Viktor Zvarych

Lviv Polytechnic National University · Department of Automated Control Systems

Anthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates the potential of a series of new anthraquinone derivatives as anticancer agents for non-small-cell lung cancer (NSCLC). The compounds were subjected to a range of tests to assess their cytotoxic and...

A qualitative assessment of a new four-component pharmaceutical composition has been carried out using the methods of infrared spectroscopy and X-ray powder diffractometry. Qualitative characteristics for the identification of mixture components by absorption bands in infrared spectra and characteristic peaks by positions on the scattering angle 2θ...

The future of innovative robotic technologies and artificial intelligence (AI) in pharmacy and medicine is promising, with the potential to revolutionize various aspects of health care. These advances aim to increase efficiency, improve patient outcomes, and reduce costs while addressing pressing challenges such as personalized medicine and the nee...

Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telome...

The synthesis of new N-(9,10-dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) acetamides was carried out using reaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracene-1(2)-yl)acetamides with functionalized thiols in the presence of potassium carbonate in N,N-dimethylformamide (DMF) at room temperature. Evaluation of the synthesized compounds on su...

The [1,2,3]triazin-4(3H)-one ring is a synthetically important molecular platform for a variety of chemical transformations. Despite this, currently, there has been little research on the reaction of the thermal opening of the [1,2,3]triazin-4(3H)-one nucleus. In this work, we describe the synthetic potential of anthra[1,2-d][1,2,3]triazine-4,7,12(...

The ketene dithioacetal 3 generated from 2-nitroperchlorobutadiene 1 reacted with various heterocyclic amines and aliphatic, aromatic and heterocyclic thiols to produce functionalized new ketene- N,S,S -acetals and S,S,S -acetals 4a-f, 5a-h as heterocyclic dithiolanes. They were separated/purified by chromatographic methods and their exact structur...

9,10-Anthracenediones an important class among quinonic compounds of natural and synthetic origin with many applications. Amino- and diaminosubstituted 9,10-anthracenediones are one of the main classes among 9,10-anthracenedione derivatives. Primarily, they are the key structures for obtaining various dyes. Besides applying their dye properties, am...

Researches with nitro compounds mainly relates to the synthesis of their derivatives used as unusual intermediate compounds. Because of their high reactivity in SNvin reactions, polyhalo-nitro-butadienes have been shown in many studies to have many properties as well as medical and pharmaceutical effects such as antitumor, bactericidal, fungicide a...

Marketing research of the market of antithrombotic agents of the B01 group in Ukraine in 2021, represented by 112 registered trade names, was carried out. A quantitative assessment of the ratio on the pharmaceutical market to the assortment of pharmaceutical products and dosage forms, and their manufacturers are given. The leaders of the countries-...

A preparatively convenient one-pot method for the synthesis of new 7-thioxo[1,3]thiazolo[3,2-c]pyrimidine derivatives 3a–3l by the cyclocondensation of 5-methyl(1,3-thiazolidin-2-ylidene)ketones 1a–1c with aroyl 2a–2d and 2-thienyl 2e isothiocyanates for 6–10 h boiling in acetone has been developed. Studies of the antimicrobial and antioxidant acti...

The analysis of the biological potential of derivatives of 4-alkenyl-and imino functionalized pyrazoles is carried out, based on which the expediency of design of new structures with pharmacophore 5-(4-nitrophenyl)furanyl fragment is substantiated. Their synthesis method using a structural modification of 3-[5-(4-nitrophenyl)furan-2-yl]pyrazole-4-c...

A marketing analysis of the pharmaceutical market for drugs - derivatives of 9,10-anthraquinone was carried out. It is shown that in the Ukrainian market, the vast majority of the assortment of these drugs is formed by foreign-made drugs, the leaders of which are the manufacturing countries Austria, Italy, Germany and India. It has been determi ned...

Onychomycosis is one of the most acute problems of modern medicine, which accounts for about 50% of all nail diseases. Fungi of dermatophytes of the genus Trichophyton are the most studied etiological factor of onychomycosis. Non-dermatophytes can also cause onychomycosis. Fungi of the genus Aspergillus is one of the main pathogens among the non-de...

The aim of this study is to characterize the 1-aminoanthraquinone metabolite isolated from rat’s urine after the oral administration of the initial compound using high-performance liquid chromatography-mass spectrometry (HPLC-MS). In the study of aminoanthraquinone metabolic profile the urine samples of experimental animals have been used as a biom...

The global emergence and dissemination of multidrug-resistant fungal and bacterial pathogens is a serious public health threat. The development of novel highly active antimicrobial compounds simultaneously targeting several targets in bacterial or fungal pathogens could help to fight antimicrobial resistance. The four-component one-pot two-step fac...

