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Mild Traumatic Brain Injury Screening, Diagnosis, and Treatment

Authors:
  • Defense and Veterans Brain Injury Center

Abstract and Figures

The majority of combat-related traumatic brain injury (TBI) within the U.S. Armed Forces is mild TBI (mTBI). This article focuses specifically on the screening, diagnosis, and treatment aspects of mTBI within the military community. Aggressive screening measures were instituted in 2006 to ensure that the mTBI population is identified and treated. Screenings occur in-theater, outside the contiguous United States, and in-garrison. We discuss specific screening procedures at each screening setting. Current diagnosis of mTBI is based upon self-report or through witnesses to the event. TBI severity is determined by specific Department of Defense criteria. Abundant clinician resources are available for mTBI in the military health care setting. Education resources for both the patient and the clinician are discussed in detail. An evidence-based clinical practice guideline for the care of mTBI was created through collaborative efforts of the DoD and the U.S. Department of Veterans Affairs. Although symptoms following mTBI generally resolve with time, active treatment is centered on symptom management, supervised rest, recovery, and patient education. Medical specialty care, ancillary services, and other therapeutic services may be required.
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MILITARY MEDICINE, 177, 8:67, 2012
Mild Traumatic Brain Injury Screening, Diagnosis, and Treatment
Kathryn R. Marshall, MS, MPH, PA-C*; Sherray L. Holland, PA-C*; Kimberly S. Meyer, MSN, ACNP*†;
Elisabeth Moy Martin, RN-BC, MA*; Michael Wilmore, MPAS, PA-C*; Col Jamie B. Grimes, MC USA*
ABSTRACT The majority of combat-related traumatic brain injury (TBI) within the U.S. Armed Forces is mild TBI
(mTBI). This article focuses specifically on the screening, diagnosis, and treatment aspects of mTBI within the military
community. Aggressive screening measures were instituted in 2006 to ensure that the mTBI population is identified and
treated. Screenings occur in-theater, outside the contiguous United States, and in-garrison. We discuss specific screening
procedures at each screening setting. Current diagnosis of mTBI is based upon self-report or through witnesses to the
event. TBI severity is determined by specific Department of Defense criteria. Abundant clinician resources are available
for mTBI in the military health care setting. Education resources for both the patient and the clinician are discussed in
detail. An evidence-based clinical practice guideline for the care of mTBI was created through collaborative efforts of the
DoD and the U.S. Department of Veterans Affairs. Although symptoms following mTBI generally resolve with time,
active treatment is centered on symptom management, supervised rest, recovery, and patient education. Medical specialty
care, ancillary services, and other therapeutic services may be required.
INTRODUCTION
Traumatic brain injury (TBI) is a widely recognized injury
resulting from the current conflicts in Afghanistan and Iraq.
TBI occurs when a trauma-induced external force results in
temporary or permanent neurologic dysfunction. TBI severity
ranges from mild to severe; TBI may be classified as a closed
or penetrating injury. The majority of combat-related TBI
within the U.S. Armed Forces fall in the mild TBI (mTBI)
range, which is commonly known as concussion.
1
The overall
Department of Defense (DoD) approach to TBI care follows a
continuum of care. This continuum includes the prevention,
surveillance, screening/assessment, diagnosis, case manage-
ment, treatment, rehabilitation, and reintegration of service
members who have suffered a TBI.
2
This article focuses spe-
cifically on the screening, diagnosis, and treatment aspects of
mTBI within the military community.
SCREENING
Approximately 77% of TBI cases seen within the U.S. military
population are classified as mTBI.
1
Aggressive screening mea-
sures were instituted in 2006 to ensure that the mTBI popula-
tion is captured by military TBI surveillance.
3
TBI screenings
occur in-theater, at Landstuhl Regional Medical Center
(LRMC) in Germany, at military treatment facilities (MTFs),
at home duty stations after deployment, and within the Vet-
erans Affairs (VA) system. From the year 2000 through
November 15, 2011, there have been 233,425 medically diag-
nosed TBIs worldwide within the DoD, of which 178,961
were classified as mild.
4
Reliance on service member self-
report,
5,6
and co-occurring conditions
7,8
can make TBI screen-
ing very challenging. If a service member has been exposed to
an external force or mechanism of injury that could potentially
cause TBI (i.e., blast exposure, vehicular crash and/or rollover,
blunt trauma, fall, sports-related injury, gun-shot wound
above the neck, or a combination of these entities), immediate
screening is indicated.
9
In-theater, event-based screening occurs as soon as safely
possible following exposure to a traumatic event.
10
This initial
evaluation is commonly performed by combat medics/corpsmen
on the front line or by forward operating bases. Severe inju-
ries are usually easily recognized, requiring resuscitation and
evacuation. Those without obvious injuries are then assessed
for TBI. The Military Acute Concussion Evaluation (MACE)
is widely used as a screening tool for mTBI (Table. 1).
11
The cognitive evaluation portion of the MACE uses the
Standardized Assessment of Concussion (SAC),
3
which is
well validated in sports concussion. The MACE has recently
been updated in February, 2012 (Table I) with different versions
of the SAC to avoid familiarization with repeated adminis-
trations. The MACE typically takes less than 10 minutes to
administer. In addition to the history and brief neurologic
exam (eye, motor, speech, and balance testing), it measures
four cognitive domains including orientation, immediate
memory, concentration, and delayed recall.
12
Appropriate
administration of the MACE requires that the clinician avoid
altering the word lists, digit spans, or order of the exam.
According to the new version of the MACE, All three com-
ponents of the MACE should be recorded in the medical
record following the mnemonic CNS
Cognitive results (Total out of 30)
Neurologic exam results (Green =allnormalexam,
Red =any abnormal exam results)
Symptom results (A =No symptoms, B =1ormore
symptoms)
The MACE is intended to be given during the initial
assessment and as part of the cognitive evaluation during
*Defense and Veterans Brain Injury Center, 1335 East West Highway,
Suite 6-100, Silver Spring, MD 20919.
†Trauma Institute, University of Louisville Hospital, 530 South Jackson
Street, Louisville, KY 40202.
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exertional testing.
11
If no loss of consciousness (LOC) or
alteration of consciousness (AOC) is noted during the initial
portion of the MACE, the MACE can be stopped, and clini-
cians should consider other causes for the service member’s
symptoms. The concussion management algorithm states that
a cognitive score of <25 or the presence of symptoms requires
consultation with a provider. It is important to remember that
MACE scores do not diagnose a concussion.
11
Acute assessment of concussion is very important on the
battlefield as it may lead to better outcomes and increased
rates of return to duty (RTD).
12
Medics must determine
which level of care is required next for the service member
based on the Concussion Management Algorithms for the
deployed setting (discussed in the “Treatment” section).
10
The Concussion Management Algorithm for deployed set-
tings (CMA) was recently updated in 2012 (Table II). A copy
of the updated CMA can be requested online: http://www
.dvbic.org/material/concussion-management-algorithm-cma-
pocket-.cards. Important updates to the CMA are included
(Table II). All service members exposed to a blast or other
mechanism of injury, including those who screened nega-
tive, are mandated to rest for 24 hours before returning to
duty. The commander/commanding officer, however, has
the right to waive the rest period if the service member is
deemed vital to the mission.
10
Mandatory events requiring concussion evaluation include:
1) Any service member in a vehicle with a blast event,
collision or rollover
2) Any service memeber within 50 meters of a blast
3) Anyone who sustains a direct blow to the head
4) Command directed-such as, but not limited to, repeated
exposures
If there are any red flags noted immediate provider con-
sultation or emergent evacuation is indicated.
