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An option contract for vaccine procurement using the SIR epidemic model

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Abstract

Timely and adequate supply of vaccines in disastrous situations has a key role in controlling communicable diseases. This paper develops a specific option contract for proactively provisioning required vaccine doses from two suppliers (a main and a backup). The model aims to minimize the procurement and social costs using the SIR epidemic model. A novel hybrid solution procedure is developed using the optimal control theory, Stackelberg game model and nonlinear programming approaches. To evaluate the performance of the developed solution method, a number of numerical examples are presented and their results are discussed.

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... Option contracts (Patra and Jha 2022, Aghajani et al. 2020, Liang et al. 2012) and quantity flexibility contracts , Balcik and Ak 2014 are most widely studied. Another stream aims to optimize the governmentprivate FAs from a variety of perspectives, such as considering two or more (competitive) suppliers (Liu et al. 2019, Nikkhoo et al. 2018, Shamsi et al. 2018, combining physical reserve and production capacity reserve (Liu et al. 2022). Although the existing FAs could provide useful strategies for emergency supplies prepositioning at pre-disaster and emergency purchasing at post-disaster, "bounded rationality" of decision-makers has received less attention. ...
... It shows that the proposed flexible mechanism by two collaborative partners is effective in elevating the victims' satisfaction level on the supply of emergency supplies. Analogously, Shamsi et al. (2018) exert an option contract to establish a purchasing mode for vaccine doses from two competitive suppliers. The results indicate that the innovative procurement mechanism plays an essential role in guaranteeing the timely supply of vaccines and lowering the total social cost. ...
... How to measure the supplier's utility is a key question. Despite not retaining the property of diminishing sensitivity in the prospect theory, piecewiselinear loss aversion utility functions have been frequently used in production and operations management (POM), behavioral supply chain (BSC), finance, and economics (Long and Ghavamifar et al. (2022) single ✓ hybrid contract Liu et al. (2022) single ✓ option contract Patra and Jha (2022) single ✓ bilateral option contract single ✓ quantity flexibility contract single ✓ option contract single ✓ option contract Liu et al. (2019) multiple ✓ option contract Wang et al. (2019) multiple bonus contract Nikkhoo et al. (2018) two quantity flexibility contract Shamsi et al. (2018) two option contract Wang et al. (2015) single ✓ ✓ option contract this paper single ✓ ✓ ✓ option contract Fig. 1. The game timing between the agency and the supplier. ...
... Parvin et al. (2018) examine the optimal allocation of malaria medications in a three-layer centralized health supply chain system, in which the market demand uncertainty is modeled by a two-stage stochastic programming approach. Shamsi et al. (2018) develop a specific "options contract" for vaccine procurement under demand uncertainty. The authors build an analytical epidemic model to capture the establishment and spread of an infectious disease. ...
... Their experimental results indicate that the capacity bottleneck, as well as the level of supply disruptions, will be reduced significantly by implementing the "voluntary quarantine" mechanism. Shamsi et al. (2018) analytically develop a specific option contract for vaccine procurement by adopting the bi-level optimization approach with a nonlinear optimization problem. In their model, two suppliers, called the "main" and "back-up" suppliers, are explored in the presence of supply disruption. ...
... (iii) Establishing an emergency supply chain with contingency plans is necessary (Dasaklis et al., 2017), especially for the pre-pandemic stage (Choi, 2021). We suggest that firms, especially those who produce essential products, establish a plan to properly increase their production capacity, provide resource reservations, and adopt an emergency sourcing and collaboration strategy to combat both demand and supply disruption risks (Mishra & Singh, 2020;Paul & Chowdhury, 2020;Shamsi et al., 2018). ...
Article
The recent outbreak of COVID-19 has posed serious threats and challenges to global supply chain management (GSCM). To survive the crisis, it is critical to rethink the proper setting of global supply chains and reform many related operational strategies. We hence attempt to reform the GSCM from both supply and demand sides considering different pandemic stages (i.e., pre, during, and post-pandemic stages). In this research paper, we combine a careful literature review with real-world case studies to examine the impacts and specific challenges brought by the pandemic to global supply chains. We first classify the related literature from the demand and supply sides. Based on the insights obtained, we search publicly available information and report real practices of GSCM under COVID-19 in nine top global enterprises. To achieve 3Rs (responsiveness, resilience, and restoration), we then propose the "GREAT-3Rs" framework, which shows the critical issues and measures for reforming GSCM under the three pandemic stages. In particular, the "GREAT" part of the framework includes five critical domains, namely "Government proactive policies and measures", "Redesigning global supply chains", "Economic and financing strategies under risk", "Adjustment of operations", and "Technology adoption", to help global enterprises to survive the pandemic; "3Rs" are the outputs that can be achieved after using the "GREAT" strategies under the three pandemic stages. Finally, we establish a future research agenda from five aspects.
... Vaccination, medication, education, lockdown, quarantine, using face masks, and home health care are just a few of the techniques available to combat epidemics [2][3][4]. One of the most promising treatments for dealing with epidemic diseases is vaccination [5,6]. However, several elements of COVID-19 conditions, such as unclear identification, cause vaccine production to be delayed, with varying yields. ...
... In order to measure the social cost of infected people, the disability-adjusted life years (DALY) index is used. The cost of spreading a disease epidemic in unaffected areas by an infected individual as the host is included in the DALY [5,39,40]. ...
... As a result, another goal of this problem is to reduce vaccine supply procurement costs. Shamsi G, Ali Torabi [5] and Gamchi, Torabi [24] present some solutions for such multi-objective issues. ...
