The medical sector has entered an epoch of rapid innovation and strengthened competition that demands more creativity. That rapidly changing environment demand more flexibility for the operations. Although, various studies are available on the effects of multiple approaches on operational flexibility still JIT, TQM, and SCM never have been verified in the same study. This is empirically varification, a questionnaire has been distributed by convenience sampling in the medical sector of Jordan. Total 318 responses received and SPSS have been applied for multiple regression analysis. It has found that all three approaches have positive effects on operational flexibility but very minor even no approach has significant effects. This study is unique because it applies three diversified approaches in the same study and findings are unique. It is recommended for all managers of a medical sector that JIT, TQM, and SCM are not beneficial for operational flexibility for developing countries due to lack of resources, technology, and education. This study will help the researches that more studies need to verify for Jordan hospitals. Moreover, future studies can be done to identify the reasons behind these unique findings.