Zhang Shaokun

Guangxi University

Intervertebral disc (IVD) degeneration (IDD) is a worldwide spinal degenerative disease. Low back pain (LBP) is frequently caused by a variety of conditions brought on by IDD, including IVD herniation and spinal stenosis, etc. These conditions bring substantial physical and psychological pressure and economic burden to patients. IDD is closely tied...

Using bone tissue engineering strategies to achieve bone defect repair is a promising modality. However, the repair process outcomes are often unsatisfactory. Here we properly designed a multi-functional microsphere system, which could deliver bioactive proteins under the dual response of ultrasound and microenvironment, release microenvironment-re...

Excellent biocompatibility, mechanical properties, chemical stability, and elastic modulus close to bone tissue make polyetheretherketone (PEEK) a promising orthopedic implant material. However, biological inertness has hindered the clinical applications of PEEK. The immune responses and inflammatory reactions after implantation would interfere wit...

Intervertebral disc (IVD) degeneration (IDD) is a common disorder that affects the spine and is a major cause of lower back pain (LBP). The extracellular matrix (ECM) is the structural foundation of the biomechanical properties of IVD, and its degradation is the main pathological characteristic of IDD. Matrix metalloproteinases (MMPs) are a group o...

Spinal tuberculosis, also known as Pott's disease or tuberculous spondylitis, is usually secondary to primary infection in the lungs or other systems, and in most instances, is thought to be transmitted via blood. Typical manifestations of infection include narrowing of the intervertebral disc by erosion and bone destruction of adjacent vertebrae....

Intervertebral disc degeneration (IVDD) is a degenerative disease characterized by lower-back pain, causing disability globally. Antioxidant therapy is currently considered one of the most promising strategies for IVDD treatment, given the crucial role of reactive oxygen species (ROS) in IVDD pathogenesis. Herein, a ROS-responsive magnesium-contain...

Spinal cord injuries (SCIs) are devastating. In SCIs, a powerful traumatic force impacting the spinal cord results in the permanent loss of nerve function below the injury level, leaving the patient paralyzed and wheelchair-bound for the remainder of his/her life. Unfortunately, clinical treatment that depends on surgical decompression appears to b...

Polyetheretherketone (PEEK) has gradually become the mainstream material for preparing orthopedic implants due to its similar elastic modulus to human bone, high strength, excellent wear resistance, radiolucency, and biocompatibility. Since the 1990s, PEEK has increasingly been used in orthopedics. Yet, the widespread application of PEEK is limited...

Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI is characterized by high disability and tends to occur among the young, seriously affecting patients’ lives and quality of life. The key aims of repairing SCI include preventing secondary nerve injury, inhibiting glial scarring and inflammatory response,...

Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on. The pathological changes of...

Postoperative infections following implant-related spinal surgery are severe and disastrous complications for both orthopaedic surgeons and patients worldwide. They can cause neurological damage, disability, and death. To better understand the mechanism of these destructive complications and intervene in the process, further research is needed. The...

Objective: To study the effectiveness of a new spinal protection device for preventing and treating osteoporotic vertebral compression fractures (OVCFs) by finite element analysis (FEA). Methods: One healthy volunteer and one patient with 1-segment lumbar vertebral compression fractures were included in this experimental study. The DICOM files o...

Peripheral blood was extracted from a 45-year old female patient clinically diagnosed with Stickler syndrome harboring a heterozygous splicing mutation in COL2A1 (NM_033150, IVS22-1C>T). Induced pluripotent stem cells (iPSC) were reprogrammed by sendai virus encoding Klf-4, c-Myc, Oct-4, and Sox-2. The iPSC line showed pluripotency, which was verif...

Peripheral blood was extracted from a 48-year old healthy male donor. Induced pluripotent stem cells (iPSC) were reprogrammed by sendai virus encoding Klf-4, c-Myc, Oct-4, and Sox-2. The iPSC line showed pluripotency, which was verified by immunofluorescence staining. The iPSC line showed normal karyotype, and could form embryoid bodies in vitro an...

Bacterial infections and antibiotic resistance have become a global healthcare crisis. Herein, we designed and synthesized a series of cationic amphiphilic dendrons with cationic dendrons and hydrophobic alkyl chains for potential antibacterial applications. Our results showed that the antimicrobial activities of the cationic amphiphilic dendrons w...

Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. IDD is mainly caused by aging, trauma, genetic susceptibility, and other factors. It is closely associated with changes in tissue stru...

Surgical site infections (SSIs) after spinal surgery are one of the serious complications of spinal surgery, which can lead to failure of spinal surgery, central nervous system infection, and even threaten patient lives. Although existing antibiotics can effectively control and treat postoperative infections in the spine, bacterial resistance conti...

A new series of main-chain copolymers constructed by linkage of both soft and rigid cationic rings has been developed. The imidazolium-DABCO copolymers possess good biocompatibility, high antimicrobial activity and lower...

Meningitis and encephalitis caused by bacteria and fungi are among the top 10 lethal types of infectious diseases. The treatment of brain infection is principally limited by the blood-brain barrier (BBB), which restricts the entry of antimicrobial agents to the desired central nervous system (CNS). To address this issue, many different nanoparticle...

