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EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTI-ARTHRITIC ACTIVITY OF MAHANARAYANA TAILAM IN LABORATORY ANIMALS 1 2 1 2 2

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Sharad D Pawar at Central Ayurveda Research Institute, Kolkata
Sharad D Pawar
  • Central Ayurveda Research Institute, Kolkata
Sudesh Gaidhani at Central Council for Research in Ayurvedic Sciences
Sudesh Gaidhani
T Anandan
T Anandan
T Anandan
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Gandhidas Sonajirao Lavekar at • Free Lance Ayurved Herbal Industry Pharma Consultant Scientist and Clinician • Lybrate- Online Clinical Consultation
Gandhidas Sonajirao Lavekar
  • • Free Lance Ayurved Herbal Industry Pharma Consultant Scientist and Clinician • Lybrate- Online Clinical Consultation
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Abstract

Pharmacology), CCRAS 61-65, Institutional area, Opposite 'D' block, JANAKPURI, New Delhi. The present study was conducted to evaluate the anti-inflammatory, analgesic and anti-arthritic activities of Mahanarayana tailam (MT) in laboratory animals. Carrageenan induced rat paw oedema, Freund's adjuvant induced arthritis in rats and Eddy's hot plate induced pain in mice were used as experimental models. MT was applied to the planter surface of the hind paw by gently rubbing to treatment groups. The external application of MT, showed significant inhibition of inflammation (P < 0.01) as compared to control and less than Piroxicam gel 0.5%. Analgesic effect as compared to control was found to be significant (P<0.01) and almost equal to the standard drug. Anti-arthritis activity of the oil was observed almost equal to the standard drug used in the study. Histopathology of ankle joint revealed that Piroxicam as well as MT inhibits the inflammation in the treated animals. However, mild mononuclear infiltration of surrounding tissue was observed in the MT treated animals. These observations suggest that MT may be used to treat inflammation, pain and arthritis. INTRODUCTION Rheumatoid arthritis (RA) is a common human autoimmune disease characterized by chronic inflammation of the synovial membranes with concomitant destruction of cartilage and bone. It affects approximately 5 million people worldwide of which 50 % are unable to work beyond 10 years of diagnosis. Anti-inflammatory agents are administrated as long-term treatments for patients with rheumatoid arthritis. However, anti-inflammatory agents carry the risk of gastrointestinal toxicity hence, their use are limited. Non-steroidal anti-inflammatory drugs are commonly used in practices for the treatment of various inflammatory conditions. It is known that all conventional analgesics and anti-inflammatory agents produce various adverse effects. In an attempt to avoid adverse gastrointestinal effects, research is now focusing on Ayurvedic drugs which are devoid of such adverse effects.
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EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC
AND ANTI-ARTHRITIC ACTIVITY OF MAHANARAYANA
TAILAM IN LABORATORY ANIMALS
1 2 1 2 2
S. D. Pawar , S.N. Gaidhani *, T. Anandan , G.S. Lavekar , B.S. Sharma ,
2 2 2
Suman Kumari , M.M. Padhi and Ramesh Babu
Research Officer (Pharmacology) Central Research Institute for Siddha, CHENNAI.
Assistant Director (Pharmacology), CCRAS 61-65, Institutional area, Opposite 'D' block,
JANAKPURI, New Delhi.
The present study was conducted to evaluate the anti-inflammatory,
analgesic and anti-arthritic activities of Mahanarayana tailam (MT) in
laboratory animals.
Carrageenan induced rat paw oedema, Freund's adjuvant induced
arthritis in rats and Eddy's hot plate induced pain in mice were used as
experimental models. MT was applied to the planter surface of the hind paw by
gently rubbing to treatment groups.
The external application of MT, showed significant inhibition of
inflammation (P < 0.01) as compared to control and less than Piroxicam gel
0.5%. Analgesic effect as compared to control was found to be significant
(P<0.01) and almost equal to the standard drug. Anti-arthritis activity of the oil
was observed almost equal to the standard drug used in the study.
Histopathology of ankle joint revealed that Piroxicam as well as MT inhibits the
inflammation in the treated animals. However, mild mononuclear infiltration of
surrounding tissue was observed in the MT treated animals. These observations
suggest that MT may be used to treat inflammation, pain and arthritis.
INTRODUCTION
Rheumatoid arthritis (RA) is a common human autoimmune disease characterized
by chronic inflammation of the synovial membranes with concomitant destruction of
cartilage and bone. It affects approximately 5 million people worldwide of which 50 % are
unable to work beyond 10 years of diagnosis. Anti-inflammatory agents are administrated as
long-term treatments for patients with rheumatoid arthritis. However, anti-inflammatory
agents carry the risk of gastrointestinal toxicity hence, their use are limited. Non-steroidal
anti-inflammatory drugs are commonly used in practices for the treatment of various
inflammatory conditions. It is known that all conventional analgesics and anti-inflammatory
agents produce various adverse effects. In an attempt to avoid adverse gastrointestinal
effects, research is now focusing on Ayurvedic drugs which are devoid of such adverse
effects.
* Corresponding Author
Adv. Pharmacol. Toxicol. Vol. 12 (3) 2011, 33-42
ISSN - 0973-2381
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... Six groups were selected containing four animals in each group. I group received standard drug-aspirin (100 mg/kg); II, III group received tripeptides MRY, MVY; and IV, V and VI group received tetrapeptides MICY, FWKY and MWKY, respectively (Pawar et al., 2011). The test drug having respective dose as similar to previous method was injected and the reaction time at 15, 30 and 45 min after the administration of test drugs was noted. ...
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INTRODUCTION India from times immemorial has been blessed by nature with the wealth of fascinating and alluring medicinal plants. In the oldest repositories of human knowledge, plants and plant products have been positively recognized as supportive agents in the treatment of various diseases. [1] Ayurveda was not in theoretical form but was passed on from generation to generation by teacher in the practical form till the Ayurveda was compiled and found its rightful place at the end of the fourth Veda, the Atharvaveda. Due to a different Study Background: Roscoea purpurea (Kakoli) is a wonder plant used by Saints/Rishies since ages, however, entered the list of plants facing extinction due to enumerable reasons. Ancient texts claim very potent uses of kakoli-containing formulations, but the information is available in regional languages and hence the real usages of the plant are not well understood by scientific fraternity. Hence, it becomes important to know the real status of the mentioned therapeutic potentials as well as practiced potentials by tradomedical practitioners. Hence, the major objective of the work was to conduct the ethnomedicinal survey for intended formulations and compares it with therapeutic usage mentioned in text/modern system of medicine. Materials and Methods: A field survey was conducted in Himachal Pradesh, Punjab, Uttrakhand, and Uttar Pradesh followed by discussion with 18 shopkeepers, 24 local medical practitioners, and 4 traditional healers. The information regarding usage of these formulations were recorded and compared. Results: Results showed that usage of formulations containing kakoli was highest in Himachal Pardesh and Uttrakhand. Only few clinical studies have been done by scientists on these formulations. Conclusion: The efficacy of the remedies alluded by the respondents claimed to be exact as per the Ayurvedic textual literature. This survey provides a template for scientists for further screening and research on these formulations useful in plethora of disorders. How to cite this article: Kaur G, Gupta V, Kumar S, Singhal RG, Maithani M, Bansal P. Compliance level of textual therapeutic usage of kakoli-containing formulations with ethnomedicinal survey and modern system of medicine. Imam J Appl Sci 2019;4:62-8. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
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