... Thus, the impact of the aging of the population, the need to incorporate therapeutic innovations in clinical therapy (Decreto Real Ley 16/2012, Section I) and the development of personalized medicine and regenerative medicine are going to suppose, undoubtedly, an increase in health expenditure (HSCIC, 2015;Busse, Blümel, Scheller-Kreinsen, & Zentner, 2009;Curtis , 2012). Therefore, reforms and new forms of management are needed to strengthen sustainability, improve efficiency and introduce new models and management tools with coordination of socio-health services (Barr, et al. 2003;Boult, Kane, Pacala, & Wagner, 1999;Cabo-Salvador, de-Castro, Cabo, Ramos, & López, 2017;Cabo-Salvador, Ramírez, Cabo, Ramos, & de-Castro, 2018;Coleman, Austin, Brach, & Wagner, 2009;Sylvia et al., 2008;Weiss, 2007;Wagner, 1998;WHO, 2002;Zwar et al., 2006). Currently, having into account a greater longevity and life expectancy of the population, as well as an increase in the number of people over 60 years of age, the increase in chronic pathologies has meant an increase in healthcare costs in a global manner. ...