghabit,andhavingaseparateroomathomedidnotshow
significantassociationwithsymptomsofdepression.
Posthocmultiplecomparisonsfoundthatfemalerespondents,elderlyabovetheageof70years,
andtherespondentswithahighschoolorlowerlevelofeducationscoredsignificantlyhigheronthe
symptomsofdepressionscale.Therespondentswithafamilysizeofonetofour,
single/divorced/widowedstatus,andwithfamilyasthecurrentsourceofincomehadsignificantly
highersymptomsofdepression.Furthermore,therespondentswhosemonthlyincomewaslessthan
30,000PKR,livingwithothers(children/relatives),andinterestingly,non‐disabled,scoredhigheron
symptomsofdepression.Lastly,theparticipantswhoconsideredtheirchildrenasfuturesecurity
anddidnothaveaseparateroomathomescoredhighersymptomsofdepression.
Table2showsthePearsoncorrelationcoefficientanalysisamongphysicaldisability,perceived
socialsupport,familysupport,friends’support,significantothers’support,andsymptomsof
depression.Physicaldisabilityandsymptomsofdepressionweredirectlycorrelated(r=0.469,p<
0.01),signifyingthatgreaterphysicaldisabilityintheelderlywasdirectlyassociatedwithahigher
levelofsymptomsofdepression,whereasperceivedsocialsupport,familysupport,friends’support,
andsignificantothers’supportwereindirectlyassociatedwithsymptomsofdepression(r=−0.411,
−0.344,−0.343,−0.379,p<0.01),indicatingthatahigherlevelofperceivedsocialsupport,family
support,friends’support,andsignificantothers’supportwasassociatedwithalowerlevelof
symptomsofdepression.Thisstudyfoundanindirectcorrelationbetweenperceivedsocialsupport
andphysicaldisability(r=−0.432,p<0.01).Likewise,threedimensionsofperceivedsocialsupport
(familysupport,friends’support,significantothers’support)wereinverselycorrelatedwithphysical
disability(r=−0.177,−0.275,−0.263,p<0.01),suggestingthatgreaterphysicaldisabilitywas
associatedwithalowerleveloffamilysupport,friends’support,andsignificantothers’support.
Table2.DescriptivestatisticsandPearsoncorrelationanalysis.
VariablesRangeMeanSD
Perceived
Social
Support
Family
Support
Friends’
Support
Significant
Others’
Support
Symptoms
of
Depression
Physicaldisability
(ADL,IADL)22–5235.976.61−0.432**−0.177**−0.275**−0.263**0.469**
Perceivedsocial
support 21–7143.4410.03‐ 0.699**0.472**0.667**−0.411**
Familysupport4–2615.144.53‐ ‐0.231**0.480**−0.344**
Friends’support4–2613.035.34‐ ‐ ‐ 0.215**−0.343**
Significantothers’
support4–2615.723.95‐ ‐ ‐ ‐ −0.379**
Symptomsof
Depression15–5732.358.79‐ ‐ ‐ ‐ ‐
SD=Standarddeviation,**=Correlationissignificantat0.01level.
Int.J.Environ.Res.PublicHealth2020,17,14858of14
Thesocio‐demographicvariableswithasignificantinfluenceonsymptomsofdepressionwere
involvedinamultiplelinearregressionmodel.Hence,thegender,age,levelofeducation,marital
status,whotheywerelivingwith,familysize,currentsourceofincome,averagemonthlyincome,
physicaldisability(birth/accidental),andchildrenasfuturesecuritywereconsideredconfounding
variablesandwerecontrolledinthecurrentanalysis.Priortorunningmultiplelinearregression,it
wasensuredthattherewasnoviolationofassumptionslikenormality,linearity,and
multicollinearity.Theresults(R2=0.452,F=10.935,p<0.01)showthesignificanceoftheregression
model.Adirectassociationwasfoundbetweenphysicaldisabilityandsymptomsofdepression(β=
0.244,p<0.01),aspredictedinH1,andalowerlevelofphysicaldisabilitywasassociatedwithalower
levelofsymptomsofdepressioninelderlypeople.Theresultsdemonstratethatfamilysupport(β=
−0.152,p<0.01),friends’support(β=−0.136,p<0.01),andsignificantothers’support(β=−0.120,p<
0.05)wereinverselyassociatedwithsymptomsofdepressionamongolderpeople.Moreover,family
support(β=−0.152)hadmorenegativeassociationwithsymptomsofdepressionascomparedto
friends’support(β=−0.136),andsignificantothers’support(β=−0.120)(Table3).
