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CASE REPORT
Pancreatic herniation: a rare cause of acute
pancreatitis?
Prashant Kumar,
1
Matthew Turp,
1
Sarah Fellows,
1
Jonathan Ellis
2
1
Department of Surgery, Milton
Keynes General Hospital,
Milton Keynes, Bucks, UK
2
Department of Radiology,
Milton Keynes General
Hospital, Milton Keynes,
Bucks, UK
Correspondence to
Dr Prashant Kumar,
prashant.kumar916@gmail.com
To cite: Kumar P, Turp M,
Fellows S, et al.BMJ Case
Rep Published online:
[please include Day Month
Year] doi:10.1136/bcr-2013-
201979
SUMMARY
Acute pancreatitis is a common and potentially fatal
condition, with several well-known causes including
gallstones, excessive alcohol consumption and specific
medications. We report a case of an 89-year-old man
presenting with acute pancreatitis, which we believe to
be secondary to a diaphragmatic herniation of the
pancreas. This extremely rare anatomical abnormality can
be found incidentally in the asymptomatic patient or may
present with a variety of acute symptoms. However,
there have been only isolated reports of these cases
presenting as acute pancreatitis. While the majority of
acute pancreatitis cases can be explained by common
causes, it is important that clinicians be aware of and
should consider investigating for other more unusual
possibilities, such as pancreatic herniation, before
labelling an episode as ‘idiopathic’.
BACKGROUND
Acute pancreatitis is a common condition encoun-
tered worldwide, with a potentially fatal outcome.
There is a well-known list of differential causes, of
which gallstones and excess alcohol consumption
are the most common in the UK.
1
In the majority
of patients, a cause can be identified following
simple investigations. However, in a significant
number of cases, no aetiology is identified, and
these are subsequently labelled as being idiopathic.
Current guidelines suggest that this proportion of
cases being classified as idiopathic should number
no more than 20%.
1
We present an extremely rare case of acute pan-
creatitis likely to have been caused by pancreatic
herniation, as opposed to other better-known
aetiologies.
CASE PRESENTATION
An 89-year-old man presented to the accident and
emergency department following a 1-day history of
epigastric pain associated with nausea and vomit-
ing. His medical history included hypertension and
ischaemic heart disease. There were no recent
changes to medications, no recent trauma and no
known history of alcohol abuse or gallstones. On
admission, he was tachycardic and hypotensive.
Initial blood work-up showed white cell count
(WCC) of 22.2×10
9
/L, C reactive protein 2.7 mg/L,
aspartate aminotransferase 242 iu/L, γ-glutamyl
transpeptidase 207 iu/L, alkaline phosphatase
165 iu/L, bilirubin 29 umol/L, albumin 39 g/L,
lactate dehydrogenase (LDH) 694 iu/L and amylase
5256 iu/L. The patient scored 3 on the Modified
Glasgow Scoring System (WCC, age & LDH), and
9 on the Acute Physiology and Chronic Health
Evaluation II score, and was therefore aggressively
resuscitated with intravenous fluids and antibiotics.
As per hospital protocol, the intensive care team
was made aware of the patient. However, following
their review, no further intensive care input was
deemed necessary at that point of time. The aeti-
ology of his pancreatitis was, at this stage, unknown.
FURTHER INVESTIGATIONS
A thorough review of the patient’s background and
medications along with initial tests found no dis-
cernable cause for pancreatitis.
The patient was shown to have a hiatus hernia
on chest X-ray from 8 years previously. The con-
tents of the hernia were not identifiable and no
other comparative imaging was available.
An abdominal ultrasound scan was requested to
investigate the possibility of gallstones, but was
reported as normal with no evidence of gallstones
or duct dilation.
Subsequently, a CT scan was performed 4 days
post-admission, which not only confirmed the pres-
ence of acute pancreatitis with inflammation of the
peripancreatic fat but also revealed a rare case of a
pancreatic herniation into the thoracic cavity
(figures 1–4). Owing to a lack of previous imaging,
we cannot be certain as to when the herniation first
appeared.
Figure 1 shows the pancreatic tail correctly fixed
in its conventional anatomical position at the level
Figure 1 Axial CT image demonstrating the pancreatic
tail fixed in its conventional anatomical position with
inflammation of the peripancreatic fat.
Kumar P, et al.BMJ Case Rep 2013. doi:10.1136/bcr-2013-201979 1
Unusual association of diseases/symptoms
of T12. Similarly, the head of the pancreas is seen to be in its
conventional anatomical position, at the level of T12 (figure 2).
The distal section of the common bile duct is dilated but is
found to be in a normal position. Unfortunately, the personnel
required to perform an additional endoscopic ultrasound to
further evaluate this finding were unavailable at Milton Keynes
Hospital.
Meanwhile, the body of the pancreas can clearly be seen, on
both axial and sagittal views (figures 3–4), to herniate above the
diaphragm, through into the thoracic cavity.
Figure 3 shows the pancreatic head at the level of T12, with
the pancreatic neck pulled superiorly into the hiatus hernia. The
apex of the pancreatic body lies at the level of the T9/T10 disc
space. The pancreatic body then takes a hair-pin turn, with the
distal aspect of the pancreatic body moving inferiorly towards
the pancreatic tail.