The results of using a computer approach in the search for new potential biologically active compounds in a series of 9,10-anthraquinone derivatives using free online programs PASS Online, CLC-Pred (Cell Line Cytotoxicity Predictor), Acute Rat Toxicity and determining the level of binding of the studied structures of anthraquinones with target prot...

For the first time, the literature sources concerning the chemical transformations of diazonium salts of 1(2)-amino-9,10-anthracenediones are generalized and systematized. The potential of 9,10-dioxoanthracenyldiazonium salts as key substrates in the preparation of various linear-functionalized, acyclic and heterocyclic derivatives has been determi...

The nitro group–substituted perhalogenobuta-1,3-diene (1) is important synthetic precursor in the synthesis of different heterocycles groups with high biological activity. Firstly, new N,S-substituted-perhalonitro-1,3-butadiene compounds were synthesized by the reactions of various amino or thiol containing nucleophiles with 1. The structures of al...

The pleiotropic pharmacological actions of 9,10-anthraquinone dithiocarbamates were studied. The Way2Drug web portal was used to establish that cytotoxic, antiviral, and anticonvulsant actions were predicted for the study molecules, along with moderate toxicity. In vitro experimental studies showed that all study compounds had cytotoxic effects on...

The development and spread of resistance of human pathogenic bacteria to the action of commonly used antibacterial drugs is one of the key problems in modern medicine. One of the especially dangerous and easily developing antibiotic resistant bacterial species is Staphylococcus aureus. Anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-triones 22–38 have been...

Derivatives of 2(5H)-furanone (γ-crotonolactone) are important intermediate synthetic products with a wide range of biological effects that have become widely used in the pharmaceutical industry, medicine, and veterinary medicine, in particular in the prevention and treatment of fish diseases. However, the environmental issue of obtaining these com...

A series of new 1,4-naphtho- and benzoquinone derivatives possessing N-, S-, O-substituted groups which has not been reported yet has been synthesized from 2,3-dichloro-1,4-naphthoquinone 1 and 2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione 15 involving a Michael addition. In the synthesized compounds, antimicrobial activity at low concentrations...

Proton-initiated conversion of dithiocarbamate derivatives of the 9,10-anthracenedione under conditions of acid-catalyzed cyclodehydration using the action of a mixture of H2SO4-AcOH and further treatment with perchloric acid was investigated. Based on the data of the spectral methods (1H, 13C NMR, IR, UV spectroscopy), it is established that the r...

Computational approaches are widely used in drug design, in the finding and optimization of lead compounds. The Way2Drug platform [http://www.way2drug.com/dr] provides access to information about drugs launched in U.S. and Russian Federation, and the opportunities of computer-aided prediction of biological activity for drug-like compounds. Using t...

9,10-Dioxoanthracenyl-1(2)-diazonium hydrosulfates reacted with pyridine under both the modified Gomberg–Bachmann reaction conditions and in the presence of catalytic amounts of CuCl2 to form a mixture of isomeric 2-, 3-, and 4-pyridylanthraquinones, of which 2-pyridyl derivatives were isolated in an analytically pure form.

Novel functionalized thiazoles were prepared by the Hantzsch reaction from 3-[(4- hydroxyphenyl)carbamothioylamino]-2-methylpropanoic acid and the corresponding α-halocarbonyl compounds in good yields. A series of chemical transformations of the obtained products were carried out, and new functionalized thiazole derivatives with aliphatic, aromatic...

The new anthraquinonylhydrazones were obtained by the interaction of 9,10-dioxoanthracene-1-diazonium sulfates with a number of α- and β-carbonyl-containing compounds under modified conditions of the Japp–Klingemann reaction, and a probable mechanism of the formation has been proposed. It was found that hydrazones, unsaturated in the second positio...

9,10-Anthraquinonylhydrazones containing nitrile, acyl, and ethoxycarbonyl groups reacted with hydrazine hydrate upon refluxing in dioxane or with sodium azide upon heating in DMF, giving the corresponding pyrazole and tetrazole derivatives.

The substituted aminothiazoles were prepared by the Hantzsch method and were used as precursors for the synthesis of polyfunctionalized N,N-disubstituted aminothiazoles. The structures of the synthesized compounds were determined by NMR and mass spectroscopies. All the synthesized compounds were screened for their antimicrobial activity against bac...

A new derivatives of 9,10-anthracenedione with mono-, bisdithiocarbamate, and hydrazynyl moieties in water and non-catalytic conditions have been synthesized based on diazonium sulfates. The compounds with antimicrobial activity against bacteria Escherichia coli, Staphylococcus aureus, Mycobacterium luteum, and fungi Candida tenuis and Aspergillus...

Diazonium salts are extremely useful agents in modern organic synthesis. Regardless of the long history, the diazonium compounds still attract attention and new developments have been emerging constantly. Despite the fact that the chemistry of 9,10-anthraquinone has been well studied, many anthraquinone derivatives are remain poorly known. High rea...

