Wei Zhang

Fudan University · Hospital of Obstetrics and Gynecology

Previous studies have documented the negative association between school connectedness and deviant peer affiliation among adolescents. The potential mediating mechanisms linking school connectedness to deviant peer affiliation, however, have not fully examined. Thus, the present study aimed to examine the potential mediating effect of sleep problem...

Background Simultaneous detection of multiple molecular biomarkers is helpful in the prediction of treatment response and prognosis for colorectal cancer (CRC) patients. Methods A 22-gene panel consisting of 103 hotspot regions was utilized in the formalin-fixed paraffin-embedded (FFPE) tissue samples of 207 CRC patients, using the next-generation...

The distributions of HLA allele and haplotype are variable in different ethnic populations and the data for some populations have been published. However, the data on HLA‐C and HLA‐DQB1 loci and the haplotype of HLA‐A, HLA‐B, HLA‐C, HLA‐DRB1 and HLA‐DQB1 loci at a high‐resolution level are limited in Zhejiang Han population, China. In this study, t...

This paper investigates the robust stability of inertial bidirectional association memory (BAM) neural networks with time delays and uncertainties via impulsive control. Firstly, utilizing suitable variable substitution, the seconded-order inertial BAM neural networks can be transformed into first-order differential equations. Secondly, Under the f...

Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions. Evidence is growing that epigenetic variation, particularly DNA methylation, is associated with...

Stock markets are efficient in the weak form in the sense that no significant autocorrelations can be identified in the returns. However, the microscopic mechanisms are unclear. We aim at understanding the impacts of order flows on the weak-form efficiency through computational experiments based on an empirical order-driven model. Three possible de...

Deep learning (DL) training-as-a-service (TaaS) is an important emerging industrial workload. The unique challenge of TaaS is that it must satisfy a wide range of customers who have no experience and resources to tune DL hyper-parameters, and meticulous tuning for each user's dataset is prohibitively expensive. Therefore, TaaS hyper-parameters must...

In this paper, we determine the impact of searching behavior on the evolutionary minority game (EMG). We introduce searching behavior in two ways: optimal neighbor searching and global searching. Our study investigates the distribution equilibriums of probabilities that agents follow a given strategy and on system performance of the game. The resul...

In this article, a new process for the synthesis of metal-organic framework (MOF) particles that uses water as the only solvent is presented. High-quality Cu3(BTC)2 (BTC = 1,3,5-benzenetricarboxylate) crystals were obtained via a facile and environmentally benign route in water at room temperature by directly mixing aqueous solutions of Cu(NO3)2 an...

Large area/delay/power overheads are required to support the reconfigurability of field-programmable gate arrays (FPGAs). We proposed a hybrid CMOS/nanotechnology dynamically reconfigurable architecture, called NATURE, earlier to address this challenge. It uses the concept of temporal logic folding and fine-grain (i.e., cycle-level) dynamic reconfi...

Aim: To investigate the potential genetic effect on metformin efficacy in overweight or obese Chinese Type 2 diabetes mellitus (T2DM) patients. Patients & methods: 768 SNPs in or close to 207 genes were genotyped in 84 patients treated with metformin + glibenclamide/Xiaoke Pill. Significant SNPs were then verified in 107 recent-onset overweight...

The eukaryotic translation initiation factor 3a (eIF3a) is one of the core subunits of the translation initiation complex eIF3, responsible for ribosomal subunit joining and mRNA recruitment to the ribosome. Our previous study identified that it was correlated with platinum response in lung cancer. The current study aims to test the hypothesis that...

Dual-functional drug delivery system was developed by decorating c(RGDyK) (cyclic RGD [arginine-glycine-aspartic acid] peptide) with Pluronic polymeric micelles (c[RGDyK]-FP-DP) to overcome the drawbacks of low transport of chemotherapeutics across the blood–tumor barrier and poor multidrug-resistant (MDR) tumor therapy. c(RGDyK) that can bind to t...

AKT and ERK pathways are known to be activated in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), which play crucial roles in the pathogenesis and joint destruction of RA. Sprouty2 (SPRY2) has been known as a tumor suppressor by preventing both ERK and AKT signaling activations. Whether SPRY2 can function as a suppressor in tumo...

This paper focuses on the hybrid effects of Markovian switching, stochastic perturbation, and impulsive delay on neural networks. First, some novel generic criteria for Markovian switching neural networks with stochastic perturbation and impulsive delay are derived by establishing an extended Halanay differential inequality on impulsive dynamical s...

