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Comprehensive Geriatric Assessment as a Versatile Tool to Enhance the Care of the Older Person Diagnosed with Cancer

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The comprehensive geriatric assessment (CGA) is a versatile tool for the care of the older person diagnosed with cancer. The purpose of this article is to detail how a CGA can be tailored to Ambulatory Geriatric Oncology Programs (AGOPs) in academic cancer centers and to community oncology practices with varying levels of resources. The Society for International Oncology in Geriatrics (SIOG) recommends CGA as a foundation for treatment planning and decision-making for the older person receiving care for a malignancy. A CGA is often administered by a multidisciplinary team (MDT) composed of professionals who provide geriatric-focused cancer care. CGA can be used as a one-time consult for surgery, chemotherapy, or radiation therapy providers to predict treatment tolerance or as an ongoing part of patient care to manage malignant and non-malignant issues. Administrative support and proactive infrastructure planning to address scheduling, referrals, and provider communication are critical to the effectiveness of the CGA.
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geriatrics
Review
Comprehensive Geriatric Assessment as a Versatile
Tool to Enhance the Care of the Older Person
Diagnosed with Cancer
Janine Overcash 1, * , Nikki Ford 2, Elizabeth Kress 2, Caitlin Ubbing 2and Nicole Williams 2
1
The College of Nursing, The Ohio State University, 1585 Neil Ave, Newton Hall, Columbus, OH 43201, USA
2Stephanie Spielman Comprehensive Breast Center, The Ohio State University, 1145 Olentangy River Road,
Columbus, OH 43121, USA; Nikki.Ford@osumc.edu (N.F.); Eizabeth.Kress@osumc.edu (E.K.);
Caitlin.Ubbing@osumc.edu (C.U.); Nicole.Williams@osumc.edu (N.W.)
*Correspondence: Overcash.1@osu.edu
Received: 20 May 2019; Accepted: 20 June 2019; Published: 24 June 2019


Abstract:
The comprehensive geriatric assessment (CGA) is a versatile tool for the care of the older
person diagnosed with cancer. The purpose of this article is to detail how a CGA can be tailored to
Ambulatory Geriatric Oncology Programs (AGOPs) in academic cancer centers and to community
oncology practices with varying levels of resources. The Society for International Oncology in
Geriatrics (SIOG) recommends CGA as a foundation for treatment planning and decision-making for
the older person receiving care for a malignancy. A CGA is often administered by a multidisciplinary
team (MDT) composed of professionals who provide geriatric-focused cancer care. CGA can be
used as a one-time consult for surgery, chemotherapy, or radiation therapy providers to predict
treatment tolerance or as an ongoing part of patient care to manage malignant and non-malignant
issues. Administrative support and proactive infrastructure planning to address scheduling, referrals,
and provider communication are critical to the eectiveness of the CGA.
Keywords: comprehensive geriatric assessment; CGA; multidisciplinary team; senior adult; cancer
Caring for the older adult who is diagnosed with cancer can be a complex orchestration of
managing existing comorbid conditions, cancer care, caregiver concerns, while maintaining quality of
life [
1
4
]. Older people have unique healthcare needs compared to younger adults who may not have
challenges regarding comorbidities [
4
7
], functional ability [
8
], transportation and social support [
9
].
Many academic and community cancer centers establish some type of multidisciplinary geriatric
oncology program to meet the needs of the older person [
10
15
]. The central element associated with
a geriatric oncology program is a comprehensive geriatric assessment (CGA). Despite the evidence
showing the benefits of CGA, only 9% and 8% of Phase II and Phase III clinical trials use CGA [
16
]. Many
healthcare settings do not use CGA also because of time constraints, availability of a multidisciplinary
team, and lack of professionals trained in geriatrics/gerontology. Conducting a CGA is feasible in
ambulatory geriatric oncology programs (AGOPs) [
10
,
17
] including radiation therapy and surgical
oncology [
18
20
]. There are strategies to reduce the time and resources often required to conduct a
CGA. The purpose of this article is to illustrate how CGA can be used in dierent types of AGOPs and is
a feasible option despite limited time and personnel. A review of the classic and current literature was
conducted using the Ohio State University (OSU) Health Sciences Library (HSL) including PubMed
and Cumulative Index to Nursing and Allied Health Literature (CINAHL) to support this article.
1. Defining a Comprehensive Geriatric Assessment
A CGA is a battery of screening tools necessary to uncover actual and potential limitations that
can compromise cancer diagnosis and treatment [
21
]. The Society for International Oncology in
Geriatrics 2019,4, 39; doi:10.3390/geriatrics4020039 www.mdpi.com/journal/geriatrics
Geriatrics 2019,4, 39 2 of 13
Geriatrics (SIOG) recommends a CGA be administered to older patients who are receiving cancer
care [
22
,
23
]. Benefits of a CGA are prolonged survival [
24
], prediction of those who may not benefit
from treatment [
25
], prediction of mortality [
26
], of cancer treatment tolerance [
27
], of chemotherapy
toxicities [
28
], of surgical complications [
29
], and aid in decision-making to help avoid over- and
undertreatment of cancer [
30
]. The battery of screening tools is generally assembled to address common
problems associated with aging; however, any number of valid and reliable clinical instruments can
be included, depending on the resources. Some cancer centers may be able to conduct large-scale
CGA with a robust multidisciplinary team (MDT), and others may limit assessment instruments and
MDT members.
The comprehensive character of geriatric assessment allows clinicians to gain perspective beyond
the traditional oncology-related history and physical exam [
31
]. A CGA can detect previously
unidentified problems in approximately 70% of patients [
32
], which can impact cancer treatment [
19
]
and provide the foundation for a treatment plan to address malignant and nonmalignant conditions [
33
].
CGA is used to develop and refine a cancer management plan specific to the needs of the person
diagnosed with cancer [
20
]. A prime goal of geriatric oncology is helping an older person achieve the
best health possible while receiving cancer care to maintain independence [4].
2. Instruments Included in a Comprehensive Geriatric Assessment
Generally, screening tools to detect depression [
34
], comorbidity [
35
], cognitive impairment [
36
],
functional status [
37
,
38
], risk for falls [
39
], and nutritional status [
40
] are commonly included in a
CGA. The CGA is multidimensional in that many types of screening instruments can be included to
meet the needs of people who are diagnosed with cancer or who are receiving end-of-life care [
41
],
caregivers [
42
], and providers [
43
]. SIOG recommends a variety of instruments that can be tailored to
any patient population [44].