The review is systematized literature data of the structural modification methods of 1(2)-amino-9,10-anthracenedione derivatives with alkyl, aryl, acyl, sulfur- and nitrogencontaining acyclic and heterocyclic condensed and non-condensing fragments, the results of experimental studies of the biological activity of this class of compounds. The condit...

Anticancer activity as an associated action for a series of dithiocarbamates of 9,10-anthracenedione was predicted using the PASS computer program and analysed with PharmaExpert software. The predicted cytotoxic activity of the dithiocarbamate derivatives of 9,10-anthracenedione was evaluated in vitro on cancer cells of the human lung (A549), prost...

The reactions of 1,4(1,5)-diazido-9,10-anthracenediones with phenylacetylene and methyl propiolate under copper(I)-catalyzed reaction of the azide-alkyne cycloaddition conditions have been studied and a series of new 1,2,3-triazole derivatives of 9,10-anthracendione have been obtained. The computer screening of synthesized compounds was carried out...

An efficient procedure has been proposed for the synthesis of previously unknown 1-hydrazinylanthraquinones containing acyl and/or ester fragments convenient for subsequent transformations.

The antiplatelet activity of dithiocarbamate derivatives of 9,10-anthracenedione was studied. The activity of the compounds was tested in vitro using platelet-rich plasma. Two dithiocarbamates (compounds 11 and 12) with high antiaggregative activity have been established as a result of the screening test. The concentration -dependent inhibitory eff...

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The title compounds are prepared from (amino)anthracenediones and (dimethoxy)tetrahydrofuran via Clauson—Kaas reaction using I2 as catalyst.

A variety of new derivatives of 9,10-anthracenedione with mono- and bisdithiocarbamate moiety in the non-catalytic conditions have been synthesized. The obtained compounds were screened for their antioxidant capacity using the cupric-reducing antioxidant capacity (CUPRAC) method. Three of the compounds showed CUPRAC-Trolox equivalent antioxidant ca...

A method for the preparation of (1H-pyrrol-1-yl)anthracene-9,10-diones under the conditions of an iodine-catalyzed Clauson–Kaas reaction is proposed.

The influence of new derivatives of 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity of membrane-associated tyrosine kinases was investigated. Inhibitors of protein tyrosine kinase activity of the membrane fraction, as promising agents to search for new potential anticancer agents among the studie...

The significance of acylation reaction of amines is presented in the literary reference information. The products of this reaction – the corresponding amides – are important intermediates in obtaining practically useful compounds. It has been shown that the most common methods of acylfunctionalization of amines are acetylation, trifluoroacetyla-tio...

Interaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide with α-, β- and ω-amino acids was used to synthesize new amino-acid derivatives of 9,10-anthraquinone. Experimental testing of the antimicrobial actions of the compounds synthesized demonstrated antibacterial activity against Mycobacterium luteum and antifungal activity agai...

Carbohydrazides of N-substituted β-amino acids exhibit a variety of different biological activities including antibacterial, antiviral, fungicidal, antihelminthic, anticancer, antiinflammatory, etc. New potentially biologically active N-(4-iodophenyl)-β-alanine derivatives, N-(4-iodophenyl)-N-carboxyethyl-β-alanine derivatives, and their cyclizatio...

Interaction of an order of aminoanthraquinones with benzoylisothiocyanate resulting in the formation of new N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthacen-1-yl)-thioureas was investigated. Quantum-chemical calculations using Gaussian 03W and HyperChem 8 were carried out. On their basis nucleophilic addition of aminoanthraquinones to benzoylisothiocy...

via cyclocondensation of thioureas (I) with in situ generated α-bromoacetone

New thiazole and 1,2,4-triazole derivatives of 9,10-anthraquinone were obtained by the reaction of N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracene-1-yl)-thioureas with bromoacetone in the presence of triethylamine and hydrazine hydrate in chloroform, respectively. The PASS computer program was used to predict the biological activity spectra and to...

New thiazole and 1,2,4-triazole derivatives of 9,10-anthraquinone were obtained by the reaction of N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthracene-1-yl)-thioureas with bromoacetone in the presence of triethylamine and hydrazine hydrate in chloroform, respectively. The PASS computer program was used to predict the biological activity spectra and to...

New acyl derivatives of anthraquinone by interaction of 1-nitro-2-acylisothiocyanateanthracenedione- 9,10 with glycine, 2-aminobenzoic acid, aminothiazole, 2-mercaptobenzthiazole, ophenylenediamine, thioglycolic acid and ethyl cyanoacetate were obtained. New derivatives of 1- nitro-2-acylisothiocyanate-anthracenedione-9,10 with antimicrobial activi...