Soil saturated hydraulic conductivity (K s) is one of the most important parameters that determine soil water redistribution. However, it is little known in a karst area with thin, discontinuous, and rocky soils. The purpose of this paper was to investigate the spatial variability of K s and its influencing factors in a small karst catchment with h...

There is substantial literature documenting the negative association between secure parental attachment and lower adolescent delinquency, but little is known about the mediating mechanisms (i.e., how does parental attachment relate to delinquency?) underlying this relation. The present study examined whether secure parental attachment would be indi...

Chemoresistance is a major challenge in cancer treatment. miR-506 is a potent inhibitor of the epithelial-to-mesenchymal transition (EMT), which is also associated with chemoresistance. We characterized the role of miR-506 in chemotherapy response in high-grade serous ovarian cancers. We used Kaplan-Meier and log-rank methods to analyze the relatio...

The Botryosphaeriaceae represents an important, cosmopolitan family of pathogens infecting woody plants. Grapevines (Vitis vinifera) suspected of being affected by Botryosphaeria dieback were collected from different Provinces of China and several Botryosphaeriaceae species were identified. This research was conducted to further study the species o...

Pseudocercospora is an important plant pathogenic genus causing leaf spots on grapevine leaves and other hosts worldwide. A survey of vineyards in four provinces of China was carried out to identify the causal agent of Pseudocercospora leaf spot. A phylogenetic analysis based on a combination of LSU, ITS and ACT loci, coupled with morphology, showe...

Activation of platelet implicated a series of signal conduction including outside-in and inside-out related receptor-mediated signaling pathways. Ticagrelor is the first reversible P2Y12 receptor antagonist that exhibits rapid antiplatelet effect. Given that platelet aggregation varies among individuals, genetic polymorphisms in P2Y12 and subsequen...

Acute graft-versus-host disease (aGVHD) is one of the major causes of morbidity and mortality in patients receiving allogeneic hematopoietic cell transplantation (allo-HSCT). MicroRNAs (miRs) were found to have the potential to be the new biomarkers of aGVHD. In this study, we collected samples from 98 patients who underwent allo-HSCT; 63 patients...

A botryosphaeriaceous taxon causing fruit pedun-cle and pedicel discolouration was found infecting grapevines in Hubei and Jiangsu Provinces in China. Morphological and phylogenetic analyses showed the taxon to be Lasiodiplodia pseudotheobromae. Pathogenicity testing and Koch's postulates proved that Lasiodiplodia pseudotheobromae caused fruit pedu...

Synchronization of an array of linearly coupled memristor-based recurrent neural networks with impulses and time-varying delays is investigated in this brief. Based on the Lyapunov function method, an extended Halanay differential inequality and a new delay impulsive differential inequality, some sufficient conditions are derived, which depend on i...

Background and aims Nitrogen (N) and/or phosphorus (P) limitation to primary productivity and other biological processes can change in a variety of ways as ecosystems develop. How N limitation and P limitation change from the early to the late stages of a secondary succession following farmland abandonment remains unclear in karst ecosystems in sou...

Key message Soil nitrogen and phosphorus are the most important factors influenced the leaf N:P ratios across plant functional groups in the karst region of southwestern China, and plant diversity are also important to certain groups. Abstract Leaf nitrogen:phosphorus (N:P) stoichiometry, which affects plant growth, nutrient cycling, and primary...

Fibroblast growth factor receptor (FGFR) is a potential target for cancer therapy. Based on the structure of AZD4547 and NVPBGJ-398, we designed novel 1H-indazol-3-amine scaffold derivatives by utilizing scaffold hopping and molecular hybridization strategies. Consequently, twenty-eight new compounds were synthesized and evaluated for their inhibit...

Hepatocellular carcinoma (HCC) is a multi-factor, multi-step, multi-gene and complicated process resulting from the accumulation of sequential genetic and epigenetic alterations. An important change among them is from precancerous lesions to HCC. However, only few studies have been reported about the sequential genetic changes during hepatocarcinog...

In the current study, we examined a moderated mediation model using the risk and resilience framework. Specifically, the impact of family material hardship on adolescent problem behaviors was examined in a Chinese sample; we used the family stress model framework to investigate parental depression and negative parenting as potential mediators of th...