Int.J.Environ.Res.PublicHealth2020,17,14859of14
Table3.Multiplelinearregressiononsymptomsofdepression.
DependentVariable:SymptomsofDepressionUnstandardizedCoefficientStandardizedCoefficient
B(SE)Β
Gender−2.503(0.944)−0.128**
Age(Years)(Ref.60‐69)
70–79
80orabove
−0.430(0.997)
2.899(1.480)
−0.023
0.117*
LevelofEducation(Ref.Primaryorless)
Middle(8Years)
Highschool(10years)
Highersecondaryschool(12years)
Bachelor’sorabove
0.977(1.268)
−3.074(1.313)
−2.749(1.507)
−1.207(1.731)
0.051
−0.154*
−0.108
−0.044
Maritalstatus −0.816(0.968)−0.045
Livingwith 1.516(1.064)0.085
Familysize(Ref.1–4members)
5–8
Above8
0.180(0.918)
−1.617(1.418)
0.010
−0.057
Currentsourceofincome(Ref.Salary)
Pension
Agriculture/property
Family
1.082(1.283)
2.191(1.536)
1.550(1.183)
0.049
0.080
0.088
Averagemonthlyincome(PKR)−1.478(0.855)−0.083
Physicaldisability(birth/accidental)−1.205(1.045)−0.056
Childrenasfuturesecurity0.617(0.915)0.034
Physicaldisability(ADL,IADL)0.325(0.078)0.244**
Familysupport−0.294(0.102)−0.152**
Friends’support−0.224(0.082)−0.136**
Significantothers’support−0.268(0.122)−0.120*
R20.452
F10.935**
Ref=Reference,SE=StandardError,**=p˂0.01,*=p˂0.05.
Themediatingeffectofthreedimensionsofperceivedsocialsupport(familysupport,friends’
support,significantothers’support)ontheassociationbetweenphysicaldisabilityandsymptomsof
depressionismentionedinTable4.PROCESSmacromodel‐4(v3.3)
(http://www.processmacro.org/download.html)wasusedtoanalyzethedirectandindirecteffectof
threedimensionsofperceivedsocialsupportandphysicaldisability[41].Thisanalysiswas
performedthroughbootstrappingstrategywith5000resamples.Statusofresidenceandaverage
monthlyincomewereusedascovariates.
Table4.MediationeffectanalysisbasedonPROCESS(Model4).
VariablesB(SE)LLCIULCI
Outcomevariable:Symptomsofdepression
Physicaldisability0.4952**(0.074)0.34830.6421
Averagemonthlyincome−2.7784**(0.883)−4.5172−1.0395
Statusofresidence3.4804**(1.005)1.50165.4591
R2
F
0.273
37.207**
Outcomevariable:Symptomsofdepression
Familysupport−0.296**(0.102)−0.498−0.094
Friends’support−0.287**(0.080)−0.445−0.128
Significantothers’support−0.331**(0.120)−0.568−0.093
Physicaldisability0.377**(0.071)0.2360.518
Averagemonthlyincome−2.621**(0.821)−4.238−1.004
Statusofresidence2.518**(0.948)0.6524.385
R2
F
0.379
29.902**
Ref=Reference,SE=StandardError,LLCI=Lowerlevelconfidenceinterval,ULCI=Upperlevel
confidenceinterval,**=p˂0.01.
