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Some pathogenetic mechanisms of infectious-allergic asthma in paecilomycosis.

January 2000
Clinical Medicine (Russian Journal)

January 2000

Authors:

Alima Muratovna Akhunova

Moscow city policlinic № 166, № 3 branch

2-week to 18 year follow-up data are analysed for 190 patients aged 3 to 70 years (91 females and 99 males) with bronchial asthma in paecilomycosis.. Paecilomyces fungi play the role of a specific agent responsible for development of intrinsic bronchial asthma. The bronchial spasm was provoked, on the one side, by hypersensitivity with participation of IgE defending the organism from the fungi persisting in the blood and pulmonary tissue, on the other side, by biologically active substances produced by fungal cells, exogenic phospholipase A2, in particular. Clinical characteristics, course and outcome of intrinsic bronchial asthma in paecilomycosis depend on the resistance of immune system to hematogenic fungal infection and immune reactions running in elimination of the agent.

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