Zhibi Wang

Huawei Technologies

Acquired amegakaryocytic thrombocypenia (AAMT) is an extremely rare hematologic disorder and standard treatment strategy has not been established. We described herein two cases of AAMT who were fully responded to eltrombopag and immunosuppressant. Patient 1 was refractory to steroid, IVIG and recombinant human thrombopoietin (rhTPO). Patient 2 did...

Glanzmann's thrombasthenia (GT) is a severe hemorrhagic disease. It is caused by mutations in ITGA2B or ITGB3, which are the respective genes encoding integrin αIIb and β3. Despite widespread mutational analysis, the mechanisms underlying the extensive variability in bleeding severity observed among affected individuals remains poorly understood. I...

Background: Hematidrosis is an extremely rare and mysterious disorder. The etiology and pathophysiology of this disorder remain mostly unknown, and there is no specific therapeutic strategy available up to now. Methods: The clinical features, hemostatic and other laboratory tests, and bloody exudates of seven patients were investigated, and histolo...

Hereditary thrombotic thrombocytopenic purpura (TTP) is an autosomal recessive thrombosis disorder, caused by loss‐of‐function mutations in ADAMTS13. Mutations in the CUB domains of ADAMTS13 are rare, and the exact mechanisms through which these mutations result in the development of TTP have not yet been fully elucidated. In this study, we identif...

Inherited thrombocytopenia is a group of hereditary diseases with a reduction in platelet count as the main clinical manifestation. Clinically, there is an urgent need for a convenient and rapid diagnosis method. We introduced a high-throughput, next-generation sequencing (NGS) platform into the routine diagnosis of patients with unexplained thromb...

The present study aimed to illuminate the role of circulating T follicular helper (TFH) cells in patients diagnosed with chronic immune thrombocytopenia (cITP). Fifty-four patients with cITP and 30 age-matched healthy control subjects were enrolled in the present study. TFH cell frequencies, expression of CD4⁺ TFH cell-associated cytokines, includi...

Introduction: Immune thrombocytopenia (ITP) is a common hematologic disorder characterized by isolated thrombocytopenia. In adults, ITP is more likely to be chronic, requiring individualised treatment and management. Corticosteroids and splenectomy are the most common therapy for ITP. However, these routine approaches failed in these patients with...

Background: Transplant-associated microangiopathy (TMA) is an uncommon but devastating complication in patients undergoing hematopoietic stem-cell transplantation (HSCT). It may be confused with severe graft-versus-host disease (GVHD), infection, and other transplant related thrombotic diseases. Limited studies have shown the changes in plasma VWF/...

Gene mutations play an important role in the pathogenesis of von Willebrand disease (VWD), resulting in the qualitative defect or quantitative deficit of von Willebrand factor (VWF). VWF propeptide is composed of D1 and D2 domain, which acts as a covalent oxidoreductase in the multimerization. In addition, the propeptide is necessary for the transp...

Objective: Immune thrombocytopenia (ITP) is an autoimmune bleeding disease in which autoantibodies are directed against the patient’s own platelets, leading to platelet destruction and bleeding. Currently, platelet destruction in ITP is thought to be mediated by monocytic and phagocytic cells, and the antibody-coated platelets are removed from circ...

Many immune thrombocytopenia (ITP) patients, particularly patients with anti-glycoprotein (GP) Ib-IX autoantibodies, do not respond to the conventional treatments such as splenectomy. However, the underlying mechanism remains unclear. Here we found that anti-GPIbα N-terminus antibody AN51, but not other anti-GPIbα antibodies (AK2, HIP1, VM16d, or W...

As a new press, cylinder-crown integrated hydraulic press (CCIHP) is analyzed firstly in this paper. The hydraulic cylinder consists of a hemispherical shell, which also functions as a main proportion of press crown. Compared with the conventional hydraulic press which has a hydraulic cylinder mounted in the press crown, the structure and force dis...

Background Microparticles (MPs) are small membrane vesicles that are classified as red blood cell MPs (RMPs), platelet-derived MPs (PMPs), tissue factor MPs (TF+MPs) and endothelial MPs (EMPs) based on their origins. Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPN) are disorders characterized by abnormal hematopoiesis, thrombo...

Congenital afibrinogenaemia is a rare autosomal recessive disorder caused by various mutations within the fibrinogen genes FGA, FGB and FGG. Ins/del mutations in FGB are extremely rare. We report a patient with afibrinogenaemia who suffered from umbilical cord bleeding and repeated bleeding episodes. His plasma fibrinogen levels could not be detect...

