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... However, an ensemble of nanoparticles with a higher concentration may result in the occurrence of heat flux and, accordingly, the appearance of temperature heterogeneity if this ensemble occupies an area of higher dimensionality compared to the size of nanoparticles. In particular, this effect was investigated numerically in Ref. 29 and the analytical solution for the particular case is given in Ref. 31 The possibility of nanoparticles for clusterization around bacteria is well demonstrated. 32,33 In Fig. 6a, TEM images of an E. coli fragment after incubation with carbon nanotubes (CNTs) is shown, 32 arrows indicate CNT clusters at the bacteria wall in the form of multilayer cloud of nanoparticles. ...
Methods for solving analytically and numerically the problem of multiscale modelling of the laser hyperthermia processes in a medium with nanoparticles are developed with regard to composite spherical nanoparticles (nanoshells). The features of the laser radiation field localisation on nanoscale inhomogeneities are investigated. Issues related to the control of the tissue hyperthermia processes by choosing the parameters of spatiotemporal localisation of the laser beam and of the absorbing nanoparticles are discussed.
We have developed a nanoplasmonic-based approach to induce nanometer-sized local defects in the phospholipid membranes. Here, gold nanorods and nanoparticles having plasmon resonances in the nearinfrared (NIR) spectral range are used as optical absorption centers in the lipid membrane. Defects optically induced by NIR-laser irradiation of gold nanoparticles are continuously monitored by high-precision ion conductance measurement. Localized laser-mediated heating of nanorods and nanoparticle aggregates cause either (a) transient nanopores in lipid membranes or (b) irreversible rupture of the membrane. To monitor transient opening and closing, an electrophysiological setup is assembled wherein a giant liposome is spread over a micrometer hole in a glass slide
forming a single bilayer of high Ohmic resistance (so-called gigaseal), while laser light is coupled in and focused on the membrane. The energy associated with the localized heating is discussed and compared with typical elastic parameters in the lipid membranes. The method presented here provides a novel methodology for better understanding of transport across artificial or natural biological membranes.