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Pancreatic herniation: A rare cause of acute pancreatitis?

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Abstract

Acute pancreatitis is a common and potentially fatal condition, with several well-known causes including gallstones, excessive alcohol consumption and specific medications. We report a case of an 89-year-old man presenting with acute pancreatitis, which we believe to be secondary to a diaphragmatic herniation of the pancreas. This extremely rare anatomical abnormality can be found incidentally in the asymptomatic patient or may present with a variety of acute symptoms. However, there have been only isolated reports of these cases presenting as acute pancreatitis. While the majority of acute pancreatitis cases can be explained by common causes, it is important that clinicians be aware of and should consider investigating for other more unusual possibilities, such as pancreatic herniation, before labelling an episode as 'idiopathic'.
CASE REPORT
Pancreatic herniation: a rare cause of acute
pancreatitis?
Prashant Kumar,
1
Matthew Turp,
1
Sarah Fellows,
1
Jonathan Ellis
2
1
Department of Surgery, Milton
Keynes General Hospital,
Milton Keynes, Bucks, UK
2
Department of Radiology,
Milton Keynes General
Hospital, Milton Keynes,
Bucks, UK
Correspondence to
Dr Prashant Kumar,
prashant.kumar916@gmail.com
To cite: Kumar P, Turp M,
Fellows S, et al.BMJ Case
Rep Published online:
[please include Day Month
Year] doi:10.1136/bcr-2013-
201979
SUMMARY
Acute pancreatitis is a common and potentially fatal
condition, with several well-known causes including
gallstones, excessive alcohol consumption and specic
medications. We report a case of an 89-year-old man
presenting with acute pancreatitis, which we believe to
be secondary to a diaphragmatic herniation of the
pancreas. This extremely rare anatomical abnormality can
be found incidentally in the asymptomatic patient or may
present with a variety of acute symptoms. However,
there have been only isolated reports of these cases
presenting as acute pancreatitis. While the majority of
acute pancreatitis cases can be explained by common
causes, it is important that clinicians be aware of and
should consider investigating for other more unusual
possibilities, such as pancreatic herniation, before
labelling an episode as idiopathic.
BACKGROUND
Acute pancreatitis is a common condition encoun-
tered worldwide, with a potentially fatal outcome.
There is a well-known list of differential causes, of
which gallstones and excess alcohol consumption
are the most common in the UK.
1
In the majority
of patients, a cause can be identied following
simple investigations. However, in a signicant
number of cases, no aetiology is identied, and
these are subsequently labelled as being idiopathic.
Current guidelines suggest that this proportion of
cases being classied as idiopathic should number
no more than 20%.
1
We present an extremely rare case of acute pan-
creatitis likely to have been caused by pancreatic
herniation, as opposed to other better-known
aetiologies.
CASE PRESENTATION
An 89-year-old man presented to the accident and
emergency department following a 1-day history of
epigastric pain associated with nausea and vomit-
ing. His medical history included hypertension and
ischaemic heart disease. There were no recent
changes to medications, no recent trauma and no
known history of alcohol abuse or gallstones. On
admission, he was tachycardic and hypotensive.
Initial blood work-up showed white cell count
(WCC) of 22.2×10
9
/L, C reactive protein 2.7 mg/L,
aspartate aminotransferase 242 iu/L, γ-glutamyl
transpeptidase 207 iu/L, alkaline phosphatase
165 iu/L, bilirubin 29 umol/L, albumin 39 g/L,
lactate dehydrogenase (LDH) 694 iu/L and amylase
5256 iu/L. The patient scored 3 on the Modied
Glasgow Scoring System (WCC, age & LDH), and
9 on the Acute Physiology and Chronic Health
Evaluation II score, and was therefore aggressively
resuscitated with intravenous uids and antibiotics.
As per hospital protocol, the intensive care team
was made aware of the patient. However, following
their review, no further intensive care input was
deemed necessary at that point of time. The aeti-
ology of his pancreatitis was, at this stage, unknown.