Article
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Infectious diseases drive countries to provide vaccines to individuals. Due to the limited supply of vaccines, individuals prioritize receiving vaccinations worldwide. Although, priority groups are formed based on age groupings due to the restricted decision-making time. Governments usually ordain different health protocols such as lockdown policy, mandatory use of face masks, and vaccination during the pandemics. Therefore, this study considers the case of COVID-19 with a SEQIR (susceptible–exposed–quarantined–infected–recovered) epidemic model and presents a novel prioritization technique to minimize the social and economic impacts of the lockdown policy. We use retail units as one of the affected parts to demonstrate how a vaccination plan may be more effective if individuals such as retailers were prioritized and age groups. In addition, we estimate the total required vaccine doses to control the epidemic disease and compute the number of vaccine doses supplied by various suppliers. The vaccine doses are determined using optimal control theory in the solution technique. In addition, we consider the effect of the mask using policy in the number of vaccine doses allocated to each priority group. The model’s performance is evaluated using an illustrative scenario based on a real case.
... Parvin et al. (2018) examine the optimal allocation of malaria medications in a three-layer centralized health supply chain system, in which the market demand uncertainty is modeled by a two-stage stochastic programming approach. Shamsi et al. (2018) develop a specific "options contract" for vaccine procurement under demand uncertainty. The authors build an analytical epidemic model to capture the establishment and spread of an infectious disease. ...
... Their experimental results indicate that the capacity bottleneck, as well as the level of supply disruptions, will be reduced significantly by implementing the "voluntary quarantine" mechanism. Shamsi et al. (2018) analytically develop a specific option contract for vaccine procurement by adopting the bi-level optimization approach with a nonlinear optimization problem. In their model, two suppliers, called the "main" and "back-up" suppliers, are explored in the presence of supply disruption. ...
... (iii) Establishing an emergency supply chain with contingency plans is necessary (Dasaklis et al. 2017), especially for the pre-pandemic stage (Choi 2021). We suggest the firms, especially those who produce essential products, establish a plan to properly increase their production capacity, provide resource reservation as well as adopt an emergency sourcing and collaboration strategy to combat both demand and supply disruption risks (Shamsi et al. 2018, Mishra and Singh 2020, Paul and Chowdhury 2020. (iv) Rerouting the vehicles and having alternative logistics choices (e.g., using third-party logistics (Li et al. 2018)) under travel restrictions can be considered. ...
... In this case, Nosoohi and Nookabadi [75] developed an outsourcing model to analyze optimal ordering strategy under disruptions in final processing costs and customer demand. Torabi [76] studied the impact of timely and adequate vaccine delivery in catastrophic infectious disease conditions, considering two suppliers, including a main and a backup to provide the vaccine doses needed. In addition, Heydari, Govindan, Nasab and Taleizadeh [77] investigated the role of outsourcing in a supply chain and concluded that such a strategy enhances the earnings of both channel and its members. ...
... This contract can be used for humanitarian services to ensure efficient service in case of catastrophic events. Torabi [76] analyzed an option contract to create coordination between two suppliers to provide the requirements for the epidemic. Most studies surveyed the effect of this contract on traditional channels, while such a mechanism is also widely used in e-channels and actually addressed in various industries. ...
... x x x Ivanov (2022) x x x x x Llaguno et al. (2021) x Kaur and Singh (2021) x Kellner et al. (2019) x Kinra et al. (2020) x Li and Zobel (2020) x Lowe et al. (2020) x x Lücker et al. (2020) x Mamani et al. (2013) x Nagurney (2021) x Naqvi and Amin (2021) x Nuss et al. (2016) x Park et al. (2021) x Paul and Chowdhury (2020) x Paul and Chowdhury (2021) x x x Queiroz et al. (2022) x Rothan and Byrareddy (2020) x Sawik (2022) x Sawik (2023) x Ouardighi et al. (2021) x x Shamsi et al. (2018) x Sinha et al. (2020) x Torabi et al. (2015) x Torabi et al. (2018) x Vahidi et al. (2018) x Li et al. (2023) x Yusuf and Benyah (2012) x Our paper x x x x portfolio selection problem with past supplier data and four criteria: purchasing cot, logistic service, risk, and sustainability. Hosseini et al. (2019) propose a stochastic multi-objective optimization model for resilient supplier selection and demand allocation using probabilistic graphical model for computing the probability disruption of the supplier. ...
... All such models only consider a macro-economic or social policy framework and implicitly assume that production facilities are not affected by the epidemic. Shamsi et al. (2018) looks into the procurement of vaccines and uses an optimal control model to minimize the procurement and social costs using the SIR epidemic model. Whereas Enayati and Özaltın (2020) addresses the optimal influenza vaccine doses number for distribution. ...
Article
The COVID-19 pandemic has illustrated the unprecedented challenges of ensuring the continuity of operations in a supply chain as suppliers' and their suppliers stop producing due the spread of infection, leading to a degradation of downstream customer service levels in a ripple effect. In this paper, we contextualize a dynamic approach and propose an optimal control model for supply chain reconfiguration and ripple effect analysis integrated with an epidemic dynamics model. We provide supply chain managers with the optimal choice over a planning horizon among subsets of interchangeable suppliers and corresponding orders; this will maximize demand satisfaction given their prices, lead times, exposure to infection, and upstream suppliers' risk exposure. Numerical illustrations show that our prescriptive forward-looking model can help reconfigure a supply chain and mitigate the ripple effect due to reduced production because of suppliers' infected workers. A risk aversion factor incorporates a measure of supplier risk exposure at the upstream echelons. We examine three scenarios: (a) infection limits the capacity of suppliers, (b) the pandemic recedes but not at the same pace for all suppliers, and (c) infection waves affect the capacity of some suppliers, while others are in a recovery phase. We illustrate through a case study how our model can be immediately deployed in manufacturing or retail supply chains since the data are readily accessible from suppliers and health authorities. This work opens new avenues for prescriptive models in operations management and the study of viable supply chains by combining optimal control and epidemiological models.
