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Publications (62)
An effective approach to separate chiral ((2S, 4S)-1-(tert-butoxy carbonyl)-4-(methoxymethyl) pyrrolidine-2-carboxylic acid ((2S, 4S)-TBMP)) from mixed (2S, 4S)-TBMP and (2S, 4R)-1-(tert-butoxy carbonyl)-4-(methoxymethyl) pyrrolidine-2-carboxylic acid ((2S, 4R)-TBMP), an important intermediate for anti-HCV...
Two organo‐bimetallic complexes of ferrocene and organotin were synthesized and evaluated as potential anticancer drugs. MTT results indicated that the two complexes showed excellent antitumor activity against a variety of cancer cell lines compared with cisplatin and ferrocene alone. Different from the previous similar metal drugs available, the c...
A series of half-sandwich ruthenium complexes containing quinoline derivative ligands was synthesized, which had excellent antitumor toxicity toward a variety of cell lines and could localize lysosomes. The damage of lysosomes promotes the release of cathepsin B and initiates downstream apoptotic cascade signals. The increase in reactive oxygen spe...
Interest in targeted cancer therapies with fewer side effects has increased in recent years. Photodynamic therapy(PDT) uses photosensitizers(PS) and light to selectively kill cancer cells, generating highly reactive reactive oxygen...
To overcome the resistance of tumour cells to cis-diaminedichloroplatinum(II) (cisplatin, DDP), we designed and synthesised platinum(II) complexes with copper coordination active sites using vitamin B6 and benzohydrazide derivatives as raw materials.The 3D structures of the complexes were confirmed by X-ray single-crystal diffraction. The results o...
Molybdenum disulfide (MoS2), as an alternative electrocatalyst, has great potential to drive the hydrogen evolution reaction (HER). However, due to the catalytic inertness of the base surface and limited active sites, the HER performance of MoS2 has not yet reached the ideal state. Herein, we have successfully fabricated nanoflower-like MoS2 with t...
Here, we first combined the catalytic hairpin assembly (CHA) reaction and oxygen reduction reaction (ORR) to amplify the electrochemical signal for the determination of miRNA-21. In the presence of target microRNA-21, C-Ag⁺-C structure probe formed by hairpin DNA1 (H1) and Ag⁺ could be opened and catalytic hairpin assembly reaction could be carried...
An ultrasensitive photochemical biosensor based on the target miRNA-triggered catalytic hairpin assembly (CHA) reaction between Au nanoparticles (AuNPs)/C3N4 nanosheets and CdS quantum dots (QDs) was developed for the determination of miRNAs. Firstly, AuNPs/C3N4 nanosheets were immobilized onto a working glassy carbon electrode. Then, the hairpin p...
The Class A1 flame retardant eco-material with excellent comprehensive properties is strongly needed to replace the low-level flame retardant products for potential applications in the building industry. In this work, modified titanium sol with the re-dispersible latex powder (VAE) is compounded to prepare non-combustible flame retardant composites...
Contact lens care solution was prepared via hydroxypropyltrimethyl ammonium chloride chitosan (HACC) and sucrose lauric acid ester (SML) via self-assembly in borate buffer solution (BBS). The elution efficiency of lipids, micellization, and wettability properties of HACC-SML in BBS was studied systematically using high-performance liquid chromatogr...
In this work, we report AuNPs-decorated pyrolyzed Co-BDC nanosheets (p-Co-BDC/AuNPs) as high-performance electrocatalyst for developing an electrochemical platform. p-Co-BDC/AuNPs as a new electrocatalyst showed superior electrocatalytic activity towards the electrochemical oxidation of methylene blue (MB). Besides, magnetic p-Co-BDC/AuNPs can be w...
Taking a composite of a nanomaterial and a signal molecule as a substrate material can provide a label-free electrochemical platform. Besides, the nanomaterial with a high catalytic activity towards the signal molecule can improve the sensitivity of the platform. Herein, a thionine functionalized Fe-N-C nanocomposite was employed as the substrate....
MicroRNAs (miRNAs) are becoming biomarkers for the clinical diagnosis of many diseases. However, their intrinsic properties such as low enrichment and short sequence restrict their applications. Here, we designed an ultrasensitive dual signal amplification electrochemical biosensor based on sodium alginate-polypyrrole/Au nanoparticles (SA-PPy/AuNPs...