When choosing instruments to include in a CGA, consider that there are performance-based
evaluations and self-report measures. Performance-based evaluations provide a depiction of a person’s
capability using tools such as the Timed Up and Go Test (TUAGT) [
45
], balance testing [
46
], grip
strength [
47
], sit-to-stand test [
48
], cognitive screening using the Clock Drawing Test [
49
], and other
empirically measured tests. Self-report measures are also commonly included in the CGA, such
as the Geriatric Depression Scale (GDS) [
34
], Activities of Daily Living Scale [
37
], Instrumental
Activities of Daily Living [
38
], quality-of-life measures [
50
], and nutritional assessment [
40
]. Self-report
measures tend to be rather easy to use and have validity and reliability metrics for clinical and research
use. Including both self-report and performance-based evaluations provides patient perception
of functioning at home in conjunction with an objective assessment. Some patients may tend to
over-estimate their functional ability, and the empirical observation of task performance may help
providers develop realistic management plans.
Supporting the caregiver is also important to the health of the person with cancer [
51
]. The Modified
Caregiver Strain Index [
52
,
53
] is a 13-item tool that measures the financial, psychological, personal,
physical, and social domains of caregiving which can be incorporated into a CGA. Caregivers of people
diagnosed with cancer who have functional impairment [
54
] and have increased comorbidity [
55
]
report greater strain and burden. CGA can stratify people with cancer into levels of caregiver burden
risk so that clinicians can recognize caregivers who may need help [
42
]. Caregivers of people with
advanced cancer often neglect their own health and wellness and report high levels of depression
and anxiety [
56
]. Depression is not rare among caregivers (42%), and clinicians must support and
encourage health maintenance and wellness [
57
]. If caregiver health is not maintained and perceptions
of strain and burden exist, the individual with cancer is at risk for re-hospitalization [
58
] and increased
morbidity/mortality [
59
]. Help for caregivers navigating community resources, Medicare, insurance,
and cancer treatment can be very welcomed [
60
]. Cancer can be overwhelming and expensive, and
providing psychosocial support can reduce caregiver stress associated with financial toxicity [
61
],
Geriatrics 2019,4, 39 3 of 13
address depression, and establish coping strategies [
62
]. No matter the scale of the CGA, caregiver
support is important to geriatric oncology.
3. Multidisciplinary Team
A MDT has historically been used in geriatrics to administer the CGA and manage the many
interwoven concerns that can aect older people [
63
,
64
]. An MDT can be composed of physicians,
social workers, pharmacists, nurses, nurse practitioners, dietitians, physical therapists, and other
types of healthcare professionals. Not every clinic may have access to a variety of specialists, and
it is important to remember that geriatric care and screening can be provided by physicians, nurse
practitioners, and nurses. An MDT may simply include a physician and a nurse who are trained in
geriatrics. Administering and coordinating a CGA is well within the scope of practice of nursing and
can be central to the eectiveness of the MDT [65].
Whatever the size, an MDT functions symbiotically to assess, manage, and monitor many
limitations and complications associated with aging and deconditioning [
66
]. Geriatric oncology
has adopted the MDT approach to improve or maintain independence [
67
] and to provide CGA by
which to impact the cancer management plan [
20
]. Key to an eective MDT are communication,
collaboration, and coordination [
68
]. A social worker, nurse practitioner, and dietitian can evaluate
a patient simultaneously and hear the responses from individual assessments, so that questions are
not duplicated. This method requires a cohesive teamwork, does save some time, and enhances
communication within the MDT. An MDT with a perception of cohesive teamwork provides higher
quality of care and less attrition in the nursing sta[
69
]. Communication with primary care providers
and other specialists is critical to geriatric oncology and successful interventions [
70
]. When primary
care providers and oncology providers agree on recommendations, adherence to CGA recommendations
is more likely to occur [71].
For providers who lack a MDT, nurse-conducted CGA is a viable option. Nurses and/or advanced
practice nurses often function in the role of coordinator, provider, communicator, and organizer.
Awareness of the current knowledge in normative aging, geriatric syndromes, wellness, and prevention
are components of nursing best practices [
72
]. Best practices in geriatric/gerontological competencies
are provided by the American Association of Colleges of Nursing (AACN) for advanced practice and
baccalaureate nurses and largely guide curriculum development for colleges of nursing throughout the
United States [
73
,
74
]. However, geriatric training is often lacking in nursing schools throughout the
country [
75
], and geriatric education is often received outside of the academic curriculum. The National
Hartford Center of Gerontological Nursing Excellence (NHCGNE) aims to enhance gerontological
education among nurses in the academic and clinical workforce [
76
]. The NHCGNE recognizes
gerontological nurse educators as
Distinguished Educators in Gerontological Nursing Program
for
working with faculty to enhance university and college curricula, educate nursing students at all levels,
and work with other providers to better care for the older person [
77
]. It is important that nurses are
educated in gerontology/geriatrics so they are prepared to assess and contribute to the care of the older
person who is diagnosed with cancer [78].
4. Management of Problems Detected by Comprehensive Geriatric Assessment
Geriatric syndromes (poor functional status, cognitive impairment, frailty), life expectancy, and
comorbidity are realities that oncology providers must consider when caring for older individuals.
The mean number of geriatric syndromes is 2.9 in community-dwelling older people [
79
] and when
uncontrolled, may interfere with cancer treatment. Complex problems associated with geriatric
syndromes often cannot be addressed in one clinic visit or with a single medication or intervention.
For frailer people, determining the cause of a problem may require an MDT-administered CGA and
several clinic visits to detect and manage complex problems [
80
]. Good general health and absence of
severe comorbidity allow older people to be considered for surgical [
81
] and other types of standard
treatments [82].
Geriatrics 2019,4, 39 4 of 13
People who have well-managed comorbidities may not have any deterioration in their functional
status or life expectancy. In non-metastatic prostate cancer patients receiving treatment, 10-year life
expectancy was not impacted by comorbid conditions nor age [
83
]. However, data show that for every
chronic condition, life expectancy decreases 1.8 years [
61
]. Life expectancy, comorbid conditions, and
functional status are sentinel factors in geriatric oncology [
84
]. Functional status and not chronological
age is an important consideration in cancer treatment planning for the older adult [28,85].
Initiating a CGA requires a process to manage the limitations uncovered by the evaluation, and
providers should be trained on how to incorporate the MDT recommendations in the decision-making
process [
86
]. The mean number of CGA recommendations to address the uncovered limitations ranges
from seven [
87
] to two [
88
], depending on the type of patient (frail, vulnerable, or fit) [
89
]. A CGA
performed upon an initial oncology encounter can render three interventions [
90
]. Patients are most
likely to adhere to four or less recommendations unless they present cognitive decline, in which case
adherence is lower [87].
Follow-up care is important to determine adherence to recommendations and to reassess the
issues that were previously detected [
91
]. The problems detected in the CGA should be managed or
referred and detailed in the medical record [
92
,
93
]. How often to administer the CGA depends on
the degree of fitness or frailty of the patient. A primary care nurse who is trained in geriatrics can be
eective in coordinating the recommendations [94].