FURTHER INVESTIGATIONS
A thorough review of the patients background and
medications along with initial tests found no dis-
cernable cause for pancreatitis.
The patient was shown to have a hiatus hernia
on chest X-ray from 8 years previously. The con-
tents of the hernia were not identiable and no
other comparative imaging was available.
An abdominal ultrasound scan was requested to
investigate the possibility of gallstones, but was
reported as normal with no evidence of gallstones
or duct dilation.
Subsequently, a CT scan was performed 4 days
post-admission, which not only conrmed the pres-
ence of acute pancreatitis with inammation of the
peripancreatic fat but also revealed a rare case of a
pancreatic herniation into the thoracic cavity
(gures 14). Owing to a lack of previous imaging,
we cannot be certain as to when the herniation rst
appeared.
Figure 1 shows the pancreatic tail correctly xed
in its conventional anatomical position at the level
Figure 1 Axial CT image demonstrating the pancreatic
tail xed in its conventional anatomical position with
inammation of the peripancreatic fat.
Kumar P, et al.BMJ Case Rep 2013. doi:10.1136/bcr-2013-201979 1
Unusual association of diseases/symptoms
of T12. Similarly, the head of the pancreas is seen to be in its
conventional anatomical position, at the level of T12 (gure 2).
The distal section of the common bile duct is dilated but is
found to be in a normal position. Unfortunately, the personnel
required to perform an additional endoscopic ultrasound to
further evaluate this nding were unavailable at Milton Keynes
Hospital.
Meanwhile, the body of the pancreas can clearly be seen, on
both axial and sagittal views (gures 34), to herniate above the
diaphragm, through into the thoracic cavity.
Figure 3 shows the pancreatic head at the level of T12, with
the pancreatic neck pulled superiorly into the hiatus hernia. The
apex of the pancreatic body lies at the level of the T9/T10 disc
space. The pancreatic body then takes a hair-pin turn, with the
distal aspect of the pancreatic body moving inferiorly towards
the pancreatic tail.
OUTCOME AND FOLLOW-UP
The patient was treated successfully with uid resuscitation and
antibiotics and recovered well over the course of a 10-day
inpatient admission. He was subsequently reviewed in an out-
patient appointment. The patient was not keen for any further
investigations or invasive treatment and is therefore being
managed conservatively with omeprazole for symptomatic relief.
Surgical intervention was deemed inappropriate given his
complex comorbidities and personal wishes.
DISCUSSION
A hiatal hernia can be classied into one of the four types. Type
I, otherwise known as a sliding hernia, consists of a simple her-
niation of the gastro-oesophageal junction into the chest,
2
accounting for up to 95% of all cases.
3
The remaining 5% of
cases are classied as types IIIV or paraesophageal hernias.
3
While types II and III involve gastric herniation only, a type IV
hernia is more advanced, characterised by herniation of add-
itional abdominal organs alongside the stomach.
2
A type IV herniation is extremely rare, accounting for only
between 5% and 7% of all paraesophageal hernias,
4
with the
colon being the most common viscera to herniate in addition to
the stomach.
5
A pancreatic herniation, however, has only been
reported a handful of times.
513
Of these cases, there are even
fewer reported cases of this anatomical phenomenon leading to
acute pancreatitis.
1113
In most cases, the body and tail of the
pancreas have herniated above the diaphragm. To our knowledge,
there is only one other documented case where the head and tail
of the pancreas remain in their normal anatomical planes, with
only the body of the pancreas herniating into the thoracic cavity.
5
Our ndings have important implications for patients with
acute pancreatitis for which no aetiology has been identied.
Our patient demonstrates a rare anatomical abnormality that
may have been the cause of his pancreatitis. We believe that our
case contributes to the growing repertoire of similar cases in the
Figure 3 Sagittal CT image showing the folding of the pancreatic
body within the hiatus hernia.
Figure 4 Axial CT image demonstrating the apex of the body of the
pancreas within the hiatal hernia sac.
