Book in CHINESE: Cavitational Osteonecrosis of Jawbone – Documentation and introduction towards a maxillo-mandibulary therapy of chronic diseases

Abstract

Jawbone cavitations (JC) are hollow dead spaces in jaw bone with dying or dead bone marrow. These areas are defined as fatty degenerative osteonecrosis of jawbone (FDOJ). or “Neuralgia Inducing Cavitational Osteonecrosis/NICO” and may produce facial pain. They have been linked with the immune system and chronic illnesses. Little is known about the underlying cause\effect relationship. Surgical debridement of JC is reported to lead to an improvement in immunological complaints such as rheumatic, allergic and other inflammatory diseases (ID). Samples of FDOJ have been extracted from nearly 300 patients with systemic and immunological diseases (ID) and from 19 patients with normal jawbone. The specimens were analyzed by bead-based multiplex technology and tested for 7 immune messengers.to assess the expression and quantification of immune modulators which can play a role in the pathogenesis of ID. The study supports a potential mechanism where JC is a mediating link in ID.
RANTES/CCL5 and FGF-2 (Fibroblast growth factor-2) are found at high levels in the JC tested. Other cytokines could not be detected at exceeding levels. The book confirms that JC is able to produce inflammatory messengers, primarily RANTES secondary FGF-2. Both are implicated in many serious illnesses and might serve as a possible cause of breast cancer. The exceeding levels of RANTES /FGF-2 in JC patients with amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), rheumatic arthritis (RA) and breast cancer (BC) are compared to levels published in medical journals. Levels detected in JC are higher than in serum and cerebrospinal fluid of MS/ALS patients and four fold higher than in BC tissue. The book suggests that FDOJ might serve as a fundamental cause of ID, through RANTES/FGF-2 that they produce. Thus FDOJ and implicated immune messengers give an integrative aspect of ID and serve as a possible cause. Removing JC may be a key to reversing ID. There is the need to raise awareness of JC throughout medicine and dentistry. Data presented in this book suggest that there is a critical attitude toward the use of dental X-ray (Orthopantomograph/2D-OPG) as a sole imaging diagnostic tool for assessing chronic inflammatory processes in the jawbone. Specifically, 2D-OPG is objectively not suitable for depicting FDOJ.