Malignant tumors have become one of the challenges to global human health today, and the development of new drugs has become a research hotspot for tumor treatment. In order to prove that copper(II)-thiosemicarbazone complexes can be used as antibacterial and antitumor agents, we have synthesized and characterized three copper(II) complexes (C1-C3)...
We have prepared six thiosemicarbazone ligands and synthesized the corresponding Ga(III) complexes. The antitumor activity of the ligand increases with its lipophilicity, and the antitumor activity of the Ga(III) complexes is affected by the ligands. Since C6 has the highest anticancer proliferative activity (0.14 ± 0.01 μM) against HepG-2 (Human h...
A new high waterproof and flame‐retardant material was developed by using polylactic acid as a binder. Fireproof composite materials have excellent physical, mechanical, and flame‐retardant properties. The water resistance property of fireproof composites increases as the polylactic acid doping ratio increases. Also, the mechanical performance test...
We synthesized five iron chelator derived from 2,6-diacetylpyridine bis(acylhydrazones) and proved their iron complexes structure by X–ray single crystal diffraction. These ligands have a significant anticancer proliferative activity and low cytotoxicity against normal cells. The Fe(III) complexes show reduced cytotoxic activity compared to the met...
Six gallium(III) complexes (Ga1–Ga6) with 2‑quinolinecarboxaldehyde thiosemicarbazone analogues were synthesized and characterized. These gallium(III) complexes exhibited potent anticancer activity and exceeded that of the corresponding metal free ligands. Importantly, these gallium(III) complexes have a strong selectivity for tumor cells. Through...
A novel kind of hydroxypropyltrimethyl ammonium chloride chitosan (HACC) mixed colloid was developed to improve the hydrophilicity of silicone hydrogel films (SHFs) via self-assembly. The contact angle of the modified SHF decreased from 33.24° to 12.98°, whereas the atomic force microscopy image verified that the roughness of the modified films dec...
A novel kind of hydroxypropyltrimethyl ammonium chloride chitosan (HACC) mixed colloid was developed to improve the hydrophilicity of silicone hydrogel films (SHFs) via self-assembly. The contact angle of the modified SHF decreased from 33.24° to 12.98°, whereas the atomic force microscopy image verified that the roughness of the modified films dec...
Herein, we report a facile enzyme-free microRNA (miRNA) target-triggered strand displacement reaction (SDR) amplification strategy with ferrocene (Fc) as a signal molecule to fabricate a two-dimensional electroactive molybdenum carbide (Mo2C)-based biosensor. In the presence of miRNA-21, SDR was initiated and many hairpin DNA1 (HDNA1) and hairpin D...
Copper(II) complexes efficiently catalyze hydrogen peroxide to generate reactive oxygen species (ROS), which is the major reason for its significant anti-tumor activity. We synthesized three Cu(II) piperidylthiosemicarbazone complexes and examined their structures by X-ray single crystal diffraction. These Cu(II) complexes have significant apoptosi...
Ionic liquids have been powerful solvents for cellulose. Mechanistic investigations of the dissolution processes have been extensively studied. In this paper, an experimental study has revealed that temperature also comes into play in cellulose dissolution. The supramolecular stuctrure of cellulose has been measured by X-ray diffraction, Fourier tr...
Ga(III) compounds are very promising candidates for antitumor therapy. Studies have shown that intracellular Reactive Oxygen Species (ROS) is significantly increased after Ga(III) complexes treatment, while these complexes are redox-inactive. To investigate how Ga(III) complexes affects the levels of ROS, we have synthesized three bis-liganded gall...
An ultrasensitive electrochemical circulating tumor cells (CTCs) detection strategy was developed based on magnetic field-induced, targeted separation and enrichment, and reduced graphene oxide/molybdenum disulfide (rGO/MoS2) composites and Fe3O4NPs binanozyme synergistic catalysis for signal amplification. Immunomagnetic beads (Fe3O4NPs) act as bo...
Five thiosemicarbazone ligands were synthesized and characterized by condensation with different aldehydes or ketones by 4-phenylthiosemicarbazone. The representative dichlorido[2-(Di-2-pyridinylmethylene)-Nphenylhydrazinecarbothioamide-N,N,S]-gallium(III) (Ga4) was characterized by X-ray single crystal diffraction, which was 1:1 ligand/Ga(III) com...