... This seminal work has been then extended in Mamani et al. (2013) by considering the contract design problem with multiple governments and the possibility of intranational transmission of the disease. More recently, Torabi et al. (2018), using the SIR epidemic model, devise a procedure including an optimal control model to decide on post-disaster vaccine supply with consideration of demand uncertainty. The models proposed in Torabi et al. (2018); Chick et al. (2008); Mamani et al. (2013) implicitly assume that workforce availability is not affected by the epidemic. ...
... More recently, Torabi et al. (2018), using the SIR epidemic model, devise a procedure including an optimal control model to decide on post-disaster vaccine supply with consideration of demand uncertainty. The models proposed in Torabi et al. (2018); Chick et al. (2008); Mamani et al. (2013) implicitly assume that workforce availability is not affected by the epidemic. Enayati and Özaltın (2020) address optimal influenza vaccine distribution. ...
Article
Full-text available
A pandemic can wreak havoc in supply chains, as witnessed in the COVID-19 context. As workers get infected, production level drops and demand from customers goes unfulfilled. Combining in a novel way an epidemic model with optimal control theory, our model provides a plant manager with the optimal level of prophylactic effort she needs to deploy over a planning horizon to protect the workforce from a pandemic in its early stage and so maintain production levels. Given the production planning problem, the effort in terms of prophylactic measures can be optimally determined in closed form, balancing worker protection against production requirements in a single step. The manager must initially implement the strictest measures before relaxing them in time. Three extensions are presented:, (1) determine the optimal period of time over which the prophylactic measures should be maintained; (2) determine the optimal effort in terms of prophylactic measures in the case of an endemic disease; and (3) assess the effect of a stochastic exogenous shock on the total number of infected. This research provides a production planning model that allows a decision-maker to mitigate the impact of worker absenteeism at the onset of a pandemic, thus improving supply chain resilience.
... In OR applications, we also register two additional (and opposite) situations: on the one hand, works in which the calibration is implicit, because researchers borrow models already calibrated in the literature and use these models to perform further investigations -see Enayati & Özaltın (2020) ; Kaplan et al. (20 02,20 03) ; Lin et al. (2020) ; Ren et al. (2013) ; Tebbens & Thompson (2009) . On the other hand, works in which inputs are elicited are either directly assigned by the modelers or derived from experts' opinions, as in Shamsi G et al. (2018) . This happens especially when models involve poorly known compartments, e.g., a network compartment in Rahmandad & Sterman (2008) , or a mobile medical team in Rachaniotis et al. (2012) . ...
... Kaplan et al. (20 02,20 03) study the marginal behavior of the number of fatalities varying five model inputs, that comprise the number of initially infected individuals and of available vaccinators, over predetermined ranges. Shamsi G et al. (2018) use several one-way sensitivity plots to study the variation of several outputs, such as the social cost and percentage of recovered individuals, respond-ing to changes in vaccine delivery time. Tebbens & Thompson (2009) use one-way sensitivity functions to study the impact of population size and population structure on policy decision rules, such as the incremental cost-effectiveness ratio and the time until disease elimination. ...
Article
Operations researchers worldwide rely extensively on quantitative simulations to model alternative aspects of the COVID-19 pandemic. Proper uncertainty quantification and sensitivity analysis are fundamental to enrich the modeling process and communicate correctly informed insights to decision-makers. We develop a methodology to obtain insights on key uncertainty drivers, trend analysis and interaction quantification through an innovative combination of probabilistic sensitivity techniques and machine learning tools. We illustrate the approach by applying it to a representative of the family of susceptible-infectious-recovered (SIR) models recently used in the context of the COVID-19 pandemic. We focus on data of the early pandemic progression in Italy and the United States (the U.S.). We perform the analysis for both cases of correlated and uncorrelated inputs. Results show that quarantine rate and intervention time are the key uncertainty drivers, have opposite effects on the number of total infected individuals and are involved in the most relevant interactions.
... Some scholars divide relief supplies into two categories: perishable products and non-perishable commodities, and propose different strategies (outsourcing and insourcing) to pre-position the two kinds of relief supplies (Wang et al., 2016;Yao et al., 2018). Many researchers pay attention to the pre-positioning problem of a certain type of relief supplies such as food (Zhang et al., 2019) and vaccine (Shamsi et al., 2018) because these relief supplies are critical products which are in great demand in the early post-disaster. It can be seen that the classification of relief supplies largely determines pre-positioning strategies for different types of relief supplies. ...
... Similar results can be seen in Yao et al. (2018). Shamsi et al. (2018) presented an option contract between the buyer and two competing suppliers and determined the optimal amount of the required vaccine doses provided by the two suppliers. Zhang et al. (2019) built a quantity commitment contract framework where there was a government authority and an agreement supplier. ...
Article
Full-text available
It is vital to pre-position a certain amount of relief supplies at pre-disaster. But governments are often confronted with a dilemma of coordinating inventory cost and stock-out cost in pre-positioning relief supplies. Pre-positioning strategies for relief supplies depend on the natural characteristic of relief supplies and the most urgent needs at post-disaster. Therefore, we classify relief supplies by their natural characteristic and priority, and introduce an option contract into relief supplies pre-positioning system which consists of a single government and an agreement enterprise. Specially, a consumable and relatively urgent relief supplies pre-positioning (C-RUP) model and a non-consumable and urgent relief supplies pre-positioning (NC-UP) model are established. The optimal decisions of the government and the enterprise are derived, respectively. The relief supply chain coordination is achieved with the option contract. Under channel coordination, the two models can not only improve the government’s emergency ability and support capacity, but also reduce the government’s inventory risk when compared to the government single pre-positioning model. Moreover, we give out the conditions that the two sides can reach a win-win situation. Lastly, we propose important managerial insights for pre-positioning strategies related to different types of relief supplies.
