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MolCom system with downlink/uplink biocyber interface for Internet of Bio‐NanoThings

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Saied M. Abd El-atty at Menoufia University
Saied M. Abd El-atty
Reda Bidar
Reda Bidar
Reda Bidar
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El-Sayed Mahmoud El-Rabaie at Faculty of Electronic Engineering, Menouf
El-Sayed Mahmoud El-Rabaie
  • Faculty of Electronic Engineering, Menouf
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Abstract and Figures

Inspired by wireless communication systems, we propose a feasible downlink/uplink biocyber interface for the expected targeted drug delivery system based on Internet of Biological NanoThing (IoBNT) paradigm. The downlink/uplink biocyber interface of IoBNT comprises Fluorescence Resonance Energy Transfer (FRET) and Molecular Communication (MolCom) technology. On the downlink (from Internet to targeted nanonetwork), the biocyber interface transduces electromagnetic (EM) signal to biochemical signals, and thus with the help of mobile MolCom system based on FRET nanocommunication, the drug information delivers to the diseased cell within the targeted intrabody nanonetwork. On the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical signal to EM signal. As a result, the paradigm of IoBNT responses by proper functions to these changes according to the decision of medical health care. The performance analysis of the proposed IoBNT system is numerically investigated through MolCom system‐based FRET, while the performance evaluation is evaluated by employing spreading epidemic scheme in terms of successful probability of drug delivery, channel capacity, average drug‐delivery time, and throughput. The simulation results show that the proposed IoBNT is a promising paradigm for smart drug delivery system, and its performance is mainly based on the nanostructure and the characteristic of molecular nanomachines in the targeted nanonetwork.
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RESEARCH ARTICLE
MolCom system with downlink/uplink biocyber interface
for Internet of Bio‐NanoThings
Saied M. Abd El‐atty | Reda Bidar | El‐Sayed M. El‐Rabaie
Department of Electronics and Electrical
Communications Engineering, Faculty of
Electronic Engineering the Menoufia
University, 32952 Menouf, Egypt
Correspondence
Saied M. Abd El‐atty, Department of
Electronics and Electrical
Communications Engineering, Faculty of
Electronic Engineering, the Menoufia
University, 32952 Menouf, Egypt.
Email: sabdelatty@gmail.com;
sabdelatty@el‐eng.menofia.edu.eg
Summary
Inspired by wireless communication systems, we propose a feasible
downlink/uplink biocyber interface for the expected targeted drug delivery
system based on Internet of Biological NanoThing (IoBNT) paradigm.
The downlink/uplink biocyber interface of IoBNT comprises Fluorescence
Resonance Energy Transfer (FRET) and Molecular Communication
(MolCom) technology. On the downlink (from Internet to targeted nano-
network), the biocyber interface transduces electromagnetic (EM) signal
to biochemical signals, and thus with the help of mobile MolCom system
based on FRET nanocommunication, the drug information delivers to
the diseased cell within the targeted intrabody nanonetwork. On the
uplink, the MolCom system consists of embedded sensor/actuator nano-
network to detect the biochemical changes in the targeted cell, and hence
biocyber interface transduces the biochemical signal to EM signal. As a
result, the paradigm of IoBNT responses by proper functions to these
changes according to the decision of medical health care. The perfor-
mance analysis of the proposed IoBNT system is numerically investigated
through MolCom system‐based FRET, while the performance evaluation
is evaluated by employing spreading epidemic scheme in terms of success-
ful probability of drug delivery, channel capacity, average drug‐delivery
time, and throughput.The simulation results show that the proposed IoBNT
is a promising paradigm for smart drug delivery system, and its performance is
mainly based on the nanostructure and the characteristic of molecular
nanomachines in the targeted nanonetwork.
KEYWORDS
biocyber interface, FRET, IoBNT, molecular communication (MolCom), nanomachine, nanonetwork
1|INTRODUCTION
Inspired by a conventional communication system, a molecular communication (MolCom) system has been accom-
plished. In the MolCom system, the nanoscale information transfers between nanotransmitter and nanoreceiver in
the form of molecules instead of electromagnetic (EM) wave.
1
Additionally, the Forster resonance energy transfer
(FRET) phenomenon has been exploited to transfer nanoscale information in the form of exciton [31].The main
application of the MolCom system is in the field of nanomedical and drug delivery system.
2-4
Moreover, the
Received: 17 March 2019 Revised: 16 July 2019 Accepted: 11 August 2019
DOI: 10.1002/dac.4171
Int J Commun Syst. 2020;33:e4171.
https://doi.org/10.1002/dac.4171
© 2019 John Wiley & Sons, Ltd.wileyonlinelibrary.com/journal/dac 1of21
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