Marc Jegers has made a remarkable and multifaceted contribution to the literature on the non-profit governance. For example, his 2009 review article (Jegers, 2009) does not only provide an interesting overview of the economic perspective on non-profit governance, it also summarises what Marc does best: i.e. a no-nonsense clarification of the research questions that matter. Similarly, his book ‘Managerial Economics of Non-Profit Organisations’ – which is currently in its fifth edition (2021) – is used by many scholars, including the authors of this chapter, for research and teaching. Moreover, Marc has enabled through several third-party funding projects to hire, engage, and co-author with a hand-full of scholars that proudly represent his non-profit governance succession for years to come. Non-profit governance refers to the systems and processes concerned with ensuring the overall direction, control, and accountability of non-profit organisations (Cornforth, 2014, p. 4–5). It has emerged as a separate field of study, with contributions from a wide range of disciplines (Jegers, 2009; Cornforth and Brown, 2014; Van Puyvelde, 2016). This chapter builds further on the abovementioned research by exploring some determinants of board effectiveness in non-profit organisations. Board effectiveness constitutes an important topic in the non-profit governance literature (Ostrower and Stone, 2006; Cornforth, 2012; Renz and Andersson, 2014; Wellens and Jegers, 2014; Van Puyvelde, 2016). For example, it has been found to be positively associated with judgments of organisational effectiveness (Green and Griesinger, 1996; Herman and Renz, 1997, 2004; Brown, 2005) as well as to shape innovation in non-profit organisations (Jaskyte, 2012, 2018). Based on previous literature (Cornforth, 2003; Miller-Millesen, 2003; Brown and Guo, 2010; Van Puyvelde, 2016), a distinction is made between three major governance roles (a controlling role, a partnership role, and a boundary-spanning role). We analyse the relationship between board human capital, board chair leadership, and the perceived effectiveness of the board in performing these roles. Although deemed important, empirical evidence pertaining to the effects of board human capital (Cornforth, 2001; Jaskyte, 2018) and board chair leadership (Harrison, Murray, and Cornforth, 2013; Van Puyvelde et al., 2018) is rather limited. The aim of this chapter is to add to this literature. Our results show that board chair leadership and the human capital of the board are positively associated with board effectiveness as perceived by board chairs as well as chief executives. In addition, board size is positively associated with board effectiveness in the boundary-spanning role. We conclude by formulating implications for theory and practice.