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Review
Integr Med Int 2015;2:56–62
A Practical Consensus Guideline for
the Integrative Treatment of
Parkinson’s Disease in Shanghai, China
Weidong Pan
a Jun Liu
e Xiangjun Chen
h Qiudong Wang
j Yuncheng Wu
f
Yu Bai
b Yi Liu
c Wentao Li
c Wenwei Li
i Canxing Yuan
d Weiguo Hou
k
Xiaoying Bi
k Jianhua Zhuang
l Qin Dong
g Dingfang Cai
i
Specialized Committee of Neuroendocrinology and Specialized Committee of
Neurology, Shanghai Association of Chinese Integrative Medicine;
Subcommittee of Neurology, Shanghai Chinese Medicine Society
a Department of Neurology, Shuguang Hospital,
b Department of Neurology, Putuo District
Center Hospital,
c Department of Neurology, Shanghai Hospital of Traditional Chinese
Medicine, and
d Department of Neurology, Longhua Hospital, Shanghai University of
Traditional Chinese Medicine,
e Department of Neurology, Ruijin Hospital,
f Department of
Neurology, Shanghai First Hospital, and
g Department of Neurology, Renji Hospital,
Shanghai Jiaotong University,
h Department of Neurology, Huashan Hospital, and
i Laborator y for Neurology, Institute of Integrative Medicine, Zhongshan Hospital, Fudan
University,
j Department of Integrative Neurology, Pudong Hospital of Traditional Chinese
Medicine, and
k Department of Neurology, Changhai Hospital, and
l Department of
Neurology, Changzheng Hospital, Third Military Medical University, Shanghai , China
Key Words
Consensus guideline · Parkinson’s disease · Integrative medicine · Traditional Chinese
medicine · Complementary and alternative medicine · Acupuncture · Tai chi chuan · Yoga ·
Preventive treatment
Abstract
Integrative medicine, including traditional Chinese medicine (TCM), is a new concept in clini-
cal practice for the treatment of neurodegenerative and most chronic diseases. However, in-
tegrative consensus or a guideline for the management of patients with Parkinson’s disease
(PD) is still lacking. The aim of this paper is to provide a review of experiences in clinical prac-
tice from Chinese neurologists and physicians (including TCM doctors) in Shanghai, China, and
try to provide a clinical guideline for the treatment of the complex and progressive disease of
PD with integrative medicine. We included the following treatments: common Western med-
ication, surgery, TCM decoction and patent medicines, acupuncture and Tui na, Yoga, Tai chi
chuan, hyperbaric oxygenation, rehabilitation, and other complementary and alternative
Received: June 5, 2015
Accepted after revision: June 7, 2015
Published online: September 12, 2015
Prof. Weidong Pan, MD, PhD
Department of Neurology
Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Shanghai, 201203 (China)
E-Mail panwd
@ medmail.com.cn
www.karger.com/imi
DOI: 10.1159/000435813
This is an Open Access article licensed under the terms of the Creative Commons Attribution-
NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to
the online version of the article only. Distribution permitted for non-commercial purposes only.
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Integr Med Int 2015;2:56 –62
DOI: 10.1159/000435813
Pan et al.: A Practical Consensus Guideline for the Integrative Treatment of Parkinson’s
Disease in Shanghai, China
www.karger.com/imi
© 2015 S. Karger AG, Basel
medicines for the integrative management of the disease. Neurologists and physicians in
Shanghai, China, and all over the world should pay attention to integrative medicine, which
may be a good choice of treatment for PD. © 2015 S. Karger AG, Basel
Background
Integrative treatment for Parkinson’s disease (PD) such as dopaminergic therapy, neuro-
protective therapy, and traditional Chinese medicine (TCM) might be the unmet medical
needs to slow down or stop disease progress
[1, 2] . The current therapies include Western
medicine (oral medicine), surgery, physical therapy (kinesiotherapy), psychological coun-
seling, and nursing care, whereas traditional medicines provide beneficial effects on symptoms
that help to control the classic motor features of the disease (i.e., tremor, rigidity, and brady-
kinesia) as well as the non-motor symptoms, including autonomic disturbance, dementia,
sleep disturbance, psychiatric disorders, and depression; however, eventually, intolerable
disability and invalid clinical effects develop in most patients with PD
[3] . Over the past 3
decades, significant progress has been achieved in the diagnosis and treatment of PD in China.