Two types of α-N-heterocyclic piperidylthiosemicarbazone ligands and related Ga(III) complexes were synthesized. The structure of Ga4 and Ga5 were characterized by X-ray single crystal diffraction. We generated the related α-N-heterocycliperidinylthiosemicarbazone analogs to examine the effect of aldehydes or ketones in the Schiff base. The antitum...
Reducing the quantity of sludge produced in Fenton reactions can be partly achieved by improving their efficiency. This paper firstly studies the effect of uniform deceleration feeding (ferrous iron and hydrogen peroxide) on the efficiency of a Fenton reaction by measuring the yield of hydroxyl radicals (˙OH) and chemical oxygen demand (COD) remova...
Enzyme mimics have been developed for bioassay of nucleic acids, with some of them involving complicated labeling. Herein, we report a label-free bioassay for ultrasensitive electronic determination of microRNA at an ultralow concentration based on target-triggered long-range self-assembly DNA-based hybridization chain reaction (HCR) protocol coupl...
An ultrasensitive electrochemical circulating tumor cells (CTCs) detection strategy was developed based on magnetic field-induced, targeted separation and enrichment, and reduced graphene oxide/molybdenum disulfide (rGO/MoS2) composites and Fe3O4NPs binanozyme synergistic catalysis for signal amplification. Immunomagnetic beads (Fe3O4NPs) act as bo...
An ultrasensitive electrochemical detection method was developed to detect circulating tumor cells (CTCs) by using reduced graphene oxide/gold nanoparticles composites (rGO/AuNPs composites) as a support material with CuO nanozyme as a catalyst. MCF-7 circulating tumor cells were detected by an electrochemical cytosensor with effective surface reco...
Any microorganisms killing molecules have some cytotoxicity more or less. The effective way of reducing cytotoxicity mainly included two approaches: One was reducing the concentration of antiseptic, while this would lead to the decreased antimicrobial efficiency; the other way was choosing suitable antiseptics and then combining of them, which can...
Nanocellulose from eucalyptus (Eucalyptus robusta Smith) pulp was extracted by simply disrupting the hydrogen bond network of celluloses with high pressure homogenization (HPH). It was found that nanocellulose was 20–100 nm in diameter, and presented a narrower molecular weight distribution, lower thermal stability and crystallinity index. Fourier...
Thiosemicarbazone Ga(III) complexes (C3-C5) were synthesized and characterized by X-ray single crystal diffraction, and they were all 1:1 ligand/Ga(III) complexes. The antiproliferative activity of these Ga(III) complexes was tested against three cancer cell lines, demonstrating that Ga(III) complexes showed about 3-10 folds more anticancer activit...
Gold nanoparticles (AuNPs) superlattice and small molecule dyes such as toluidine blue have remarkable effect on signal amplification. In this report, a label-free and simple electrochemical microRNA biosensor is developed by employing toluidine blue (TB) as a redox indicator and AuNPs superlattice as a support material. Conductive polymer, polypyr...
Benzimidazole is an important intermediate in pharmaceutical and dyeing industry and it is usually difficult to be degraded by many treatment technologies. Looking for a highly effective, low cost, environment-friendly degradation process for wastewater containing these compounds is of great significance to reduce environmental pollution. Based on...
Two types of 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes, which are 2:1 and 1:1 ligand/Ga(III) complexes, were synthesized and determined by X-ray single crystal diffraction. The antiproliferative activity of these Ga(III) complexes have been examined to illuminate the structure-activity relationships essential to form Ga(III) com...
Quaternized chitosan is a cationic biopolymer with good antibacterial activity, biocompatibility, and biodegradability, and it has been widely applied in many fields. We have developed a convenient method to evaluate the antibacterial activity of hydroxypropyltrimethylammonium chloride chitosan (HACC) with a nonionic surfactant poloxamer in aqueous...
The surface morphology and growth pattern of some molecules could be altered by the recognition of ferrous tartrate (FeC4H4O6, FeTA). We have explored this phenomenon in the aspect of growth rate and morphology alteration of sodium chloride crystals where few researches have been done. In this paper, the crystallization behavior of NaCl with added...
The preparation of well-dispersed nanoparticles (NPs) has been one of the challenges in the development of nanoscale processing. Here, we firstly prepared well-dispersed Pt-Pd NPs (average particle diameter 6.5 nm) by using octa-maleamic acid silsesquioxanes as the stabilizing agent with hydrothermal method and determined the best OM-POSS/metal pre...