3335 Objective Immune thrombocytopenia (ITP) is an immune-mediated disorder characterized by antibody- and cell-mediated platelet destruction and impaired platelet production. In addition of antibody-mediated platelet clearance, T-cell is also involved in platelet destruction or marrow suppression. During immune responses CD4+ T cells can differen...

3329 BACKGROUND Thrombotic disorders are common and potentially fatal complications in patients undergoing hematopoietic stem-cell transplantation (HSCT). Plasma ADAMTS13, a von willebrand factor (VWF)–cleaving protease, may play a role in the pathogenesis of HSCT related thrombosis by cleaving the prothrombotic ultralarge VWF into less active VWF...

4674 Congenital thrombotic thrombocytopenic purura (TTP) is caused by gene mutations of von Willebrand factor-cleaving protease (a disintegrin and metalloprotease with thrombospondin type I domains 13, ADAMTS13). In this study, one novel mutation in the ADAMTS13 gene was found in a woman whose presents are first cousins. Thrombocytopenia occurred d...

3076 Background Hemostatic disorders are common and potentially fatal complications in patients undergoing hematopoietic stem-cell transplantation (HSCT). Limited data exist on early diagnosis and prevention of these complications. In this study, we retrospectively investigated the outcome and risk factors associated with thrombotic and bleeding c...

2515 Objective Phytosterolemia is a rare autosomal recessive sterol storage disease, characterized by increased serum concentrations of plant sterols (phytosterols). It is caused by gene mutations of ABCG5 and ABCG8. The patients suffer from xanthomas and premature atherosclerosis. In this study we demonstrate that macrothrombocytopenia and hemoly...

4505 Background F Thrombotic and bleeding events are common and potentially fatal complications in patients receiving hematopoietic stem-cell transplantation (HSCT), which is profoundly associated with the survival of HSCT recipients. The hemostatic imbalance and endothelial injury are main manifestations in the course of HSCT, leading to thrombot...

In this work, we investigate the emission of the nano-hole array in an ultrathin silver film at infrared regime. It is shown that when the incident light illuminates the nano-hole array, the localized surface plasmons are excited and serve as electric dipoles. The emission of the nano-hole array presents a strong directivity. The maximum radiation...

We present a concrete picture of spoof surface plasmons (SSPs) combined with cavity resonance to clarify the basic mechanism underlying extraordinary light transmission through metal films with subwavelength slits or holes. This picture may indicate a general mechanism of metallic nanostructure optics: When light is incident on a non-planar conduct...

We study the optical transmission through a silver film with subwavelength hole arrays, which is sandwiched by super-thin SiO2 layers. Based on finite-difference time-domain method, optical transmission and dispersion relation of surface plasmons are obtained. It is shown that surface plasmons are coherent in the top layer of the sandwich, which af...

We demonstrate that the electronic property of a mesoscopic ring can be alternatively tuned between metallic and insulative states by changing the Fermi level. The one-dimensional mesoscopic ring is constructed based on random n-mer model and threaded by magnetic flux. Multiple localization-delocalization transitions of electrons have been found. W...

In this paper we report the nano-phase separation structure in the polymer blend film and its optical properties. Polystyrene (PS)/polymethyl methacrylate (PMMA) blend film is spin-coated on substrate. A sandwiched structure consisting of a depleted PMMA layer, a PS/PMMA blend layer and a PS-rich top layer has been formed. By selectively dissolving...

Object In order to compare the influences of wortmannin on platelet aggregation and platelet membrane surface glycoproteins GPIb expression after thrombin receptors activation, then to investigate the role of phosphatidylinositol 3-kinase (PI3-K) and myosin light chain kinase (MLCK) in the course of thrombin receptors activation. Methods Peptide SF...

CDMA 1x evolution–data optimized (1x EV-DO) is defined in the TIA/EIA IS-856 and IS-835 standards. The security of 1x EV-DO offers authentication, integrity, and encryption capabilities. 1x EV-DO supports authentication of the access terminal (AT) to authorize access to the wireless network, as well as authentication of a subscription to authorize...

Introduction: The inherited risk factors for venous thromboembolism differ between Caucasians and Chinese, antithrombin (AT), protein (PC) and protein (PS) deficiencies being the most common in Chinese patients. However, the age- and gender-related normal activity ranges of AT, PC, PS and the prevalence of their deficiencies in the general Chinese...