Int.J.Environ.Res.PublicHealth2020,17,148510of14
Theresultsindicatethesignificanceofoverallmodels(R
2
=0.273,0.379,F=37.207,29.902,p<
0.01).Itwasfoundthatphysicaldisabilitywasstronglyassociatedwithsymptomsofdepression(B
=0.495,p<0.01)beforeenteringperceivedsocialsupportintotheequation,whereasthiseffectwas
thenmediatedto(B=0.377,p<0.01)byfamilysupport(B=−0.296,p<0.01),friends’support(B=
−0.287,p<0.01),andsignificantothers’support(B=−0.331,p<0.01).Theindirecteffectoffamily
support,friends’support,andsignificantothers’supportwas0.024(−0.084×−0.296),0.058(−0.203×
−0.287),0.034(−0.103×−0.331),respectively.Thetotaldirectandindirecteffectwas0.493(0.377+
0.024+0.058+0.034).Theresultsdemonstrate,ashypothesizedinH2,thatthreedimensionsof
perceivedsocialsupport(familysupport,friends’support,significantothers’support)play
mediatingrolesontheassociationbetweenphysicaldisabilityandsymptomsofdepressioninsenior
citizens(Figure3).
Figure3.Mediatingeffectofperceivedsocialsupportaffectingphysicaldisabilityandsymptomsof
depressionamongseniorcitizensofPakistan(N=300).
4.Discussion
Thepresentresearchconcurrentlydiscoveredtheassociationsamongperceivedsocialsupport,
physicaldisability,andsymptomsofdepressionandexaminedthemediatingeffectoffamily
support,friends’support,andsignificantothers’supportontheassociationbetweenphysical
disabilityandsymptomsofdepressioninseniorcitizens.Controlvariableslikethestatusofresidence
andaveragemonthlyincome,ifnotincluded,couldperhapsconfusetheassociationsbetween
perceivedsocialsupport,physicaldisability,andsymptomsofdepression.
Thesociodemographiccharacteristicsthatweresignificantlyassociatedandshowedhigher
levelsofsymptomsofdepressionindicatethesecuresocialstatus,higherself‐adjustment,greater
adaptabilitytothesocialsituationsandtheproperutilizationofavailablesocialsupport.Hence,
unavailabilityofthesameleadstogreatermentaldistress[42].Therisksoflate‐lifedepressionmay
beminimizedbyimprovingsocialrelationships,strengtheningties,andmostimportantly,enhancing
theutilizationofexistingsocialsupportratherthanstipulatingotherresourcesofsupport[24].
Thecurrentstudydiscoveredasignificantdirectassociationbetweenphysicaldisabilityand
symptomsofdepressionbyconfirmingthepreviousresearchfindingsoftheassociationbetween
limitationsinactivitiesandsocio‐psychologicalproblems[17,24].AstudydoneinPakistanonrural
elderlypeoplewhichincluded146respondentsfoundadirectrelationshipbetweenphysical
disabilityanddepression[43].Furthermore,astudyfoundsimilarresultsthatlowerADL(activities
ofdailyliving)functioningwasassociatedwithagreaterlevelofdepressionintheelderly[29],and
ithasanegativeimpactoncognitivehealthandisafundamentalcauseofsocio‐psychological
problemsinolderpeople[19,21,22,44].