... Each major natural disaster or public health crisis has had a significant impact on the economy and the safety of human lives. Sufficient emergency material reserves are crucial for the mitigation of the threat of disasters [1]. ...
Article
Full-text available
Sustainable Emergency Material Reserve Systems (SEMRSs) are complex frameworks comprising three types of reserves, namely, physical, capacity, and agreement reserves, and involve various stakeholders such as local governments and enterprises. However, multiple stockpiling methods have not been considered in investigations on the influencing factors and inter-factor relationships within an emergency material stockpiling system. In this study, we achieved consensus through a questionnaire, established an evaluation system encompassing various reserve methods and participating entities, and delineated the key factors affecting SEMRSs while analyzing their causal relationships using the decision-making trial and evaluation laboratory–based analytic network process. Results reveal that (1) local governments and participating enterprises play crucial roles in ensuring the sustainable supply of emergency provisions; (2) the capacity to guarantee emergency funds serves as a pivotal link among all key influencing factors, emergency funds should be augmented, and the utilization of contingency funds should be rationalized; and (3) the integration of physical, production capacity, and agreed stockpiling methods in the emergency reserve system requires enhancement, and the incorporation of capital reserves should be considered as part of the stockpiling strategy. These insights hold significant implications for refining emergency stockpiling practices and fostering the development of SEMRSs.
... Pazirandeh (2011) presents a decision-making framework for strategic sourcing and distribution of vaccines in developing countries. Shamsi et al. (2018) propose an option contract using the Stackelberg game approach to procure required vaccine doses from two suppliers. In a similar context, Martin et al. (2020) propose three vaccine procurement contract designs to encourage pharmaceutical companies to bring vaccines to developing countries. ...
... There are several differences between the vaccine supply chain (VSC) and the traditional supply chain, which can provide unique characteristics of VSC. For instance, the non-profit identity of the buyer, high associated risks in terms of products' perishability, supply and demand uncertainties, and very limited reliable information (Shamsi G. et al. 2018). ...
... Finally, demand for vaccines during pandemics greatly outstrips supply, which causes a shortage of supply. A new decision model for vaccine supply in response to an uncertain vaccine demand can also be considered in future research (Jahani et al., 2022;Shamsi G. et al., 2018). links with added vaccine production (ω ∈ {1, ..., A 1 }) A 2 links with fixed vaccine production (γ ∈ {1, ..., A 2 }) δ a,p 1 if an element of incidence matrix of link a on path p, and 0 otherwise W t the total number of vaccine which is distributed in period t x t,p the number of vaccine production for path p in period t f a,t vaccine flows on link a in period t f ω,t vaccine flows on link ω in period t f γ,t vaccine flows on link γ Γ t,ω the upper bound of vaccine production per week t on link ω Γ t,γ the upper bound of vaccine production per week t on link γ Γ t,ω vaccine capacity per week t on links ω I t h the number of infected humans in period t I t m the number of infected animals in period t S t h the number of susceptible humans in period t V t h the number of vaccinated susceptible humans in period t S t m the number of susceptible animals in period t E t h the number of exposed humans in period t E t m the number of exposed animals in period t R t h the number of removed humans in period t R t m the number of removed animals in period t σ t the percentage of vaccine coverage in period t α h population vaccination rate Λ m animal birth rate Λ h human birth rate µ m animal natural death rate µ h human natural death rate d m animal MPX related death rate d h human MPX related death rate ρ m animal recovery rate ρ h human recovery rate ν m animal infection rate ν h human infection rate β mm animal to animal transmission rate rate β hh human to human transmission rate rate β mh animal to human transmission rate rate ϖ price of vaccine Symbol Description(continued) Θ M P X infection loss of MPX N population (human population N h ,animal population N m ) ϖ(W t ) the total purchasing cost of vaccineŝ c a (f a,t ) the total operation cost on link â π t,α (Γ t,α ) the investment cost on link α ...
Article
Full-text available
After a pandemic, all countries experience a shortage in vaccine supply due to limited vaccine stocks and production capacity globally. One particular problem is that it's hard to predict demands for vaccines during the global crisis. On the other hand, vaccines are usually made and packaged in different places, raising logistical issues and concerns that can further delay distribution. In this paper, we propose an optimization model to link infectious disease dynamics and supply chain networks considering a one-to-one relationship between demand and supply for vaccines. We focus on designing a vaccine coordination system using government subsidy that considers the equilibrium behaviors of manufacturers under an actual demand for the vaccine. This study evaluates vaccine manufacturers and government behaviors that help the vaccine market to reach the socially optimal. Different decisions, such as vaccine demands and vaccine production and distribution are investigated. A study of the monkeypox pandemic in the U.S. is performed to validate our model and its results. The obtained results from testing the proposed system problem revealed that the vaccine coverage increased by up to 35%, while the unmet demand reduced by up to 60%, in comparison to when vaccine manufacturers act individually.
... Hence, designing option contracts in DRL has received increasing attention from researchers. For example, Shamsi et al. (2018) presented a new provisioning model under option contract with the goal of minimizing procurement and social costs to proactively supply the needed vaccine doses from a main supplier and a backup supplier. introduced a put option contract into DRL and proposed a relief items purchasing model, which can not only ensure the profits of suppliers, but also reduce the inventory risk of governments. ...
