Yara Hökerberg

Fundação Oswaldo Cruz | FIOCRUZ · Instituto de pesquisa Clínica Evandro Chagas (IPEC)

Introduction: Contrary to international studies, there was an increase in sickle-cell disease (SCD) mortality rate in Brazil after the implementation of the neonatal screening program, probably due to improving access to diagnosis. Aim: To assess differences in the temporal trend of the mortality rate and median age at death from SCD in Brazil, con...

Rio de Janeiro is a dengue-endemic city that experienced Zika and chikungunya epidemics between 2015 and 2019. Differential diagnosis is crucial for indicating adequate treatment and assessing prognosis and risk of death. This study aims to derive and validate a clinical rule for diagnosing chikungunya based on 3,214 suspected cases consecutively t...

Dear Colleagues, I invite you to participate in the defense of the thesis entitled "Sickle Cell Disease in Brazil: Temporal trend and sociodemographic profile of deaths and hospitalizations, 1996 to 2020" by Karen Cordovil Marques de Souza under the guidance of Yara Hökerberg, Raquel de Vasconcellos Carvalhaes de Oliveira and de Wagner de Souza Ta...

Purpose We aimed to estimate the prevalence and delineate the profile of children with special healthcare needs (CSHCN) in the three municipalities of Brazil's southern and southeastern regions from 2015 to 2017. Design and methods This cross-sectional study included 6853 children aged 0–11 years. Participants were selected through complex samplin...

Background: Population aging and mobility have increased the exposure of elderly individuals to dengue. This study evaluated the clinical features of dengue in the elderly during the epidemic (2008 and 2012) and interepidemic (2009 and 2010) periods. Methods: This cross-sectional study was based on dengue surveillance data from Rio de Janeiro, B...

Background Diagnosing neuritis in leprosy patients with neuropathic pain or chronic neuropathy remains challenging since no specific laboratory or neurophysiological marker is available. Methods In a cross-sectional study developed at a leprosy outpatient clinic in Rio de Janeiro, RJ, Brazil, 54 individuals complaining of neural pain (single or mu...

Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testing of easy-to-perform optimized immunochromatographic methods...

Background: Although performance of rapid immunochromatographic tests (RITs) for dengue virus (DENV) serotypes 1, 2 and 3 is relatively settled, evidence on accuracy of RITs for DENV-4 are based on studies with small sample sizes and with discrepant results. Objectives: To assess accuracy and inter-observer agreement of RITs targeting dengue non...

Resumo: A pesquisa objetivou avaliar a qualidade metodológica de diretrizes do Ministério da Saúde brasileiro, da Organização Pan-Americana da Saúde (OPAS) e da Organização Mundial da Saúde (OMS) sobre vigilância e manejo clínico de dengue e chikungunya. Trata-se de um estudo descritivo, no qual a ferramenta Appraisal of Guidelines for Research & E...

In 2007–2008, the city of Rio de Janeiro underwent an epidemiological change, with increases in the incidence in children and in severe forms of dengue. To describe the clinical profile and spatial distribution of dengue we performed an ecological study based on dengue surveillance data using the Brazilian classification (2005): dengue fever, dengu...

Background Rapid immunochromatographic tests (ICT) for dengue non-structural protein 1 (NS1) have shown good performance for diagnosing acute-phase dengue in serum in laboratory settings, but rarely have been assessed in whole blood and at point of care (POC). This study compare the accuracy and inter- and intra-observer reliability of the NS1 Bioe...

Abstract An error occurred during the publication of the original article [1].

The use of highly active antiretroviral therapy has resulted in changes of comorbidity profile in people living with HIV (PLHIV), increasing non-AIDS-related events. The occurrence of cardiovascular events is greater in PLHIV, but the mechanism responsible for it is still controversial. This article aimed to investigate factors associated with the...

Objective: To evaluate the validity of clinical and laboratory signs to serious dengue disease in hospitalized children. Methods: Retrospective cohort of children (19 and negative likelihood ratio

Objective The aim of this study was to describe the use of dengue warning signs by pediatric healthcare staff in the Brazilian public health care system. Methods Cross-sectional study (2012) with physicians, nurses, and nurse technicians assisting children in five health care facilities. Participants reported the use and importance of dengue warni...

Existe um questionamento sobre aumento do risco de infecções graves pelo uso de medicamentos biológicos por pacientes com artrite reumatoide. Esta revisão sistemática de estudos observacionais objetivou avaliar o risco de infecções graves associadas ao uso de anakinra, rituximab e abatacept em pacientes com artrite reumatoide. Foram pesquisadas as...