Int.J.Environ.Res.PublicHealth2020,17,148511of14
Thethreedimensionsofperceivedsocialsupport(familysupport,friends’support,and
significantothers’support)werefoundtobeinverselyassociatedwithsymptomsofdepression.A
studycarriedonTurkishelderlywith102participantsfoundthathigherperceivedsocialsupport
predictedlowerlevelofdepression[29].Furthermore,subjectivesupport(perceivedsocialsupport)
showedaninverserelationshipbetweenactivitiesofdailylivinganddepressivesymptomsin
Chineseelderly[24].Inaddition,ourfindingsshowedthatfamilysupportandfriends’supporthave
moresignificantassociationswithsymptomsofdepressionascomparedtosignificantothers’
support.Citizenwelfaretrustconductedresearchanddiscoveredthatalmost98%ofthesenior
citizensofPakistanfavorlivingwithfamilyratherthanstayingatoldagehomesorsomewhereelse
[45].Sufficientliteratureisavailablesuggestingthatfamilysupportandinformalfriendsupportare
theprimarysourcesofemotionalsupportfortheelderly[46–48].Moreover,itwasfoundthatfamily
supportandfriends’supportisimportantforelderlypeopleofAsia[49–51].Conventionally,elderly
peoplemostlyseekcareandsupportfromthefamilymembers[52].
Thefindingsofthemediationeffectmodelshowthatfamilysupport,friends’support,and
significantothers’supportmediatedtheeffectontherelationshipbetweenphysicaldisabilityand
symptomsofdepression.Lowerphysicaldisabilitywassignificantlyassociatedwithalowerlevelof
symptomsofdepression.Astudyconductedon372Chineseelderlyfoundthatperceivedsocial
supportandutilizationofsupportmediatedtherelationshipbetweenimpairmentofADLand
depression[24].Ourresearchcontributestoexistingliteraturewithin‐depthdiscoveriesandhas
imperativeinferencesforgeriatricprofessionals,careproviders,andpolicyinterventions,as
perceivedsocialsupportismoreacquiescenttocope.Previousstudiesfocusedondifferent
dimensionsofsocialsupportandmostlycheckedthedirecteffect,buttherecentinvestigationis
uniqueonthebasisofitsobjectivesandmethodology.Ourfindingssuggestthatintheabsenceof
anyofthethreedimensionsofperceivedsocialsupport,seniorcitizenswithphysicaldisabilityhave
agreaterriskofsufferingfromsymptomsofdepressioninlateryearsoflife,andemphasizethe
significanceoftheperceivedsupportfromfamily,friends,andsignificantotherstopreventphysical
andcognitivehealthobstaclesinlatelife.
Thecurrentresearchhasstrengthsandsomelimitations.Accordingtoourknowledge,basedon
theexistingliterature,thisisthefirst‐everstudy,especiallyforthePakistancontext,whichhas
investigatedtheroleofperceivedsocialsupportontheassociationbetweenphysicaldisabilityand
depressioninseniorcitizensofthreemetropolitancitiesofthePunjabprovinceofPakistan.This
researchfilledtheliteraturegapfromadifferentpointofview,byfindingtheinfluenceofphysical
disabilityonsymptomsofdepressionratherthanfindingtheinfluenceofsymptomsofdepression
onphysicaldisability,asinpreviousstudies.Inlimitations,thedatawerecollectedfromthree
differentcities,whichmayaffectthegeneralizabilityofthefindings.Furthermore,thesamplesizeof
thestudymaybeconsideredasalimitation,andthecross‐sectionalapproachcanaffectthedirect
casualevidence;thus,furtherstudiesbasedonthelongitudinalapproachandwithalargersample
sizearerecommendedtodiscovercausality.
5.Conclusions
Thecurrentstudyattemptedtodiscovertheroleofperceivedsocialsupport(familysupport,
friends’support,significantothers’support)asamediatorontheassociationbetweenphysical
disabilityandsymptomsofdepressioninseniorcitizensofPakistan.Themajordiscoveriesinthis
researchmaynotbesurprising,becausePakistan’scultureisbasedoncollectivism,asacollectivist
culturereferstothestructureofsocietyinwhichindividualsgiveprioritytocommitment,
conformity,andgrouployalty,andpossessionofasenseofbelongingratherstayinginisolation[53].