Article
Disaster relief logistics (DRL) provides adequate relief supplies to victims of natural disasters (e.g., earthquakes and volcanic eruptions). This study explicitly considers supplier selection and inventory pre-positioning corresponding to static preparedness decisions, and post-disaster procurement and delivery associated with dynamic response decisions in actual DRL operations. To tackle issues triggered by shortage and surplus of multi-class relief resources, a flexible option contract is adopted to purchase relief items from suppliers. To measure the risk of demand ambiguity, a worst-case mean-quantile-deviation criterion is introduced to reflect the decision-maker's risk-averse attitude. To handle the ambiguity in the probability distribution of demand, a novel two-stage distributionally robust optimization (DRO) model is developed for the addressed DRL problem. The proposed DRO model can be transformed into equivalent mixed-integer linear programs when the ambiguity sets incorporate all distributions within L1-norm and joint L1- and L∞-norms from a nominal (reference) distribution. A computational study of earthquakes in Iran is conducted to illustrate the applicability of the proposed DRO model to real-world problems. The experimental results demonstrate that our proposed DRO model has superior out-of-sample performance and can mitigate the effect of Optimization Bias compared to the traditional stochastic programming model. Some managerial insights regarding the proposed approach are provided based on numerical results.
... The SIR epidemic model is used for analysis of the post-disaster situation considering the delivery of vaccines. Shamsi et al. (2018) propose a game formulation for vaccine procurement exploring option contracts considering a backup supplier. The aim of the buyer is to minimize cost (including social cost) and the objective of the suppliers is to maximize profit. ...
Article
Full-text available
The increasing damage caused by disasters is a major challenge for disaster management authorities, especially in instances where simultaneous disasters affect different geographical areas. The uncertainty and chaotic conditions caused by these situations combined with the inherent complexity of collaboration between multiple stakeholders complicates delivering support for disaster victims. Decisions related to facility location, procurement, stock prepositioning and relief distribution are essential to ensure the provision of relief for these victims. There is a need to provide analytical models that can support integrated decision-making in settings with uncertainty caused by simultaneous disasters. However, there are no formulations tackling these decisions combining multiple suppliers, multiple agencies, and simultaneous disasters. This article introduces a novel bi-objective two-stage stochastic formulation for disaster preparedness and immediate response considering the interaction of multiple stakeholders in uncertain environments caused by the occurrence of simultaneous disasters. At the first stage, decisions related to the selection of suppliers, critical facilities, agencies involved, and pre-disaster procurement are defined. Resource allocation, relief distribution and procurement of extra resources after the events are decided at the second stage. The model was tested on data from the situation caused by simultaneous hurricanes and storms in Mexico during September of 2013. The case is contrasted with instances planning for disasters independently. The results show how planning for multiple disasters can help understand the real boundaries of the disaster response system, the benefits of integrated decision-making, the impact of deploying only the agencies required, and the criticality of considering human resources in disaster planning.
... Xie et al. (2021) analyzed subsidy selection in a vaccine supply chain with risk-averse buyers using evolutionary game methods. Shamsi et al. (2018) used optimal control theory, Stackelberg game model, and a nonlinear programming method to construct SIR epidemic model to minimize procurement and social costs in the vaccine supply chain. Pan et al. (2022) discussed the impact of public and private hospital supply on the vaccine supply chain. ...
Article
Currently, the global spread of COVID-19 is taking a heavy toll on the lives of the global population. There is an urgent need to improve and strengthen the coordination of vaccine supply chains in response to this severe pandemic. In this study, we consider a closed-loop vaccine supply chain based on a combination of artificial intelligence and blockchain technologies and model the supply chain as a two-player dynamic game with inventory level as the dynamic equation of the system. The study focuses on the applicability and effectiveness of the two technologies in the vaccine supply chain and provides management insights. The impact of the application of the technologies on environmental performance is also considered in the model. We also examine factors such as the number of people vaccinated, positive and side effects of vaccines, vaccine decay rate, revenue-sharing/cost-sharing ratio, and commission ratio. The results are as follows: the correlation between the difficulty in obtaining certified vaccines and the profit of a vaccine manufacturer is not monotonous; the vaccine manufacturer is more sensitive to changes in the vaccine attenuation rate. The study’s major conclusions are as follows: First, the vaccine supply chain should estimate the level of consumers’ difficulty in obtaining a certified vaccine source and the magnitude of the production planning and demand forecasting error terms before adopting the two technologies. Second, the application of artificial intelligence (AI) technology is meaningful in the vaccine supply chain when the error terms satisfy a particular interval condition.
... There is a growing interest in optimizing VSCs from operational management perspectives. Torabi [8] construct a Stackelberg game model based on the susceptible infected recovered (SIR) epidemic model and developed a vaccine procurement option contract to minimize procurement and social costs. Ng et al. [9] study an influenza VSC to derive optimal solutions with the aim of improving vaccination efficiency and finding the best combination of vaccination strategies. ...
Article
People can choose to be vaccinated to prevent diseases at their own expense. There are specific vaccines for many diseases. Meanwhile, for a particular disease, there might be multiple vaccines available to choose from. Based on that, we constructed a stylized vaccine supply chain (VSC) model for the market where domestic vaccines and imported vaccines co-exist. We explored the effect of government tariff policies on the game behaviors between a domestic vaccine manufacturer (DVM) and an imported vaccine manufacturer (IVM). This paper analyzes the short-term game and long-term evolutionary game behaviors of the VSC from both the entirely rational and boundedly rational perspectives. The analysis considers three tariff policies: no tariffs on imported vaccines, tariffs borne by the IVM, and tariffs borne by buyers. Results suggest that in the short-term game, buyers bearing tariffs on imported vaccines can enable the DVM to gain the most market share. The buyers willingness-to-pay is relatively low for imported vaccines, which makes the DVM more profitable. Imposing tariffs on imported vaccines can reduce the IVMs profit margin. However, the IVM still prefers to bear the tariffs itself. Lowering the cold chain transportation level and reducing the retail price of imported vaccines are both feasible solutions for the IVM to relieve the pressure from tariffs. It is also feasible for the IVM to increase the retail price of imported vaccines when the buyers willingness to pay for imported vaccines is high. In long-term evolutionary game, the DVM can gain more room for price adjustment if the IVM bears tariffs. The IVM can obtain greater cost tolerance if buyers bear tariffs. However, from governments prospective, tariffs borne by buyers is the optimal option, which makes the VSC stable and controllable.
