Ongoing (1996-present) volcanic unrest near South Sister, Oregon, is accompanied by a striking set of hydrothermal anomalies, including elevated temperatures, elevated major-ion concentrations, and 3He/4He ratios as large as 8.6 RA in slightly thermal springs. These observations prompted the U.S. Geological Survey to begin a systematic hydrothermal-monitoring effort encompassing 25 sites and 10 of the highest-risk volcanoes in the Cascade Range volcanic arc, from Mount Baker near the Canadian border to Lassen Peak in northern California. A concerted effort was made to develop hourly, multiyear records of temperature and (or) hydrothermal solute flux, suitable for retrospective comparison with other continuous geophysical monitoring data. Targets included summit-fumarole groups and springs/streams that show clear evidence of magmatic influence in the form of high 3He/4He ratios and (or) anomalous fluxes of magmatic CO2 or heat. As of 2009-2012 summit-fumarole temperatures in the Cascade Range were generally near or below the local pure-water boiling point; the maximum observed superheat was 0.001 J/m3 during periods of hourly record. Hydrothermal responses to these small seismic stimuli were generally undetectable or ambiguous. Evaluation of multiyear to multi-decadal trends indicates that whereas the hydrothermal system at Mount St. Helens is still fast-evolving in response to the 1980-present eruptive cycle, there is no clear evidence of ongoing long-term trends in hydrothermal activity at other Cascade Range volcanoes that have been active or restless during the past century (Baker, South Sister, and Lassen). Experience gained during the Cascade Range hydrothermal-monitoring experiment informs ongoing efforts to capture entire unrest cycles at more active but generally less accessible volcanoes such as those in the Aleutian arc. This article is protected by copyright. All rights reserved.