Yuhan Mai

Fuzhou University · Department of Chemistry

Quaternary ammonium compounds (QACs) are inexpensive and readily available disinfectants, and have been widely used, especially since the COVID-19 outbreak. However, the toxicity of QACs to humans has raised increasing concerns in recent years. Here, a new type of QACs was synthesized by replacing the alkyl chain with zinc phthalocyanine (ZnPc), wh...

Air pollution caused by bacteria and viruses has posed a serious threat to public health. Commercial air purifiers based on dense fibrous filters can remove particulate matter, including airborne pathogens, but do not kill them efficiently. Here, we developed a double-grafted antibacterial fiber material for the high-efficiency capture and inactiva...

ZnO is an important component in skin-protection products and wound-care medicines. However, ZnO's antibacterial activity is moderate. We developed two types of ZnO microparticles loading with phthalocyanine-type photosensitizers (ZnO/PSs) introducing the photodynamic effects to complement ZnO's insufficient antimicrobial activity. These photosensi...

The ongoing pandemic of coronavirus disease 2019 (COVID-19) posed a major challenge to the public health. Currently, no proven antiviral treatment for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is available. Here we report compounds pentalysine β-carbonylphthalocyanine zinc (ZnPc5K) and chlorin e6 (ce6) potently inhibite...

To improve of the potency of IR780 in this field of anticancer research, we designed and synthesized two novel IR780-based derivatives (L1 and L2) possessing different chainlength tethered morpholine groups. Their properties were verified through both in vitro and in vivo experiments, including good photo- and chemical stability, dual tumor-targete...

In the fight against cancer, it is urgently necessary to design a single-molecular theranostic agent (SMTA) for simultaneous diagnosis and therapy. However, this goal has not been accomplished. Here, to achieve this ambition, a chemotherapy drug of the aromatic nitrogen mustard class is covalently conjugated onto a small molecule, rhodamine, as an...