... In their contract design, the buyer purchases certain options from a supplier that provides the buyer with the right to exercise the options when a disaster occurs. Using the Stackelberg game and optimal control theory, Shamsi et al. (2018) proposed an OPC for procuring vaccines under an SIR epidemic model. Liu et al. (2019b) established an OPC to determine how many items should be pre-purchased from multiple suppliers and the amounts that should be prepositioned by the government. ...
Article
This paper proposes a novel hybrid relief procurement contract in which the specific features of option contract and quantity flexible contract are used to coordinate the supply of a relief item between a supplier and a humanitarian organization. First, a mathematical statistics approach is used to categorize different provinces according to a multi-hazard risk approach. Then, the proposed contract is elaborated. Different managerial insights are derived from conducting several sensitivity analyses in our case study. The results reveal that using the proposed contract can significantly improve the procurement process by reducing the shortage and overstocking risks in humanitarian organizations.
... [25]. The risk spread of pandemic models is widely used in finance, with contagion caused by shocks to complex financial networks [26]; how to use the SIR epidemic model to develop contracts that minimize procurement and social costs after disasters is considered [27]. Despite the SIR epidemic model being well developed, it has not been used for the risk propagation mechanism in the automotive supply chain. ...
Article
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Risk propagation is occurring as an exceptional challenge to supply chain management. Identifying which supplier has the greater possibility of interruptions is pivotal for managing the occurrence of these risks, which have a significant impact on the supply chain. Identifying and predicting how these risks propagate and understanding how these risks dynamically diffuse if control strategies are installed can help to better manage supply chain risks. Drawing on the complex systems and epidemiological literature, we research the impact of the global supply network structure on risk propagation and supply network health. The SIR model is used to dynamically identify and predict the risk status of the supply chain risk at different times. The results show that there is a significant relationship between network structure and risk propagation and supply network health. We demonstrate the importance of supply network visibility and of the extraction of the information of node firms. We build up an R package for geometric graphs and epidemics. This paper applies the R package to model the supply chain risk for an automotive manufacturing company. The R package provides a firm to construct the complicated interactions among suppliers and display how these interactions impact on risks. Theoretically, our study adapts a computational approach to contribute to the understanding of risk management and supply networks. Managerially, our study demonstrates how the supply chain network analysis approach can benefit the managers by developing a more holistic framework of system-wide risk propagation. This provides guidance for network governance policies, which will lead to healthier supply chains.
... The priority of various people groups is the most useful policy in discounting the pandemics' impacts on vaccines' distribution (Uscher-Pines et al. 2006). This policy plays an essential role in reducing the total social cost related to an infected person (the medicine drugs, hospitalization cost, and other disease costs) (Torabi 2018). Healthcare providers, vital services providers, and people with a high risk of outbreaks are priority groups for vaccination recommended by WHO. ...
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Vaccination is one of the most efficient ways to restrict and control the spread of epidemic outbreaks such as COVID-19. Due to the limited COVID-19 vaccine supply, an equitable and accessible plan should be prepared to cope with. This research focuses on designing a vaccine supply chain while aiming to achieve an equitable and accessible network. We present a novel mathematical formulation that helps to optimize vaccine distribution to inoculate people with various priority levels to achieve an equitable plan. The transshipment strategy is also incorporated into the model to enhance the accessibility of COVID-19 vaccine types between health facilities. The nature of COVID-19 is dynamic over time due to mutations, and the protection level of each vaccine type against this disease is not exact. Besides, complete information about the demand for different vaccine types is not available. Hence, we use Multi-Stage Stochastic Programming as a reliable strategy that is organized to manage stochastic data in a dynamic environment for the first time in the vaccine supply chain network. The scenarios in this approach are generated using a Monte Carlo simulation method, and then a forward scenario reduction technique is conducted to construct a suitable scenario tree. The practicality and capability of the model are shown in a real-life case of Iran. The results show that the performance of the Multi-Stage Stochastic Programming is significantly improved compared with the two-stage stochastic programming regarding the total cost of the vaccine supply chain and the number of the shortage units.
... They used the epsilon-constraint method, multi-objective genetic algorithm (MOGA), and multi-objective particle swarm optimization (MOPSO) to solve their model. Torabi (2018) developed an option contract to prevent the required dose of vaccine. They designed a model with the aim of minimizing purchasing and social costs, which had two suppliers (main and backup). ...
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In this paper, a new responsive-green-cold vaccine supply chain network during the COVID-19 pandemic is developed for the first time. According to the proposed network, a new multi-objective, multi-period, multi-echelon mathematical model for the distribution-allocation-location problem is designed. Another important novelty in this paper is that it considers an Internet-of-Things application in the COVID-19 condition in the suggested model to enhance the accuracy, speed, and justice of vaccine injection with existing priorities. Waste management, environmental effects, coverage demand, and delivery time of COVID-19 vaccine simultaneously are therefore considered for the first time. The LP-metric method and meta-heuristic algorithms called Gray Wolf Optimization (GWO), and Variable Neighborhood Search (VNS) algorithms are then used to solve the developed model. The other significant contribution, based on two presented meta-heuristic algorithms, is a new heuristic method called modified GWO (MGWO), and is developed for the first time to solve the model. Therefore, a set of test problems in different sizes is provided. Hence, to evaluate the proposed algorithms, assessment metrics including (1) percentage of domination, (2) the number of Pareto solutions, (3) data envelopment analysis, and (4) diversification metrics and the performance of the convergence are considered. Moreover, the Taguchi method is used to tune the algorithm’s parameters. Accordingly, to illustrate the efficiency of the model developed, a real case study in Iran is suggested. Finally, the results of this research show MGO offers higher quality and better performance than other proposed algorithms based on assessment metrics, computational time, and convergence.