In recent years, great effort has been made to explore new biomarkers for early detection of prostate cancer. Our previous study has demonstrated the high prevalence of TTTY15-USP9Y in prostate cancer samples from a Chinese population. Our aim was to evaluate the clinical utility of TTTY15-USP9Y in predicting the prostate biopsy outcome. We retrosp...

Organic anion transporting polypeptide 1B1 (OATP1B1) is the most important transporter in the organic anion transporting polypeptide family. OATP1B1 plays an important role in the hepatic uptake of many endogenous compounds and xenobiotics, including many clinical drugs. At present, the combinational usage of Chinese traditional herbal medicines an...

This paper aims to design an appropriate switching law to stabilize the switched neural networks with time-varying delays when all subsystems are unstable. By using the discretized Lyapunov function approach and the extended comparison principle for impulsive systems, the stability of switched delayed neural networks composed full of unstable subsy...

The receptor-binding specificity of influenza A viruses is a major determinant for the host tropism of the virus, which enables interspecies transmission. In 2013, the first human case of infection with avian influenza A (H6N1) virus was reported in Taiwan. To gather evidence concerning the epidemic potential of H6 subtype viruses, we performed com...

AKT and ERK pathways have been implicated as therapeutic targets for human rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) inhibition, and thus RA treatment. Sprouty2 (SPRY2) has been known as a tumor suppressor by blocking both ERK and AKT signaling cascades. Whether SPRY2 can function as a suppressor of tumor-like inflammatory FLS a...

Objective To present our experience on pyelolithotomy with simultaneous endoscopic lithotripsy for the treatment of staghorn calculi in a solitary kidney.MethodologyFive patients were recruited from January 2010 to April 2012. A small oblique lumbar incision was used to expose the renal pelvis for pyelolithotomy. The cystoscope and/or ureteroscope...

Trunk diseases in grapevine (Vitis spp.) are major problems in the wine and table-grape industries reducing the productivity, quality and longevity of vineyards. Species of Diaporthe are important fungal pathogens of grapevine trunk disease worldwide. A survey of 14 grape vineyards located in different provinces of China was yielded Diaporthe isola...

Ge2Sb2Te5 (GST) is an important phase-change material used in optical and electronic memory devices. In this work, crystal growth of GST at 600 K is investigated by ab initio molecular dynamics. Simulations of two different crystallization processes are performed. In the first set of simulations, the growth of crystalline nuclei generated using the...

Background Human cytomegalovirus (CMV) is an opportunistic pathogen that can be treated with ganciclovir. Mutations in the UL97 gene of CMV render the virus ganciclovir resistance. These include H520Q and C603W mutations, against which we developed a novel genotyping assay for their identification.MethodsPCR reactions were performed to amplify frag...

Adhensive small-bowel obstruction (SBO) remains a common cause of admission to surgical wards around the world. Given the growing elderly population, the number of elderly patients with adhensive SBO can be expected to increase substantially. Timely and appropriate treatment would improve morbidity and mortality rates in elderly patients with adhen...

To investigate the microRNA101(miR101) expression and its clinical significance in colorectal cancer. Tissue microarrays containing 56 specimens of normal mucosa, 51 adenoma and 735 colorectal cancer were examined by locked nucleic acid in-situ hybridization(LNA-ISH) for miR101 expression. Relationship between miR101 expression and clinicopathologi...

Transition nuclear proteins (TNPs), major proteins found in the chromatin of condensing spermatids, have been implicated in spermatogenesis and male fertility. In this study, DNA samples were collected from 404 Chinese Holstein bulls and sequenced to identify genetic variants in the 3'-untranslated region (UTR) of TNP1 and to investigate genetic va...

Although doxorubicin (DOX) and paclitaxel (PTX) are widely used in clinic as chemotherapeutics, both drug substances are found to be glycoprotein P (P-gp) substrates which are liable to develop the multidrug resistance (MDR). Additionally, the use of single chemotherapeutic drug has known limitations such as high toxicity profile due to the relativ...

This study is aimed to find the best predictive model for warfarin stable dosage. Seven models, namely multiple linear regression (MLR), artificial neural network, regression tree, boosted regression tree, support vector regression, multivariate adaptive regression spines and random forest regression, as well as the genetic and clinical data of two...

Cyantraniliprole is the newest anthranilic diamide insecticide acting on ryanodine receptors with higher efficacy, broader spectrum than chlorantraniliprole on pest control. To study effects of its residues on the environment and food samples, an enzyme-linked immunosorbent assay (ELISA) has been developed. The hapten was synthesized and conjugated...

