The western coast of South America [5–30°S lat] is dominated by desert conditions that form a continuous, hyper-arid belt, broken only by occasional river valleys. The native, non-riparian vegetation of these deserts is largely confined to localities where recurring fogs meet the near-shore terrain. The fogs supply moisture for the development of plant communities here termed lomas formations. The lomas formations range over 3500 km and contain a combined vascular flora of over 1400 species. Individual lomas formations are isolated and endemism is high, reaching over 40% in some localities. This paper summarizes the current state of knowledge on the distribution and origin of the family Solanaceae within the lomas formations. The family is represented by 18 genera and 128 species arrayed in five subfamilies: Cestroideae, Nicotianoideae, Petunioideae, Schizanthoideae, and Solanoideae. Among the genera with endemic species are Exodeconus, Grabowskia, Jaltomata, Leptoglossis, Lycium, Nicotiana, Nolana, Reyesia, Schizanthus, Salpiglossis, and Solanum (including Lycopersicon). No fewer than 90 endemic species are recorded from the lomas formations, and Nolana, with 70 endemic lomas species, stands out as the largest and most wide-ranging genus of the lomas flora and the only genus to be encountered in all lomas formations. Different biogeographic patterns, i.e., autodisjunctions and allodisjunctions, are displayed and these reflect different arrival times and origins for the members of this specialized floristic community. Short-term climatic fluctuations, such as El Niño events, and long-term climatic change associated with glacial cycles have been influential in expansions and contractions in the floras of the Andean Cordillera. 7 132 A FESTSCHRIFT FOR WILLIAM G. D' ARCY F or nearly 3500 km along the western coast of South America [5°–30°S latitude], the Atacama and Peruvian Deserts form a con-tinuous, hyper-arid belt, broken only by occasional river valleys from the Andean Cordillera. Though this is one of the driest places on Earth, it is home to an extraordinary type of vegetation termed lomas formations (Dillon, 1997; Dillon & Hoffmann, 1997; Rundel et al., 1991). These highly endemic plant communities occur in near-shore locations where ocean fog provides sufficient moisture for the development of vegetation. Each locality is an island of vegeta-tion among a virtual ocean of arid desert, and over 100 such localities have been identified from northern Peru to central Chile (Fig. 1). The size and topography of individual formations vary greatly, as does the distance between formations. Rundel et al. (1991) provided a detailed discussion of the climate, geomorphology, and vegetation of this region, but a brief review of the major points is warranted for the current discussion.