Not only TCM but also other integrative medicine proved more and more important in treating
the disease in Shanghai, China
[4] . Movement disorder clinics and associated centers only
exist in part of the tertiary hospitals, and the resources cannot satisfy the need of most patients
with PD
[5] . In many cases, both general neurologists and physicians are responsible for the
diagnosis and treatment of PD patients and are sometimes treating them without adhering to
the guidelines. For almost 5 years, the management of PD has been improving. A consensus
was prepared according to the guideline from the Chinese Parkinson’s Disease and Movement
Disorders Society for the management of PD (third edition)
[6] which summarized the inte-
grative clinical research in China
[4, 7–10] . It is important that neurologists and TCM doctors
offer more effective and reasonable integrative treatment to their patients. However, the
opinions of physicians, general neurologists, and movement disorder specialists in the clinical
practice for the treatment of PD are diverse, which will have a significant influence on the
actual benefits of patients suffering from the disease.
Principle of Treatment
Integrative Treatment
Most patients with PD have motor and/non-motor symptoms in the early or later stages
of the disease. These symptoms not only influence the ability to work but also the activities of
daily living (ADL). PD cases should be treated individually, including oral medicine, operations,
exercise, psychotherapy, and health care as effective treatment options. Oral medicine is the
main treatment choice, and surgery, such as deep brain stimulation (DBS), may be initiated as
independent therapy or a complementary and alternative method to assist oral medicine
[11,
12] . So far, all therapies have improved the symptoms of PD, but they could not stop disease
progression. We should thus focus on the long-term management of PD in order to extend the
treatment period, delay disease progression, and decrease the side effects of medical therapy.
Principle of Medication
Both motor and non-motor symptoms can influence the ADL of patients suffering from
PD, and neurologists or physicians should aim to control the symptoms early, thus improving
the ability to work and the ADL. Early diagnosis and early medication can improve symptoms,
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Integr Med Int 2015;2:56 –62
DOI: 10.1159/000435813
Pan et al.: A Practical Consensus Guideline for the Integrative Treatment of Parkinson’s
Disease in Shanghai, China
www.karger.com/imi
© 2015 S. Karger AG, Basel
delay progression, and prevent motor fluctuation and dyskinesia. The compound levodopa or
dopamine receptor agonist used for the treatment of motor symptoms should be started at a
small dosage and increased slowly according to the progression of the disease. Individual
medication management may be more effective and lessen the side effects with regard to
tremor (with/without), dementia (with/without), age at morbidity, occupation, combinative
diseases, potential side effects, aspiration, and the economic situation of the patients. Dopa-
minergic treatment should not be stopped abruptly in order to avoid dopaminergic dysregu-
lation syndrome
[6] .
Internal Medicine (Oral Medication)
According to its severity, PD has been divided into two stages – the early stage (Hoehn-
Yahr 1–2.5), and the middle and severe stages (Hoehn-Yahr 3–5).
PD Patients in the Early Stage
As evidence indicates that the development of PD in the early stage is faster than in the
middle and severe stages
[13, 14] , it is necessary to treat PD patients with oral medication in
the early stage, which includes Western medicine and/or TCM and/or other complementary
and alternative medicine (CAM). Dopaminergic medicine and/or monoamine oxidase B inhib-
itors, vitamin E, herbs, complementary nutrition, and even physical therapy (kinesiotherapy),
psychological counseling, and nursing care can be used. The aim of the treatment is to improve
the mild movement disorders, such as rigidity, tremor, and some non-motor symptoms, and
delay disease progression.
In the case of early-onset PD without dementia, we suggest that neurologists or physi-
cians use a non-egret dopamine receptor agonist, such as pramipexole, piribedil, and ropin-
irole, monoamine oxidase B inhibitors, such as selegiline and rasagiline, adamantanamine, or
compound levodopa, such as Madopar or Sinemet combined with or without entacapone [6] .