Glanzmann thrombasthenia (GT) is a homozygous or compound heterozygous autosomal recessive bleeding disorder caused by the qualitative or quantitative deficiency of integrin GPIIb-IIIa, which acts as the receptor of platelet fibrinogen. Here we report a case of GT with a compound heterozygous mutation in GPIIb according to the results of flow cytom...

Introduction Hepatic veno-occlusive disease (VOD) and thrombotic microangiopathy (TMA) are important and serious thrombotic complications after hematopoietic stem cell transplantation (HSCT), but the early diagnosis remains difficult since their clinical manifestations are similar to those of other transplantation-related complications. Our aim in...

The multimer distribution of Von Willebrand factor (VWF) in plasma is regulated by the specific VWF cleaving protease ADAMTS13, which cleaves at the Y1605-M1606 bond in the A2 domain of VWF under the shear stress, plays paramount roles in mediating platelet adhesion to the subendothelium during vascular damage. Quantitative deficiency or qualitativ...

In this work, we have both theoretically and experimentally investigated the photonic transmission in a one-dimensional random n-mer (RN) dielectric system. Due to the positional correlation in the RN structure, the localization-delocalization transitions of photons happen at expected frequencies of photons. Multiple resonant transmissions are foun...

The data about association of Idiopathic Thrombocytopenic Purpura (ITP) with Helicobacter pylori (H pylori) infection are always contradictory, and the factors that incite ITP remain uncertain. Several hypotheses have been suggested about the striking discrepancies between the reported results, one of which is variable effects of genetically divers...

Background and Objective. Sitosterolemia is a rare autosomal recessive inherited disorder of lipoprotein metabolism characterized by xanthomas, premature coronary artery disease, arteriosclerosis and increased plasma levels of phytosterols, while hematological abnormalities such as large platelets have seldom been described. Recently, we found a Ch...

Nodular fasciitis (NF) is a benign, reactive proliferation of fibroblasts in subcutaneous tissues which commonly occurs in the deep fascia. It can only be diagnosed by histopathological examination of a biopsy. A total of 23 orofacial NF patients was analysed, including those reported in the English language literature and six new patients from the...

We report here the theoretical studies on electronic delocalization and resonant transmission in symmetric metallic nanowires (SMNs). Resonant transmissions, which are characterized by multiple perfect transmission peaks, have been found in the electronic band gap. The resonant energy and the number of modes of resonant transmission therein can be...

We have investigated the reflection of electromagnetic waves on the Si/SiO2 multilayer films. The film is fabricated by magnetron sputtering technique. For all polarizations of incident light, reflectance measurements demonstrate a wide omnidirectional photonic band gap. The resonant modes within the photonic band gap are observed at the telecommun...

Dendritic cells (DCs), as primary antigen-presenting cells with the capacity to activate naïve T lymphocytes, are considered to be promising adjuvants for immunity against cancer. In this study, the effect of T lymphocyte-mediated immunity induced by a DC vaccine against Tca8113 cells in vivo and in vitro was evaluated. DCs were from human peripher...

Disintegrin is a kind of small native peptides derived from the snake venom, containing RGD sequences. Its interaction with integrins, such as aIIbb3, anb3 and a5b1, can inhibit platelet aggregation. hinder the process of angiogenesis and tumor metastasis. In order to further investigate the function of disintegrin in platelet aggregation, cell adh...

Heparin or heparin-like compounds present in human plasma in minute amounts. It has been reported that a very few patients with such diseases as plasma cell neoplasms, acute monoblastic leukemia and acquired immune deficincy syndrome have an increased plasma heparin-like anticoagulant activity. Recently, we found a 10-year-old girl who was physical...

Pyrolyzed polyaniline–SiO2 substrates with the rough surface containing some holes were prepared by the pyrolysis of polyaniline–SiO2 composites at temperature of 900 °C. Carbon nanotubes/nanofibers (CNTs/CNFs) were grown on the rough surface and inside the holes using a CVD method with a xylene–ferrocene mixture as a carbon and catalyst precursor...

We investigate the propagation of electromagnetic wave through dielectric heterostructures with transfer-matrix method. It is shown that if a dimerlike positional correlation (DPC) is introduced to the heterostructure, resonant transmission of light waves will definitely take place. The resonant transmissions are characterized by perfect transmissi...

We present the structural fabrication and the optical transmission of dielectric multilayer films with a defect both theoretically and experimentally. With the transfer-matrix method, the transmission of electromagnetic waves through the multilayer can be theoretically analyzed. It is shown that a defect layer in the structure can induce the locali...

