Although domestic pigs (Sus scrofa domesticus Erxleben) are generally accepted as appropriate human taphonomic proxies, taphonomic studies have used a wide variety of mammalian analogues. These include, among others, cattle (Bos taurus Linnaeus), sheep (Ovis aries Linnaeus), mice (Mus musculus Linnaeus) and brown rats (Rattus norvegicus Berkenhout), and their respective laboratory-reared subspecies. Furthermore, organs/tissue types from different species have been used, both with and without molecular analysis, notably in forensic entomology studies. The relevance, applicability and limitations of common, disparate and novel approaches must, therefore, be deliberated within the multi-disciplinary forensic ecogenomics and related forensic sub-disciplines. The implications of differences in animal model species, their organs/tissues and related parameters are explored and assessed to inform protocol standardization and knowledge transferability to often restricted cadaver-based analyses. The ultimate goal is potential validation and adoption of forensic ecogenomics in real crime scene toolkits in the determinations of postmortem, postmortem submersion, and postburial intervals.