If the symptom of tremor cannot be controlled, benzhexol is also a good choice. Most tonify-
ing TCM components or patent medicines can be used in treating this stage of PD, such as
‘Liu-Wei-Di-Huang-Wan’ (六味地黃丸), ‘Zhen-Gan-Xi-Feng-Tang’ (鎮肝熄風湯), ‘Tian-
Ma-Gou-Teng-Yin’ (天麻勾藤飲), ‘Ma-Ren-Zi-Pi-Wan’ (麻仁滋脾丸), ‘Cong-Rong-Tong-Bian-
Kou-Fu-Ye’ (蓯蓉通便口服液), and others [4, 12] .
In the case of later-onset PD, cognitive impairment, or dementia, the compound levodopa
is the first-choice treatment. With progression of the disease, dopamine receptor agonist,
monoamine oxidase B inhibition, or compound levodopa combined with entacapone are
beneficial choices. Cholinergic resistance should be avoided, especially for elderly, later-onset
PD patients with cognitive impairment
[6] .
PD Patients in the Middle and Severe Stages
Symptoms will become more complex for patients in the middle and severe stages, due
to the development of the disease, the side effects of medication, and motor complications
such as motor fluctuation and dyskinesia. The scope of treatment in these stages is to improve
the movement disorders, motor complications, and non-motor symptoms.
Motor fluctuations such as end-of-dose deterioration, on-off phenomenon, and dyskinesia
(abnormal involuntary movements) are common motor complications in the severe stages of
PD. Changing the kind of medication as well as modifying the dose and dosing time may help to
improve the complex symptoms. Insect TCM drugs such as stiff silkworm (僵蠶), earthworm
(地龍), scorpio (全蝎), and centipede (蜈蚣), as well as tonifying ‘Gan’ (liver) and ‘Shen’ (kidney)
TCM herbs are helpful in modifying the doses and dosing times of Western medicine adminis-
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Integr Med Int 2015;2:56 –62
DOI: 10.1159/000435813
Pan et al.: A Practical Consensus Guideline for the Integrative Treatment of Parkinson’s
Disease in Shanghai, China
www.karger.com/imi
© 2015 S. Karger AG, Basel
tered to these patients. TCM doctors not only use oral TCM decoction or patent medicine, but
they also individually use TCM as external application to improve complex complications. Some-
times, DBS, Tai chi chuan, and acupuncture can be used as additional non-drug treatments.
Traditional Chinese Medicine
The Theory of TCM in PD Treatment
TCM has gained increasing attention in the treatment of PD. Although it is not curative, it
may play a significant role in delaying disease progression and reducing the side effects of
Western medicine, as well as improving the patients’ ability to perform their ADL
[7, 8] . TCM
ameliorates various symptoms, particularly the age-related symptoms that are called ‘Shen xu’
(kidney deficiency) in Chinese. ‘Shen’ (the kidney) denotes a functional visceral system (‘Zang’)
that plays a central role in the regulation of growth, maturation, and aging and is subdivided
into ‘Shen yang’ (kidney ‘yang’) and ‘Shen yin’ (kidney ‘yin’). Kidney ‘yang’ can be described as
the driving force of all metabolic processes that improve the movements of the body. The
production of kidney ‘yin’ is considered to be effective in increasing nutrition to the muscles and
improving the smoothness of body movements by constituting the constructive potential for
the production of kidney ‘yang’. Based on this concept, TCM aims to potentiate the diminishing
vitality of this transformative cycle caused by a decline in the essence (‘Jing’), which is stored in
the kidneys and underpins the functions of both kidney ‘yin’ and ‘yang’ [7] . In TCM theory, most
PD patients (about two thirds) belong to ‘deficiency in ‘‘yin’’ or ‘‘Jing’’ and ‘‘yang’’ or ‘‘Qi’’ in
‘‘Gan’’ (liver) and ‘‘Shen’’ (kidney)’ by TCM ‘Zheng’ classification, whereas the other ‘Zheng’ such
as blood stasis, deficiency in ‘Qi’ with blood, and phlegm are much less than the first ‘Zheng’ [15] .