5. Comprehensive Geriatric Assessment with Limited Resources
A CGA conducted by an MDT can require an hour or more to administer; however, there are
strategies to conduct CGA in a timely and ecient manner. Targeting the person who would most
likely benefit from the CGA with a prescreening instrument can help preserve the resources of clinical
time and personnel and reduce the respondent burden (Figure 1).
Geriatrics 2019, 4 FOR PEER REVIEW 4
People who have well-managed comorbidities may not have any deterioration in their
functional status or life expectancy. In non-metastatic prostate cancer patients receiving treatment,
10-year life expectancy was not impacted by comorbid conditions nor age [83]. However, data show
that for every chronic condition, life expectancy decreases 1.8 years [61]. Life expectancy, comorbid
conditions, and functional status are sentinel factors in geriatric oncology [84]. Functional status and
not chronological age is an important consideration in cancer treatment planning for the older adult
[28,85].
Initiating a CGA requires a process to manage the limitations uncovered by the evaluation, and
providers should be trained on how to incorporate the MDT recommendations in the decision-
making process [86]. The mean number of CGA recommendations to address the uncovered
limitations ranges from seven [87] to two [88], depending on the type of patient (frail, vulnerable, or
fit) [89]. A CGA performed upon an initial oncology encounter can render three interventions [90].
Patients are most likely to adhere to four or less recommendations unless they present cognitive
decline, in which case adherence is lower [87].
Follow-up care is important to determine adherence to recommendations and to reassess the
issues that were previously detected [91]. The problems detected in the CGA should be managed or
referred and detailed in the medical record [92,93]. How often to administer the CGA depends on the
degree of fitness or frailty of the patient. A primary care nurse who is trained in geriatrics can be
effective in coordinating the recommendations [94].
5. Comprehensive Geriatric Assessment with Limited Resources
A CGA conducted by an MDT can require an hour or more to administer; however, there are
strategies to conduct CGA in a timely and efficient manner. Targeting the person who would most
likely benefit from the CGA with a prescreening instrument can help preserve the resources of clinical
time and personnel and reduce the respondent burden (Figure 1).
Figure 1. Prescreening using CGA to Determine Further Treatment or Diagnostics.
Prescreens have been developed, such as the abbreviated CGA [95], the G8 [96], and the
Vulnerable Elders Survey-13 [97]. SIOG recommends several valid and reliable pre-screen tools [1].
The purpose of pre-screen tools is to target those who most benefit from conducting the entire CGA,
rather than to replace a CGA. People who have functional decline and a higher risk of mortality and
of cancer treatment complications tend to benefit from the CGA [98,99]. For those people who are
independent and with minimal comorbid conditions, a CGA may not be as beneficial [100].
Depending on resources and type of healthcare setting, a CGA can be fashioned to include only
several instruments rather than an exhaustive battery of tools requiring hours of clinic encounter
time. Creating a smaller version of CGA which can include two or three screening instruments (GDS,
Mini-Cog, TUAGT) will allow time to gain experience administering the instrument and managing
the limitations. Using only two or three screening instruments has reasonable benefit to people who
are diagnosed with cancer and to their families. The detection and management of depression can
contribute to better cancer treatment outcomes, particularly with adherence to recommendations
[101]. Benefits of screening for cognitive limitations are inconclusive [102]; however, other
Figure 1. Prescreening using CGA to Determine Further Treatment or Diagnostics.
Prescreens have been developed, such as the abbreviated CGA [
95
], the G8 [
96
], and the Vulnerable
Elders Survey-13 [
97
]. SIOG recommends several valid and reliable pre-screen tools [
1
]. The purpose
of pre-screen tools is to target those who most benefit from conducting the entire CGA, rather than
to replace a CGA. People who have functional decline and a higher risk of mortality and of cancer
treatment complications tend to benefit from the CGA [
98
,
99
]. For those people who are independent
and with minimal comorbid conditions, a CGA may not be as beneficial [100].
Depending on resources and type of healthcare setting, a CGA can be fashioned to include only
several instruments rather than an exhaustive battery of tools requiring hours of clinic encounter
time. Creating a smaller version of CGA which can include two or three screening instruments (GDS,
Mini-Cog, TUAGT) will allow time to gain experience administering the instrument and managing
the limitations. Using only two or three screening instruments has reasonable benefit to people who
are diagnosed with cancer and to their families. The detection and management of depression can
contribute to better cancer treatment outcomes, particularly with adherence to recommendations [
101
].
Benefits of screening for cognitive limitations are inconclusive [
102
]; however, other considerations
Geriatrics 2019,4, 39 5 of 13
such as planning, awareness of limitations, preparation for future and other important tasks can be very
helpful for patients and families. Screening using the TUAGT can lead to physical therapy consults [
88
]
to enhance lower extremity strength and to provide falls education and proactive planning should a
fall occur (determining how to get help, keeping a phone on the bathroom floor near the bathing area).
The use of three tools can provide the opportunity to address common problems that can be associated
with aging without requiring the time to conduct a more robust CGA (Figure 2).
Geriatrics 2019, 4 FOR PEER REVIEW 5
considerations such as planning, awareness of limitations, preparation for future and other important
tasks can be very helpful for patients and families. Screening using the TUAGT can lead to physical
therapy consults [88] to enhance lower extremity strength and to provide falls education and
proactive planning should a fall occur (determining how to get help, keeping a phone on the
bathroom floor near the bathing area). The use of three tools can provide the opportunity to address
common problems that can be associated with aging without requiring the time to conduct a more
robust CGA (Figure 2).
Figure 2. Smaller CGA to Determine Further Treatment or Diagnostics.
The use of pre-screens and a smaller battery of assessment instruments is a viable option when
using CGA with limited clinical resources. Understanding the versatility of CGA may motivate more
clinicians to employ best practices in geriatric assessment.
Cost and resources are a factor when establishing a geriatric oncology program; however, not
all data indicate that CGA is cost-prohibitive when looking at long-term expenses and hospital stay.
The SIOG suggests that CGA is cost-effective and reduces hospitalizations [103]. CGA in people who
experience a hip fracture reduces hospital costs and hospital length of stay and improves health
outcomes [104]. However, for those people admitted to the hospital for nonmalignant conditions,
CGA is thought to slightly increase costs [105]. A Swedish study found ambulatory oncology CGA
to have increased costs due to the number of interventions and increased survival [25]. Another
Swedish study found ambulatory CGA to increase survival in frail people, with fewer hospital days
and without higher costs [106]. In the United States, the cost savings or expenses may be different,
however, people tend to benefit from CGA [85,107].