Currently,rapiddemographicchangetoindividualismandthenuclearfamilysystemhasledsenior
citizenstosufferfromsocialisolation,withalackofperceivedsocialsupport.Ourfindingssuggest
thatallthreedimensions,familysupport,friends’support,andsignificantothers’support,of
perceivedsocialsupportareimportanttomediatetheassociationbetweenphysicaldisabilityand
symptomsofdepression.Thefindingsfacilitatetheevidencethatperceivedsocialsupport,including
itsdimensions,haspassiveconsequencesonphysicallimitationsandsymptomsofdepressionamong
Int.J.Environ.Res.PublicHealth2020,17,148512of14
seniorcitizens.Furthermore,itwasfoundthatalowerlevelofperceivedsocialsupportleadsto
greatersymptomsofdepression.
Inshort,themajordiscoveriesrevealedthatperceivedsocialsupportanditsdimensionsare
negativelycorrelatedwithsymptomsofdepression,whilephysicaldisabilityshowedadirect
associationwithsymptomsofdepressionandthethreedimensionsofperceivedsocialsupportplay
theroleofmediatorontheassociationbetweenphysicaldisabilityandsymptomsofdepression.The
findingsrevealthedifficultiesinthelivesfacedbyseniorcitizens.Developinginterventionpolicies
andprogramstosafeguardseniorcitizensfromdebilitatingeffectsintheabsenceofperceivedsocial
supportandprovidingbothmaterialandnonmaterialaidforindependentlivingtodiminishthe
vulnerabilitytophysicalandcognitivehealthdisordersinseniorcitizensarehighlyneededto
facilitatethemwithabetterqualityoflifeintheirlateyearsoflife.
AuthorContributions:Conceptualization,A.T.;datacuration,A.T.andW.Y.;formalanalysis,A.T.;
investigation,N.A.andS.A.;methodology,N.A.;software,W.Y.andM.I.;supervision,T.B.;validation,S.A.;
writing—originaldraft,A.T.;writing—reviewandediting,T.B.Allauthorshavereadandagreedtothe
publishedversionofthemanuscript.
Funding:Thisresearchreceivednoexternalfunding.
Acknowledgments:TheauthorsacknowledgeMuhammadZubair(CollegeofVeterinaryMedicine,Huazhong
AgriculturalUniversity,Wuhan,China)andMuhammadFaisal(PostdoctoralResearchscientist,TheOhioState
UniversityWexnerMedicalCenter,Ohio,Columbus,USA)fortheirguidanceandmoralsupportthroughout
theresearch.Furthermore,theauthorsaregratefultotheanonymousreviewersfortheirhelpfulcommentsand
suggestionsonanearliermanuscript.
ConflictsofInterest:Theauthorsdeclarednoconflictofinterestinthismanuscript.
References
1. UnitedNationsDepartmentofEconomicandSocialAffairs,PopulationDivision.WorldPopulationAgeing
2017—Highlights(ST/ESA/SER.A/397);UnitedNations:NewYork,NY,USA,2017.
2. Ashiq,U.;Asad,A.Z.TherisingoldageprobleminPakistan.J.Res.Soc.Pakistan2017,2,325–333.
3. Janssen,B.M.;VanRegenmortel,T.;Abma,T.A.Identifyingsourcesofstrength:Resiliencefromthe
perspectiveofolderpeoplereceivinglong‐termcommunitycare.Eur.J.Ageing2011,8,145–156.
4. Lino,V.T.S.;Portela,M.C.;Camacho,L.A.B.;Atie,S.;Lima,M.J.B.;Rodrigues,N.C.P.;Barros,M.B.D.L.;
Andrade,M.K.D.N.Screeningfordepressioninlow‐incomeelderlypatientsattheprimarycarelevel:Use
ofthepatienthealthquestionnaire‐2.PLoSONE2014,9,e113778.
5. Burke,K.E.;Schnittger,R.;O’Dea,B.;Buckley,V.;Wherton,J.;Lawlor,B.A.Factorsassociatedwith
perceivedhealthinolderadultIrishpopulation.AgingMent.Health2012,16,288–295.
