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CORRECTION
published: 18 December 2018
doi: 10.3389/fped.2018.00399
Frontiers in Pediatrics | www.frontiersin.org 1December 2018 | Volume 6 | Article 399
Edited and reviewed by:
Graeme R. Polglase,
Monash University, Australia
*Correspondence:
Vishal S. Kapadia
vishal.kapadia@utsouthwestern.edu
Specialty section:
This article was submitted to
Neonatology,
a section of the journal
Frontiers in Pediatrics
Received: 12 November 2018
Accepted: 30 November 2018
Published: 18 December 2018
Citation:
Kapadia VS and Wyckoff MH (2018)
Corrigendum: Epinephrine Use During
Newborn Resuscitation.
Front. Pediatr. 6:399.
doi: 10.3389/fped.2018.00399
Corrigendum: Epinephrine Use
During Newborn Resuscitation
Vishal S. Kapadia*and Myra H. Wyckoff
Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States
Keywords: epinephrine, neonatal resuscitation, asphyxia, newborn, delivery room, infants
A Corrigendum on
Epinephrine Use During Newborn Resuscitation
by Kapadia, V. S., and Wyckoff, M. H. (2017). Front. Pediatr. 5:97. doi: 10.3389/fped.2017.00097
In the original article, there was a typographical error in Table 1, as published. The endotracheal
(ET) epinephrine dose should be “0.05–0.1 mg/kg.” In Table 1, it was mistakenly written as “0.05–1
mg/kg.” The corrected Table 1 appears below.
The authors apologize for this error and state that this does not change the scientific conclusions
of the article in any way. The original article has been updated.
Copyright © 2018 Kapadia and Wyckoff. This is an open-access article distributed under the terms of the Creative Commons
Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s)
and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Kapadia and Wyckoff Corrigendum: Epinephrine During Newborn Resuscitation
TABLE 1 | Epinephrine use during newborn resuscitation: route, dose, and summary of evidence.
Route Dose Summary of evidence
Intravenous 0.01–0.03 mg/kg • Preferred route and appear to be more efficacious than other routes
• Dose extrapolated from adult experience
• High dose epinephrine offers no advantage and is associated with increased post-resuscitation adverse
effects and increased mortality
• Dose escalation studies in neonatal animal model with transition physiology are urgently needed
Endotracheal
(ET)
0.05–0.1 mg/kg • Less effective than IV route
• Achieved plasma concentration is less and it peaks slower with ET epinephrine compared to IV
epinephrine
• Can be used until IV access is available
Intraosseous 0.01–0.03 mg/kg • Limited evidence compared to IV route
• Providers frequently involved in newborn resuscitation feel more comfortable with rapid UVC insertion
compared to IO route
Intramuscular Not recommended • Very limited evidence
• Significant tissue damage at local site
Frontiers in Pediatrics | www.frontiersin.org 2December 2018 | Volume 6 | Article 399
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