6. Models of Geriatric Oncology Programs using CGA
AGOPs often include regular CGAs and manage a patient throughout cancer care. There are
different types of AGOPs, such as those that provide ongoing geriatric oncology management, one-
time consult programs, site specific programs, and programs that address patients according to age
and not a particular tumor type. Scale also varies among AGOPs, with some using large MDTs and
others consisting of an oncologist and a geriatric trained nurse. Regardless of the structure, AGOPs
can provide CGA and offer management strategies to enhance the care of the older person diagnosed
with cancer.
The CGA can be administered by a nurse or nurse practitioner, and scores on the measures can
be shared with the entire MDT, so that more in-depth screening can be conducted by the appropriate
specialists. In some situations, the MDT members individually screen new patients to establish a
baseline condition prior to cancer treatment. The MDT members can then evaluate the patient as
needed throughout cancer treatment. Established patients who have received a baseline CGA can
receive regular geriatric assessment screening every 6 months or every year. No data exist on how
often to conduct a CGA; however, frail or vulnerable patients may require more frequent screening.
Figure 2. Smaller CGA to Determine Further Treatment or Diagnostics.
The use of pre-screens and a smaller battery of assessment instruments is a viable option when
using CGA with limited clinical resources. Understanding the versatility of CGA may motivate more
clinicians to employ best practices in geriatric assessment.
Cost and resources are a factor when establishing a geriatric oncology program; however, not
all data indicate that CGA is cost-prohibitive when looking at long-term expenses and hospital stay.
The SIOG suggests that CGA is cost-eective and reduces hospitalizations [
103
]. CGA in people
who experience a hip fracture reduces hospital costs and hospital length of stay and improves health
outcomes [
104
]. However, for those people admitted to the hospital for nonmalignant conditions, CGA
is thought to slightly increase costs [
105
]. A Swedish study found ambulatory oncology CGA to have
increased costs due to the number of interventions and increased survival [
25
]. Another Swedish study
found ambulatory CGA to increase survival in frail people, with fewer hospital days and without
higher costs [
106
]. In the United States, the cost savings or expenses may be dierent, however, people
tend to benefit from CGA [85,107].
6. Models of Geriatric Oncology Programs Using CGA
AGOPs often include regular CGAs and manage a patient throughout cancer care. There are
dierent types of AGOPs, such as those that provide ongoing geriatric oncology management, one-time
consult programs, site specific programs, and programs that address patients according to age and not
a particular tumor type. Scale also varies among AGOPs, with some using large MDTs and others
consisting of an oncologist and a geriatric trained nurse. Regardless of the structure, AGOPs can
provide CGA and oer management strategies to enhance the care of the older person diagnosed
with cancer.
The CGA can be administered by a nurse or nurse practitioner, and scores on the measures can be
shared with the entire MDT, so that more in-depth screening can be conducted by the appropriate
specialists. In some situations, the MDT members individually screen new patients to establish a
baseline condition prior to cancer treatment. The MDT members can then evaluate the patient as
needed throughout cancer treatment. Established patients who have received a baseline CGA can
receive regular geriatric assessment screening every 6 months or every year. No data exist on how
Geriatrics 2019,4, 39 6 of 13
often to conduct a CGA; however, frail or vulnerable patients may require more frequent screening.
The National Comprehensive Cancer Network (NCCN) has established guidelines for using CGA
when caring for the older adult [
108
]. A pre-cancer treatment decision tree addresses how and when to
use a prescreening and an entire CGA and how CGA can impact treatment decisions for the patient,
family, and provider [108].
Scheduling new and established patients visits for any type of AGOP requires planning for
extra time to conduct the CGA. For AGOPs conducting the entire CGA with an MDT in addition
to establishing a cancer management plan, a new patient visit may require two hours. For those
AGOPs using limited measures in the CGA and a limited MDT, perhaps a 30 min visit is appropriate.
One-time CGA consults can be easier to schedule in that all patients tend to receive the same screening
instruments and assessment from the MDT. Generally, the consult can be conducted in approximately
1.5 to 2 h per patient. Depending on the physical environment of the clinic, three patients can be
scheduled every 2–2.5 hour and be accommodated with rotating members of the team conducting
the assessments.
An AGOP one-time CGA consult functions to provide recommendations for cancer treatment,
identifies comorbid conditions, and addresses actual and potential risk factors that can aect health and
independence. A one-time CGA consult can be helpful to surgical teams to predict complications [
109
]
and post-surgical delirium when administered prior to surgery [
110
]. A one-time CGA conducted by a
geriatrician prior to emergency surgery reduces hospital length of stay by 55 days [
111
]. Despite the
positive contributions of CGA, many surgeons and other providers fail to consult geriatric services [
112
].
Education on the benefits of CGA in cancer treatment decision-making is critical for all cancer specialties
and providers.
Conducting a CGA and incorporating an MDT require infrastructures and administrative support
to lay the foundation for a sustainable geriatric oncology. Often, facilities and providers have diculty
launching and maintaining senior adult programs, for many reasons [
113
]. Patient scheduling to
accommodate longer visit times [
114
], avenues of referral when limitations are found, adapting the
medical record to accommodate scores and recommendations are important tasks to address before
initiating geriatric assessment [
13
]. AGOPs require continued evaluation and maintenance to ensure
the process of clinic is working well and the MDT is functioning eectively and productively. Regular
team meetings can be helpful to discuss assessment process, patients, and research activities. Regular
meetings should include administration, oce stawho schedule patient visits, as well as people who
work with medical records, who can be helpful in establishing highly functioning clinics, especially in
big medical centers. MDT meetings prior to geriatric oncology clinic are very useful to review new
and established patients.
A prime component of infrastructure is communication with other providers, which is key to the
eectiveness of AGOPs. Many providers feel under-utilized in the development of cancer management
plans, and communication is often poor between oncologists and primary care providers [
94
]. Proactive
planning to establish avenues of communication to coordinate the CGA recommendations can reduce
redundant assessments and increase eectiveness. Follow-up care and adherence to recommendations
are likely to be improved with better communication between geriatric MDTs and other providers and
typically require organizational modifications for adequate transfer of patient information [115].
Patient referral to an AGOP is also a consideration when establishing a clinic or a process for other
oncology providers to refer patients for a one-time CGA consult or ongoing management. Awareness
of the AGOP should be created within the organization and the community. Often, community
members are not aware of geriatric oncology services, and providing educational symposiums or brief
presentations at various sites common to potential patients and families can oer the opportunity to
receive a CGA and cancer care.
An AGOP can provide valuable clinical data to enhance the care of the older person diagnosed
with cancer. Establishing a research protocol incorporating CGA data can help improve the science
of geriatric oncology and establish a foundation for future funding. Select CGA instruments can be
Geriatrics 2019,4, 39 7 of 13
useful clinically as well as appropriate for research. Dissemination is critical to geriatric oncology and
helps address the importance of CGA in the care of the older person diagnosed with cancer.