6. Volkert,J.;Schulz,H.;Härter,M.;Wlodarczyk,O.;Andreas,S.Theprevalenceofmentaldisordersinolder
peopleinWesterncountries—Ameta‐analysis.AgeingRes.Rev.2013,12,339–353.
7. Zubair,B.U.;Mansoor,S.Prevalenceofdepressionandassociatedsociodemographicfactorsinelderly
ruralpopulation.J.PakistanPsychiatr.Soc.2015,12,19–22.
8. Javed,S.;Mustafa,N.Prevalenceofdepressioninvariousdemographicvariablesamongelderly.Open
AccessSci.Rep.2013,2,1–4.
9. Qadir,F.;Haqqani,S.;Khalid,A.;Huma,Z.;Medhin,G.Apilotstudyofdepressionamongolderpeople
inRawalpindi,Pakistan.BMCRes.Notes2014,7,409.
10. Taqui,A.M.;Itrat,A.;Qidwai,W.;Qadri,Z.Depressionintheelderly:Doesfamilysystemplayarole?A
cross‐sectionalstudy.BMCPsychiatry2007,7,57.
11. Bassett,E.;Moore,S.Mentalhealthandsocialcapital:Socialcapitalasapromisinginitiativetoimproving
thementalhealthofcommunities.InCurrentTopicsinPublicHealth;IntechOpen:London,UK,2013.
12. Alexopoulos,G.S.Depressionintheelderly.Lancet2005,365,1961–1970.
13. InternationalClassificationofFunctioningDisabilityandHealth,WorldHealthOrganization,WHO:Geneva,
Switzerland,2001.
14. Bruce,M.L.Depressionanddisabilityinlatelife:Directionsforfutureresearch.Am.J.Geriatr.Psychiatry
2001,9,102–112.
15. Verbrugge,L.M.;Jette,A.Thedisablementprocess.Soc.Sci.Med.1994,38,1–14.
Int.J.Environ.Res.PublicHealth2020,17,148513of14
16. Topinkova,E.Aging,disabilityandfrailty.Ann.Nutr.Metab.2008,52,6–11.
17. Bowen,M.E.;Ruch,A.Depressivesymptomsanddisabilityriskamongolderwhiteandlatinoadultsby
nativitystatus.J.AgingHealth2015,27,1286–1305.
18. Hybels,C.F.;Pieper,C.F.;Blazer,D.G.Thecomplexrelationshipbetweendepressivesymptomsand
functionallimitationsincommunity‐dwellingolderadults:Theimpactofsubthresholddepression.Psychol.
Med.2009,39,1677–1688.
19. Hirsch,J.;Walker,K.L.;Chang,E.C.;Lyness,J.M.Illnessburdenandsymptomsofanxietyinolderadults:
Optimismandpessimismasmoderators.Int.Psychogeriatrics2012,24,1614–1621.
20. Jang,Y.;Haley,W.E.;Small,B.J.;Mortimer,J.A.Theroleofmasteryandsocialresourcesintheassociations
betweendisabilityanddepressioninlaterlifeforacomprehensivereviewonlate‐lifedisabilityandde‐
pression.Gerontologist2002,42,807–813.
21. Paukert,A.L.;Pettit,J.W.;Kunik,M.E.;Wilson,N.;Novy,D.M.;Rhoades,H.M.;Greisinger,A.J.;
Wehmanen,O.A.;Stanley,M.A.Therolesofsocialsupportandself‐efficacyinphysicalhealth’simpacton
depressiveandanxietysymptomsinolderadults.J.Clin.Psychol.Med.Settings2010,17,387–400.
22. Thompson,W.W.;Zack,M.M.;Krahn,G.L.;Andresen,E.M.;Barile,J.Health‐relatedqualityoflifeamong
olderadultswithandwithoutfunctionallimitations.Am.J.PublicHealth2012,102,496–502.