Since March 2006, all service members arriving at LRMC
and all Operation Enduring Freedom (OEF) and Operation
Iraqi Freedom (OIF) (changed to Operation New Dawn
[OND] October 2010) service members returning from theater
receive a TBI screen regardless of the medical condition or
injury that required medical evacuation. This ensures that the
majority of service members get an assessment before
returning to their home duty station. LRMC uses a standard
patient questionnaire which inquires about any blast exposures,
motor vehicle accidents, falls, or direct blows to the head
that may have resulted in loss or AOC.
13
From May 2006
to October 2008, nearly 18,000 patients completed this
initial screening questionnaire at LRMC.
13
Of these patients,
16% of outpatients and 31% of inpatients screened positively
for being at risk for TBI.
13
If the service member cannot be
screened because of medical issues such as intubation and/or
heavy sedation, a notation is made in the medical record to
re-evaluate for TBI at a later time. The mTBI screen includes
the date of injury, service member’s recollection of the injury,
distance of the blast, position in the vehicle (if applicable), use
of protective gear, symptoms at the time of injury, specific
injuries to the head/face/neck, and whether there was an
on-scene evaluation.
13
The screener also asks about current
symptoms and any previous concussion/head injury history. If
it is determined that there was a change in consciousness and it
is clinically appropriate (e.g., the service member is not
heavily medicated, in pain, or psychiatrically impaired), the
MACE is then administered to determine cognitive status.
11
Obtaining the history, MACE, initial Glasgow Coma Scale
(GCS) score, and reviewing of the computed tomography (CT)
scan or magnetic resonance imaging (MRI) scan (if performed),
TABLE II. Major Changes in the 2012 Version of the
Concussion Management in Deployed Settings
Combat Medic/Corpsman Algorithm:
Includes recommendations for initial management of concussion
in consultation with a provider
Provides instruction to consult provider with exertional test results
for return to duty determination
Clarifies directives and emphasizes assessment, identification of
red flags, consultation with a provider, and distribution of
educational brochures to patients
Initial Provider Algorithm:
Includes concussion history with added guidance for first, second
and third concussion in 12 months
Clarifies guidance on neuroimaging/CT and consulation
Comprehensive Concussion Algorithm:
Advises to consider NCAT and functional assessment
Recurrent concussion Algorithm:
Advises to consider NCAT and functional assessment
Includes the Balance Error Scoring System (BESS) to guide the
balance assessment
Other:
The list of information sheets now includes: Acute Stress
Reaction Fact Sheet, Acute Concussion Educational Brochure,
Neurobehavioral Symptom Inventory, Line Leader Fact Sheet,
Coding Guidance, and DCoE NeuroCognitive Assessment Tool
(NCAT) recommendations
Exertional testing clarified
ICD-9 coding tips added
TABLE I. Major Changes in the 2012 Version of the MACE
Instructions are now embedded with the questions
The first two pages focus only on whether or not there was an injury
event and AOC/LOC/PTA. Questions about symptoms and previous
concussions have been moved to the end of the tool
The second page clarifies when to stop the MACE
Three more versions of the cognitive tests have been added
A balance test has been added to the neurological evaluation
The neurological evaluation provides better guidance
The summary page provides more room to record cognitive test
scores results
The last page explains the proper interpretation of the cognitive
score, evaluating concussion recovery, and ICD-9 coding tips
MILITARY MEDICINE, Vol. 177, August Supplement 201268
mTBI Screening, Diagnosis, and Treatment
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allows for accurate determination of whether a service member
has sustained a concussion. If deemed negative, this is doc-
umented and the service member does not need further testing;
this service member may potentially RTD if no other medical
conditions are present. However, if it is determined that the
servicemembersustainedamTBI,thescreeningteammakes
recommendations for disposition. This disposition may be a
home duty station or a designated TBI center based upon
anticipated treatment needs of the service member.
If the service member’s prognosis is presumed critical from
other injuries and/or unlikely to report to duty or managed at
the LRMC outpatient clinic, he/she is medically evacuated to a
major MTF for ongoing care, such as Walter Reed National
Military Medical Center (WRNMMC) in Bethesda, Maryland,
or San Antonio Military Medical Center (SAMMC) in Texas.
Both treat service members from deployments with mTBI and
have the added capability of managing severe comorbidities
and injuries that may co-occur with mTBI.
At the treatment facility, a screener reassesses all inpatients
and outpatients based on their mechanism of injury. For exam-
ple, if a service member screened positive for a mTBI at
LRMC, but was medically evacuated for an unrelated condi-
tion, a mTBI consult note including a treatment plan is still
completed and recorded in the electronic medical record.
Obtaining a good interview is critical, and it is essential that
LOC, AOC, post-traumatic amnesia (PTA), imaging findings,
and initial and current symptoms are clearly noted. The screen-
ing process can be further complicated by ongoing treatment
for other injuries such as frequent surgeries for wound cleaning
and orthopedic surgeries, necessary sedation, pain, and fatigue.
When able, service members fill out symptom questionnaires
on concussion-related symptoms and acute stress symptoms.
A service member’s current state of health is evaluated
soon after returning from the theater (no later than 30 days),
using the Post Deployment Health Assessment (PDHA)
14
at
the unit during out-processing. The PDHA is an electronic
questionnaire mandated by the Assistant Secretary of Defense
for Health Affairs that assesses the service member and
assists military health providers in identifying and providing
present and future medical care.
14
Questions on the PDHA
include whether the service member (1) has experienced any
mechanism of injury that may have caused a head injury,
(2) was diagnosed with a concussion/head injury in theater,
(3) is experiencing symptoms, and (4) circumstances follow-
ing the event (see “Diagnosis” section for specifics).
14
If the
service member answers “yes” to any of the questions, a refer-
ral is made to a provider for further evaluation. A recent study
showed that out of these four questions, questions 1 and 2 above
demonstrated a higher correlation to clinician-diagnosed TBI.
15
Another screening tool used within the Defense Depart-
ment is the Warrior Administered Retrospective Casualty
Assessment tool (WARCAT). This was developed at Evans
Army Community Hospital, Fort Carson, Colorado, in June
2005. It has subsequently been adopted by some of the other
stateside concussion clinics. This tool is used in addition to the
PDHA and PDHRA to capture more detailed information
about possible injuries and symptoms. In comparison, the
WARCAT is more detailed about type of improvised explo-
sive device blast, direction and approximate distance from
blast, specific vehicle type and position, helmet information,
and initial treatment on the scene. It also inquires about prior
history of concussions, whereas the PDHA and PDHRA
inquire only about the recent deployment. The WARCAT is a
standardized form that the service member fills out for the
provider to review. It can be found at: http://evans.amedd
.army.mil/srp/.
In April 2007, the VA health care system implemented a
mandatory computer-based screening tool to identify OEF/
OIF veterans who sustained a mTBI.
16
This screen is com-
pleted whenever a veteran presents at the VA for any clinical
appointment including but not limited to primary care, mental
health, or dental appointments.
16
It is not indicated if the
veteran has a separation date before September 11, 2001 or
did not serve in OEF/OIF or current conflicts. The screen
is not necessary if a prior diagnosis of concussion was made.