A question is raised about an increased risk of severe infection from the use of biological drugs in patients with rheumatoid arthritis. This systematic review of observational studies aimed at assessing the risk of severe infection associated with the use of anakinra, rituximab, and abatacept in patients with rheumatoid arthritis. The following da...

This study aimed to elaborate the Brazilian version of the Children with Special Health Care Needs Screener to assess internal consistency and inter-observer agreement. The stages included translation, back-translation, expert committee review, and pretest. Participation included 140 family members of children 0-12 years of age at health services i...

Objective: To evaluate the validity of clinical and laboratory signs to severe dengue disease in hospitalized children. Methods: Retrospective cohort of children (<18 years) hospitalized with dengue diagnosis (2007-2008). Severe dengue disease was defined as death or use of advanced life support therapy. Accuracy measures and area under the rece...

Background Early diagnosis of dengue infection is important for decision-making and timely implementation of therapeutic measures. Although rapid NS1 assays have been used for dengue diagnosis since 2008, their performance in DENV-4 cases has not yet been fully assessed. Methods We evaluated the accuracy of NS1 Bioeasy™ immunochromatographic strip...

Early recognition of warning signs and treatment of severe dengue cases is the main strategy for reducing case-fatality, especially in children, who usually present few symptoms and can progress rapidly to dengue shock syndrome. The objective of this study was to elaborate the Brazilian version of the World Health Organization (WHO) staff questionn...

A identificação precoce de sinais de alarme e o tratamento de dengue grave são as principais estratégias para reduzir a letalidade da doença, principalmente em crianças, usualmente oligosintomáticas e com rápida progressão para o choque. O objetivo foi elaborar a versão brasileira do instrumento proposto pela Organização Mundial da Saúde (OMS) para...

OBJECTIVE To evaluate the cross-cultural validity of the Demand-Control Questionnaire, comparing the original Swedish questionnaire with the Brazilian version. METHODS We compared data from 362 Swedish and 399 Brazilian health workers. Confirmatory and exploratory factor analyses were performed to test structural validity, using the robust weighte...

Guidelines have been proposed for assessing the quality of clinical trials, observational studies and validation studies of diagnostic tests. More recently, the COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) initiative extended those in regards to epidemiological measurement tools in general. Among various fa...

Objective: To evaluate psychiatric comorbidities in outpatients receiving care for HIV and Chagas disease at Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Methods: Cross-sectional study with a consecutive sample of 125 patients referred to an outpatient psychiatric clinic from Febru...

The scope of this study is to investigate the association between occupational stress and self-perception of oral health. Data were obtained through a self-administered questionnaire filled out in a Pró-Saúde Study by 3253 administrative technical staff from Rio de Janeiro's State University. Occupational stress was measured by means of a questionn...

This study's objective was to revisit the internal consistency and convergent and discriminant factorial validity of the Brazilian version of WHOQOL-BREF, in a cross-sectional study of 386 health workers. Confirmatory factor analysis was used to test WHOQOL-BREF's structure (24 and 26 items) and the model suggested by exploratory factor analysis. I...

O objetivo foi reavaliar a estrutura dimensional da versão brasileira do WHOQOL-BREF, consistência interna e validade fatorial convergente e discriminante. Estudo seccional em 386 trabalhadores de saúde. A análise fatorial confirmatória testou a estrutura do WHOQOL-BREF (24 e 26 itens) e a sugerida pela análise fatorial exploratória. Consistência i...

Karasek's demand-control model has been used to investigate association between job strain and health outcomes. However, different instruments and definitions have been utilized to assess the exposure 'high strain at work', which makes difficult the comparison of results across studies. To describe the measurement instruments and the definitions ad...

We evaluated the accuracy and interobserver variation of three clinical decision rules for streptoccocal pharyngitis diagnosis. Oropharyngeal swab culture was the reference. The Abu Reesh rule had the highest sensitivity and the WHO rule showed the highest specificity. The interobserver variation of those rules indicates the need for better trainin...

Although medication is acknowledged as a key element in treating health problems, there is little information available on the use of medication by hospital workers. To estimate the prevalence and describe the patterns of medication consumption by hospital workers and to identify the factors associated with such consumption in this population, data...

Objective: To evaluate psychiatric comorbidities in outpatients receiving care for HIV and Chagas disease at Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundaçã o Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Methods: Cross-sectional study with a consecutive sample of 125 patients referred to an outpatient psychiatric clinic from Februar...

Karasek postulated that high job strain, an interaction between high psychological demands and low control at work, increases the risk of ill-health. Objective Systematic review/meta-analysis of the association between job strain and blood pressure (BP). Methods Target studies were published on Pubmed, Lilacs, SciELO, PsycInfo, Embase and Web of...