OUTCOME AND FOLLOW-UP
The patient was treated successfully with fluid resuscitation and
antibiotics and recovered well over the course of a 10-day
inpatient admission. He was subsequently reviewed in an out-
patient appointment. The patient was not keen for any further
investigations or invasive treatment and is therefore being
managed conservatively with omeprazole for symptomatic relief.
Surgical intervention was deemed inappropriate given his
complex comorbidities and personal wishes.
DISCUSSION
A hiatal hernia can be classified into one of the four types. Type
I, otherwise known as a sliding hernia, consists of a simple her-
niation of the gastro-oesophageal junction into the chest,
2
accounting for up to 95% of all cases.
3
The remaining 5% of
cases are classified as types II–IV or paraesophageal hernias.
3
While types II and III involve gastric herniation only, a type IV
hernia is more advanced, characterised by herniation of add-
itional abdominal organs alongside the stomach.
2
A type IV herniation is extremely rare, accounting for only
between 5% and 7% of all paraesophageal hernias,
4
with the
colon being the most common viscera to herniate in addition to
the stomach.
5
A pancreatic herniation, however, has only been
reported a handful of times.
5–13
Of these cases, there are even
fewer reported cases of this anatomical phenomenon leading to
acute pancreatitis.
11–13
In most cases, the body and tail of the
pancreas have herniated above the diaphragm. To our knowledge,
there is only one other documented case where the head and tail
of the pancreas remain in their normal anatomical planes, with
only the body of the pancreas herniating into the thoracic cavity.
5
Our findings have important implications for patients with
acute pancreatitis for which no aetiology has been identified.
Our patient demonstrates a rare anatomical abnormality that
may have been the cause of his pancreatitis. We believe that our
case contributes to the growing repertoire of similar cases in the
Figure 3 Sagittal CT image showing the folding of the pancreatic
body within the hiatus hernia.
Figure 4 Axial CT image demonstrating the apex of the body of the
pancreas within the hiatal hernia sac.
Figure 2 Axial CT image demonstrating the pancreatic head fixed in
its conventional anatomical position and dilation of the common bile
duct.
2 Kumar P, et al.BMJ Case Rep 2013. doi:10.1136/bcr-2013-201979
Unusual association of diseases/symptoms
literature which report pancreatic herniation as a potential cause
for pancreatitis. We suggest that prior to such cases being
labelled as ‘idiopathic’, clinicians should at least consider further
imaging to assess for any anatomical abnormalities. In cases
where pancreatic herniation may be the cause, surgical repair of
the hernia may help to prevent repeated episodes of acute pan-
creatitis. However, the benefit of such an intervention remains
unknown.
Learning points
▸Patients with pancreatic herniation may present with acute
pancreatitis.
▸It is imperative that the clinicians perform a thorough
diagnostic work up to elicit the cause of acute pancreatitis.
If the common causes are ruled out, then one should
consider exploration of rarer possibilities, such as anatomical
abnormalities, before labelling the cause as ‘idiopathic’.
▸Those patients fit for surgery may benefit from repair of the
hernia, so as to help prevent repeat episodes of acute
pancreatitis. However, the benefit of such an intervention
remains unknown.
Contributors All the authors were involved with patient care in this case. All the
authors have made valuable contributions to the initiation, research and writing up
of this case report.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
REFERENCES
1 UK Working Party on Acute Pancreatitis. UK guidelines for the management of
acute pancreatitis. Gut 2005;54:1–9.
2 Norton JA, Bollinger RR, Chang AE, et al.Essential practice of surgery: basic
science and clinical evidence. New York: Springer-Verlag, 2003.
3 Shieman C, Grondin SC. Paraesophageal hernia: clinical presentation, evaluation,
and management controversies. Thorac Surg Clin 2009;19:473–84.
4 Grushka JR, Grenon SM, Ferri LE. A type IV paraesophageal hernia containing a
volvulized sigmoid colon. Dis Esophagus 2008;21:94–6.
5 Coughlin M, Fanous M, Velanovich V. Herniated pancreatic body within a
paraesophageal hernia. World J Gastrointest Surg 2011;3:29–30.
6 Katz M, Atar E, Herskovitz P. Asymptomatic diaphragmatic hiatal herniation of the
pancreas. J Comput Assist Tomogr 2002;26:524–5.
7 Saxena P, Konstantinov IE, Koniuszko MD, et al. Hiatal herniation of the pancreas:
diagnosis and surgical management. J Thorac Cardiovasc Surg 2006;131:1204–5.
8 Coral A, Jones SN, Lees WR. Dorsal pancreas presenting as a mass in the chest.
AJR Am J Roentgenol 1987;149:718–20.
9 Shah N, Fernandes R, Thakrar A, et al. Diaphragmatic hernia: an unusual
presentation. BMJ Case Rep 2013;2013:pii: bcr2013008699.
10 Ahmed S, Fontaine JP, Ng T. Pancreatic herniation after transhiatal esophagectomy.
Ann Thorac Surg 2010;89:308–9.
11 Chevallier P, Peten E, Pellegrino C, et al. Hiatal hernia with pancreatic volvulus: a
rare cause of acute pancreatitis. AJR Am J Roentgenol 2001;177:373–4.
12 Maksoud C, Shah AM, DePasquale J, et al. Transient pancreatic hiatal herniation
causing acute pancreatitis—a literature review. Hepatogastroenterology
2010;57:165–6.
13 Kafka NJ, Leitman IM, Tromba J. Acute pancreatitis secondary to incarcerated
paraesophageal hernia. Surgery 1994;115:653–5.
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