... At the same time, DES paradigm was used for the analysis of resulting data of ABS paradigm. Shamsi et al. (2018) constructed a specific option contract for proactively provisioning required vaccine from two suppliers (main supplier and a backup supplier). This model goal is to minimize procurement and social cost. ...
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The black swan event caused by the novel coronavirus (COVID-19) has majorly exposed the vulnerabilities of the supply chain of many of the firms. However, healthcare sector is one of the significant areas which majorly got disrupted during this pandemic event. The majority of the studies focus on the reviews on supply chain disruption modelling to analyse the risk and their effect on supply chains. This study provides a systemic literature review of various supply chain disruption models in the healthcare sector, analyses them based on different parameters identified from the literature. Some of our key findings include (1) analysis of quantitative and analytical modelling approaches used for dealing with disruption in healthcare sector; (2) managerial implications that derive potential future research avenues and insights for practitioners in the domain of healthcare supply chain disruption in post-pandemic era to improve international competitiveness and operational excellence.
... The proper distribution of emergency supplies is essential for controlling the spread of epidemics (Deng, Shen, & Vorobeychik, 2013;Kasaie & David Kelton, 2013;Liu & Ming, 2016). Most of the studies on the allocation of emergency supplies during large-scale epidemics are based on the SIR model of infectious disease, which is used to dynamically allocate medical supplies based on their demand (Shamsi et al., 2018). Vaccines are crucial during epidemics, as they can delay the spread of an epidemic; however, the allocation of vaccines is relatively concentrated (Westerink- Duijzer, Schlicher, & Musegaas, 2020;Yarmand, Ivy, Denton, & Lloyd, 2014). ...
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... Some disruptions, such as machines needing repairs or a fire in the factory of the manufacturer or their supplier, only disrupt one supply chain (Li et al., 2017;Son and Orchard, 2013;Paul et al., 2014Paul et al., , 2015, while others, such as an earthquake, Hurricane, or other natural disasters, affect partners in a particular location (e.g. a state or district of a country or the entire country) Chen et al., 2015). On the other hand, a major epidemic such as the 2014 Ebola outbreak in West Africa and the 1991-94 Cholera outbreak in South America, and pandemic disruption such as severe acute respiratory syndrome (SARS) in 2003 and H1N1 in 2009, affect a large region or the entire world simultaneously and have more severe impacts (B€ uy€ uktahtakın et al., 2018;Huff et al., 2015;Min, 2012;Shamsi et al., 2018). However, the current pandemic, COVID-19, has broken all previous records for its levels of interruption, as it has already affected almost all supply chains around the world, and its impacts are greater than those of any prior pandemic (Chowdhury et al., 2020a, b;Laing, 2020;van Barneveld et al., 2020;Sen, 2020;Koonin, 2020). ...
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... A special type of cost-sharing and coordinating can improve cost-benefit in public health and provide incentives for both players. Shamsi et al. (2018) extend Chick et al. (2008) by (i) considering a backup supplier to overcome uncertainties and (ii) adding a new social cost objective. An option contract is developed between a buyer, a governmental organization, and two vaccine suppliers. ...
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We reviewed research papers related to pandemics/epidemics (disease outbreaks of a global/regional scope) published in major operations management, operations research, and management science journals through the end of 2019. We evaluate and categorize these papers. We study research trends, explore research gaps, and provide directions for more efficient and effective research in the future. In addition, our recommendations include the lessons learned from the ongoing pandemic, COVID-19. We discuss papers in the following categories: (a) warning signals/surveillance, (b) disease propagation leading to pandemic conditions, (c) mitigation, (d) vaccines and therapeutics development, (e) resource management, (f) supply chain configuration, (g) decision support systems for managing pandemics/epidemics, and (h) risk assessment.
... Davis et al. (2013) proposed a stochastic programming model to determine how supplies should be positioned and distributed among a network of cooperative warehouses for HSC coordination. Shamsi et al. (2018) developed an options contract model to proactively procure necessary vaccine from the suppliers using a Susceptibility-Infection-Recover (SIR) epidemic model. Fathalikhani et al. (2018Fathalikhani et al. ( , 2019 used the Stackelberg games, where the humanitarian NGO's were considered as leaders and donors were represented as followers. ...
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Procurement of aid material such as vaccines by a humanitarian agency (HA) is often fraught with uncertainties. For example, an epidemic outbreak can increase the demand for materials (such as vaccines) in a very short period. Most of the HAs depend on external donations (funding) to procure necessary vaccines to meet this demand. Hence, it is financially infeasible and operationally inefficient for the HA to procure large quantities of aid material in anticipation of a demand spike during an epidemic outbreak. Thus, the procurement processes for aid materials such as vaccines need to be flexible enough to meet these demand fluctuations. HAs can achieve this flexibility by employing a procurement mechanism portfolio that includes upfront buying, capacity reservation, spot market purchase, etc. However, the challenge lies in identifying the optimal combination of multiple procurement mechanisms and how they can be utilized to coordinate the humanitarian supply chain. In this study, we explore the feasibility of quantity flexibility contracts along with discount incentives combined with spot market procurement in humanitarian supply chains for aid material procurement. We also derive the conditions under which the contract can achieve systemic coordination between the supplier and HA. Furthermore, we also illustrate that under optimal conditions, the procurement of aid material using multiple procurement mechanisms by HA can also reduce the humanitarian supply chain’s total cost.
... Chick et al. [9] formulate a contract between a supplier and the government who aims to minimize the expected social cost under stochastic yield, moral hazard, and adverse selection. Shamsi et al. [10] design an option contract for vaccines needed at the time of emergencies or outbreaks. Mamani et al. [11] study the inefficiencies in the allocation of influenza vaccine through a game-theoretical model. ...