To evaluate the effectiveness and safety of assisted reproduction techniques (ART) in human immunodeficiency virus (HIV) serodiscordant couples. Systematic review of five databases of noncomparative open intervention and observational studies of serodiscordant couples undergoing ART, with study selection and data extraction performed independently...

According to Karasek, job strain results from an interaction between high demands and low decision latitude. To reassess the dimensional structure and evaluate the internal consistency of demand control support questionnaire (DCSQ), a shortened version of job content questionnaire that was not sufficiently evaluated in validation studies. The study...

The clinical and epidemiological characteristics, adverse events, treatment adherence and effectiveness of isoniazid chemoprophylaxis were analyzed in a cohort of 138 tuberculosis/HIV-coinfected patients. An open, non-randomized, pragmatic prophylactic trial was conducted on adult patients with a normal chest X-ray and positive tuberculin skin test...

One of the main challenges for clinical research in dengue is the low validity of clinical diagnosis. To analyze clinical and laboratory data as predicitve factors of dengue diagnosis at Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, during the 2001-2002 dengue outbreak in Rio de Janeiro. Cross sectional study comparing clinic...

The paper presents a discussion about the experience of building a risk map by workers in a public hospital, in Rio de Janeiro city, resting on concepts of occupational health surveillance, total quality and biosafety. It goes from the first step to persuade the workers and managers, to identify the potential sources of risk in the work environment...

The paper presents a discussion about the experience of building a risk map by workers in a public hospital, in Rio de Janeiro city, resting on concepts of occupational health surveillance, total quality and biosafety. It goes from the first step to persuade the workers and managers, to identify the potential sources of risk in the work environment...

Neste estudo, estimativas de prevalência de cinco doenças crônicas - cirrose, depressão, diabetes, insuficiência renal crônica e tuberculose - obtidas pelo Suplemento Saúde da PNAD/98 foram comparadas com as obtidas no Projeto Carga Global de Doença no Brasil. Essas estimativas foram baseadas em análise sistemática de literatura e banco de dados de...

In this study, prevalence estimates of five chronic disease cirrhosis, depression, diabetes, chronic rhenal insufficiency and tuberculosis based on the 1998 PNAD Health Supplement were compared to those obtained by the Brazilian Global Burden of Disease Project. These estimates were based on systematic literature review as well as on available data...

This study assesses the health care provided to Kaingáng Indians in Rio Grande do Sul, Brazil. Deaths preventable by primary health care among the Indians and occurring from 1985 to 1995 were compared to the same rates for the State of Rio Grande do Sul as a whole. Secondary data on health care services were supplemented by field interviews with in...

Este estudo pretende avaliar o atendimento à saúde prestado aos índios Kaingáng do Rio Grande do Sul. Os óbitos evitáveis por assistência básica de saúde dos indígenas, ocorridos entre 1985 e 1995, foram comparados aos óbitos do Estado do Rio Grande do Sul. Os dados secundários relativos aos serviços de saúde foram complementados por entrevistas re...

Resumo -A vigilância em saúde, especialmente as sub-áreas de vigilância epidemiológica e biossegurança, necessita de identificação precoce e confirmação rápida de casos suspeitos, visando a aplicação oportuna de medidas de controle. A lentidão nesta identificação tem pressionado os gastos públicos em saúde e contribuído para a piora da qualidade da...

The paper presents a discussion about the experience of building a risk map by workers in a public hospital, in Rio de Janeiro city, resting on concepts of occupational health surveillance, total quality and biosafety. It goes from the first step to persuade the workers and managers, to identify the potential sources of risk in the work environment...

Health surveillance needs early detection and fast confirmation for suspected cases, aiming opportune application of control measures. Informatics incorporation to health surveillance processes is a strategic initiative. The VIGINet proposal includes development of a decision support network for health surveillance activities, through the developme...

O modelo demanda e controle de Karasek, elaborado na década de 1970, postula que os trabalhadores expostos a situações de alta exigência no trabalho, decorrente da combinação entre altas demandas psicológicas e baixo controle sobre o processo de trabalho, tem maior risco de apresentar eventos em saúde relacionados ao estresse, em particular doenças...

Estuda a saude das populacoes indigenas com as especificidades numericas e culturais da maioria destes grupos, com o intuito de integrar a informacao com a pratica dos servicos de saude nas areas onde estao inseridos, partiu-se dos dados de saude produzidos para a etnia Kaingang no Rio Grande do Sul. A metodologia consiste da analise dos dados quan...