... Full loss of the Bax gene is not lethal and the mice develop without any major developmental abnormalities, although Bax À/À male mice are infertile (Knudson, Tung, Tourtellotte, Brown, & Korsmeyer, 1995). More subtle effects of Bax deletion have been observed, particularly in the brain and eye, including increased neuronal number (Deckwerth et al., 1996;White, Keller-Peck, Knudson, Korsmeyer, & Snider, 1998), absence of size differences in two sexually dimorphic nuclei (Forger & Peskin, 2005), cerebellar migration defects (Jung et al., 2008), increased retinal cell numbers, glial cell density, and altered microglial shape (Kawai et al., 2009;Mac Nair, Schlamp, Montgomery, Shestopalov, & Nickells, 2016;Mosinger Ogilvie, Deckwerth, Knudson, & Korsmeyer, 1998). Importantly, Bax deficiency reduces neuronal and retinal cell death resulting from various injuries (Deckwerth et al., 1996;Robinson, Conley, & Kern, 2003;Semaan, Li, & Nickells, 2010;W. ...