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Experimental models of neural tube defects: a review and clinical implications

January 1986
Journal of Pediatric Neurosciences 2(1):47-69

January 1986
2(1):47-69

Authors:

Università degli Studi di Perugia

A review of experimental models of neural tube defects

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Neuroal tube defects

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Dec 1987

Recent developments in the field of experimentally induced neural tube defects (NTD) indicate that specific substances, namely the glycosaminoglycans (GAGs) may play a role in the genesis of spinal malformations. The authors report the results obtained by evaluating the GAGs in rat fetuses with NTD, secondary to the administration of Trypan Blue during pregnancy. A characteristic decrease in GAGs formation in the spinal and cranial structures as well as in the subependymal regions of the brain was found in the malformed fetuses. The authors hypothesize that this anomaly in GAGs formation is responsible for both the NTD and the associated malformations, namely hydrocephalus and hypoplasia of the posterior cranial fossa.

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Recent developments in the field of experimentally induced neural tube defects (NTD) indicate that specific substances, namely the glycosaminoglycans (GAGs) may play a role in the genesis of spinal malformations. The authors report the results obtained by evaluating the GAGs in rat fetuses with NTD, secondary to the administration of Trypan Blue during pregnancy. A characteristic decrease in GAGs ... [Show full abstract] formation in the spinal and cranial structures as well as in the subependymal regions of the brain was found in the malformed fetuses. The authors hypothesize that this anomaly in GAGs formation is responsible for both the NTD and the associated malformations, namely hydrocephalus and hypoplasia of the posterior cranial fossa.

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