Yuzhou Chen

RMIT University | RMIT · Department of Applied Science

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage therapy. In this work, the second near-infrared (NIR-II) fluorescence imaging in vivo tracking of M2 macrophages during a pro-heali...

Skeletal muscle has a robust regeneration ability that is impaired by severe injury, disease, and aging, resulting in a decline in skeletal muscle function. Therefore, improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related disorders. Owing to their significant role in tissue regeneration, implantation of M2 ma...

Background: Corticosteroid injections (CSIs) are effective in alleviating pain in patients with rotator cuff tears, but controversy still exists regarding their potential adverse effects on clinical outcomes after rotator cuff repair. Purpose: To compare both the functional and the structural outcomes in patients who underwent arthroscopic rotat...

Advancements in lymphography technology are essential for comprehensive investigation of the lymphatic system and its function. Here, a shortwave infrared (SWIR) luminescence imaging of lymphatic vessels is proposed in both normal and lymphatic dysfunction in rat models with PbS quantum dots (PbS Qdots). The lymphography with PbS Qdots can clearly...

The degradation of collagen in different body parts is a critical point for designing collagen-based biomedical products. Here, three kinds of collagen labeled by NIR-II quantum dots (QD) including collagen with low crosslinking degree (LC), middle crosslinking degree (MC) and high crosslinking degree (HC) were injected into the subcutaneous tissue...

During bacterial infection, it is crucial to duly implement antibiotic treatment at a bottleneck time window when uncontrollable bacteria invasion exacerbates the condition. Here, we present a second near-infrared (NIR-II) fluorescence imaging strategy based on lead sulfide quantum dots clustered microspheres (PbS [email protected]) to guide seekin...

Purpose To investigate the effects of the number and location of anchors for remplissage on postoperative glenohumeral biomechanics. Methods A biomechanical study was conducted involving finite element model constructed based on data from the intact glenohumeral joint. Seven models were established, including a normal model, a model of Bankart les...

Peripheral nerve injury gives rise to devastating conditions including neural dysfunction, unbearable pain and even paralysis. The therapeutic effect of current treatment for peripheral nerve injury is unsatisfactory, resulting in slow nerve regeneration and incomplete recovery of neural function. In this study, nerve suture combined with ADSCs inj...

Background The influence of patient sex on clinical outcomes after arthroscopic anterior shoulder stabilization is unclear. Purpose To investigate sex-based differences in clinical outcomes after arthroscopic anterior shoulder stabilization. Study Design Cohort study; Level of evidence, 3. Methods A retrospective study was conducted among 76 pat...

Background Age at surgery plays a crucial role in the frequency of recurrent shoulder instability. However, there are few studies that evaluate the relationship between age at initial shoulder instability and overall outcomes after stabilization surgery. Purpose To compare clinical outcomes and structural changes after arthroscopic Bankart repair...

Background Most patients return successfully to shoulder involving sports or activity after rotator cuff repairs. It has not been decided yet whether postoperative participation in shoulder activity adds to the risk of retear. Purpose/Hypothesis The purpose was to verify whether patients who participate in shoulder activities after rotator cuff re...

Purpose To assess patients with and without postoperative residual pain and to compare clinical function and magnetic resonance imaging (MRI) appearance of the repaired supraspinatus tendon between patients with and without pain. Methods One-hundred and seventeen patients with supraspinatus tear were included in this study. Visual Analog Scale (VA...

Mesenchymal stem cells (MSCs) are capable of exerting strong therapeutic potential for the treatment of supraspinatus tendon tear. However, MSC therapy remains underutilized and perhaps underrated due to the limited evidence of dynamic visualization of cellular behavior in vivo. Here, second near‐infrared fluorescence imaging with biocompatible PbS...

Purpose The purpose of this study is to compare pain patterns and identify factors associated with residual shoulder pain after rotator cuff repairs using double-row and single-row techniques. Methods A cohort study was performed using patients who underwent arthroscopic rotator cuff repairs at our center in 2015. Patients were allocated according...

Background: The critical shoulder angle (CSA) is the angle created between the superior and inferior bone margins of the glenoid and the most lateral border of the acromion. A few studies recently investigated the relation between CSA and functional outcomes after rotator cuff repair. However, there is a lack of research investigating the effect o...

Background: Rotator cuff tears with shoulder stiffness remain a difficult issue. Despite the reported satisfactory results of 1-stage surgery, little information is available regarding the factors that affect clinical outcomes. Purpose/Hypothesis: To evaluate the 1-stage arthroscopic treatment of rotator cuff tears with shoulder stiffness and to p...