23. Bhamani,M.A.;Khan,M.M.;Karim,M.S.;Mir,M.U.Depressionanditsassociationwithfunctionalstatus
andphysicalactivityintheelderlyinKarachi,Pakistan.AsianJ.Psychiatry2015,14,46–51.
24. Xie,H.;Peng,W.;Yang,Y.;Zhang,D.;Sun,Y.;Wu,M.;Zhang,J.;Jia,J.;Su,Y.Socialsupportasamediator
ofphysicaldisabilityanddepressivesymptomsinChineseelderly.Arch.Psychiatr.Nurs.2018,32,256–262.
25. Lin,I.‐F.;Wu,H.‐S.DoesinformalcareattenuatethecycleofADL/IADLdisabilityanddepressive
symptomsinlatelife?JGerontol.B‐Psychol.2011,66,585–594.
26. Cooke,B.D.;Rossmann,M.M.;Mccubbin,H.I.;Joan,M.;Mccubbin,H.;Patterson,J.M.DefinitionResource
SocialSupport :IndividualsFamilies.Fam.Relat.1988,37,211–216.
27. Revenson,A.T.;Gibofsky,A.NoTitleMarriage,socialsupport,andadjustmenttorheumaticdisease.Bull.
Rheum.Dis.1995,44,5–8.
28. Xiao,S.Y.Thetheoreticalbasisandapplicationsofsocialsupportquestionaire.J.Clin.Psychol.Med.Settings
1994,4,98–100.
29. Bozo,Ö.;Toksabay,N.E.;Kürüm,O.Activitiesofdailyliving,depression,andsocialsupportamong
elderlyturkishpeople.J.Psychol.Interdiscip.Appl.2009,143,193–206.
30. Azam,W.M.Y.W.M.;Din,N.C.;Ahmad,M.;Ghazali,S.E.;Ibrahim,N.;Said,Z.;Ghazali,A.R.;Shahar,S.;
Razali,R.;Maniam,T.Lonelinessanddepressionamongtheelderlyinanagriculturalsettlement:
Mediatingeffectsofsocialsupport.AsiaPac.Psychiatry2013,5,134–139.
31. Taylor,M.G.;Lynch,S.M.Trajectoriesofimpairment,socialsupport,anddepressivesymptomsinlaterlife.
JGerontol.B‐Psychol.2004,59,S238–S246.
32. Yang,Y.Howdoesfunctionaldisabilityaffectdepressivesymptomsinlatelife?Theroleofperceivedsocial
supportandpsychologicalresources.J.HealthSoc.Behav.2006,47,355–372.
33. Väänänen,J.‐M.;Marttunen,M.;Helminen,M.;Kaltiala‐Heino,R.Lowperceivedsocialsupportpredicts
laterdepressionbutnotsocialphobiainmiddleadolescence.HealthPsychol.Behav.Med.2014,2,1023–1037.
34. Thoits,P.A.Stress,coping,andsocialsupportprocesses:Wherearewe?Whatnext?J.HealthSoc.Behav.
1995,35,53–79.
35. Beck,A.T.;Steer,R.A.;Brown,G.K.ManualfortheBeckDepressionInventory,2nded.;Psychological
Corporation:SanAntonio,TX,USA,1996.
36. Katz,S.;Ford,A.B.;Moskowitz,R.W.;Jackson,B.A.;Jaffe,M.W.Studiesofillnessintheaged.Theindexof
ADL:Astandardizedmeasureofbiologicalandpsychosocialfunction.Jama1963,185,914–919.
37. Lawton,M.P.;Brody,E.M.Assessmentofolderpeople:Selfmaintainingandinstrumentalactivitiesofdaily
living.Gerontologist1969,9,1979–1986.
