Wasfi A. Al-Masoudi

University of Basrah · Department of Physiology (Veterinary Medicine)

Herein, a novel series of 1,5‐disubstituted‐1,2,3‐triazolines containing 1‐(4‐chlorobenzhydryl) piperazine moiety (8–18) were synthesised and evaluated for their anticancer activity across eight human tumor cell lines. Remarkably, compound 11 substituted with 3‐acetylphenyl group was the most potent anticancer agent against three selected human can...

To investigate the antiproliferative activity associated with the piperazine framework, a series of benzhydryl piperazine derivatives 8–18 were synthesized and characterized both spectroscopically and structurally. The antiproliferative activity of these compounds against eight human tumor cell lines was assessed. Among the tested compounds, compou...

Condensation 2-hydroxy-1-naphthaldehyde with L-methionine yielded E-((2)-(((2-hydroxynapthalene-1-yl)ethylene)amino)-4-(methylthio) butanoic acid 1 in a good yield. Metal complexes of Schiff base 1 have also been derived with Cu(II), Pb(II), and Co(II) metal salts were synthesized. Elemental analysis (CHN), IR, 1H, 13C, and NMR spectroscopy were us...

Tritrichomonas foetus causes a venereal disease in cattle called bovine trichomoniasis. T. foetus lives in the reproductive tract of the cow, the surface of the penis and prepuce of the bull and causing early fetal loss and sometimes late term abortions. It can also extend breeding / calving season. In this study, 155 cows of different ages (2-6 ye...

An important cause of sexually transmitted diseases, Trichomonas vaginalis is a parasite that inhabits the vaginal cavity. Several ways (direct contact, or using unhealthy public toilets) can spread trichomoniasis to children, adults, and pregnant women. This study aims to compare and determine between (microscopic observation of motile parasite in...

One hundred fifty urine samples from males and females patients were collected during eleven months from February to December 2020 .The samples were microbiologically examined, and the E. coli isolates were confirmed biochemically and by PCR targeting the 16S rRNA gene of E. coli. The prevalence of the iutA and iroN virulence genes was determined u...

Avian pathogenic strains of Escherichia coli (APEC) cause various illnesses in birds and are responsible for significant economic losses in the avian industry around the world. Escherichia coli strains isolated from dead chickens in the north of Basrah city commercial farms for four months between February and November 2020 were analyzed for their...

Trichomoniasis is a sexual transmitted disease that affects human fertility, abortion, low birth weight, in women, caused by the protozoan parasite Trichomonas vaginalis. The aim of the study was to determine the efficacy of different techniques for diagnosing of trichomoniasis in women. A case control study was carried out 230 women their age from...

Abstract Amino-2- (trifluoromethyl) benzimidazole was condensed with a number of aldehydes to produce Schiff bases as new derivatives of benzimidazole with good yields. The synthesized compounds were characterized by infrared spectroscopy, 1H, 13C- NMR, and two-dimensional (HSQC, HMBC)-NMR spectroscopy. The antibacterial activity was tested using i...

The effect of oral administration of 200mg/kg BW of aspirin on mitotic study in albino male rats were investigated, the aspirin and colchicine drugs were administrated for two hours and the samples were collected for studies. The results showed, treatment of rats for two hours with 200mg/kg BW of aspirin orally caused reduction in cell division at...

Condensation of Sulfamethoxazole with 3,4-dihydroxy benzaldehyde yielded Schiff base derivative in good yield. Characterization of synthesized compound detected by Infra-red (IR) and 1 HNMR spectroscopy via nuclear magnetic resonance 600 MHz. The synthesized compound was screened for antibacterial activity against gram positive and gram negative ba...

Pathogenic Escherichia coli strains cause a wide range of extra intestinal infections including urinary tract infection in humans and colibacillosis in poultry. They are classified into uropathogenic E. coli (UPEC) and avian pathogenic E. coli (APEC) with genetic similarities and variations. According to the relationship between UPEC and APEC genes...

Condensation of Sulfamethoxazole with 3,4-dihydroxy benzaldehyde yielded Schiff base derivative in good yield. Characterization of synthesized compound detected by Infra-red (IR) and 1 HNMR spectroscopy via nuclear magnetic resonance 600 MHz. The synthesized compound was screened for antibacterial activity against gram positive and gram negative ba...