Figure 2 Axial CT image demonstrating the pancreatic head xed in
its conventional anatomical position and dilation of the common bile
duct.
2 Kumar P, et al.BMJ Case Rep 2013. doi:10.1136/bcr-2013-201979
Unusual association of diseases/symptoms
literature which report pancreatic herniation as a potential cause
for pancreatitis. We suggest that prior to such cases being
labelled as idiopathic, clinicians should at least consider further
imaging to assess for any anatomical abnormalities. In cases
where pancreatic herniation may be the cause, surgical repair of
the hernia may help to prevent repeated episodes of acute pan-
creatitis. However, the benet of such an intervention remains
unknown.
Learning points
Patients with pancreatic herniation may present with acute
pancreatitis.
It is imperative that the clinicians perform a thorough
diagnostic work up to elicit the cause of acute pancreatitis.
If the common causes are ruled out, then one should
consider exploration of rarer possibilities, such as anatomical
abnormalities, before labelling the cause as idiopathic.
Those patients t for surgery may benet from repair of the
hernia, so as to help prevent repeat episodes of acute
pancreatitis. However, the benet of such an intervention
remains unknown.
Contributors All the authors were involved with patient care in this case. All the
authors have made valuable contributions to the initiation, research and writing up
of this case report.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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science and clinical evidence. New York: Springer-Verlag, 2003.
3 Shieman C, Grondin SC. Paraesophageal hernia: clinical presentation, evaluation,
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4 Grushka JR, Grenon SM, Ferri LE. A type IV paraesophageal hernia containing a
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5 Coughlin M, Fanous M, Velanovich V. Herniated pancreatic body within a
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diagnosis and surgical management. J Thorac Cardiovasc Surg 2006;131:12045.
8 Coral A, Jones SN, Lees WR. Dorsal pancreas presenting as a mass in the chest.
AJR Am J Roentgenol 1987;149:71820.
9 Shah N, Fernandes R, Thakrar A, et al. Diaphragmatic hernia: an unusual
presentation. BMJ Case Rep 2013;2013:pii: bcr2013008699.
10 Ahmed S, Fontaine JP, Ng T. Pancreatic herniation after transhiatal esophagectomy.
Ann Thorac Surg 2010;89:3089.
11 Chevallier P, Peten E, Pellegrino C, et al. Hiatal hernia with pancreatic volvulus: a
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12 Maksoud C, Shah AM, DePasquale J, et al. Transient pancreatic hiatal herniation
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Kumar P, et al.BMJ Case Rep 2013. doi:10.1136/bcr-2013-201979 3
Unusual association of diseases/symptoms
... Herniation of pancreas can be without symptoms and found accidentally on imaging or as a sequel to acute pancreatitis. Acute pancreatitis as a sequela of this mechanism is very rare and has been previously reported in 13 patients [13][14][15][16][17][18][19][20][21][22][23][24][25]. Table 1 lists acute pancreatitis caused by the herniation of pancreas in HH from previous reports. ...
... Cases of pancreatic herniation with pancreatitis are rare; therefore, the ideal treatment is still unclear [20,21]. Some HH cases with pancreatitis were treated with surgery in the past [13,14,17,24], but in other cases, physicians chose conservative treatment including administration of intravenous fluids, pain killers, and diet as tolerated because of high risk of surgery [15,16] or patient's refusal to undergo operation [16,[18][19][20][21]. ...
... Cases of pancreatic herniation with pancreatitis are rare; therefore, the ideal treatment is still unclear [20,21]. Some HH cases with pancreatitis were treated with surgery in the past [13,14,17,24], but in other cases, physicians chose conservative treatment including administration of intravenous fluids, pain killers, and diet as tolerated because of high risk of surgery [15,16] or patient's refusal to undergo operation [16,[18][19][20][21]. ...
