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Phyto-polyphenols as potential inhibitors of breast cancer metastasis

Authors:
Dimiter B Avtanski at Lenox Hill Hospital
Dimiter B Avtanski
Leonid Poretsky at Northwell Health
Leonid Poretsky
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Breast cancer is the most common cancer among women as metastasis is currently the main cause of mortality. Breast cancer cells undergoing metastasis acquire resistance to death signals and increase of cellular motility and invasiveness. Plants are rich in polyphenolic compounds, many of them with known medicinal effects. Various phyto-polyphenols have also been demonstrated to suppress cancer growth. Their mechanism of action is usually pleiotropic as they target multiple signaling pathways regulating key cellular processes such as proliferation, apoptosis and differentiation. Importantly, some phyto- polyphenols show low level of toxicity to untransformed cells, but selective suppressing effects on cancer cells proliferation and differentiation. In this review, we summarize the current information about the mechanism of action of some phyto-polyphenols that have demonstrated anti-carcinogenic activities in vitro and in vivo. Gained knowledge of how these natural polyphenolic compounds work can give us a clue for the development of novel anti-metastatic agents.
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Phyto-polyphenols as potential inhibitors of breast cancer metastas
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... Studies conducted mainly in vitro have shown that polyphenols have chemopreventive and chemotherapeutic effects on breast cancer cells by influencing numerous molecular pathways. [35][36][37][38][39] They inhibit, among others, DNA-methyltransferase (DNMT) and histone deacetylase (HDAC), which -through increased acetylation and demethylation of suppressor genes -contributes to the prevention of proliferation and migration of breast cancer cells. [35,36,37] Polyphenols also inhibit STAT3 -signal inducer and activator of transcription -thereby inhibiting the expression of genes involved in cell proliferation, as well as in the processes of angiogenesis and metastasis. ...
... [35,36,37] Polyphenols also inhibit STAT3 -signal inducer and activator of transcription -thereby inhibiting the expression of genes involved in cell proliferation, as well as in the processes of angiogenesis and metastasis. [35,36,38,39] In recent years, attention has also been paid to the importance of overexpression of PD-L1 -programmed death ligand 1 -in various stages of carcinogenesis, metastasis and treatment resistance. In relation to breast cancer, polyphenols reduce PD-L1 expression. ...
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  • Feb 2024
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