The design and production of innovative and safer drugs attracted to organic chemists is urgently required in order to synthesize new compounds with the potential of biological and chemotherapeutic activities. We're reporting here, the condensation of 4-aminobenzene-1-sulfonamide (sulphanilamide drug) with 4-Hydroxy-3-methoxy-benzaldehyde (vanillin...

Condensation of cefotaxime drug with aromatic aldehydes (Piperonal, 2-hydroxy-1-naphthaldehyd, 4-hydroxy-3-methoxy benzaldehyde, 3,4-dihydroxy benzaldehyde and p-phthaldehyde yielded Schiff bases in good yield. Spectroscopic characterization such as, IR and NMR of new compounds have been obtained by using nuclear magnetic resonance 600 MHz. The syn...

There is an urgent need for the design and development of new and safer drugs for the treatment of HIV infection, active against the currently resistant viral strains by development of new non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of pregnenolone analogues, 3-((aryl)-1-(5-pregnen-3β-ol-17-yl)prop-2-en-1-ones, were synthesiz...

A novel steroid namely 15-((2-(5-(1-(6-methoxynaphthalen-2-yl)ethyl)-1,3,4-oxadiazol-2-yl)ethyl)thio)-5-pregnen-3β,17-diol (Monoxeprol) has been synthesized from reaction of the steroid ((5-pregnen-3β,17-diol-15-yl)thio)propane hydrazide and naproxen in the presence of POCl3. It is well-known that steroids possess biological importance, in addition...

A novel steroid namely 15-((2-(5-(1-(6-methoxynaphthalen-2-yl)ethyl)-1,3,4-oxadiazol-2-yl)ethyl)thio)-5-pregnen-3β,17-diol (Monoxeprol) has been synthesized from reaction of the steroid ((5-pregnen-3β,17-diol-15-yl)thio)propane hydrazide and naproxen in the presence of POCl3. It is well-known that steroids possess biological importance, in addition...

Objective: Our present investigation is based on development and synthesis for new derivatives of amoxicillin as the wide use of this antibiotic led to serious medical problem of drugs resistance. Methods: Condensation of amoxicillin trihydrate with 4-Hydroxy-3-methoxy benzaldehyde yielded a novel Schiff base derivative of amoxicillin in good yield...

The synthesis of new organic compounds has drawn the attention of organic chemists with the potential for biological and chemotherapeutic activities. New oxime derivative was prepared by 5-Bromo-1H-indole-2,3-dione with hydroxyl amine hydrochloride. In our current study, rat model was used to determine the toxicity of the synthesized compound. The...

Newcastle disease is a highly contagious and devastating viral disease of poultry that distributed worldwide causing large economic losses in the poultry industry. Although vaccines are being used to control the disease, there is no effective antiviral drug used for the treatment of infections. The aim of this study is to test garlic oil for its an...

The experiment was done to examine the effect of sulfanilamide and HSV on hematological and some biochemical parameters in addition histopathological changes in male rabbits, this experiment was carried out on 18 male rabbits, these animal acclimatized for one week before then divided into three groups (6 rabbits in each). First group as control gr...

The experiment was done to examine the effect of sulfanilamide and HSV on hematological and some biochemical parameters in addition histopathological changes in male rabbits, this experiment was carried out on 18 male rabbits, these animal acclimatized for one week before then divided into three groups (6 rabbits in each). First group as control gr...

The sulfamethaxazole derivative was prepared based on the condensation of sulfamethaxazole with aldehyde to yield Schiff base in good yield. A synthesized compound was characterized by elemental analysis (CHN), IR and NMR spectroscopy. The efficacy of this drug has been detected as a viral antagonist based on its direct effect on viral surface prot...

The Schiff-base of benzothiazole derivative was prepared by reaction of 2-Amino-6-methoxy benzothiazole with 4-Hydroxy-3-methoxy benzaldehyde in good yield. A synthesized compound was characterized by elemental analysis (CHN), IR and NMR spectroscopy. The toxicity of the compound was assayed via the determination of their LD50 value by using Dixon,...

the present study was aimed to investigate the potential effect of crude extract of brassicea juncea seed in alleveting hematological and serum biochemical altreations induced by cadmium chlorid toxicty in rats.