Article
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Background: Hiatal hernia is defined by the permanent or intermittent prolapse of any abdominal structure into the chest through the diaphragmatic esophageal hiatus. Prolapse of the stomach, intestine, transverse colon, and spleen is relatively common, but herniation of the pancreas is a rare condition. We describe a case of acute pancreatitis and bile duct dilatation secondary to a massive hiatal hernia of pancreatic body and tail. Case presentation: An 86-year-old woman with hiatal hernia who complained of epigastric pain and vomiting was admitted to our hospital. Blood tests revealed a hyperamylasemia and abnormal liver function test. Computed tomography revealed prolapse of the massive hiatal hernia, containing the stomach and pancreatic body and tail, with peripancreatic fluid in the posterior mediastinal space as a sequel to pancreatitis. In addition, intrahepatic and extrahepatic bile ducts were seen to be dilated and deformed. After conservative treatment for pancreatitis, an elective operation was performed. There was a strong adhesion between the hernial sac and the right diaphragmatic crus. After the stomach and pancreas were pulled into the abdominal cavity, the hiatal orifice was closed by silk thread sutures (primary repair), and the mesh was fixed in front of the hernial orifice. Toupet fundoplication and intraoperative endoscopy were performed. The patient had an uneventful postoperative course post-procedure. Conclusion: A rare massive hiatal hernia, involving the stomach and pancreatic body and tail, can cause acute pancreatitis with bile duct dilatation. The etiology can be flexure of the main pancreatic and extrahepatic bile ducts. Symptomatic herniation is best treated with surgery. Elective surgery is thought to be safer than emergent surgery in patients with serious complications.
... However, cases of acute pancreatitis caused by a prolapse of the pancreas with a large hiatal hernia have been reported previously (Table, Type 3) (6,7,(19)(20)(21)(22)(23)(24)(25)(26)(27). A diagnosis of acute pancreatitis is generally established based on abdominal symptoms accompanied by the significant elevation of pancreatic enzymes (i.e. ...
... Although our case included not only the head of the pancreas but also the body and tail as prolapsed parts into the mediastinum, we consider this case as one of pattern A. Meanwhile, in patients with pure type 3 pancreatic herniation, only 1 of 10 cases (10%) involved the head of the pancreas as a herniated portion of the hiatal hernia, and in most cases, the body or tail of the pancreas migrated into the mediastinum (pattern B, Fig. 4B). Kumar et al. also pointed out that most cases with pancreatitis secondary to a hiatal hernia had herniation of the pancreatic body and tail (22). Tomida et al. summarized 14 previously reported cases with acute pancreatitis secondary to a large hiatal hernia. ...
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Hiatal hernia is a common condition in elderly patients, but the additional presence of prolapse of the pancreas is extremely rare. We herein report an 89-year-old woman who presented with liver function disorders and abdominal pain. Her laboratory tests revealed cholestasis, and imaging examinations showed stenosis of the common bile duct pulled toward the hernia sac. She was diagnosed with a common bile duct stricture due to pancreatic herniation and underwent laparoscopic surgery. Our review of the literature identified three types of pancreatic herniations: asymptomatic, bile duct complication, and acute pancreatitis. Pancreatic head herniation tends to induce bile duct complications.
... Cases of pancreatic herniation with pancreatitis are rare; Therefore, the ideal treatment is still unclear [1,3,6]. However, conservative treatment including intravenous fluid supplementation, analgesia and early feeding is usually indicated [1,11,12]. ...
... Historically, HH cases with pancreatitis were treated with surgery [1,6,7,13,14]. However, the benefit of such intervention remains unknown especially that the rate of recurrence appears to be low [3,12]. Moreover, the decision to pursue surgical repair should be considered on a case-by-case basis since most affected patients are of advanced age. ...