7. Conclusions
CGA is a versatile tool that can be integrated into various oncology clinics and specialties to
provide the best care for the older person. Integrating a CGA does require administrative support,
infrastructure for patient scheduling, MDT involvement, and a great deal of planning. The importance
of understanding the needs of older people with cancer and of their caregivers underscores the
significance of CGA and inspires a comprehensive view, helpful to make treatment decisions. CGA
is the central element of geriatric oncology and the gold standard of practice to meet the needs of
older people.
Author Contributions:
Individual contributions are as follows: conceptualization, writing original—draft
preparation, writing- review and editing draft preparation was performed by J.O., conceptualization
writing—review and editing draft preparation was completed by E.K., N.F., C.U. and N.W.
Funding: This research received no external funding.
Acknowledgments:
We would like to thank the Stephanie Spielman Comprehensive Breast Cancer for continued
support of geriatric oncology and our Senior Adult Oncology Program.
Conflicts of Interest: We have no conflicts of interest to declare.
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2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
... The health and economic burden of cancer around the world is increasing steadily, primarily because of population aging. 1 In 2021, 48% of all new cancer cases in Canada were detected in those age 70 years and older. 2 Older individuals have complex health care demands owing to coexisting diseases and impaired functional capacity, which contribute to their need for more services and greater expenditures. 3 Previous research has shown that substantial portion of emergency department (ED) and inpatient spending for patients with cancer were avoidable. 4 Therefore, early identification and management of preventable conditions or events could represent an important method for reducing cancer care costs. ...
... [5][6][7] To enable individualized treatment approaches, GA evaluates comorbidities, cognitive and mental health, functional and nutritional status, social support, and assesses tolerance to chemotherapy to avoid overtreatment or undertreatment of cancer. 3,5 Recent randomized controlled trials (RCTs) and a systematic review concluded that GA had a favorable impact on outcomes in patients with cancer, namely decreased treatment toxicity, 8,9 improved treatment completion, 10 quality of life (QoL), 11 and improved patient-provider communication. 12 A single, model-based economic evaluation reported that GA can be marginally cost-effective depending on setting. ...
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PURPOSE Geriatric assessment (GA) is a guideline-recommended approach to optimize cancer management in older adults. We conducted a cost-utility analysis alongside the 5C randomized controlled trial to compare GA and management (GAM) plus usual care (UC) against UC alone in older adults with cancer. METHODS The economic evaluation, conducted from societal and health care payer perspectives, used a 12-month time horizon. The Canadian 5C study randomly assigned patients to receive GAM or UC. Quality-adjusted life-years (QALYs) were measured using the EuroQol five dimension-5L questionnaire and health care utilization using cost diaries and chart reviews. We evaluated the incremental net monetary benefit (INMB) for the full sample and preselected subgroups. RESULTS A total of 350 patients were included, of whom 173 received GAM and 177 UC. At 12 months, the average QALYs per patient were 0.728 and 0.751 for GAM and UC, respectively (ΔQALY, −0.023 [95% CI, −0.076 to 0.028]). Considering a societal perspective, the total average costs (in 2021 Canadian dollars) per patient were $46,739 and $45,177 for GAM and UC, respectively (ΔCost, $1,563 [95% CI, −$6,583 to $10,403]). At a cost-effectiveness threshold of $50,000/QALY, GAM was not cost-effective compared with UC (INMB, −$2,713 [95% CI, −$11,767 to $5,801]). The INMB was positive ($2,984 [95% CI, −$7,050 to $14,179]; probability of being cost-effective, 72%) for patients treated with curative intent, but remained negative for patients treated with palliative intent (INMB, −$9,909 [95% CI, −$24,436 to $4,153]). Findings were similar considering a health care payer perspective. CONCLUSION To our knowledge, this is the first cost-utility analysis of GAM in cancer. GAM was cost-effective for patients with cancer treated with curative but not with palliative intent. The study provides further considerations for future adoption of GAM in practice.
... Cancer patients identified as frail are more likely to experience adverse outcomes [24]. CGA is considered the gold standard for identifying and stratifying patients into the frailty spectrum [6,[25][26][27]. ...
... Older adults with cancer may be a recipient of care, require increased care, or may themselves be a caregiver. CGA should typically include family member(s) or other support person(s), and they too should be assessed for unmet needs and/or desire for increased support [27,[60][61][62]. The carer may contribute to the provision of information, provide support for the person, and aid in asking questions on behalf of the patient; therefore, CGA can improve patient-centred and caregiver-centred communications between clinicians [56]. ...
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The ANZSGM position statement recommends the use of comprehensive geriatric assessment (CGA) for older adults with cancer to guide treatment decisions, health optimisation, and care provision. A two-step approach using brief geriatric screening tools or a modified assessment approach could be used to target CGA. All older adults with cancer should have access to clinicians with expertise in the care of older people, including geriatricians. Patient preferences and priorities should be central to healthcare management. Carers and families should be involved in communication and decision-making where feasible. Education about geriatric oncology and the principles of managing health issues of older adults for all clinicians caring for older adults with cancer is advocated. Improvements in linkages, pathways, and communication between geriatric medicine, oncology, primary care, and other services are recommended. Care models for delivering CGA-based interventions should be driven by local context, with geriatricians involved in establishing and implementing geriatric oncology/haematology services in Australia and New Zealand.
... The gold standard geriatric assessment is Comprehensive Geriatric Assessment (CGA), which is a multi-dimensional diagnostic process focused on determining an older person's medical, functional and psychosocial capabilities in order to develop a coordinated and integrated plan for treatment and follow-up [3]. Whilst the identification of frailty is an indication for CGA, CGA can also help place patients along the fitness-frailty continuum [4], inform patient optimization strategies, help personalization of treatments, and improve prognostication in older oncologic patients [5][6][7][8]. ...
... Vulnerability assessment, Multidimensional Geriatric Assessment (MGA) or Comprehensive Geriatric Assessment (CGA) are evaluation tools developed by geriatric medicine with the aim of planning medical and socio-health care for the patient [7,8]. MGA has been defined as a methodology "with which the multiple problems of the elderly individual are identified and explained, their limitations and resources are assessed, their care needs are defined and an overall care program is developed to interventions to meet these needs". ...
