This paper describes the reliability MicroKernel (RMK) framework, a loadable kernel module (or a device driver) for providing application-aware reliability, and dynamically configuring reliability mechanisms. Characteristics of application/system execution are exploited transparently through application-aware reliability techniques to achieve low-latency detection, and low-overhead checkpointing. The RMK prototype is implemented in both Linux, and Windows; and it supports detection of application/OS failures, and transparent application checkpointing. Experiment results show that the system hang detection and application hang detection, which exploit characteristics of application, and system behavior, can achieve high coverage (100% observed in our experiments) with a low false positive rate. Moreover, the performance overhead of RMK, and its detection/checkpointing mechanisms, is small: 0.6% for application hang detection, and 0.1% for transparent application checkpointing in the experiments.