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Introduction and importance Hiatal hernia (HH) contents commonly include stomach, transverse colon, small intestine, and spleen but herniation of the pancreas is an extremely rare phenomenon, even rarer when HH is associated with acute pancreatitis. Case presentation A 56-year-old female with hypertension and gastroesophageal reflux disease presented with abdominal pain, vomiting and chest discomfort evolving for 24 h. Physical examination revealed left-upper quadrant tenderness without guarding. Blood tests showed elevated serum amylase and lipase levels. An abdominal CT scan demonstrated a large type-IV hiatal hernia involving the entire stomach, transverse and right colon, small intestine, duodenum as well as the head, body and the tail of pancreas. The pancreas was enlarged consistent with pancreatitis. Patient clinical status improved with conservative treatment. Clinical discussion The stomach is the most common organ to herniate through the diaphragm and pancreatic herniation is extremely rare with only few cases in the literature. Even rarer when associated with acute pancreatitis. This diagnosis is a major diagnostic and therapeutic challenge that has to be evoked in elderly presenting with chest pain and a negative cardiopulmonary evaluation. The ideal treatment is still unclear, however, conservative treatment is the initial management and surgery may be considered in case of recurrent episodes of acute pancreatitis. Conclusion HH associated with acute pancreatitis is a major diagnostic and therapeutic challenge. Clinicians should consider this rare diagnosis in every case of chest pain with negative cardiopulmonary evaluation.
... In the last 25 years, 17 cases of intrathoracic herniation of (parts of) the pancreas have been reported (Table 1) [2][3][4]6,[8][9][10][11][12][13][14][15][16][17][18][19][20]. In the majority of cases, the pancreatic herniation itself was asymptomatic and found incidentally [2,4,[8][9][10][11][12][16][17][18][19][20] on CT-scans made for evaluating complaints befitting a large or giant hiatal hernia such as abdominal pain [4,10,11,[16][17][18][19], vomiting [17,18], dysphagia [4] or dyspnea [2,16,20]. ...
... In the majority of cases, the pancreatic herniation itself was asymptomatic and found incidentally [2,4,[8][9][10][11][12][16][17][18][19][20] on CT-scans made for evaluating complaints befitting a large or giant hiatal hernia such as abdominal pain [4,10,11,[16][17][18][19], vomiting [17,18], dysphagia [4] or dyspnea [2,16,20]. Five cases, however, were diagnosed with pancreatitis secondary to intrathoracic pancreatic herniation [3,6,[13][14][15], one of which was associated with pancreatic torsion [6]. While pancreatitis is known to occur as a result of pancreatic herniation, large and giant hiatal hernia without pancreatic involvement may also present with acute or recurrent pancreatitis. ...
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Transhiatal herniation of the pancreas is rare with only 17 cases reported in 25 years. Presentation of pancreatic herniation is diverse. In the majority of cases, the pancreatic herniation is found incidentally on CT-scans made for evaluating complaints related to a large or giant hiatal hernia. We present a literature review and case series of three patients with symptomatic type IV hiatal hernia with incidental, asymptomatic pancreatic herniation. All cases were managed laparoscopically with robotic assistance.
... Trans-diaphragmatic hernia of pancreas can be asymptomatic and found incidentally on imaging or result in acute pancreatitis. Table 1 [3,[7][8][9][10][11][12][13][14][15] lists the cases of acute pancreatitis from pancreatic herniation in hiatal hernias from published literature. All cases were diagnosed based on exclusion of other etiologies for acute pancreatitis. ...
... However, herniation of the pancreas is extremely rare, as the pancreas is a well-fixed organ. There are few reported cases about herniation of the body of the pancreas when the head and tail remain in normal anatomical cavities [2]. ...
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Hiatus hernia is defined as herniation of the abdominal elements through the esophageal hiatus into the madiastinum. Type IV hiatal herniation is the rarest of all paraoesaphagial hernias. Herniation of pancreas is extremely rare. A 63-year-old male was admitted to the department of oncology with a periauricular squamous cell carcinoma (SCC). Abdominal CT was performed for organ metastasis. No metastasis was found, but hiatal herniation of the stomach along with the body of the pancreas into the thorax was observed. To our knowledge, this is the first case of herniated pancreatic body complicated with a carcinoma in the literature.
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