Although the theme of academic spin-off has received increasing consideration in entrepreneurship literature, little attention has been devoted to identifying the factors that drive young researchers to set up ventures based on the results of their research. To identify the determinants of academic entrepreneurial intention (AEI), we tested a model on a sample of Italian researchers using structural equation modeling and integrating the Triple Helix Model with the theory of planned behavior (TPB). The findings highlight that all psychological variables of TPB are relevant in predicting AEI, whereas only some contextual and exogenous variables (namely, government and industrial/financial support) directly influence AEI.