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Colorectal cancer (CRC) is among the most common malignancies in Western countries. It is the second most commonly diagnosed cancer in women and the third in men, with 1,340,000 new diagnoses worldwide. In Italy, around 45,000 new cases are diagnosed each year, likely related to the increased life expectancy, since aging plays a significant causative role. Minimally invasive surgery is widely accepted as a safe, feasible and oncologically adequate treatment for CRC. Laparoscopic surgery offers favorable short-term results, a good procedure tolerance, a low conversion rate and postoperative complication rate, with a significant shortening of the postoperative stay. All these benefits also apply to the older population. The robotic technique is considered the evolution of conventional laparoscopic surgery. Few randomized clinical trials have compared the results of robotic versus laparoscopic surgery and the effects of the robotic approach in elderly patients. Nonetheless, published results support robotic surgery for CRC treatment in the elderly, as it is as feasible and safe as laparoscopic surgery, with favorable reports and similar oncological outcomes. However, an increased operating time is widely observed. The aim of this chapter is to evaluate whether old age alone should be one of the exclusion criteria for robotic surgery in CRC.
... Several methods have emerged to systematically assess frailty and functional status to identify which patients are at increased risk for adverse outcomes, including the CGA and Geriatric 8 (G8). [49][50][51][52][53] The CGA is a very thorough assessment developed by the International Society of Geriatric Oncology (SIOG), and can be impractical to complete in the clinical setting, potentially limiting its use. 54 Since publication of the CGA, subsequent abbreviated versions of this survey, such as the G8 questionnaire, have been efficacious in predicting the survival of elderly cancer patients. ...
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Daniel R Dickstein,1,* Ann E Powers,2,* Dragan Vujovic,1 Scott Roof,2 Richard L Bakst1 1Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA*These authors contributed equally to this workCorrespondence: Richard L Bakst, Icahn School of Medicine at Mount Sinai, 1184 5th Avenue 1st Fl, Box 1236, New York, NY, 10029, USA, Tel/Fax +1 212 241 3545, Email Richard.Bakst@mountsinai.orgAbstract: Approximately 30% of patients with head and neck squamous cell carcinoma (HNSCC) are at least 70 years of age, and this percentage is expected to increase as the population increases and lives longer. Elderly patients are underrepresented in head and neck oncology clinical trials, and there is minimal evidence on the management of HNSCC for this population. Subsequently, despite their best intentions, physicians may unknowingly recommend an ill-suited course of therapy, which may result in suboptimal oncological or functional outcomes or adverse events. Surgical approaches have the potential to carry a higher risk of morbidity and mortality in older adults, especially in patients with multiple comorbidities. Definitive radiation therapy treatment in patients with HNSCC frequently involves 7 weeks of daily radiation, sometimes with concurrent chemotherapy, and this demanding treatment can be difficult for older adult patients, which may lead to treatment interruptions, potential removal of concurrent systemic therapy, compromised outcomes, and diminished quality of life. There are clinical trials currently underway investigating altered fractionation regimens and novel, less toxic systemic treatments in this population. This review provides an overview of how best to approach an older adult with HNSCC, from initial work-up to treatment selection.Keywords: elderly, older adult, geriatric, head and neck squamous cell carcinoma, oropharynx, hypofractionation
... Self-report measures are also commonly included in the CGA, such as the Geriatric Depression Scale (GDS) [13], Activities of Daily Living Scale [14], Instrumental Activities of Daily Living [15], qualityof-life measures [16], and a nutritional assessment [17]. Including both self-report and performance-based evaluations, the CGA provides the patient with a perception of functioning at home in conjunction with an objective assessment that may help providers develop realistic management plans [18]. In addition to the accurate and prompt identification of vulnerable and frail individuals through the CGA, appropriate supportive care is essential to support all patients during treatment, regardless of the degree of frailty. ...
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Currently, the management of older cancer patients is directed by a personalized approach and, where possible, a tailor-made treatment. Based on our previous experiences and considering the opportunity of combining a geriatric department and a radiation-oncology department, we have developed a path that follows the patient from the beginning of the treatment, taking into account the complications/late toxicities and the survivors. This study aimed to evaluate the impact of remodeling and restructuring some oncology, radiotherapy, and geriatrics services based on the primary evidence for managing older cancer patients. In 2020, Gemelli ART underwent 60,319 radiation-oncology treatments, admitted 943 patients in the radiation-oncology and supportive care ward, and treated and followed 15,268 patients in clinics. The average length of stay of the admitted patients was reduced from 20.6 days to 13.2 days. In 2021, 1196 patients were assessed for frailty, 847 were admitted for toxicity, and 349 patients were evaluated within the geriatric oncology and supportive care outpatient clinic, and it was found that 59.2% were fit, 31.6% were vulnerable, and 9.2% were frail. This experience has shown a reduction in hospitalizations and the average hospital stay of patients in the case of side effects, a high toxicity to treatments, and the possibility of treating patients with a high level of complexity. This approach should represent the future target of geriatric oncology with the global management of older or complex patients with cancer.
... CGA is a multidisciplinary process focused on evaluating an older patient's parameters of physical function, co-morbidity, social support systems, cognitive function, psychological status, nutrition, and medication 53,54 . It is highly recognized in oncology, with the International Society of Geriatric Oncology and the National Comprehensive Cancer Network recommending its incorporation into cancer treatment planning 55 . Current literature on CGA is mainly related to cancer surgery and oncological therapies such as administration of chemotherapy. ...
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X Consenso Nacional de Cancro da Mama, desenvolvido por dezenas de profissionais dos vários centros de todo o país e das diferentes especialidades dedicadas ao tratamento do cancro da mama, convocados para a revisão da literatura científica e elaboração das recomendações nacionais com o apoio da Sociedade Portuguesa de Senologia, nas seguintes áreas: recomendações de rastreio e diagnóstico precoce; relatório anatomopatológico estruturado; guidelines de abordagem da axila cN1 após neoadjuvância; tratamento da doença oligometastática; tratamento do cancro da mama metastático luminais; tratamento do cancro da mama metastático triplo negativo e HER2+; guidelines de tratamento e seguimento da mulher idosa e inteligência artificial.
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Background: Frailty assessment is an important marker of the older adult's fitness for cancer treatment independent of age. Pretreatment geriatric assessment (GA) is associated with improved mortality and morbidity outcomes but must occur in a time sensitive manner to be useful for cancer treatment decision making. Unfortunately, time, resources and other constraints make GA difficult to perform in busy oncology clinics. We developed the Cancer and Aging Interdisciplinary Team (CAIT) clinic model to provide timely GA and treatment recommendations independent of patient's physical location. Methods: The interdisciplinary CAIT clinic model was developed utilizing the surge in telemedicine during the COVID-19 pandemic. The core team consists of the patient's oncologist, geriatrician, registered nurse, pharmacist, and registered dietitian. The clinic's format is flexible, and the various assessments can be asynchronous. Patients choose the service method-in person, remotely, or hybrid. Based on GA outcomes, the geriatrician provides recommendations and arrange interventions. An assessment summary including life expectancy estimates and chemotoxicity risk calculator scores is conveyed to and discussed with the treating oncologist. Physician and patient satisfaction were assessed. Results: Between May 2021 and June 2022, 50 patients from multiple physical locations were evaluated in the CAIT clinic. Sixty-eight percent was 80 years of age or older (range 67-99). All the evaluations were hybrid. The median days between receiving a referral and having the appointment was 8. GA detected multiple unidentified impairments. About half of the patients (52%) went on to receive chemotherapy (24% standard dose, 28% with dose modifications). The rest received radiation (20%), immune (12%) or hormonal (4%) therapies, 2% underwent surgery, 2% chose alternative medicine, 8% were placed under observation, and 6% enrolled in hospice care. Feedback was extremely positive. Conclusions: The successful development of the CAIT clinic model provides strong support for the potential dissemination across services and institutions.