Multiple perfect transmissions of electromagnetic waves are found in the photonic band gap of the symmetric dielectric heterostructures (SDH) constructed as (AB)B-n(m)(BA)(n), where A and B stand for different dielectric materials, and m and n are the repeating numbers of the units. The photonic frequency and the mode number of resonant transmissio...

The Universal Mobile Telecommunications System (UMTS) is the third-generation (3G) wireless technology that will offer the expanded bandwidth to allow for enhanced services in data and multimedia. UMTS will support both circuit-switched and packet-switched access to Internet services. However, the introduction of the 3G wireless technology will inc...

To study the C807T polymorphism of the platelet collagen receptor alpha(2) gene coding sequence in Suzhou Han population. This polymorphism was associated with the expression density of integrin alpha(2)beta(1) on the platelet surface. An amplified 1332 bp fragment of human alpha(2) gene from 110 unrelated individuals was analyzed by Bgl II and Ase...

To investigate the change of platelet membrane glycoproteins and its fibrinogen binding reaction in patients with cerebral infarction and type II diabetes mellitus (DM), and assess their value in the study of thrombosis and pro-thrombosis state. By flow cytometry, the platelet glycoprotein (GP) I b, GP II b, GP III a, GP II b- III a complex and P-s...

This study aimed at the use of computer for identifying fundus lesions quickly and reliably. We adopted the 'area filling' method to program in Visula C++, used the program to mesure the retina cotton-wool patches in diabetics (15 eyes), and then calculated the coefficient of variation to evaluate its reproducibility. The results showed that the co...

The first synchrotron radiation beamline using a 4-m-long undulator at the 12 GeV storage ring PETRA delivers hard x- ray photons usable up to 300 keV. In order to reduce the low energy photon flux and the related thermal load on the beamline optics, graphite, beryllium, aluminum, copper, and iron filters or windows are installed. With a planned up...

In order to utilize the full potential of high power wiggler beam lines with heat loads up to several kW and large white beam cross sections, a variety of monochromator crystal designs are in use. Either the crystal is efficiently cooled or the unwanted distortions are compensated by different means which require external control mechanisms. Based...

The undulator beamline at the storage ring PETRA of the Hamburger Synchrotronstrahlungslabor HASYLAB delivers hard x-ray photons usable up to 300 keV. The total power of the beam is now up to 7.5 kW with closed gap and 60 mA stored particle beam. After a planned upgrade of the undulator, the power can increase to about 15 kW. The vertical white bea...

Third‐generation synchrotron x‐ray facilities, such as the Advanced Photon Source, produce x‐ray beams that generate a very high heat flux in a very small area. In order to preserve the brilliance of the source, optical components have to be designed to undergo very small thermal deformation (or a change of slope of a flat surface). When an optical...

A ‘‘critical thickness’’ for a synchrotron radiation x-ray filter exists. Because x-ray absorption in media is an exponential function of depth and because radiation and conduction both play a role in the cooling of the filter assembly, the heat transfer mechanism changes from radiation dominant to conduction dominant as the thickness increases. Fo...

Metallic filters are needed by APS users in their beamlines. Two general areas of use for the white-beam metallic filters are: (1) to attenuate the x-ray beam to reduce the thermal load during routine operations and (2) to attenuate the x-ray beam during alignment and for special testing of optics at low power. Metallic filters are important for us...

Third‐generation synchrotron x‐ray facilities, such as the Advanced Photon Source, generate a very high heat flux in a very small area. When an optical component is subjected to a heat load, there will be thermal deformation caused by a temperature increase. For a plate‐like structure, the temperature difference over the thickness causes bending, a...

XRAP is a computer code developed for analysis of optical elements in synchrotron radiation facilities that can generate BM (bending magnet) and ID (insertion device) spectra and calculate their absorption in media, such as variable thickness windows/filters and crystals, and provide a finite difference engine for fast but sophisticated thermal and...

In this paper, the finite difference formulations for variable thickness thermal analysis and variable thickness plane stress analysis are presented. In heat transfer analysis, radiation effects and temperature-dependent thermal conductivity are taken into account. While in thermal stress analysis, the thermal expansion coefficient is considered as...

The pin-fin configuration is widely used in high-heat-flux applications. Recently, the pin-fin design with liquid-metal coolant was also applied to synchrotron-radiation beamline devices. This article investigates the pressure drop in a pin-post crystal with liquid gallium as the coolant. Because the pin-post configuration is a relatively new conce...