The screen consists of questions very similar to other screen-
ing tools. These questions are:
Whether the veteran experienced any exposures to blast/
explosion, vehicular accident, fragment, bullet wound,
or fall
Which symptoms were immediately noticed neurologi-
cally and physically
Symptoms that may have begun or gotten worse after
the event
Current symptoms
When a veteran answers “yes” to one or more questions in
each of the four sections, then the VA considers the veteran to
have screened positive for a possible mild TBI and this veteran
should be offered a follow-up evaluation with a specialty pro-
vider who can determine whether the veteran has a mild TBI.
DIAGNOSIS
TBI severity is determined by specific criteria: initial GCS
score (if available), AOC, LOC, PTA, and structural imaging
(Table III).
9
The initial GCS score with mTBI is normally
between 13 and 15. Theater conditions are often challenging
as the attending combat medic/corpsman may be treating sev-
eral casualties under grueling conditions while under fire and
assessing for life or death injuries. The GCS can also be
obscured by other factors such as medications or hypovolemic
shock. AOC must be immediately related to the head trauma.
9
Typical symptoms are looking and feeling dazed and uncertain
of what is happening, confusion, difficulty thinking clearly or
responding appropriately to mental status questions, and being
unable to describe events immediately before or after the
event.
9
An AOC of less than 24 hours is considered a mTBI
according to the Defense Department severity rating.
17
PTA is any loss of memory for events immediately before
or after the injury.
9
With a mTBI, this period can extend up to
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24 hours.
9
Abnormal structural imaging attributed to the injury
will result in the individual being considered clinically to have
greater than mild injury.
9
Symptoms especially the cluster of headaches, dizziness,
nausea, and vomiting are common after an acute concus-
sion
18,19
. However, it is important to note that these symptoms
alone do not constitute a diagnosis of mTBI. Further work is
needed to identify clinically useful self-report measures that
assess mTBI and post-traumatic stress disorder (PTSD) and
associated symptoms among OEF/OIF Veterans.
5,20
Abnormal physical findings on exam, whether noted on the
brief neurological exam (completed by the attending combat
medic/corpsman), or the more comprehensive evaluations
(Level II–Level V facilities and the VA) are critical signs of
potentially serious health conditions. The neurologic exam
should include assessment of eyes (pupillary reflex, extraocular
movements), speech (fluency and word finding), motor (grip
strength and pronator drift), balance (tandem Rhomberg test),
and a cognition (concentration, delayed recall). CPGs exist to
guide the primary care management of symptoms after the diag-
nosis is confirmed and are reviewed in the “Treatment” section
below.
9
Those with neurologic deficits should be considered for
management at a location where imaging is available.
A service member who has prolonged symptoms without
signs of improvements should be screened for concomitant
psychological distress, which is most commonly an acute
stress reaction or PTSD. If positive, the service member is
referred to behavioral health for further evaluation.
9
Conventional head CT and MRI scans are normal for the
majority of mTBI patients
21,22
. Furthermore, these tools are not
sensitive to detecting diffuse axonal injuries (DAI) in mTBI.
22
The MRI technique of diffusion tensor imaging (DTI) can detect
microscopic white matter tract lesions in the brain.
23
DTI has
provided a tool for detecting DAI and other microstructural
changes in white matter
24,25
associated with mTBIinjury sever-
ity.
26
The DoD is currently interested in using DTI as a bio-
marker and has assisted in the research on this modality. Other
research studies proposed for TBI diagnosis are serum bio-
markers,
27
other advanced neuroimaging studies (including
spectroscopy and positron emission tomography scans),
28,29
brain acoustic monitoring,
30
state-of-the art developments in
research with blast waves,
31
and cumulative concussions.
32
TREATMENT
There are abundant resources for clinicians caring for mTBI in
the military health care setting. Because these resources must
undergo revisions as new information becomes available, it is
best for the provider to access the most up-to-date resources
online. Resources and references for mTBI treatment in the
military are discussed in the following sections.
In general, treatment of mTBI is centered on symptom man-
agement, supervised rest, and recovery. Symptoms usually fall
into three categories: somatic (e.g., headache, dizziness, weak-
ness, sensitivity to light and sound), cognitive (e.g., difficulties
with attention, memory, and language), and psychological/
behavioral
33
(e.g., irritability, depression, anxiety, personality
changes). All of these symptom areas need to be addressed.
Often, there is an overlap of symptoms of concussion and
psychological/psychiatric disorders that need to be treated
concurrently.
7,34–37
Physical injuries sustained in addition
to the mTBI must also be taken into consideration.
36,38
Clinicians are being encouraged to treat nonspecific symp-
toms regardless of etiology.
39,40
Sleep disorders are also
common.
41
In addition to medical specialty care, ancillary
services, neuropsychological testing,
42
and other therapeu-
tic services may be required.
41
In addition to symptom management, patient education
regarding expected outcomes can play an important role in
mTBI treatment.
43
Education should emphasize rest and
recovery, gradual supervised resumption of work and social
responsibilities, compensatory strategies, and modification of
the environment.
9
Additionally, the service member should
be educated about prevention of further injuries.
9
It is impor-
tant that the service member understands what their diagno-
sis is and what the expected course of recovery will be.
Approximately 85% to 90% of patients who have sustained
a combat mTBI improve with no lasting clinical difficul-
ties.
9,41
Service members should be reassured and encour-
aged that their condition is transient and that full recovery is
expected. Typically, recovery is seen within hours to days,
with a small portion taking longer.
9,41
In a small minority,
symptoms may persist
44
beyond 6 months to a year.
9
In the
civilian sector, it has been shown that educating individuals
regarding this positive expectation for recovery is associated
with positive outcomes.
45
Many free educational resources are offered online. The
Defense and Veterans Brain Injury Center (DVBIC) website,
dvbic.org,
46
offers resources about mTBI and include symp-
tom management for memory, sleep, mood changes, and
headache difficulties. The Defense Centers of Excellence for
Psychological Health and Traumatic Brain Injury (DCoE),
47
TABLE III. Severity Ratings for TBI
Criteria Mild Moderate Severe
Structural Imaging Normal Normal or Abnormal Normal or Abnormal
LOC 0–30 minutes >30 minutes and <24 hours >24 hours
AOC/Mental State £24 hours >24 hours >24 hours
PTA £24 hours >24 hours and <7 days >7 days
GCS
a
Score: 13–15 Score: 9–12 Score: 3–8
a
GCS is not part of the official DoD definition for TBI but is commonly used in practice.
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traumaticbraininjuryatoz.org, brainlinemilitary.org, and
afterdeployment.org also offer many resources available to
service members and providers. Some education materials
are meant to be provided in combination with verbal review
of the information with their health care provider.
9
As stated earlier, most service members with recent onset
of symptoms following a single mTBI can be successfully
managed in the primary care setting. For the majority, referral
to specialty care for mTBI is not required.
9
However, because
many service members sustain an mTBI in the context of
combat, their care can be complex and multifaceted, requiring
consultation with rehabilitation therapists, neurologists, phar-
macists, mental health, and social support.
9,41,48,49
Service members who are in-garrison and have suffered an
mTBI can be cared for using the VA/DoD CPGs.
9
In April
2009, an evidence-based CPG was created through the collab-
orative efforts of the Defense Department and VA to establish
guidelines for treating service members with ongoing symp-
toms following mTBI injury. The intent of these in-garrison
guidelines is for the service member to receive care from their
primary care provider at their home duty station. The follow-
ing are the three algorithms contained in this CPG: (1) initial
presentation, (2) management of symptoms, and (3) follow-up
of persistent symptoms. The most up-to-date version of the
VA/DoD CPG guidelines with algorithms can be found online
at www.dcoe.health.mil.