TCM Treatment in PD
Our consensus guideline suggests that decoction with medicinal ingredients or Chinese
patent medicine tonifying the ‘yin’ and ‘yang’ of ‘Gan’ (liver) and ‘Shen’ (kidney) may be useful
to treat or improve rigidity, tremor, bradykinesia, sleep disorders, constipation, depression,
anorexia, and automatic symptoms using ‘Di-Huang-Yin-Z’ (地黃飲子), ‘Da-Ding-Feng-Zhu’
(大定風珠), ‘Zhen-Gan-Xi-Feng-Tang’ (鎮肝熄風湯), ‘Tian-Ma-Gou-Teng-Yin’ (天麻勾藤飲),
‘Da-Bu-Yin-Wan’ (大補陰丸), ‘Ren-Shen-Yang-Rong-Tang’ (人參養榮湯), and others, according
to the ‘Zheng’ classification of PD
[15] . Other TCM decoctions or patent medicines such as ‘Dao-
Tan-Tang’ (導痰湯), ‘Tian-Wang-Bu-Xin-Dan’ (天王補心丹), ‘Gui-Pi-Tang’ (歸脾湯), ‘Bu-Yang-
Huan-Wu-Tang’ (補陽還五湯), ‘Qi-Ju-Di-Huang-Tang’ (杞菊地黃丸), ‘Ma-Ren-Wan’ (麻仁丸),
‘Yang-Xue-Qing-Nao-Ke-Li’ (養血清腦顆粒), and others may improve some of the other non-
motor symptoms of the other ‘Zheng’ classification patients with PD. If the TCM doctor or
neurologist is an expert in TCM, he may make an individual prescription choosing ingredients
according to the individual manifestation of ‘Zheng’ and the ‘pulse’ properties of the patient.
All of the TCM therapies can be used for all stages and periods of PD
[7, 15–18] ; if the patient
suffers from dysphagia, TCM medication can be taken via a nasogastric tube.
Acupuncture and ‘Tui na’ (推拿, TCM massage) are often used as complementary
treatment for PD patients with motor and non-motor symptoms; sometimes, the two ther-
apies are used in early-onset PD as initial management to delay disease progression
[19] .
Acupuncturists and massagers may choose acupoints according to TCM theory which may
tonify the ‘yin’ and ‘yang’ of ‘Gan’ and ‘Shen’ or which may prompt the blood circulation of the
body and/or remove blood stasis. The acupoints normally used are ‘Chen Shan’ (承山, BL57),
‘Tai Xi’ (太溪, KI3), ‘Tai Chong’ (太衝, LR3), ‘Shen Shu’ (腎腧, BL23), ‘Zu San Li’ (足三里, ST36),
‘San Yin Jiao’ (三陰交, SP6), ‘Xue Hai’ (血海, SP10), ‘Yang Lin Quan’ (陽陵泉, GB34), ‘He Gu’
(合谷, LI4), ‘Qu Chi’ (曲池, LI11), ‘Du Bi’ (犢鼻, ST35), ‘Shou San Li’ (手三里, LI10), ‘Pi Shu’
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Integr Med Int 2015;2:56 –62
DOI: 10.1159/000435813
Pan et al.: A Practical Consensus Guideline for the Integrative Treatment of Parkinson’s
Disease in Shanghai, China
www.karger.com/imi
© 2015 S. Karger AG, Basel
(脾腧, BL20), ‘Gan Shu’ (肝腧, BL18), ‘Wei Zhong’ (委中, BL40), ‘Yin Lin Quan’ (陰陵泉, SP9),
‘Yao Yang Guan’ (腰陽關, DU3), ‘Ming Men’ (命門, DU4), ‘Qi Hai’ (氣海, RN6), and ‘Guan Yuan’
(關元, RN4)
[20–26] .