The analytical results and design considerations for a cryogenically cooled advanced photon source (APS) silicon monochromator are presented. The high conductivity and low thermal expansion coefficient of silicon at cryogenic temperatures are advantages that are used to solve the high‐heat‐flux problem from undulator radiation. The APS monochromato...

Finite difference formulations for variable thickness thermal analysis and variable thickness plane stress analysis are presented. In heat transfer analysis, radiation effects and temperature-dependent thermal conductivity are taken into account. While in thermal stress analysis, the thermal expansion coefficient is considered as temperature depend...

Cooling methods and thickness selection of filters and windows are investigated. Safety criteria previously proposed are used to design the filter and window parameters at the Advanced Photon Source. Results are presented on power absorption as well as analytical results from thermal and structural analyses.

To fully understand the behavior of windows after buckling so as to precisely predict failure, this paper first reviews test data and then examines the postbuckling behavior of thin-shell structures under thermal or mechanical load. The paper presents postbuckling analyses of beryllium windows subjected to X-ray thermal loads and investigates the p...

The third generation synchrotron facilities such as the 7-GeV Advanced Photon Source Project (APS) generate x-ray beams with very high heat loads and heat flux levels. The front-end and beamline components are required to sustain total heat loads of 5 to 15 kW and heat flux levels exceeding 400 W/mm². Grazing geometry and enhanced heat transfer te...

The analytical results and design considerations for a novel cryogenically cooled Advanced Photon Source (APS) monochromator are presented. Because the monochromator uses silicon crystal, cryogenic cooling enables one to take advantage of the high conductivity and low thermal expansion coefficient of silicon at cryogenic temperatures. The APS monoc...

Synchrotron x-ray windows are vacuum separators and are usually made of thin beryllium metal. Filters are provided upstream of the window to filter out the soft x-rays to protect the window from overheating and failing. The filters are made of thin carbon products or sometimes beryllium, the same material as the window. Because the window is a vacu...

With the advent of positron emission tomography (PET), a variety of techniques have been developed to measure local cerebral blood flow (LCBF) noninvasively in humans. A potential class of techniques, which includes linear least squares (LS), linear weighted least squares (WLS), linear generalized least squares (GLS), and linear generalized weighte...

The upper bound limit theorem has been used here to study the limit load of spherical shell under ring load. A closed form solution for the limit load has been found. A series of experiments was performed with different sizes and different thicknesses of the spherical shell under different diameters of ring loads. Good agreement was found between t...

The photon shutter is a critical component of the beamline front end for the 7 GeV Advanced Photon Source (APS) project, now under construction at Argonne National Laboratory (ANL). The shutter is designed to close in tens of milliseconds to absorb up to 10 kW heat load (with high heat flux). Our shutter design uses innovative enhanced heat transfe...

One of the most critical components on the Advanced Photon Source (APS) insertion device (ID) beamline front ends is the first photon shutter. It operates in two modes to fully intercept the high total power and high-heat flux ID photon beam in seconds (normal mode) or in less than 100 ms (emergency fast mode). It is designed to operate in ultra hi...

Multiple tracer steady-state experiments on a compartmental system provide implicit dependent relationships among model parameters. The derivation of explicit expressions could be a very difficult task, especially when the system is relatively complex. A graph-theory-based algorithm is developed to optimally select dependent parameters and derive t...

Perzyna's viscoplastic material model is selected to consider the strain rate effect of lead used in radioactive material shipping packages. The model is checked using data from two scale-model tests and the deformations are found to be within 10 percent. 3 refs., 4 figs.

The Advanced Photon Source (APS) is building 16 insertion device (ID) front ends for the first phase of the project. Eleven of these are to be equipped with the APS Undulator A and the other five with a Wiggler-A-type source. The Undulator A front ends are designed to operate in a ``windowless`` mode using an APS-designed differential pump. However...

Objective: Targeting the expression of VEGF on OSCC cell line Tca8113 using RNA interference observing its biological characteristic and observing its inhibitory effect on DC. Method: The the plasmids constructed were transfected into Tca8113. Then we detected its proliferative ability of Tca8113 transfected, and the cell cycle , and the apoptosis....

Objectives: To provide the comparison and initial basis in the further application of LIPUS (Low Intensity Pulsed Ultrasound) for the potential treatment of periodontal disease, we explore the biological effects of LIPUS in the alveolar bone defect models. Methods: Buccal alveolar bone under the CEJ (the Removing cementum-enamel junction)were remov...