9
Algorithm A of the CPG describes next steps that a pro-
vider should follow once a service member has been diag-
nosed with an mTBI. If he or she has no concussion-related
symptoms at the time of diagnosis, then mTBI education is to
be provided. The service member should also be screened for
stress, substance use, and mental health conditions. If the
service member is symptomatic, algorithms B, C, or in-theater
guidelines can be used depending on the situation.
9
Algorithm B of the CPG outlines management of symp-
toms of mTBI in steps (Table IV). Steps are explained in
further detail in the full version of the CPG.
9
Algorithm C is used when a concussed service member
continues to have persistent symptoms beyond 4 to 6 weeks
and is not responding to initial treatment. Reassessment of
symptoms and functional status is recommended as well as a
complete psychosocial evaluation.
9
If symptoms such as
mood, behavior, or sleep difficulties have not improved, the
service member is assessed for possible alternative causes for
the persisting symptoms. It has been found that a service
member may not demonstrate psychological impairment in
the immediate time frame following a concussion and may
arise as a result of returning home and readjusting from a
combat deployment.
20,50
Alternative causes should be treated
according to VA/DoD guidelines, and the service member
should be considered for a referral to mental health for evalu-
ation and treatment. If persisting symptoms are physical, cog-
nitive, or emotional, they may also need a specialty referral for
services.
9
Available interventions for mTBI patients through-
out the services can be found in Table V.
41
A useful tool for any clinician caring for a service member
with mTBI is the Mild Traumatic Brain Injury Pocket Guide
created by the Defense Department, DCoE and DVBIC
(Fig. 1). This pocket guide includes management guides for
common mTBI symptoms such as headache, dizziness,
fatigue, vision difficulties, irritability, and appetite changes.
It also provides guidance for physical examination, medica-
tion management, and referrals. A mobile application of this
guide is available to the provider at http://t2health.org/apps/
mtbi. Table VI describes the information contained in this
pocket guide.
The Co-occurring Conditions Toolkit: mTBI and Psycho-
logical Health, is another tool that can be accessed online
from the DCoE website. This toolkit has additional manage-
ment guides for sleep, mood, attention, and chronic pain. A
companion video is available, which is designed to show the
provider how to use the toolkit. A copy of both of these
pocket guides can be found online (www.dcoe.health.mil/
ForHealthPros/TBIInformation.aspx)
51
or obtained by con-
tacting info@dvbic.org or calling 1800-870-9244.
In addition to the CPG, another resource to consider is
the Clinical Guidance for Evaluation and Management of
Concussion/mTBI management for both acute and subacute
nondeployed care. This guide was updated in May 2008.
It was created by an interdisciplinary work group through the
DVBIC. The work group included both U.S. military services
TABLE IV. Steps Outlined in Algorithm B of the CPG for
Management of Symptoms
(1) History and physical exam (labs, MSE, psychosocial evaluation)
(2) Clarify symptoms and build therapeutic alliance
(3) Evaluate and treat co-occurring disorders
(4) Determine treatment plan
(5) Educate patient and family on symptoms and expected recovery
(6) Provide early (nonpharmacologic) interventions
(7) Sleep hygiene, relaxation techniques, limit caffeine/tobacco/
alcohol, graded exercise, monitored progressive RTD/work/activity
(8) Initiate symptom-based treatment (consider case management)
(9) Follow-up and reassess in 4– 6 weeks
(10) If symptoms are unresolved, proceed to Algorithm C: follow-up
of persistent symptoms
(11) If symptoms are resolved, follow-up with patient as needed and
address: RTD, community participation, and family/social issues
TABLE V. Core TBI Therapies and Interventions Available
Throughout the Services
12
Medication Management
Vestibular Rehabilitation
Vision Therapy
Cognitive Rehabilitation
Driving Rehabilitation
Balance Training
Life skills Training
Assistive Technology
Tinnitus Management
Complementary and Alternative Medicine Interventions
MILITARY MEDICINE, Vol. 177, August Supplement 2012 71
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and civilian representation. The group provided expert guid-
ance regarding appropriate management of symptomatic
concussed service members in a military setting. The full
report with algorithms for the clinician can be found online
(www.dcoe.health.mil).
51
Regarding concussion management in the Deployed set-
ting, the Concussion Management in the Deployed Settings
pocket guide was updated in 2012 (Table II) and offers three
algorithms which include:
1) Combat Medic/Corpsman Algorithm
2) Initial Provider Algorithm
3) Comprehensive Concussion Algorithm
This pocket guide can be obtained by submitting a
request online at: http://www.dvbic.org/material/concussion-
management-algorithm-cma-pocket-cards.
Telemedicine services are currently being used for mTBI
identification, management of symptoms in theater, and
improving the overall care of TBI throughout the Defense
Department and VA. TBI.consult@us.army.mil is an elec-
tronic consultation service specifically for deployed military
health care providers. It is monitored 7 days a week, staffed by
TBI medical specialists, and offers a response within hours.
This service provides consultation on a variety of TBI-related
questions including how to screen for a TBI, RTD decisions,
strategies for symptom management, and TBI and psycholog-
ical health overlap questions. The tele-TBI clinic
52
uses neu-
rologists, neuropsychologists, pain management specialists,
and rehabilitation therapists via video teleconferencing to
assist service members in more remote sites.
52
Duty restrictions after mTBI vary among the services. RTD
status should be based upon the service members symptoms
and allow for progressive return to full duty.
9
The service
member may need to restrict some work and other activities
to allow for healing and to decrease risk of further injury.
When a service member has recovered from symptoms that
TABLE VI. Information Contained in the mTBI Pocket
Guide (CONUS)
TBI Basics
A Summary of the CPG
A Management Guide to mTBI
A Management Guide to Headaches
A Management Guide to Other Symptoms: dizziness, fatigue, vision,
irritability, appetite changes
DoD ICD-9 Coding Guidance
Cognitive Rehabilitation for mTBI Consensus Conference Clinical
Recommendations
Patient Education
Clinical Tools and Resources
Dizziness Handicap Inventory
Epworth Sleepiness Scale
GCS
Multidimensional Assessment of Fatigue
Neurobehavioral Symptom Inventory
Patient Health Questionnaire
PTSD Checklist (PCL-M)
Other Tools
Additional Resources
FIGURE 1. Pocket guides that are available to help clinicians caring for mTBI service members.
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were previously functionally limiting, exertion testing should
be performed.
9
This includes a brief period of aerobic activity
followed by re-evaluation for both physical symptoms and
cognitive function. Before full duty status, the service member
should be able to
Pass a physical fitness test
Pass “warrior training” if needed for duty
Have psychological health issues controlled and moni-
tored by a primary care clinician
Have neuropsychological testing that is within functional
limits if cognitive impairment was noted after injury.
9
In 2008, the National Defense Authorization Act HR 4986
was signed into law, which led to the Defense Department to
establish a Neurocognitive Assessment Tool (NCAT) pro-
gram.
53
The program establishes and monitors a prede-
ployment neurocognitive battery of tests to assess and
document cognitive functioning of service members before
deployment. The Automated Neurocognitive Assessment
Metrics (ANAM) was the tool chosen by a Defense Depart-
ment expert consensus panel as an interim program pending
further evaluation of other NCATs. The Army Neuro-
cognitive Assessment Branch office has distributed to OEF
and OND numerous laptops loaded with ANAM capability
for postinjury assessments by theater providers. Following
injury, the ANAM can be repeated and compared to the
individuals own baseline when considering cognitive func-
tion and RTD.
