In interphase cells, the Golgi complex is positioned adjacent to the microtubule organizing center, and its localization has long been known to be dependent upon intact microtubules (Thyberg and Moskalewski, 1985). Addition of a microtubule depolymerizing agent such as nocodazole causes the Golgi to distribute as ministacks that become dispersed throughout the cytoplasm; upon drug washout, the Golgi returns to the microtubule organizing center in a process that utilizes the microtubule-based motor protein cytoplasmic dynein. Cells in which microtubules have been depolymerized are still capable of protein secretion; the rate of this process is rarely decreased more than 2-fold (Thyberg and Moskalewski, 1985 and Hirschberg et al., 1998). Thus, microtubule organization adds to the efficiency of the secretory pathway and plays a key role in correct positioning of the Golgi stack.