A new series of mononuclear ruthenium(II) complexes of the type [Ru(PPh3)2(N,S-L1–3)2] 2H3O⁺.(Cl⁻)2.XH2O, [RuCl(dmso)3(N,S-L1–3)], and [Ru2(Cl⁻)2(N,S-L1–3)2].XH2O, where L¹ is ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-pyrimidine-5-carboxylate (monastrol), and L² and L³ are the 4-hydroxyphenyl and 4-bromophenyl analogs of monastrol have been prepa...

There is an urgent need for the design and development of new and safer drugs, this has attracted organic chemists to synthesize new compounds with potential of biological and chemotherapeutic activities. Here we report, the condensation of phenylethylamine with 2-hydroxy naphthaldehyde yielded Schiff base derivative in good yield. Characterization...

This study was designed to investigate the impact of sulfanilamide and sulfanilamide combined with vitamin E on-some biochemical and hematological parameters in adult male rabbits, this experiment was carried out on 18 male rabbits of (1000-1600 gm) were used in this study, these animal were adapted for one week before then were split into three gr...

The pyrimidine derivative was prepared based on the cyclic condensation of 1,3- beta diketone with guanidine according to the Traube method in good yield. A synthesized compound was characterized by elemental analysis (CHN), IR and 1H-NMR spectroscopy. The toxicity of the compound was assayed via the determination of their LD50 value by using Dixon...

To examine the effect of sulfanilamid and HSV on Hematological and some biochemical parameters in addition histopathological chsnges in male rabbits, this experiment was carried out on 18 male rabbits, the treatment continues for three weeks, the result showed in group treated with sulfanilamide significantly reduction in RBC, Hb, PCV, MCH,MCHC and...

The aim of the study is to investigate the role of new schiff base derived from methionine in preventing the disturbances in sperm viability and reproductive efficiency which is induced by sodium nitrite toxicity in rats (Ratus norvegicus). Certain parameters were measured like sperm concentration, motility, Live sperm, Testosterone hormones. Moreo...

The obtained results of the present research indicated that cadmium chloride possesses a deleterious effect on reproductive parameters, induce oxidative damage, as well as effects of cadmium chloride on histological sections (liver, kidney and testes) the administration of Brassica juncea oil with cadmium chloride minimized the hazard effects of nu...

Condensation of 4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid,6-[[amino- (4-hydroxy phenyl) acetyl]amino]-3,3-dimethyl-7-oxo,trihydrate (Amoxicillin drug) with acetaldehyde yielded a novel Schiff base derivative of amoxicillin in good yield. A new compound was characterized by elemental analysis, IR and 1H, HSQC-NMR spectroscopy. The synthes...

ABSTRACT Three new ruthenium(II)-arene complexes of the general formula [{(η6-p-cymene)Ru(L)}2](Cl)2), where L are monastrol (L1), ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-pyrimidine-5-carboxylate (L2) or its 4-bromophenyl analog (L3), have been synthesized and characterized by elemental analysis, 1H, 13C, and 2-D NMR Spectroscopy. The X-ray di...

The present study aimed to investigate the effect of new compound L-arginine derivative (AVO) alone or in combination with cadmium chloride on the reproductive efficiency in male rats. For these experiment 40 adult male rats and 16 adult female rats, the male were divided in to 4 groups (10 rats each for each group); Group (1): was daily received n...

Condensation of 6-methoxy benzothiazol-2-amine with 2-hydroxy- naphthaldehyde gave new Schiff-base derivative in good yield. The metal complex of Co(II) have been synthesized with Schiff base of benzothiazol derivative. Spectroscopic study such as, two dimensional NMR of new compound have been obtained by using nuclear magnatic resonance 600 MHz. C...

A series of phthalimido-(substituted-alkyl-2thioureido)alkyl carboxylic acid derivatives 5–13 and methyl 2-(4-(phthalimido-2-yl)butanamido)alkyl carboxylates 14–23 were synthesized with the aim to develop newly non-nucleoside reverse transcriptase inhibitors (NNRTIs). The new synthesized compounds were assayed against human immunodeficiency virus-1...

A series of 2-adamantyl-5-arylthiazolyl-1,3,4-oxadiazoles 7a–x together with thiazoles 13 and 14 were synthesized. Compounds 7a–l, 13, and 14 were tested in vitro with the aim of identifying novel lead compounds active against human immunodeficiency virus type-1 and human immunodeficiency virus type-2 activity in MT-4 cells. Title compounds were al...