While nature employs various covalent and non-covalent strategies to modulate tyrosine (Y) redox potential and pKa to optimize enzyme activities, such approaches have not been systematically applied for the design of functional metalloproteins. Through the genetic incorporation of 3-methoxytyrosine (OMeY) into myoglobin, we recapitulated important...

Previous studies have characterized the migration and invasion inhibitory protein (MIIP) as a novel putative tumor-suppressor gene that regulates cell migration and invasion as well as the mitotic checkpoint. The MIIP gene is located on chromosome 1p36.22, a common site for deletion in many solid tumors including breast cancer. In the present study...

Objective: Regulators of G-protein signaling protein 2 (RGS2) play an irreplaceable role in the control of normal blood pressure (BP). One RGS2 (-391, C>G) genetic variation markedly changes its mRNA expression levels. This study explored the relationship between this genetic variation and the responses to antihypertensive drugs in Chinese patient...

The increasing power consumption of integrated circuits (ICs) enabled by technology scaling requires more efficient heat dissipation solutions to improve overall chip reliability and reduce hotspots. Rapidly growing 3-D IC technology strengthens the requirement with more devices stacked per unit area. Thermal interface material (TIM) and MicroChann...

Currently there is no predictor for survival after adjuvant sorafenib in patients with hepatocellular carcinoma (HCC) who have undergone curative resection. Thirty-eight patients who underwent curative resection of HCC received adjuvant sorafenib therapy between August 2009 and March 2012. Clinicopathological parameters including patient factors, t...

Polyvinylpyrrolidone (PVP)-modified MoS3 nanoparticles with unusual water solubility up to 1.0 mg mL(-1) were synthesized through a facile hydrothermal method in the presence of thioacetic acid. The amorphous nanoparticles wrapped by PVP have sizes of around 2.5 nm, which represent the smallest MoS3 clusters reported. The photocatalytic performance...

The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found tha...

Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion...

Patients with microinvasive carcinoma often have favorable prognosis, but it remains unclear whether this special type of breast cancer represents a distinct morphological entity with its own biological features and clinical behavior distinct from those of ductal carcinoma in situ (DCIS). The study is a retrospective analysis of a large patient coh...

Nineteen new derivatives based on the structure of marine natural product tasiamide B were designed, synthesized, and evaluated for their inhibitory activity against BACE1, a potential therapeutic target for Alzheimer's disease. The hydrophobic substituents Val at P3 position, Leu at P1' position, Ala at P2' position, and Phe at P3' position were f...

Patients with prehypertension are more likely to progress to manifest hypertension than those with optimal or normal blood pressure. However, the mechanisms underlying the development from prehypertension to hypertension still remain largely elusive and the drugs for antihypertensive treatment in prehypertension are absent. Here we determined the e...

Price limit trading rules are adopted in some stock markets (especially emerging markets) trying to cool off traders' short-term trading mania on individual stocks and increase market efficiency. Under such a microstructure, stocks may hit their up-limits and down-limits from time to time. However, the behaviors of price limit hits are not well stu...

A number of chaos-based image encryption algorithms have been proposed in recent years, and most of them employ confusion-diffusion architecture. This paper presents a new confusion scheme based on paired interpermuting planes. In the proposed new confusion operation, an “exchange and random access strategy” is employed to replace the traditional c...

Saturated hydraulic conductivity (Ks) is one of the most important soil hydraulic parameters influencing hydrological processes. This paper aims to investigate the vertical distribution of Ks and to analyze its influencing factors in a small karst catchment in Southwest China. Ks was measured in 23 soil profiles for six soil horizons using a consta...

The aim was to investigate the clinical efficacy and safety of extracorporeal shock wave lithotripsy (ESWL) in pediatric urolithiasis. A comprehensive systematic review and meta-analysis were performed. PubMed, Embase, and the Cochrane central register of controlled trials (CENTRAL) were searched, and the stone-free rates (SFRs) of various stone si...

Although the slopes of size spectra (plots of abundance on organism size) have been widely used to assess aquatic and terrestrial communities, size spectra have not been used to assess soil nematode communities. Two forms of size spectra (one based on the average biomass of nematode genera and another based on the average biomass of nematode size c...

The complexity of rheumatoid arthritis (RA) pathogenesis makes combined blockade of key pathogenic factors an attractive therapeutic strategy. We have previously reported a novel recombinant adeno-associated virus (AAV) vector, AAV.TFCF, which mediates separate coexpression of TNFα antagonist TNFR-Fc and T cell antagonist CTLA4-FasL both in vitro a...