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In this paper, we analyze the vaccine supply chain of child immunization program of India under stochastic production yield. We show that the wholesale price contract cannot achieve channel coordination. We propose a subsidy contract to coordinate the vaccine supply chain. A case analysis in the Indian context is presented to illustrate the impact of the proposed subsidy contract.
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Disasters affect hundreds of millions of people every year and the response of governments is crucial in alleviating the suffering of those affected. Despite the importance of contracting in response to disasters, research on this topic is conspicuous by its absence. This paper begins to address this gap by investigating the choice of procurement contract type by US federal agencies during disaster management operations. The research relies on 47,560 contracts issued by the US federal government in response to 14 major disasters between 2005 and 2016. We build on agency theory to investigate the choice of the contract type made by federal agencies at the different stages of a relief operation. This research provides empirical evidence of the key factors underpinning the choice of contract in the context of disaster management, namely the amount of spend per contract and the type of acquisition (product or service), and reveals the moderating role of the stage of the relief operation.
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Le COVID-19 est une pandémie mondiale qui a bouleversé les modes de gouvernance des organisations. Les chaînes logistiques ont contribué, de plusieurs manières, à faire face et à atténuer les effets de cette épidémie. Néanmoins, ces chaînes ont été confrontées à plusieurs modifications et ont opéré plusieurs changements pour s’adapter avec les nouvelles barrières frontalières et opérationnelles. L’objet de ce papier de recherche est d’établir une analyse qualitative des effets du COVID-19 sur la logistique et le supply chain. Nous proposons alors une analyse théorique des travaux traitant la gestion des chaînes d’approvisionnement lors des épidémies et spécialement la pandémie du COVID-19. À travers une revue de littérature, nous avons synthétisé plusieurs écrits scientifiques traitant les chaînes d’approvisionnement dans une pandémie. Cet examen nous a permis de dégager les principaux challenges et opportunités des chaînes d’approvisionnement mondiales pendant et après cette épidémie. L’analyse qualitative réalisée montre différents défis et opportunités actuels et futurs des SC. Mots clefs : Supply chain, pandémie, logistique de pandémie, logistique de service, performance, performance logistique, COVID-19.
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The extant study aimed to create a kind of coordination in the humanitarian chain by using a quantity flexibility (QF) contract. The QF contract considers a kind of coordination between a relief organization and a producer for inventory management determining order volumes. Due to insufficiency of amenities or time limits during the crisis, an internal producer can outsource a part of its duties to an external producer to produce items and accelerate the relief process. Hence, this study proposed a completely novel bi-objective mathematical model to coordinate relief items' supply and distribution by using QF contracts and buying in the spot market under demand uncertainty conditions to reduce costs and accelerate relief services. The augmented epsilon constraint method was used to solve the small scales of this model and NSGA-II and NRGA algorithms were employed to solve large scales. The results indicated the powerful performance of NRGA in terms of most evaluation indicators.
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Purpose Each individual needs to be vaccinated to control the spread of the COVID-19 pandemic in the shortest possible time. However, the vaccine distribution with an already strained supply chain in low- and middle-income countries (LMICs) will not be effective enough to vaccinate all the population in stipulated time. The purpose of this paper is to show that there is a need to revolutionize the vaccine supply chain (VSC) by overcoming the challenges of sustainable vaccine distribution. Design/methodology/approach An integrated lean, agile and green (LAG) framework is proposed to overcome the challenges of the sustainable vaccine supply chain (SVSC). A hybrid best worst method (BWM)–Measurement of Alternatives and Ranking According to COmpromise Solution (MARCOS) methodology is designed to analyze the challenges and solutions. Findings The analysis shows that vaccine wastage is the most critical challenge for SVSC, and the coordination among stakeholders is the most significant solution followed by effective management support. Social implications The result of the analysis can help the health care organizations (HCOs) to manage the VSC. The effective vaccination in stipulated time will help control the further spread of the virus, which will result in the normalcy of business and availability of livelihood for millions of people. Originality/value To the best of the author's knowledge, this is the first study to explore sustainability in VSC by considering the environmental and social impact of vaccination. The LAG-based framework is also a new approach in VSC to find the solution for existing challenges.
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Purpose The already-strained vaccine supply chain (VSC) of the expanded program for immunization (EPI) require a more robust and structured distribution network for pandemic/outbreak vaccination due to huge volume demand and time constraint. In this paper, a lean-agile-green (LAG) practices approach is proposed to improve the operational, economic and environmental efficiency of the VSC. Design/methodology/approach A fuzzy decision framework of importance performance analysis (IPA)–analytical hierarchy process (AHP)–technique for order for preference by similarity in ideal solution (TOPSIS) has been presented in this paper to prioritize the LAG practices on the basis of the influence on performance indicators. Sensitivity analysis is carried out to check the robustness of the presented model. Findings The derived result indicates that sustainable packaging, coordination among supply chain stakeholders and cold chain technology improvement are among the top practices affecting most of the performance parameters of VSC. The sensitivity analysis reveals that the priority of practices is highly dependent on the weightage of performance indicators. Practical implications This study's finding will help policymakers reframe strategies for sustainable VSC (SVSC) by including new management practices that can handle regular immunization programs as well as emergency mass vaccination. Originality/value To the best of the authors' knowledge, this is the first study that proposes the LAG framework for SVSC. The IPA–Fuzzy AHP (FAHP)–Fuzyy TOPSIS (FTOPSIS) is also a novel combination in decision-making.
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This paper presents a review of the existing research studies on vaccine supply chain (VSC) management. We analyze the current VSC system in India and investigate the research on VSC management specific to India. We focus on the coordination aspect and network design in the literature review. The paper summarizes the challenges in managing the VSC and provides future research directions to improve their performance.
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