Nanocellulose from cotton cellulose was prepared by high pressure homogenization (HPH) in ionic liquids (1-butyl-3-methylimidazolium chloride ([Bmim]Cl). The nanocellulose possessed narrow particle size distribution, with diameter range of 10-20 nm. Weight average molecular weight (Mw) of nanocellulose treated by HPH was lower (173.8 kDa) than the...
Micro-pore composite films of Polyethylene Terephthalate (PET) were successfully prepared by solvent casting method using phenol and 1,1,2,2-tetrachloroethane as solvents. The micro-pore composite films were investigated by Thermo Gravimetric Analysis (TGA), Atomic Force Microscope (AFM), X-ray diffraction (XRD), UV spectrophotometry, Dynamic Mecha...
The octahedral Pt-Pd alloy nanoparticles (octahedral Pt-Pd NPs) with dominant {111} facets were successfully synthesized through a facile route in the presence of octa(3-aminopropyl) silsesquioxane as the capping agent and complexing agent, methanol as the reductant and solvent. Their morphology, composition and structure were charactered by transm...
The effect of oleic acid on the superparamagnetic Fe3O 4 nanoparticles has been investigated in this study. The addition of oleic acid could improve the particle size distribution by the formed protective layer on the surface of Fe3O4 nanoparticles. All of Fe3O4 coated with oleic acid displayed superparamagnetic characterizations, and the interacti...
Bismuth telluride (Bi2Te3) nanorods (NRs) of n-type thermoelectric materials were prepared using an electrogenerated precursor of tellurium electrode in the presence of Bi3+ and mercapto protecting agent in aqueous solution under atmosphere condition. The optimal preparation conditions were obtained with ratio of Bi3+ to mercapto group and Te coulo...
Single-walled bismuth nanotubes (sw-BiNTs) were self-assembled with octa(3-aminopropyl) silsesquioxane as a framework and to govern morphology. Deposited on a glassy carbon electrode (GCE), the sw-BiNTs were used for the simultaneous analysis of Pb(II) and Cd(II) by square wave stripping voltammetry. The sw-BiNTs were prepared by (a) coordination i...
The enterprise safety culture index system, which mainly consists of enterprise decision-making level, management level, implementation level, and external environmental factor, is constructed based on human errors theory. Then, a corresponding enterprise safety culture evaluation model adapting to the characteristics of this index system is presen...
Considering that the current evaluation methods for enterprise safety climate are relatively simple and subjective, an enterprise safety climate index system, which consists of enterprise decision-making level, management level, and implementation level, is constructed based on the principle of SMART. Then, a corresponding enterprise safety climate...
In view of the phenomenon that there are not so many measures of risk evaluation in progress goal programming of expressway construction project, this paper defined the contents of risk evaluation in progress goal programming of expressway construction project, and then established a model of progress goal programming of expressway construction pro...
The highway projects have many problems, such as numerous construction participants, multitudinous influential factors and complex goal programming system of construction progress. In order to provide more effective management for construction schedule targets of the highway project, this paper divides the goal programming system of highway project...
In view of the crudeness and inaccuracy of current assessment index system for cities' science & technology innovative capability, this paper established a new index system through sustainable development theory and science & technology innovative capability. By taking full advantage of factor analysis method, which is useful and effective in data...
The saturated adsorption of the (3-mercaptopropyl)trimethoxysilane (SHC3H6Si(OCH3)3, 3-MPT) self-asemblied monolayers (SAMs) on silver powder was firstly determined. A quantitative analysis of 3-MPT suggests that there is a lower saturation adsorption than that of 1-octadecanethiol (C18H37SH) on Ag at room temperature. The exchange reaction of C18H...
A self-assembled monolayer (SAM) of (3-mercaptopropyl) trimethoxysilane (3-MPT) chemisorbed on a silver surface was chemically modified by 1-octadecanethiol (C18H37SH) to form the dense packed self-assembled mixed-monolayers (SAMM). The self-assembled mixed-monolayers were characterized by X-ray photoelectron spectroscopy (XPS), cyclic voltammetry...
The primary object of this contribution is to self-assemble DNA on 2-dimensional array of 1-dodecanethiol-encapsulated colloidal gold (2-DACG). The 2-DACG film was deposited by Langmuir-Blodgett (LB) technique. Through phase transfer of aqueous colloidal gold particles into ethanol solutions containing 1-dodecanethiol, the hydrophobic gold colloida...