Background Hypertension is the most common chronic disease and the calcium channel antagonist is the most popularly used antihypertensive drug in Chinese patients. Azelnidipine is a third generation and long-acting dihydropyridine calcium channel antagonist. A series of research has demonstrated that azelnidipine produced an effective antihypertens...

In this paper, we study global exponential stability problem for inertial BAM neural networks with time-varying delay via periodically intermittent control. By utilizing suitable variable substitution, the second-order system can be transformed into first-order differential equations. It is shown that the states of the inertial BAM neural networks...

Background and aims Nitrogen (N) and/or phosphorus (P) limitation to primary productivity and other biological processes can change in a variety of ways as ecosystems develop. How N limitation and P limitation change from the early to the late stages of a secondary succession following farmland abandonment remains unclear in karst ecosystems in sou...

The quenching of electrochemiluminescence by single-walled carbon nanohorn has been demonstrated for the first time. Moreover, a sensitive, label-free, and signal-on electrochemiluminescence ATP aptasensor was developed using single-walled carbon nanohorn as both quencher and scaffold.

Objective: To establish a polymerase chain reaction sequencing-based typing (PCR SBT) method for HLA-DPB1 exons 2 and 3, and to analyze their polymorphisms. Methods: Based on the sequences of HLA-DPB1 loci, locus-specific primers were designed and applied to amplify the target sequences encompassing the entire exons 2 and 3 of HLA-DPB1. The ampl...

MicroRNAs (miRNAs) are a class of highly conserved small noncoding RNAs which can regulate gene expression by post-transcriptional degradation or translational repression. miRNAs are involved in the regulation of cell apoptosis, proliferation, differentiation and other physiological processes, and are closely related with development of cancer. Mor...

There are no appropriate variables for predicting postoperative morbidity in Crohn's disease (CD) patients with severe malnutrition. We examined a retrospective cohort to clarify these. Between 2005 and 2013, 138 CD patients with severe malnutrition underwent elective intestinal resection after preoperative management, consisting of nutritional sup...

Esophageal squamous cell carcinoma (ESCC) is one of most common and fatal forms of cancer worldwide. Recent studies have suggested that an aberrant microRNA (miRNA or miR) expression signature exists in ESCC. In the present study, in order to determine the involvement of miRNA in the development and progression of ESCC, the expression profiles of m...

The objective of the study was to evaluate the feasibility and safety of balloon dilation for 'X-ray'-free ultrasound-guided percutaneous nephrolithotomy (PCNL). From January 2012 to December 2012, patients underwent 'X-ray'-free ultrasound-guided PCNL with Amplatz dilator (Group A). From January 2013 to April 2014, patients underwent 'X-ray'-free...

Varicocele repair in adolescent remains controversial. Our aim is to identify and combine clinical trials results published thus far to ascertain the efficacy of varicocelectomy in improving testis volume and semen parameters compared with nontreatment control. A literature search was performed using Medline, Embase and Web of Science, which includ...

We conducted a study to evaluate the impact of the exclusive enteral nutrition (EEN) on perioperative outcome in Crohn's disease (CD) patients following immunosuppressive therapy. Patients with CD followed at a referral center between January 2001 and March 2014 who underwent abdominal surgery were identified. Patients were divided into 4 groups: p...

The aim of the present study was to detect the susceptibility of Ureaplasma urealyticum to methylene blue-mediated photodynamic antimicrobial chemotherapy (PACT). Three U. urealyticum strains including the standard serotype 1 and 5, and a clinically collected strain were used in this study. Strains were first incubated in 96-well culture plates in...

Prostate cancer is the third most common cause of male cancer death in developed countries, and one of the most comprehensively characterized human cancers. Roughly 60% of prostate cancers harbor gene fusions that juxtapose ETS-family transcription factors with androgen regulated promoters. A second subtype, characterized by SPINK1 overexpression,...

To explore the feasibility and efficacy of docetaxel plus prednisone for Chinese population with metastatic castration refractory prostate cancer (mCRPC). A total of 228 patients recruited from 15 centers were randomized to receive 10 cycles of D3P arm (docetaxel: 75 mg/m2, intravenous infusion, every three weeks; Prednisone 10mg orally given daily...