The present study aimed to investigate the potential effect of AVO in alleviating Hematological and serum biochemical alterations induced by cadmium chloride toxicity in rats. 32 adult male rats were divided in to 4 groups (8 rats each for each group: Control group received normal saline by i.p injection and served as a control. Treated group I rec...

Abstract The present study was aimed to investigate the potential effect of crude extract of Brassica juncea L. seeds in alleviating hematological and serum biochemical alterations induced by cadmium chloride toxicity in rats. For this purpose, 32 adult male rats were selected and divided in to 4 groups (8 rats for each group), Group (1): received...

series of phthalimido-(substituted-alkyl-2-thioureido)alkyl carboxylic acid derivatives 5–13 and methyl -(4-(phthalimido-2-yl)butanamido)alkyl carboxylates 14–23 were synthesized with the aim to develop newly non-nucleoside reverse transcriptase inhibitors (NNRTIs). The new synthesized compounds were assayed against human immunodeficiency virus-1 a...

The present study was aimed to investigate the potential effect of crude extract of Brassica juncea L. seeds in alleviating hematological and serum biochemical alterations induced by cadmium chloride toxicity in rats. For this purpose, 32 adult male rats were selected and divided in to 4 groups (8 rats for each group), Group (1): received distilled...

Condensation of L‐arginine with 4‐hydroxy‐3‐methoxy benzaldehyde (vanillin) yielded a novel Schiff base derivative of arginine in good yield. This new Schiff base was characterized by elemental analysis, IR and 1 H NMR spectroscopy. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon method. Studie...

Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl 2 .6H 2 O and PdCl 2 yielded new metal complexes 2 and 3 , respe...

The reaction of 2-amino-5-carboxyphenyl mercury(II) chloride under argon atmosphere with tellurium tetrabromide gave 2-amino-5-carboxyphenyl tellurium(VI) tribromide (1) in good yield. Reaction of 1 with 4-hydroxyphenyl mercury(II) chloride under argon atmosphere gave 4-hydroxyphenyl-2-amino-5-carboxyphenyl tellurium(VI) dibromide (2). Reduction of...

The aim of study is to investigate the role of new Schiffbase derived from methionine in preventing the oxidation of hemoglobin in vitro and preventing the disturbances in lipid metabolism, and liver enzymes induce by sodium nitrite toxicity in rats (Ratus norvegicus). Certain parameters were measured as inhibit sodium nitrite induce met hemoglobin...

Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituent microtubules. The mitosis inhibiting activity of colchicine has been of great use in the study of cellular genetic. The aim of this study is to investigate the mitotic inhibitor activity of mustard oil (brassica juncea), in vivo study. A treatment with...

Condensation of L‐arginine with 4‐hydroxy‐3‐methoxy benzaldehyde (vanillin) yielded a novel Schiff base derivative of arginine in good yield. This new Schiff base was characterized by elemental analysis, IR and 1H NMR spectroscopy. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon method. Studied...

Some Schiff base compounds derived from sulfonamide drug were synthesized by reaction of 4-aminobenzenesulfonamide with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and 2-hydroxy benzaldehyde) in good yields. Characterization of synthesized compound was carried by elemental analysis, IR, 1 H, 13 C, HSQC and HMBC-NMR spe...

The present study aimed to investigate the potential effect of 4-[(Z)-(2,4-diamino-6-chloropyrimidin-5-yl)diazenyl]benzene-sulfonamide (SPI) in alleviating Hematological and serum biochemical alterations induced by sodium nitrite toxicity in rats. For this purpose 40 adult female rats and 40 adult male rats were divided in to 5 groups for each sex...

A new series of organonotellurium compounds containing azo groups were prepared by new and convenient methods. Reaction of 1‐(4‐mercuric chloride‐2,3‐dichlorophenyl)‐2‐ chlorodiazine (4) with 8‐hydroxyquinoline (5) gave the new organomercury compound 6 in good yield. Telluratio of compound 6 with tellurium tetrabromide in 1:1 and 1:2 mole ratio gav...

ABSTRACT Condensation of 4-amino-N-(1,3-thiazol-2-yl) benzenesulfonamide (sulphathiazole drug) with 3,4-dihydroxy benzaldehyde afforded Schiff base derivative in good yield. The new compound was characterized by elemental analysis, IR, 1H, 13C, and 2D (HSQC and HMBC- NMR) spectroscopy. It was screened for antibacterial activity against Staphylococc...