53,54
It is important to note that the ANAM is
not intended to be a diagnostic tool for TBI (as many other
conditions may cause decreased cognitive function), but is
meant to assist providers in making medical and report-to-
duty decisions. Capabilities are developing for web-based
access to predeployment ANAM scores, but currently pro-
viders in need of an individual’s baseline ANAM to compare
with a postinjury assessments should submit the request
with demographic information to anam.baselines@amedd
.army.mil.
There are numerous opportunities available for more in-depth
training regarding mTBI. Some of the learning opportunities
available include:
DVBIC’s Annual Defense and Veterans Military TBI
Summit
— Annual training conference held annually since
2007 in Washington, DC area
Annual Blast Conference
— Held annually since 2004 hosted by DVBIC and
the James A. Haley Veterans’ Hospital
TBI modules via Military Health System Learning Portal
Defense Department personnel may access online
training courses
Staff lecture series (WRNMMC)
First Thursday of every month 2 to 3 p.m. (EST)
Available through tele/video conference
TBI Grand Rounds
Second Tuesday of each month
Access via tele/video conference from participat-
ing sites
Table VII lists other TBI information resources in addition
to those included in this article.
CONCLUSIONS
Since 2006, many initiatives have been implemented to
improve care for service members with TBI, specifically
mTBI. Surveillance efforts aimed at identifying the incidence
and prevalence of combat-related TBI have improved the
availability of TBI-specific resources both in-theater and
in-garrison. This is largely attributable to enhanced screening
methods, which occur at various locations throughout the
deployment cycle. Mandated CPGs standardize care and pro-
vide both evaluation and treatment recommendations to those
on the battlefield as well as stateside. Opportunities for TBI
education have expanded, now including regional/national
conferences, online case studies, training modules and instruc-
tion at some deployment platforms. The evolution of tele-
health capabilities allows providers the ability to treat injured
service members in-theater, which may minimize the need for
evacuation from theater or transfer to major MTF. Finally,
ongoing research seeks to identify ways to mitigate blast expo-
sure and effects, determine similarities/differences between
blunt and blast TBI, and establish treatment paradigms to
enhance TBI care.
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... In the context of modern warfare, blast-induced traumatic brain injury (bTBI) is a common outcome for service personnel (Taber, Warden, and Hurley 2006;Marshall et al. 2012). An estimated 10-20% of soldiers deployed in the Afghanistan and Iraq experienced TBI (Elder et al. 2010;Elder and Cristian 2009), and TBI was considered a signature injury of these conflicts (Elder and Cristian 2009) with 77% of TBI cases of United states soldiers classified as mild TBI (mTBI) (Marshall et al. 2012). ...
... In the context of modern warfare, blast-induced traumatic brain injury (bTBI) is a common outcome for service personnel (Taber, Warden, and Hurley 2006;Marshall et al. 2012). An estimated 10-20% of soldiers deployed in the Afghanistan and Iraq experienced TBI (Elder et al. 2010;Elder and Cristian 2009), and TBI was considered a signature injury of these conflicts (Elder and Cristian 2009) with 77% of TBI cases of United states soldiers classified as mild TBI (mTBI) (Marshall et al. 2012). Part of this rise in incidence can be explained by the increased use of improvised explosive devices (IEDs), especially in asymmetric conflicts, such as Iraq and Afghanistan (Hoge et al. 2008;Elder et al. 2010). ...
Preprint
Full-text available
At least one traumatic brain injury (TBI) will be experienced by approximately 50-60 million of the world’s population in their lifetime and is the biggest cause of death and disability in those under 40. Mild traumatic brain injury (mTBI) can induce subtle changes but have long-lasting effects that may be difficult to detect through conventional neurological assessment, including standard clinical imaging techniques. These changes can lead to an increased risk of future neurodegeneration and emphasises the need to use more sensitive diagnostic tools such as EEG in order to identify injury and opportunities for therapeutic intervention. In this study, we investigated electrophysiological and histopathological changes in a rat model of mild blast-induced TBI. We used a 32-channel EEG electrode array to detect global and local changes in neural activity and functional connectivity in acute (3 to 4-hours) as well as chronic phases (1 and 3-months) post-injury. GABAergic inhibitory interneurons, crucial for maintaining an excitatory/inhibitory balance, were quantified using immunohistochemistry. Mild blast-induced TBI had minimal effects on resting power and connectivity at the acute timepoint but resulted in resting-state global power increases at all frequencies as well as a relative power increase in slow-wave frequencies in the chronic phase post-injury. Functional connectivity increases in the gamma frequency along with increases in power in the chronic phase pointed towards an alteration in the excitatory/inhibitory balance. Indeed, electrophysiological changes were associated with reduced density of GABAergic interneurons at 7-days, 1-month, and 3months post-injury, with a decrease in somatostatin-positive cell density in the 5th layer of all cortical regions of interest, and a parvalbumin decrease in the 5 th layer of the primary auditory cortex. In contrast, the total number of neurons, measured by NeuN did not change significantly, thus demonstrating a biased impact on inhibitory interneuron populations. Our work demonstrates that the techniques and metrics of injury assessment employed in this study are sensitive enough to reflect the subtle changes present in mTBI and therefore hold potential clinical relevance. By using non-invasive EEG assessments and histopathology, we were able to reveal direct correlates and potential sources of the abnormalities caused by mild blast-induced TBI.
... The most important tools are the Glasgow Coma Scale (GCS), the neuroimaging, the neurophysiological, and the speech and language tests. Using the GCS, the TBI is divided into three groups based on severity: severe (3)(4)(5)(6)(7)(8), moderate (9)(10)(11)(12), and mild (13)(14)(15) [4]. mTBI or concussion is the most common type of TBI. ...
... Other authors calculate that this may correspond only to the 10-25% of the total people suffering mTBI; accordingly, estimated values may vary depending on the studies [8][9][10]. The diagnosis of mTBI may differ among the studies, but it is based on the following course: GCS values, consciousness (AOC), loss of consciousness (LOC), post-traumatic amnesia (PTA), and brain imaging such as computed tomography (CT) and magnetic response imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance spectroscopy (MRS) [11][12][13]. Patients with mTBI may exhibit symptoms in several areas: cognitive (memory or concentration problems), somatics (headaches, neck pain, nausea, dizziness, vomiting), affective (irritability, depression), and sleep (insomnia). All these symptoms could be associated with brain injury; however, most of them did not have any brain damage detected by conventional neuroimaging [4,14]. ...
Article
Mild traumatic brain injury (mTBI) is the most prevalent type of TBI (80–90%). It is characterized by a loss consciousness for less than 30 minutes, post-traumatic amnesia for less than 24 hours, and Glasgow Coma Score of 13–15. Accurately diagnosing mTBIs can be a challenge because the majority of these injuries do not show noticeable or visible changes on neuroimaging studies. Appropriate determination of mTBI is tremendously important because it might lead in some cases to post-concussion syndrome, cognitive impairments including attention, memory, and speed of information processing problems. The scientists have studied different methods to improve mTBI diagnosis and enhanced approaches that would accurately determine the severity of the trauma. The present review focuses on discussing the role of biomarkers as potential key factors in diagnosing mTBI. The present review focuses on 1) protein based peripheral and CNS markers, 2) genetic biomarkers, 3) imaging biomarkers, 4) neurophysiological biomarkers, and 5) the studies and clinical trials in mTBI. Each section provides information and characteristics on different biomarkers for mTBI.
... Blast exposure, which is common in combat settings, is the leading cause of TBI [8]. TBI is characterized by temporary or permanent neurological dysfunction resulting from a head injury, such as loss of consciousness or altered mental status [9]. Among TBI diagnoses, mild TBI is the most prevalent, accounting for approximately 77 percent of cases. ...