Killer cell immunoglobulin like receptor (KIR) 3DS1 is one of the most important activating receptors and some studies revealed that KIR3DS1 combined with HLA ligand was not related to acute myeloid leukemia (AML), but rare data was reported in Chinese population. In this study, KIR3DS1 gene polymorphisms and HLA-Bw4 were investigated in 189 Chines...

Objective Growing evidence indicates that the activation of c‐Jun N‐terminal kinase (JNK) is implicated in the multiple major pathological features of Alzheimer disease (AD). However, whether specific inhibition of JNK activation could prevent disease progression in adult transgenic AD models at moderate stage remains unknown. Here we first investi...

Cancer stem-like cell (CS-like cell) is considered to be responsible for recurrence and drug resistance events in breast cancer, which makes it a potential target for novel cancer therapeutic strategy. The FDA approved flubendazole, has been widely used in the treatment of intestinal parasites. Here, we demonstrated a novel effect of flubendazole o...

Radiogenomics is the whole genome application of radiogenetics, which focuses on uncovering the underlying genetic causes of individual variation in sensitivity to radiation. There is a growing consensus that radiosensitivity is a complex, inherited polygenic trait, dependent on the interaction of many genes involved in multiple cell processes. An...

Background Long non-coding RNA (LncRNA) PCA3 has been a well-established urine biomarker for the detection of prostate cancer (PCa). Our previous study showed a novel LncRNA FR0348383 is up-regulated in over 70% of PCa compared with matched benign tissues. The aim of this study was to evaluate the diagnostic value of urinary FR0348383 for men under...

Following the first human infection with the influenza A (H10N8) virus in Nanchang, China in December 2013, we identified two additional patients on January 19 and February 9, 2014. The epidemiologic, clinical, and virological data from the patients and the environmental specimen collected from 23 local live poultry markets (LPMs) were analyzed. Th...

Since December 2013, at least three cases of human infections with H10N8 avian influenza virus have been reported in China, two of them being fatal. To investigate the epidemic potential of H10N8 viruses, we examined the receptor binding property of the first human isolate, A/Jiangxi-Donghu/346/2013 (JD-H10N8), and determined the structures of its...

Mesenteric adipose tissue hypertrophy is unique to Crohn's disease while the molecular basis of the crosstalk between MAT and the intestinal inflammation is largely unknown. Telmisartan is an angiotensin II type 1 receptor blocker and a peroxisome proliferator-activated receptor- receptor-γagonist which has beneficial effects on fat distribution an...

Bacterial DNA (bactDNA) translocation occurs frequently in patients with Crohn's disease and can be present in patients with a negative blood microbiological culture. We aimed to determine the effects of bactDNA translocation on postoperative outcomes in Crohn's patients undergoing abdominal surgery. Patients with Crohn's disease who underwent abdo...

Flag leaf-related traits (FLRTs) are determinant traits affecting plant architecture and yield potential in wheat (Triticum aestivum L.). In this study, a recombinant inbred line population with 188 lines, derived from the cross between Kenong9204 and Jing411, was developed to identify quantitative trait loci (QTL) for flag leaf width (FLW), length...

Platinum-based chemotherapy is the main treatment method for lung cancer patients. The genetic polymorphisms of Wnt-inducible signaling pathway protein 1 (WISP1) were reported to be associated with the development of diverse lung diseases. In this study, we aimed to investigate the relationship of WISP1 genetic polymorphisms with lung cancer suscep...

Ginsenosides in plant samples have been extensively studied because protopanaxadiol saponins are ubiquitous in Chinese patent medicines, in which they can be used in promoting human health as the main active ingredients. A method for rapid determination of two ginsenosides (Rg1 and Re) in Naosaitong (NST) samples using near-infrared reflectance spe...

We determined c-kit expression in the stroma and epithelia of benign, borderline, and malignant phyllodes tumors (PTs), respectively, as well as the relationship between c-kit expression in stromal elements and KIT gene copy number variations (CNVs). To assess c-kit expression and KIT CNVs, 348 PT cases were studied: 120 (34.4 %) benign cases, 115...

TrkC, a member of neurotrophin receptor family, functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. Little is known on the action of TrkC for the clinical prognosis and the progression of breast cancer according to the availability of its ligand NT-3. We sought to inve...

Multiplexed assay of analytes is of great importance for clinical diagnostics and other analytical applications. Barcode-based bioassays with the ability to encode and decode may realize this goal in a straightforward and consistent manner. We present here a microfluidic barcoded chip containing several sets of microchannels with different widths,...