Colchicine inhibit microtubule polymerization by binding to tubulin, one of the main constituent microtubules. The mitosis inhibiting activity of colchicine has been of great use in the study of cellular genetic. The Aim of this study is to investigate the mitotic inhibitor activity of [6- chloro-2- (methyl sufanyl) pyrimidine -4- amine] cobalt (II...

Condensation of 2‐amino‐4‐chloro‐6‐methoxypyrimidine with aromatic aldehydes (2‐ hydroxy‐1‐naphthaldehyde, 3,4‐dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacill...

Condensation 2-hydroxy-1-naphthaldehyde 1 with L-methionine 2 yielded E-((2)-(((2-hydroxynapthalene-1-yl)ethylene)amino)-4-(methylthio)butanoic acid 3 in a good yield. The synthesized compound was characterized by elemental analysis, IR and 1 H, 13 C, HSQC, HMBC and ROSY NMR spectroscopy. The toxicity study of the synthesized analogue 3 was assayed...

Sodium nitrite is widely used as color fixative and preservative in meat and fish.Impairment of hepatic function and disturbances in lipid metabolism are well recognized advers effecte of sodium nitrite. The aim of this study is to investigate the role of [6 -chloro-2 (methylsulfanyl) pyrimidine -4-amine]cobalt(II)] complex, in preventing the oxida...

Condensation of 2‐amino‐4‐chloro‐6‐methoxypyrimidine with aromatic aldehydes (2‐ hydroxy‐1‐naphthaldehyde, 3,4‐dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacill...

A new azo pyrimidine derivative compound was synthesized by reaction of 6 chloropyrimidine-2,4-diamine with 4-aminobenzenesulfonamide via diazotization to give novel 4-[(Z)-(2,4-diamino-6-chloropyrimidin-5-yl)diazenyl]benzene- sulfonamide in good yield. Characterization of synthesized compound was carried by elemental analysis, IR, 1H and 13C NMR s...

The reaction of potassium tellurocyanate (prepared in situ) with N-(1-chloroethylidene)arylamines (i.e., 4-RC6H4N = C(CH3)Cl, where R = H, Cl, CH3 and NO2) in DMSO solution gave unexpectedly, after hydrolysis, the corresponding N-(3-(arylamino)butan-2-ylidene)arylamines in 63–78%. Reaction of N-(3-(arylamino)butan-2-ylidene)arylamines with SOCl2 or...

A new cobalt(II) complex of pyrimidine derivative has been prepared from reaction of cobalt chloride and 6-chloro-2- (methylsulfanyl)pyrimidin-4-amine. The synthesized compound was characterized by elemental analysis (CHN), IR and 1HNMR spectroscopy. The new compound was screened for antibacterial activity against Staphylococcus aureus, Escherichia...

Condensation of 4,4-diaminodiphenyl sulfone (Dapsone) with aliphatic and aromatic aldehydes yielded a few Schiff base derivatives in good yields. The optimized structural parameters (bond lengths and bond angles) of three azomethine compounds have been obtained by using the GAUSSIAN 09 program package. Conformer of compound 1 has the highest energy...

New tellurated schiff bases were synthesized by the reaction of the corresponding mercurated Schiff bases compounds A1-A3 with tellurium tetrabromide in 1:1 mole ratio and that gave organyltellurium tribromides A4-A6. On the other hand, when mercurated schiff bases and tellurium tetrabromide brought together in 2:1 mole ratio gave diorganyltelluriu...

New tellurated schiff bases were synthesized by the reaction of the corresponding mercurated Schiff bases compounds A1-A3 with tellurium tetrabromide in 1:1 mole ratio and that gave organyltellurium tribromides A4-A6. On the other hand, when mercurated schiff bases and tellurium tetrabromide brought together in 2:1 mole ratio gave diorganyltelluriu...

In recent years, pyrazole and pyrimidine derivatives attracted organic chemists due to their widespread potential biological and chemotherapeutic activities. In this study, pyrimidine derivative namely 8-ethyl-6,7-diphenyl-7,8-dihydropteridine-2,4(1H,3H)-dione was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli,...

Reaction of 2-Chloroethanol with potassium tellurocyanate gave a new heterocycle namely 1,3-oxatellura-2-imine 1 in good yield. Halogenation of organotelluride 1 with SOCl2, bromine and iodine gave dichloro, dibromo and diiodo organic tellurium compounds. Treatment of 1 with alkyl halides gave new organic tellurium compounds. Hydrolysis of 1 afford...