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Objective: Although it has been suggested that living alone is a "social risk factor" for adverse health outcomes, poor social network may confound the association. This study aimed to examine whether the interactive effects of living alone and poor social network contribute to adverse health outcomes. Design: A 4-year prospective observational study. Setting and participants: Four hundred community-dwelling older adults living in Itabashi ward, an urban community in Tokyo. They participated in a health checkup (held in 2015 and 2017) and completed all the assessments. Methods: Participants were classified into 4 groups according to their living arrangements (living alone or not living alone) and social network size, which was assessed using an abbreviated version of the Lubben Social Network Scale-6. Poor social network was defined as the lowest quartile (4th quartile) of the Lubben Social Network Scale-6 score. Adverse health outcomes including disabilities, depressive symptoms, and physical and cognitive functions were measured. Results: Multiple and logistic regression models, adjusted for covariates such as financial status and educational level, showed that living alone and having a poor social network at baseline were significantly associated with increased depression symptoms, reduced grip strength, and disabilities of intellectual activity and social role at follow-up. Furthermore, older adults who did not live alone but had poor social networks showed significantly higher odds of subsequent homebound status and disability in activities of daily living. Conclusions and implications: We found that living alone among older adults is not always a social risk factor for health, and adverse health outcomes among older adults living alone may be confounded by poor social network. Our results also suggest that the effect of poor social network on health status may exceed the effects of living alone. Health professionals must, thus, pay attention to poor social network among older adults.
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Todays challenge in geriatric oncology is to screen patients who need geriatric follow-up. The main goal of this study was to analyze factors that identify patients, in a large cohort of patients with solid tumors, who need more geriatric interventions and therefore specific follow-up. Between April 2012 and May 2018, 3530 consecutive patients were enrolled in the PACA EST cohort (France). A total of 3140 patients were finally enrolled in the study. A Comprehensive Geriatric Assessment (CGA) was performed at baseline. We analyzed the associations between factors at baseline (geriatric and oncologic factors) and the need to perform more than three geriatric interventions. The mean age of the population was 82 years old with 59% of patients aged older than 80 years old. A total of 8819 geriatric interventions were implemented for the 3140 patients. The percentage of patients with three or more geriatric interventions represented 31.8% (n = 999) of the population. In multivariate analyses, a Mini Nutritional assessment (MNA) <17, an MNA ≤23·5 and ≥17, a performans status (PS) >2, a dependence on Instrumental Activities of Daily Living (IADL), a Geriatric Depression Scale (GDS) ≥5, a Mini Mental State Examination (MMSE) <24, and a Screening tool G8 ≤14 were independent risk factors associated with more geriatric interventions. Factors associated with more geriatric interventions could assist practitioners in selecting patients for specific geriatric follow-up.
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Purpose Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives. Methods We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms “ovarian cancer”, “endometrial cancer”, “cervical cancer”, “gynecological cancers” combined with ‘elderly’, ‘cancer’, ‘clinical trial’ and ‘geriatric assessment’. Results The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: “Endometrial cancer”, “Ovarian cancer” and “Cervical cancer”. Conclusions The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.
Article
PURPOSE We developed and validated a brief, yet sensitive, 33-item general cancer quality-of-life (QL) measure for evaluating patients receiving cancer treatment, called the Functional Assessment of Cancer Therapy (FACT) scale. METHODS AND RESULTS The five-phase validation process involved 854 patients with cancer and 15 oncology specialists. The initial pool of 370 overlapping items for breast, lung, and colorectal cancer was generated by open-ended interview with patients experienced with the symptoms of cancer and oncology professionals. Using preselected criteria, items were reduced to a 38-item general version. Factor and scaling analyses of these 38 items on 545 patients with mixed cancer diagnoses resulted in the 28-item FACT-general (FACT-G, version 2). In addition to a total score, this version produces subscale scores for physical, functional, social, and emotional well-being, as well as satisfaction with the treatment relationship. Coefficients of reliability and validity were uniformly high. The scale's ability to discriminate patients on the basis of stage of disease, performance status rating (PSR), and hospitalization status supports its sensitivity. It has also demonstrated sensitivity to change over time. Finally, the validity of measuring separate areas, or dimensions, of QL was supported by the differential responsiveness of subscales when applied to groups known to differ along the dimensions of physical, functional, social, and emotional well-being. CONCLUSION The FACT-G meets or exceeds all requirements for use in oncology clinical trials, including ease of administration, brevity, reliability, validity, and responsiveness to clinical change. Selecting it for a clinical trial adds the capability to assess the relative weight of various aspects of QL from the patient's perspective.
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Introduction: With the accumulating evidence on the added value on prediction of outcomes of geriatric assessment (GA) in older patients with cancer, the question shifts from whether performing a GA is useful, to how to implement this into standard practice in a feasible and effective way. The effect of implementing GA, and assessment of patient preferences on treatment recommendations by an onco-geriatric multidisciplinary team (MDT), was compared to the recommendation previously made by the tumor board (care as usual). Methods: Patients aged 70 years and older with a solid malignancy who were referred to a tertiary care center for diagnosis and treatment recommendations, as provided by a tumor board, were included. The intervention consisted of: a nurse-led GA and assessment of patient preferences prior to the start of oncological treatment, discussing this in an onco-geriatric MDT, and weighing all this information in a structured, stepwise manner. Treatment recommendations formulated by this onco-geriatric MDT were compared to the treatment recommendations by the tumor board. Results: Of 236 eligible patients, 197 were included. For 27%, treatment recommendations from the onco-geriatric MDT differed from the recommendations formulated by the tumor board. These modifications were mostly towards less intensive curative or palliative treatment. Thirteen percent of patients were subsequently referred to a geriatrician in order to reach a treatment recommendation. Discussion: Implementing an onco-geriatric care trajectory, using GA and assessment of patient preferences, resulted in an adjustment of treatment recommendations for a quarter of patients. Thirteen percent needed subsequent referral to a geriatrician.