Article
Full-text available
Post-traumatic stress disorder (PTSD) is a prevalent psychiatric disorder that often occurs following war trauma. Despite its high prevalence, there is still a lack of comprehensive understanding regarding the mechanisms underlying its progression and treatment resistance. Recent research has shed light on the biological basis of PTSD, with neuroimaging studies revealing altered brain connectivity patterns in affected individuals. In war contexts, traumatic brain injury (TBI) is a common occurrence and is associated with a high prevalence of PTSD. This study aimed to compare the severity of PTSD and depression in patients with and without a history of TBI to shed light on the impact of comorbid TBI on the presentation of PTSD symptoms. To achieve this goal, a cross-sectional study was conducted involving a sample of 60 outpatients who were diagnosed with both PTSD and Depressive Disorder. The inclusion criteria required participants to meet the diagnostic criteria for both disorders using validated tools. The severities of PTSD and depressive symptoms were assessed using scales that have been widely used and validated in previous research. By utilizing these standardized assessment tools, this study aimed to ensure the reliability and validity of the obtained data. The results of this study revealed that patients with comorbid PTSD and TBI exhibited a significantly higher severity of PTSD symptoms compared to those with PTSD only. Specifically, the comorbid group demonstrated higher ratings of symptom intensity across all symptom clusters. These findings are consistent with previous research that has highlighted the impact of comorbid TBI on the intensity and persistence of PTSD symptoms. When controlling for PTSD severity, no significant differences were observed in the severity of depressive symptoms between the two groups. This suggests that the increased depressive symptoms observed in the comorbid group may be primarily driven by the presence of more intense PTSD symptoms rather than TBI per se. The findings highlight the need for an accurate diagnosis of TBI in individuals with PTSD to guide appropriate treatment interventions. Further research is warranted to delve into the underlying mechanisms that contribute to the interaction between TBI and PTSD and to develop targeted interventions for individuals with comorbid PTSD and TBI.
... 8 In 2010, the DoD further mandated in-theater "event-driven" TBI protocols for those who were within 50 m of any blast explosion, were in a vehicle associated with a blast event, were involved in a collision/rollover, or sustained a direct blow to the head. 9,10 In addition to in-theater screening protocols, the Post-Deployment Health Assessment (PDHA) was mandated to be administered to all service members following each deployment. The PDHA is a self-administered electronic questionnaire that relies on service members' retrospective self-report of injury during demobilization immediately after deployment. ...
Article
Full-text available
Introduction: Since 2006, efforts have been made to increase the accurate identification of traumatic brain injuries (TBIs) in post-9/11 military personnel. The Boston Assessment of TBI-Lifetime (BAT-L) is the first validated instrument designed specifically to diagnose TBIs throughout the life span in post-9/11 Veterans. The objective was to compare the diagnostic accuracy of the BAT-L with medical records from the Department of Defense (DoD). Material and methods: Traumatic brain injury diagnosis for 153 Veterans deployed in 2011 enrolled in the Translational Research Center for TBI and Stress Disorder longitudinal cohort study from the BAT-L clinical interview was compared to DoD online medical records to determine diagnostic prevalence and injury severity for all head injury cases during deployment. Sensitivity, specificity, Cohen's kappa, and Kendall's tau-b were calculated for TBI diagnosis and severity. Concordant TBI cases and discordant TBI cases were compared using chi-square and t-test analyses. This study has been approved by VA Boston by Institutional Review Boards for human participants' protection. Results: Correspondence of TBI diagnoses from the BAT-L with DoD records was fair (κ = 0.42; sensitivity = 72.7%; specificity = 82.8%). Comparison of injury severity also showed fair correspondence (κ = 0.41). Missing TBI diagnostic data from DoD records were frequent; 43% of TBIs reported on the BAT-L did not have any documentation of assessment or diagnoses in DoD records. Conclusion: This study addresses a critical gap in research by comparing the diagnostic accuracy of a validated, semi-structured clinical interview with available medical records. Diagnosis of TBIs via the BAT-L was both sensitive and specific when compared to DoD records, supporting the validity of the BAT-L for retrospective assessment of military TBI. However, diagnostic correspondence was only fair. This lack of diagnostic agreement was related to multiple factors including lack of documentation at the time of injury by DoD, differences in assessment and goals, and other combat-related motivational factors associated with failure to report injuries while deployed. Several policies have been implemented to address underreporting and under-documentation of TBIs, yet challenges remain. Recommendations for evaluating TBI are presented. Accurate diagnosis of TBI is necessary for appropriate treatment planning, as well as service-related compensation.
... [12] TBI has been described as the signature injury of OEF and OIF. [13,14] While the exact number of SMs who sustained TBIs from these conflicts is unknown, Swanson et al. [15] reported approximately 20% of SMs returning from OEF/OIF had sustained a TBI. The VA has reported that 10 to 15% of SMs sustained a TBI in these conflicts. ...
Article
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In June 2019, the Department of Veterans Affairs (VA) launched the VA Mission Act, which expanded veterans' health-care access to the private sector. Since civilian primary care providers may see more veterans in their practice, it will be important to understand the unique experiences, comorbidities, and culture of this population in order to provide optimal care. Military service members (SMs) are at an increased risk for traumatic brain injury (TBI), and comorbidities, such as post traumatic stress disorder (PTSD), increasing the likelihood of prolonged symptoms. Military training and repetitive low-level blast exposure may cause symptoms similar to TBI or increase long-term negative effects in SMs. Military culture often has a strong influence in this population. Those who serve in the military identify with military values and have a strong team mentality, which places emphasis on the mission above all else, not accepting defeat, and not ever leaving a fellow SM behind. These values can impact the way a SM/veteran seeks care and/or communicates with his or her health-care provider. Taking a detailed history to understand how these factors apply, as well as screening for mental health comorbidities, are recommended. Understanding the military cultural influences can assist in promoting a stronger therapeutic alliance and encourage more open communication. Ultimately, it is the trusting and respectful relationship between the SM/veteran and the provider that will determine the most effective treatment and result in the most effective resolution of TBI and comorbid symptoms.
... The true number and impact of mTBI are underestimated as many mTBIs, up to 50%-90% [8], or over 600 per 100 000 [9], go unreported or are unrecognized [10]. Although 85%-90% of individuals spontaneously recover from mTBI in a matter of weeks [11], mTBI symptoms and deficits can persist for more than 1 month in a significant minority of patients. This is known as post-concussion syndrome [12], which can include symptoms such as headache, light sensitivity, mood changes, and difficulty focusing [13]. ...
Article
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Mild traumatic brain injuries (mTBIs) are the most common type of brain injury. Timely diagnosis of mTBI is crucial in making "go/no-go" decision in order to prevent repeated injury, avoid strenuous activities which may prolong recovery, and assure capabilities of high-level performance of the subject. If undiagnosed, mTBI may lead to various short and long-term abnormalities, which include, but not limited to impaired cognitive function, fatigue, depression, irritability, and headaches. Existing screening and diagnostic tools to detect acute and early-stage mTBIs have insufficient sensitivity and specificity. This results in uncertainty in clinical decision-making regarding diagnosis and returning to activity or requiring further medical treatment. Therefore, it is important to identify relevant physiological biomarkers that can be integrated into a mutually complementary set and provide a combination of data modalities for improved on-site diagnostic sensitivity of mTBI. In recent years, the processing power, signal fidelity, and the number of recording channels and modalities of wearable healthcare devices have improved tremendously and generated an enormous amount of data. During the same period, there have been incredible advances in machine learning tools and data processing methodologies. These achievements are enabling clinicians and engineers to develop and implement multiparametric high-precision diagnostic tools for mTBI. In this review, we first assess clinical challenges in the diagnosis of acute mTBI, and then consider recording modalities and hardware implementation of various sensing technologies used to assess physiological biomarkers that may be related to mTBI. Finally, we discuss possibilities that recent advances in machine learning can bring to bear in providing mTBI patients with timely diagnosis and treatment.
