The global community has stepped forward in responding to the AIDS pandemic. [1] After all these efforts to control this terrible HIV pandemic for over 30 years, we are now in a position to overcome the virus. Through this painfully long time, we have learned enough to gain the upper hand. We are able to turn the pandemic around through effective policies and programs. However, we think we should keep our eyes on the reality. Although the human immunodeficiency virus (HIV) is not a mysterious agent anymore, we have never witnessed a virus quite like this one with the multiple factors that make it so persistently unrelenting. We do know a lot about this virus but still, we are yet to find a way to protect our communities from its attack and minimize its burden effectively. HIV/ AIDS, as one of the most important current health issues globally, knows no barriers. Almost all countries, regardless of their development level, socio-economic status, and cultures are facing its considerable social, cultural, and economic impacts. But have you ever wondered why this virus is so universal? Why do we have to put its name on the top list of major health struggles, while meeting minimum promising progress, particularly in some parts of the world like the Eastern Mediterranean Region? Why cannot we just take the virus down and celebrate its end? In light of all the challenges of the last decades regarding HIV, let's take a look at the bigger picture here. When it comes to HIV transmission routes, the first thing that comes to the mind is sex and drugs. For example, in most countries (Islamic countries, in particular), both homosexual and heterosexual contacts are highly sensitive topics. Extra-marital sex, multi-partnership, male/female sex-work, injection drug use, and many other surrounding issues related to HIV are of serious concern not only for health-policy makers but also for experts from different disciplines such as sociology, medicine, law, economy, religion, and politics. On the other hand the legal status of sex work varies from country to country, from being considered a form of abuse (e.g. Norway, Iceland, and Sweden), to be a legal occupation (Netherlands, Germany), or classified as a crime deserving punishments (many Muslims countries). [2] The latter could even make taking serious actions globally, even harder. On top of sex-related concepts, a major complicated public health issue is yet to be tackled among drug users and particularly injecting drug users (IDUs). They are another core group with completely different characteristics. Similar to the previous sub-groups, IDUs are a hidden and www.mui.ac.ir