38. Zimet,G.D.;Dahlem,N.W.;Zimet,S.G.;Gordon,K.;Farley,G.K.Themultidimensionalscaleofperceived
socialsupportthemultidimensionalscaleofperceivedsocialsupport.J.Pers.Assess.1988,52,30–41.
39. Akhtar,A.;Rahman,A.;Husain,M.;Chaudhry,I.B.;Duddu,V.;Husain,N.Multidimensionalscaleof
perceivedsocialsupport:PsychometricpropertiesinaSouthAsianpopulation.J.Obstet.Gynaecol.Res.2010,
36,845–851.
Int.J.Environ.Res.PublicHealth2020,17,148514of14
40. Ashfaq,A.;Lashari,U.G.;Saleem,S.;Naveed,S.;Tariq,H.;Waqas,A.;Meraj,H.Exploringsymptomsof
post‐traumaticstressdisordersandperceivedsocialsupportamongpatientswithburninjury.Cureus2018,
10,e2669.
41. Hayes,A.F.IntroductiontoMediation,Moderation,andConditionalProcessAnalysis;TheGuilfordPress:New
York,NY,USA,2013.
42. Ma,W.;Kang,D.;Song,Y.;Wei,C.;Marley,G.;Ma,W.SocialsupportandHIV/STDsinfectionsamonga
probability‐basedsampleofruralmarriedmigrantwomeninShandongProvince,China.BMCPublic
Health2015,15,1170.
43. Tariq,A.;Beihai,T.;Ali,S.;Abbas,N.;Ilyas,A.Mediatingeffectofcognitivesocialcapitalonthe
relationshipbetweenphysicaldisabilityanddepressioninelderlypeopleofruralPakistan.Int.J.Environ.
Res.PublicHealth2019,16,4232.
44. Verbrugge,L.M.;Patrick,D.L.Sevenchronicconditions:TheirimpactonUSadults’activitylevelsanduse
ofmedicalservices.Am.J.PublicHealth1995,85,173–182.
45. Dawn,D.ChallengesforSeniorCitizens.Availableonline:
https://www.dawn.com/news/663749/challenges‐for‐senior‐citizens(accessedon24February2020).
46. Williams,B.R.;Baker,P.S.;Allman,R.M.;Roseman,J.M.BerrcavementamongAfricanAmericanandwhite
olderadults.J.AgingHealth2007,19,313–333.
47. Cheng,S.T.;Lee,C.K.L.;Chan,A.C.M.;Leung,E.M.F.;Lee,J.J.Socialnetworktypesandsubjectivewell‐
beinginChineseolderadults.JGerontol.B‐Psychol.2009,64,713–722.
48. Deng,J.;Hu,J.;Wu,W.;Dong,B.;Wu,H.Subjectivewell‐being,socialsupport,andage‐relatedfunctioning
amongtheveryoldinChina.Int.J.Geriatr.Psychiatry2009,25,697–703.
49. Chao,S.‐F.Functionaldisabilityandpsychologicalwell‐beinginlaterlife:Doessourceofsupportmatter?
AgingMent.Health2012,16,236–244.
50. Poulin,J.;Deng,R.;Ingersoll,T.S.;Witt,H.;Swain,M.Perceivedfamilyandfriendsupportandthe
psychologicalwell‐beingofAmericanandChineseelderlypersons.J.CrossCulturalGerontol.2012,27,305–
317.
51. Merz,E.;Consedine,N.S.Theassociationoffamilysupportandwellbeinginlaterlifedependsonadult
attachmentstyle.Attach.Hum.Dev.2009,11,203–221.
52. Wu,Z.;Sun,L.;Sun,Y.‐H.;Zhang,X.‐J.;Tao,F.‐B.;Cui,G.‐H.Correlationbetweenlonelinessandsocial
relationshipamongemptynestelderlyinAnhuiruralarea,China.AgingMent.Health2010,14,108–112.
53. Hogg,M.A.;Vaughan,G.M.SocialPsychology;Sage:London,UK,2003.
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