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RETRACTION
Retracted: Elevated NADPH oxidase activity contributes
to oxidative stress and cell death in
Huntington’s disease
Antonio Valencia
1
, Ellen Sapp
1
, Jeffrey S. Kimm
1
, Hollis McClory
1
,
Patrick B. Reeves
1
, Jonathan Alexander
1
, Kwadwo A. Ansong
1
,
Nicholas Masso
1
, Matthew P. Frosch
2
, Kimberly B. Kegel
1
, Xueyi Li
1
and
Marian DiFiglia
1,
*
1
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16th Street,
Charlestown, MA 02129, USA and
2
C.S. Kubik Laboratory for Neuropathology, Pathology Service, Massachusetts
General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
*To whom correspondence should be addressed at: Department of Neurology, Massachusetts General Hospital East, 114, 16th Street, Room 2002,
Charlestown, MA 02129, USA. Tel: þ1 6177268446; Fax: þ1 6177261264; Email: difiglia@helix.mgh.harvard.edu
Human Molecular Genetics, 2013, 22(6), 1112–1131.
doi: 10.1093/hmg/dds516
The corresponding author requests retraction of the above ref-
erenced article due to inappropriate manipulation and fabrica-
tion of data by the first author Dr. Antonio Valencia related to
Figures 1 A–D and Figure 9 C and F. This misrepresentation led
to an incorrect conclusion in the paper that NADPH activity is
elevated in Huntington’s disease (HD). Some original data were
missing and efforts to replicate findings using the reported
method or an alternative approach were unsuccessful. An insti-
tutional faculty panel supports the decision and the reasons for
the retraction.
V
CThe Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
4314
Human Molecular Genetics, 2017, Vol. 26, No. 21 4314
doi: 10.1093/hmg/ddx303
Advance Access Publication Date: 22 August 2017
Retraction
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