... [5][6][7] In 2006, the military services and Department of Defense (DoD) instituted a number of policies initiating screening measures to address underreporting and under-documentation of TBI among deployed service members. 8 In 2010, the DoD further mandated in-theater "event driven" TBI protocols for those who were within 50 meters of any blast explosion, were in a vehicle associated with a blast event, collision/rollover, or sustained a direct blow to the head, 9,10 In addition to screening measures and in-theater TBI protocols, the Post-Deployment Health Assessment (PDHA) was mandated to be administered to all being demobilized following deployment. The PDHA included a series of TBI screening questions, all of which must be endorsed to prompt a follow-up evaluation. ...
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Background: Since 2006, efforts have been made to increase the identification of traumatic brain injuries (TBIs) in post-9/11 military personnel. The BAT-L is the first validated instrument to diagnose TBIs throughout the lifespan in post-9/11 Veterans. The objective is to investigate the correspondence of the Boston Assessment of TBI-Lifetime (BAT-L) diagnostic prevalence and injury severity of traumatic brain injury with in-theater medical records from Department of Defense (DoD). Methods: A convenience sample of 153 Veterans deployed in 2011 enrolled in the TRACTS longitudinal cohort study was examined. Retrospective review of DoD online medical records to determine diagnostic prevalence and injury severity for all head injury cases during deployment were compared with diagnostic prevalence and injury severity from the BAT-L clinical interview using Chi-square analyses. Results: There was moderate correspondence for TBI diagnosis between the BAT-L and DoD records (κ = 0.42). Sensitivity was 72.7% and specificity was 82.8%. Comparison of injury severity also had moderate correspondence (κ = 0.41). Missing TBI diagnostic data from DoD records was frequent; 43% percent of TBIs reported on the BAT-L did not have any documentation of mTBI assessment or diagnosis in DoD records while 83% did not have in-theater documentation. Conclusions: Diagnosis of TBI via the BAT-L retrospective interview was both sensitive and specific when compared to DoD medical records. However, diagnostic correspondence was only moderate. This lack of diagnostic agreement was related to multiple factors including lack of documentation of injury, differences in assessment tools and goals, and other combat-related motivational factors associated with failure to report injuries while deployed. Several policies were implemented to address underreporting and under-documentation of TBI, yet challenges remain. Findings suggest changes at both individual-level (e.g. service members) and system-level (e.g. DoD/military branches) are needed to adequately diagnose and document all TBI during deployment.
... Specifically, the in-creased use of improvised explosives devices by enemy combatants in the recent military conflicts (ie, Operation Enduring Freedom, Operation Iraqi Freedom and Operation New Dawn) resulted in TBI being recognized as the signature injury of these conflicts and brought attention to the prevalence of concussion within the US military. 5,6 In the military, the effects of concussion can decrease individual and unit effectiveness, emphasizing the importance of prompt diagnosis and proper management. 7 Typically, patients recover from concussion within a few weeks of injury; however, some individuals experience symptoms that persist for months or years. ...
Article
Background: Military personnel are at greater risk for sustaining mild traumatic brain injury (mTBI), or concussion, whether they are in a combat or garrison setting. Consequently, mTBI is a major health concern for health practitioners to understand, in order to provide timely assessment and treatment to service members (SM) who are suspected to have mTBI. Observations: Providing early diagnosis and effective management of symptoms can optimize recovery and promote healthy outcomes. Understanding what resources and guidelines are available is important for those evaluating active duty SMs within the Military Health System. Conclusions: This article showcases clinical tools for screening, evaluating, and diagnosing concussion used within the US Department of Defense, and provides resources for practitioners to find these clinical tools online.
... The severity of TBI is classified using the Glasgow Coma Scale (GCS), Loss of Consciousness (LOC), and post-traumatic amnesia (PTA), along with a variety of other screening tools such as ANAM (Automated Neuropsychological Assessment Metrics), the Repeatable Battery for Assessment of Neuropsychological Status, the Concussion Management Algorithm (CMA), the King-Devick concussion test (North et al., 2012;Marshall et al., 2012), the Sport Concussion Assessment Tool (SCAT3), and the Acute Concussion Evaluation (Ontario Neurotrauma Foundation, 2013; Gioia and Collins, 2006). And no single classification embraces all the features of mTBI (clinical, pathological, cellular/molecular). ...
Article
Background: Teleneurology has become widely adopted during severe acute respiratory syndrome coronavirus 2 pandemic. However, provider impressions about the teleneurology experience are not well described. Methods: A novel questionnaire was developed to collect provider impressions about video teleneurology encounters. All providers in the University of Pennsylvania Health System (UPHS) Neurology Department (N = 162) were asked to complete a questionnaire after each video teleneurology patient encounter between April and August 2020. Individual patient and encounter-level data were extracted from the electronic medical record. Results: One thousand six hundred three surveys were completed by 55 providers (response rate of 10.12%). The history obtained and the ability to connect with the patient were considered the same or better than an in-person visit in almost all encounters. The quality of the physician-patient relationship was good or excellent in 93%, while the overall experience was the same as an in-person visit in 73% of visits and better in 12%. Sixty-eight percent of respondents reported that none of the elements of the neurological examination if performed in person would have changed the assessment and plan. Assessment of the visit as the same or better increased from 83% in April to 89% in July and 95% in August. Headache (91%), multiple sclerosis and neuroimmunology (96%), and movement disorder (89%) providers had the highest proportion of ratings of same or better overall experience and neuromuscular providers the lowest (60%). Conclusions: Provider impressions about the teleneurology history, examination, and provider-patient relationship are favorable in the majority of responses. Important differences emerge between provider specialty and visit characteristics groups.
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There is continuing controversy regarding predictors of poor outcome following mild traumatic brain injury (mTBI). This study aimed to prospectively examine the influence of preinjury factors, injury-related factors, and postinjury factors on outcome following mTBI. Participants were 123 patients with mTBI and 100 trauma patient controls recruited and assessed in the emergency department and followed up 1 week and 3 months postinjury. Outcome was measured in terms of reported postconcussional symptoms. Measures included the ImPACT Post-Concussional Symptom Scale and cognitive concussion battery, including Attention, Verbal and Visual memory, Processing Speed and Reaction Time modules, pre- and postinjury SF-36 and MINI Psychiatric status ratings, VAS Pain Inventory, Hospital Anxiety and Depression Scale, PTSD Checklist-Specific, and Revised Social Readjustment Scale. Presence of mTBI predicted postconcussional symptoms 1 week postinjury, along with being female and premorbid psychiatric history, with elevated HADS anxiety a concurrent indicator. However, at 3 months, preinjury physical or psychiatric problems but not mTBI most strongly predicted continuing symptoms, with concurrent indicators including HADS anxiety, PTSD symptoms, other life stressors and pain. HADS anxiety and age predicted 3-month PCS in the mTBI group, whereas PTSD symptoms and other life stressors were most significant for the controls. Cognitive measures were not predictive of PCS at 1 week or 3 months. Given the evident influence of both premorbid and concurrent psychiatric problems, especially anxiety, on postinjury symptoms, managing the anxiety response in vulnerable individuals with mTBI may be important to minimize ongoing sequelae.
