Clinical Case Reports International Clinical Image

Full text

Remedy Publications LLC., | http://clinicalcasereportsint.com/
Clinical Case Reports International
2019 | Volume 3 | Article 1088
1
Clinical Image
A 32-year-old male patient was found with laptospirosis by testing his serum anti-leptospira
(Laptospira-IgM level: >100 U/mL) and later on, hospitalized due to respiratory distress, high
grade fever and muscle weakness. Glucose-6-Phosphate Dehydrogenase (G6PDH) deciency was
detected by performing serum G-6-PD quantitative test (level: 1.5 U/g Hb). During admission, his
hemoglobin, red blood cell count, haematocrit, SaO2, bilirubin, aspartate aminotransferase, alanine
aminotransferase and album was 8.60 g/dL, 2.82 M/µL, 27.6, 83%, 40 mg/dL, 1527 U/L, 2074 U/L
and 2.7 g/dL, respectively. Patient was intubated (with tracheostomy). His acute hemolytic anemia
was severe and uncontrolled blood loss was observed (Figure 1).
G6PDH is a centrally responsible enzyme in pentose phosphate pathway of cells. G6PDH
deciency is a genetic abnormality and mostly becomes latent. G6PDH deciency can be triggered
by a stimulus and in this case, it was triggered by laptospirosis within a very short time [1].
Leptospirosis- Induced Glucose-6-Phosphate
Dehydrogenase Deciency
OPEN ACCESS
*Correspondence:
MD. Jahidul Hasan, Department of
Clinical Pharmacy, Square Hospitals
Ltd., 18/F, Bir Uttam Qazi Nuruzzaman
Sarak, West Panthapath, Dhaka-1205,
Bangladesh, Tel: +8801911011167;
E-mail: jahidrj@gmail.com
Received Date: 25 Jan 2019
Accepted Date: 01 Feb 2019
Published Date: 04 Feb 2019
Citation:
MD. Jahidul Hasan. Leptospirosis-
Induced Glucose-6-Phosphate
Dehydrogenase Deciency. Clin Case
Rep Int. 2019; 3: 1088.
Copyright © 2019 MD. Jahidul
Hasan. This is an open access
article distributed under the Creative
Commons Attribution License, which
permits unrestricted use, distribution,
and reproduction in any medium,
provided the original work is properly
cited.
Clinical Image
Published: 04 Feb, 2019
MD. Jahidul Hasan*
Department of Clinical Pharmacy, Square Hospitals Ltd., Bangladesh
Figure 1: Profuse bleeding through tracheostomy site due to G6PDH deciency.
Reference
Ong KIC, Kosugi H, oeun S, Araki H, andar MM, Iwagami M, et al. Systematic review of the clinical
manifestations of glucose-6-phosphate dehydrogenase deciency in the Greater Mekong Subregion: implications
for malaria elimination and beyond. BMJ Glob Health. 2017;2(3):e000415.
1.