Tai chi chuan is an effective treatment improving the stability of PD patients
[27–29] and
can be used to control some of the non-motor symptoms such as automatic impairment, sleep
disorders, and depression. Any type of Tai chi chuan can be used for the improvement of the
disease. Those PD patients who cannot keep a standing posture for the exercise of Tai chi
chuan may remain seated until they are gradually able to stand up for the training
[28–30] .
The core of Tai chi chuan is to move the body by mind direction slowly, which differs substan-
tially from aerobic and strength exercises
[28] .
Other Integrative Treatment or Exercises
Surgery
Most patients in the mild stage or with early-onset PD react well to anti-parkinsonism
treatment and/or TCM and/or CAM. Surgery may be used in two situations. Firstly, with the
progression of PD, motor fluctuation, dyskinesia, and even on-off phenomenon will occur, and
DBS will be used to improve the movement disorders of the patients
[11] . Secondly, if the
patients suffer from very heavy motor symptoms such as tremor or rigidity, or the medication
used shows a lack of efficacy, they may start treatment with DBS. We emphasize that DBS is most
effective against tremor and rigidity and is not the first choice for posture and balance disorders.
Age and the course of the disease are the selective factors for treatment with DBS
[11, 12] .
Aerobic Exercise, Strength Exercise, Yoga, Hyperbaric Oxygen, Rehabilitation,
Psychological Guidance, and Health Care
These integrative therapies or exercises are helpful in improving rigidity, balance
disorder, and parts of the non-motor symptoms, and some patients have self-initiated these
activities or treatments during all periods or stages of anti-parkinsonism treatment
[31–33] .
Psychological guidance is useful to reduce depression, and health care is important to prevent
inflammation, nutrition impairment, falls, and fractures. These exercises or therapies are not
the main treatment for improving the symptoms of PD
[34–40] .
Supplementary Treatment
Ginkgo supplementary, Ginseng supplementary, Rhodiola rosea supplementary, mela-
tonin, deep sea fish oil, and American ginseng are often used to improve fatigue, memory
impairment, weakness, automatic impairment, and sleep disorders of PD patients, suggested
by family members or patients themselves
[41, 42] . These CAM are not harmful, but there is
still no evidence-based research supporting their intake except for melatonin
[43–45] .
Preventive Treatment
PD is a progressive neurodegenerative disease; previous to morbidity, most patients
have various preclinical symptoms such as sleep disorders, restless leg syndrome, olfactory
dysfunction, and cognitive impairment. With the progression of these symptoms, patients
tend to suffer from PD; our consensus guideline suggests that these patients should be treated
in the preclinical stage to slow down or stop disease progression. Preventive treatment has
two implications
[44, 45] : firstly, to reduce or stop suffering from the disease, and secondly,
to slow down the progression of PD. The TCM compound cream formula (膏方), herbs which
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Integr Med Int 2015;2:56 –62
DOI: 10.1159/000435813
Pan et al.: A Practical Consensus Guideline for the Integrative Treatment of Parkinson’s
Disease in Shanghai, China
www.karger.com/imi
© 2015 S. Karger AG, Basel
may tonify the ‘yin’ and ‘yang’ functions of ‘Gan’ and ‘Shen’, vitamin E, Ginkgo supplementary,
Ginseng supplementary, R. rosea supplementary, melatonin, deep sea fish oil, and American
ginseng may partly present alternative preventive therapies
[2, 46, 47] , but there is still a lack
of evidence-based research.
Conclusion
There are no absolute fixed models for the management or treatment of PD, and thus,
patients should be treated individually according to their condition, which may have its own
individual sensitivity and specificity for each patient. Even the same patient may be treated
by different medication in different stages of the disease. The choice of diagnostic methods
and therapeutic strategies for PD varies among physicians, general neurologists, and
movement disorder specialists. Further consensus programs on the diagnosis and management
of PD patients are warranted, especially for physicians and general neurologists caring for PD
patients in China. The aim and scope of this consensus guideline was to emphasize that
neurologists and physicians (including TCM doctors) should pay attention to integrative
therapy in the treatment of PD patients.
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