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Mild traumatic brain injury (mTBI), also referred to as concussion, remains a controversial diagnosis because the brain often appears quite normal on conventional computed tomography (CT) and magnetic resonance imaging (MRI) scans. Such conventional tools, however, do not adequately depict brain injury in mTBI because they are not sensitive to detecting diffuse axonal injuries (DAI), also described as traumatic axonal injuries (TAI), the major brain injuries in mTBI. Furthermore, for the 15 to 30 % of those diagnosed with mTBI on the basis of cognitive and clinical symptoms, i.e., the "miserable minority," the cognitive and physical symptoms do not resolve following the first 3 months post-injury. Instead, they persist, and in some cases lead to long-term disability. The explanation given for these chronic symptoms, i.e., postconcussive syndrome, particularly in cases where there is no discernible radiological evidence for brain injury, has led some to posit a psychogenic origin. Such attributions are made all the easier since both posttraumatic stress disorder (PTSD) and depression are frequently co-morbid with mTBI. The challenge is thus to use neuroimaging tools that are sensitive to DAI/TAI, such as diffusion tensor imaging (DTI), in order to detect brain injuries in mTBI. Of note here, recent advances in neuroimaging techniques, such as DTI, make it possible to characterize better extant brain abnormalities in mTBI. These advances may lead to the development of biomarkers of injury, as well as to staging of reorganization and reversal of white matter changes following injury, and to the ability to track and to characterize changes in brain injury over time. Such tools will likely be used in future research to evaluate treatment efficacy, given their enhanced sensitivity to alterations in the brain. In this article we review the incidence of mTBI and the importance of characterizing this patient population using objective radiological measures. Evidence is presented for detecting brain abnormalities in mTBI based on studies that use advanced neuroimaging techniques. Taken together, these findings suggest that more sensitive neuroimaging tools improve the detection of brain abnormalities (i.e., diagnosis) in mTBI. These tools will likely also provide important information relevant to outcome (prognosis), as well as play an important role in longitudinal studies that are needed to understand the dynamic nature of brain injury in mTBI. Additionally, summary tables of MRI and DTI findings are included. We believe that the enhanced sensitivity of newer and more advanced neuroimaging techniques for identifying areas of brain damage in mTBI will be important for documenting the biological basis of postconcussive symptoms, which are likely associated with subtle brain alterations, alterations that have heretofore gone undetected due to the lack of sensitivity of earlier neuroimaging techniques. Nonetheless, it is noteworthy to point out that detecting brain abnormalities in mTBI does not mean that other disorders of a more psychogenic origin are not co-morbid with mTBI and equally important to treat. They arguably are. The controversy of psychogenic versus physiogenic, however, is not productive because the psychogenic view does not carefully consider the limitations of conventional neuroimaging techniques in detecting subtle brain injuries in mTBI, and the physiogenic view does not carefully consider the fact that PTSD and depression, and other co-morbid conditions, may be present in those suffering from mTBI. Finally, we end with a discussion of future directions in research that will lead to the improved care of patients diagnosed with mTBI.
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Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are highly prevalent among Veterans of the conflicts in Iraq and Afghanistan. These conditions are associated with common and unique neuropsychological and neuroanatomical changes. This review synthesizes neuropsychological and neuroimaging studies for both of these disorders and studies examining their co-occurrence. Recommendations for future research, including use of combined neuropsychological and advanced neuroimaging techniques to study these disorders alone and in concert, are presented. It is clear from the dearth of literature that addiitonal studies are required to examine and understand the impact of specific factors on neurocognitive outcome. Of particular relevance are temporal relationships between PTSD and mTBI, risk and resilience factors associated with both disorders and their co-occurrence, and mTBI-specific factors such as time since injury and severity of injury, utilizing comprehensive, yet targeted cognitive tasks.
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Mild traumatic brain injury (mTBI) affects a significant number of combat veterans returning from Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF). Although resolution of mTBI symptoms is expected over time, some individuals continue to report lingering cognitive difficulties. This study examined the contributions of self-reported mTBI injury characteristics (e.g., loss of consciousness, post-traumatic amnesia) and psychiatric symptoms to both subjective and objective cognitive functioning in a sample of 167 OEF/OIF veterans seen in a TBI clinic. Injury characteristics were not associated with performance on neuropsychological tests but were variably related to subjective ratings of cognitive functioning. Psychiatric symptoms were highly prevalent and fully mediated most of the relationships between injury characteristics and cognitive ratings. This indicates that mTBI characteristics such as longer time since injury and loss of consciousness or post-traumatic amnesia can lead to increased perceived cognitive deficits despite having no objective effects on cognitive performance. Psychiatric symptoms were associated with both cognitive ratings and neuropsychological performance, illustrating the important role that psychiatric treatment can potentially play in optimizing functioning. Finally, subjective cognitive ratings were not predictive of neuropsychological performance once psychiatric functioning was statistically controlled, suggesting that neuropsychological assessment provides valuable information that cannot be gleaned from self-report alone.
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Several studies have examined the relationship between concussion/mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), depression, and postdeployment symptoms. These studies indicate that the multiple factors involved in postdeployment symptoms are not accounted for in the screening processes of the Department of Defense/Veteran's Affairs months after concussion injuries. This study examined the associations of single and multiple deployment-related mTBIs on postdeployment health. A total of 1502 U.S. Army soldiers were administered anonymous surveys 4 to 6 months after returning from deployment to Iraq or Afghanistan assessing history of deployment-related concussions, current PTSD, depression, and presence of postdeployment physical and neurocognitive symptoms. Of these soldiers, 17% reported an mTBI during their previous deployment. Of these, 59% reported having more than one. After adjustment for PTSD, depression, and other factors, loss of consciousness was significantly associated with three postconcussive symptoms, including headaches (odds ratio [OR] = 1.5, 95% confidence interval [CI] = 1.1-2.3). However, these symptoms were more strongly associated with PTSD and depression than with a history of mTBI. Multiple mTBIs with loss of consciousness increased the risk of headache (OR = 4.0, 95% CI = 2.4-6.8) compared with a single occurrence, although depression (OR = 4.2, 95% CI = 2.6-6.8) remained as strong a predictor. These data indicate that current screening tools for mTBI being used by the Department of Defense/Veteran's Affairs do not optimally distinguish persistent postdeployment symptoms attributed to mTBI from other causes such as PTSD and depression. Accumulating evidence strongly supports the need for multidisciplinary collaborative care models of treatment in primary care to collectively address the full spectrum of postwar physical and neurocognitive health concerns.
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Individuals serving in Iraq and Afghanistan sustain injuries associated with physical and psychological trauma. Among such injuries, mild traumatic brain injury (mTBI) and post traumatic stress disorder (PTSD) are common. Self-report measures are frequently used to identify mTBI and/or PTSD and symptoms associated with these conditions. In addition to providing information regarding mTBI and PTSD, the goal of this literature review was to identify and present information on the psychometric properties of measures used to obtain information regarding these common conditions among Veterans who have returned from Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF). A comprehensive review of studies in which self-report measures were used to evaluate mTBI, PTSD, and associated symptoms among OEF/OIF Veterans is presented. Findings suggest that additional work is needed to identify psychometrically sound and clinically useful self-report measures that assess mTBI and PTSD and associated symptoms among OEF/OIF Veterans.