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Acute myeloid leukemia (AML) presents therapeutic challenges in older adults because of high-risk leukemia biology conferring chemoresistance, and poor functional status resulting in increased therapy-related toxicities. Recent FDA approval of 8 new drugs for AML has increased therapeutic armamentarium and also provides effective low-intensity treatment options. Rational therapy selection strategies that consider individual's risk of therapy-related toxicities and probability of disease control can maximize benefits of available treatments. Studies have demonstrated that fitness level, measured by geriatric assessment can predict therapy-related toxicities, whereas cytogenetic and mutation results correlate with the probability of responses to standard chemotherapy. We are approaching an era when we move from “one size fits all” approach to personalized therapy selection based on geriatric assessment, genetic and molecular profiling.
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Background: Studies of older patients with colorectal cancer(CRC) have found inconsistent results about the correlation of various comorbidities with overall survival(OS) and treatment tolerance. To refine our understanding, we evaluated this correlation using the Cumulative Illness Rating Scale-Geriatric(CIRS-G) and heat maps to identify subgroups with the highest impact. Methods: We retrospectively reviewed 153 patients aged 65 years and older with stage IV CRC undergoing chemotherapy. We calculated CIRS-G scores, and a Total Risk Score(TRS) derived from a previous heat map study. The association between CIRS-G scores/TRS and OS, unplanned hospitalizations, and chemotoxicity was examined by the Cox proportional hazards model. Results: Median age was 71 years. Median MAX2 score of chemotherapies was 0.134(0.025-0.231). The most common comorbidities were vascular(79.8%), eye/ear/nose/throat(68%), and respiratory disease(52.4%). Median OS was 25.1 months(95% confidence interval: 21.2-27.6). In univariate analysis, ECOG PS ≥ 2(HR 1.86(1.1-3.17), p = 0.019), poorly differentiated histology(HR 2.03(1.27-3.25), p = 0.003), primary site(rectum vs colon)(HR 0.58 (0.34-0.98), p = 0.04), age at diagnosis(HR per 5y 1.20 (1.04-1.39), p = 0.012), and number of CIRS-G grade 4 comorbidities(HR 1.86 (1.1-3.17), p = 0.019) were associated with OS. In multivariate analysis, the number of CIRS-G grade 4 comorbidities lost significance, although it retained it in the subgroup of patients with colon cancer. Conversely, the TRS was associated with OS in patients with rectal cancer. No association of comorbidity with unplanned hospitalization or chemotoxicity was observed. Conclusions: In older adults with metastatic CRC, the number of CIRS-G grade 4 comorbidities was associated with worse OS but no specific CIRS-G category was independently associated with OS, unplanned hospitalization, or toxicities.
Article
Background: The objective of this study was to describe the implementation of comprehensive geriatric assessment (CGA) in clinical trials dedicated to older patients before and after the creation of the International Society of Geriatric Oncology in the early 2000s. Subjects, materials, and methods: All phase I, II, and III trials dedicated to the treatment of cancer among older patients published between 2001 and 2004 and between 2011 and 2014 were reviewed. We considered that a CGA was performed when the authors indicated an intention to do so in the Methods section of the article. We collected each geriatric domain assessed using a validated tool even in the absence of a clear CGA, including nutritional, functional, cognitive, and psychological status, comorbidity, comedication, overmedication, social status and support, and geriatric syndromes. Results: A total of 260 clinical trials dedicated to older patients were identified over the two time periods: 27 phase I, 193 phase II, and 40 phase III trials. CGA was used in 9% and 8% of phase II and III trials, respectively; it was never used in phase I trials. Performance status was reported in 67%, 79%, and 75% of phase I, II, and III trials, respectively. Functional assessment was reported in 4%, 11%, and 13% of phase I, II, and III trials, respectively. Between the two time periods, use of CGA increased from 1% to 11% (p = .0051) and assessment of functional status increased from 3% to 14% (p = .0094). Conclusion: The use of CGA in trials dedicated to older patients increased significantly but remained insufficient. Implications for practice: This article identifies the areas in which research efforts should be focused in order to offer physicians well-addressed clinical trials with results that can be extrapolated to daily practice.
Article
Background and objectives: The complex health problems of older persons require that health professionals closely work together, in particular when an acute decline necessitates admission at an acute geriatric unit. These working conditions may cause additional stress in staff. This study aims to identify the relation between interprofessional teamwork, the quality of care and turnover intention in acute geriatric units. Design, setting, participants and methods: Perceptions of interprofessional teamwork, quality of care and turnover intention among team members of 55 acute geriatric units were measured using validated questionnaires. A multilevel linear regression model was built for quality of care and logistic regression for turnover intention, with random intercept for acute geriatric unit. Results: The overall response rate was 60%. Of the 890 respondents, 71% were nursing professionals, 20% allied health professionals, 5% physicians, and 4% administrative staff. Twenty-three percent reported poor to fair quality of care in their unit; 19% was not sure that patients or families had been given enough means to organise care after discharge. Fifteen percent reported turnover intention (18%, 8%, 9% and 11% among nursing professionals, allied health professionals, physicians and administrative workers respectively, p = 0.005). Higher perceived interprofessional teamwork was related to higher quality of care (estimated coefficient 0.05, p < 0.001) and lower turnover intention in nursing professionals only (estimated OR 0.94, p < 0.001). Conclusion: Creating a care environment of good interprofessional teamwork can help acute geriatric units to retain nursing professionals in the job and achieve higher quality of care.
Article
Introduction: The overall increase in life expectancy causes a rapid increase in number of elderly patients needing colorectal surgery. It remains unclear if there is a significant risk factor in patients over 80 years of age for postoperative morbidity and mortality. For this reason we investigated the perioperative, outcome and long-term survival after surgery for colorectal cancer in our hospital. Materials and methods: We retrospectively analysed a database containing information about patients who underwent surgery for colorectal cancer from January 2010 to December 2015 at the St. Bernhard Hospital in Kamp-Lintfort, Germany. The last follow-up date was 31th of December 2017. Results: A total of 232 patients were enrolled and analysed in this study. All patients were separated in tow groups depending in age. The first group was ≥80 years old (n=49). The second group was <80 years old (n=183). High ASA-Scores (≥3) were detectable more often in elderly patients (p<0,05). Elderly and young patients had a similar risk for postoperative anastomosic leakages (p=0,047). Likewise there were no significant differences regarding the Dindo-Clavien-Classification (p=0,13). The mortality within the first 30 days after surgery was significant elevated for elderly patients compared to younger patients (p=0,04). Also the overall 1-year survival was 90% for the younger and 73,5% for the older study group (p<0,05) Conclusion. Both the short-term outcome and long-term survival rate after colorectal surgery for cancer are worse for patients older than 80 years of age. After interpretation of all data it remains unclear if the age itself is still the biggest risk factor. When old patients have a good ASA-Score and no severe comorbidities, colorectal surgery remains safe even for patients older than 80 years.