... The success of each of these steps involves coordination of intercellular associations, some temporary and some permanent, which are facilitated in part by the selective expression of cell adhesion molecules. Complementary genetic (Seeger et al., 1993; Van Vactor et al., 1993; Salzberg et al., 1994; Kania et al., 1995; Kolodziej et al., 1995; Martin et al., 1995; Schmucker et al., 1997; Holmes et al., 1998), biochemical (Bonhoeffer and Huf, 1985; Luo et al., 1993; Serafini et al., 1994; Colamarino and TessierLavigne, 1995; Drescher et al., 1995) and molecular (Patel et al., 1987; Bieber et al., 1989; Grenningloh et al., 1991; Kolodkin et al., 1993; Harris et al., 1996; Mitchell et al., 1996) analyses have revealed some of the genes and molecules that direct neuronal pathfinding and connectivity. Analysis of development of the motoneurons of the Drosophila larva has proved particularly revealing and has enabled the characterization of an array of proteins including those involved in adhesion, anti-adhesion, attraction and repulsion, as well as signal transduction molecules with specific roles in neuronal development (reviewed in Goodman and Shatz, 1993; Chiba and Keshishian, 1996; Garrity and Zipursky, 1996; Goodman, 1996; Kolodkin, 1996; Tessier-Lavigne and Goodman, 1996; Brunner and O'Kane, 1997). ...