The structural and electronic properties of some α-diketones have been investigated theoretically by performing both Hartree–Fock and density functional theory calculations at HF/6-31G(d,p) and B3LYP/6-31G(d,p) levels of theory.The electronic spectra were calculated by ZINDO and TD methods at each level of theory. The wavelength of the n→π∗ electro...

A series of Schiff bases 7-11 derived from dibenzoylmethane have been prepared. The UV, IR, 1H NMR and mass spectra revealed theses compounds were existed mainly as the keto-enamine tautomer in the solution. The absorption bands which appeared in the range λmax = 376-406 nm were assigned to the electronic transitions which arised from the central h...

The equilibrium constants, free energies, enthalpies, and entropies for 1:1 adduct formation of N,N-_ Bis(Salicylidenepropylenediiminato)Cu(II) complex with series of nitrogen donors have been measured spectro-photometrically in benzene and in cyclohexanone and dichloroethane for comparison. The equilibrium constants for adduct formation span the r...

The rates of hydrolysis of some pyridilmonoimines have been investigated in aqueous methanol medium of acetate buffer. The hydrolysis of the studied bases found to be slower than that of benzylideneaniline. It is evident from the dependent of the rate constants upon the buffer concentration that the rate equation has the form of special and general...

A new series of unsymmetrical diaryl telluride dibromides (i.e. 4-HOCHzC6Ha(Ar)TeBr2 whereAr = 2-NHr-5-Brcotlr(l); 2-NH2-5-CH3OC6$ (2); 2'NH2-5'NO2C6H3 (3) were prepared from thereaction of-4-hyOro*yrn.tt ytptrenylmercury chloride with the corresponding 2-aminoaryltelluriumtribromides in glaciai acetii acid. Reduction ofcompounds 2 and 3 by hydrazi...

The reaction of ortho-mercurated anilines with benzaldehyde gave the ortho-mercurated Schiff bases. The reaction of the mercurated Schiff bases with tellurium tetrabromide in 1:1 and 2:1 mole ratio using dry chloroform as solvent gave the ortho-tellurated Schiff bases compounds ArTeBr3 and Ar2TeBr2, respectively, in good yields (where Ar = 5-ClC6H3...

The cyclization of primary arylselenocarboxylic amides with α-bromoketones afforded a variety of new 2,4-diaryl-1,3-selenazoles. Halogenation of the 2,4-diaryl-1,3-selenazoles with chlorine, bromine and iodine gave the new 1,1-dihalo-2,4-diaryl-1,3-selenazoles in good yields. Antiviral activity of some 1,1-dihalo-2,4-diaryl-1,3-selenazoles has been...

New acylated 5-thio-beta-D-glucopyranosylimino-disusbstituted 1,3,4-thiadiazols 8, and 11 were prepared, via spontaneous rearrangements, by cycloaddition of the glycosyl isothiocyanate 2 with the reactive intermediates 1-aza-2-azoniaallene hexachloroantimonates 4 and 6, respectively. Reaction of 2 with aminoacetone or chloroethylamine afforded the...

Reactions of alpha,alpha'-dichloroazo compounds 2 with SbCl5 gave 1-(chloroalkyl)-1-aza-2-azoniaallene salts 3 as reactive intermediates. Cycloadditions of 3 with the ribofuranosyl cyanide 4 afforded the beta-D-ribofuranosyl-1,2,4-triazolium salts 5, which rearranged spontaneously to salts 6. Hydrolysis of 6 gave the 1,2,4-triazole C-nucleosides 7,...

Some new enaminothiones derived from dibenzoylmethane were prepared. Their NMR, electronic and IR spectra were recorded. NMR spectral data exhibited a broad signal in region 15.70-16.01 ppm attributed to the S…H-N proton in enaminothiones form. Electronic spectra exhibited three strong bands, the band within the range 438-446 nm is attributed to th...

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Reactjon of (2-acetoxyethoxy)methyl bromide with the silylated lumazine bases (1-6) in the presence of n-Bu4NI leads to the formation of the nucleosides 8, 10, 12, 14, 16 and 18 respectively. Deacetylation with methanolic ammonia afforded the free nucleosides 9, 11, 13, 15, 17 and 19, respectively, in good yields. Structural proofs of the newly syn...