Hollow Ag@AgBr nanospheres were prepared by a greener version of microbial process starting with AgCl colloid formation in yeast extract (YE) and peptone solution. The Kirkendall effect has been exploited...

Ganglioneuroma (GN) is a rare benign tumor of neural crest origin usually found in the abdomen, but may occasionally present at uncommon sites including the cervical, lumbar, or sacral spine. However, GNs of thoracic spine are extremely rare. In this report, we describe a 12-year-old girl with giant GN in the thoracic spine, who underwent successfu...

Recent studies suggest that microRNAs (miRNAs) are critical regulators in many types of cancer, including osteosarcoma.miR-342-3p has emerged as an important cancer-related miRNA in several types of cancers. However, the functional significance of miR-342-3p in osteosarcoma is unknown. The aim of this study is to investigate whether miR-342-3p is d...

Peripheral blood was collected from a clinically diagnosed 79-year old male sporadic Parkinson's disease patient. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staini...

Peripheral blood was collected from a clinically diagnosed 64-year old male multiple schwannoma patient. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pl...

Peripheral blood was collected from a clinically diagnosed 60-year old female patient with multiple schwannoma. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining...

Peripheral blood was collected from a clinically diagnosed 72-year old male patient with later onset Alzheimer's disease. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescen...

In order to achieve the real-time of high performance permanent magnet synchronous motor while reducing its software development cycles and enhancing its running speed, the hardware design of a permanent magnet synchronous motor control circuit based on dual-core DSC is presented. Using TI's new 32 bit floating point dual core TMS320F28377D digital...

The limbal epithelial cells can be maintained on 3T3 feeder layer with fetal bovine serum supplemented culture medium, and these cells have been used to successfully treat limbal stem cell deficiency. However, fetal bovine serum contains unknown components and displays quantitative and qualitative lot-to-lot variations. To improve the culture condi...

Silver has widely been used as antimicrobial agent, but there is a long-standing debate over the microbiocidal potency of ionic silver versus colloidal silver. In this study, the minimum inhibitory concentrations (MICs) of AgNO3 against Gram-positive and Gram-negative bacteria were investigated in a variety of microorganism culture broths. Broth- a...

Osteosarcoma is the most bone-associated malignancy with high lethality. The current therapeutic strategy benefits little on the survival of patients. Studies have shown that aberrant activation of Wnt/β-catenin pathway is essential for the progression of osteosarcoma, implying that targeting this signaling may be an effective way of therapeutics....

In Automatic Switched Optical Network (ASON), the Generalized Mutli-Protocol Lable Switching (GMPLS) Open Shortest Route First-Traffic Engineering (OSPF-TE) is selected as routing protocol. It provides flexible distributing of routing information and automatic resource discovery. The security of GMPLE OSPF-TE is an important component of ASON netwo...

In the engineering implementation of ASON control plane, RSVP_TE protocol is widely used. Based on the specific analysis of reliability mechanisms of RSVP_TE protocol, Security problems that RSVP_TE protocol may confront with are discussed, and the corresponding countermeasures are proposed in the paper.

Unique characteristics of a near-leaky wave guide mode closely coupled to an SPP mode in a metal/dielectric structure are studied. Highly efficient optical modulation can be realized by utilizing the extremely sharp resonance of the mode.

Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy. In this paper, core-shell structured titanium dioxide-silica (TiO2-SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicity and photo-killing ability...

Silver-containing antimicrobial agents are used in various medical products. However, their toxicity to mammalian cells has not been sufficiently evaluated. Numerous studies have unveiled evidence of significant antimicrobial properties associated with Ag ions. In cell culture media or human body fluids, the free Ag(+) has rich opportunities to com...

Automatically Switched Optical Network (ASON) appear as a potential solution to cope with the increasingly growth of data traffic demands on Internet. The paper gives a tutorial overview of the control plane in ASON, concentrating on its architecture, function and security. Different kinds of protocols related to control plane and their flaws are a...

For the first time, we propose a novel polarization orthogonal modulation format with code-shift keying (CSK) generated by polarization modulator. And we demonstrate a temporal phase encoded OCDMA system using novel polarization CSK (Polm-CSK) data format and balanced detection. The proposed scheme has fixed threshold with variation of users number...

In this paper we analyze traditional authentication method based on certificate in mobile network environment. This paper proposes a privilege management system based on attribute certificate in mobile network environment. The system uses attribute certificate which is a high security privilege management method to prove user privilege in large sca...

To investigate the distribution of CD44(+)/CD24(-) cells in breast cancers in relation to tumor size before and after the administration of neoadjuvant chemotherapy. CD44(+)/CD24(-) tumor cells obtained from breast cancer specimens were characterized in vivo and in vitro using tumor formation assays and mammosphere generation assays, respectively....

To investigate the mutations of BRCA1 and BRCA2 and determine whether clinic-pathological factors related to BRCA gene mutation. Mastectomy specimens from 360 breast cancers were enrolled and examined in the study. The relationship between BRCA gene mutation and clinic-pathological factors was evaluated. Overall, 280 patients were BRCA negative and...