Victor Martinkov

Republican Research Center for Radiation Medicine and Human Ecology | RRCRM & HE · Research department

Introduction. Ph-negative myeloproliferative neoplasms (MPN) are chronic clonal disorders characterized by the proliferation of mature cells from one or more myeloid cell lines. These disorders include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The incidence of classical Ph-negative MPN varies significa...

Background: Multiple myeloma (MM) remains an incurable disease with the development of relapses, sometimes with an uncontrolled course leading to death regardless of the age of the patient. The use of new schemes and methods of treatment has not only significantly improved outcomes in younger MM patients but also improved the quality of life and su...

Background. The group of plasma cell neoplasms includes benign and malignant diseases. Sometimes there are difficulties in making a diagnosis. The study of the diagnostic and prognostic significance of immunohistochemical (IHC) markers is of current interest. Aim. To study the significance of IHC markers and histological features of the bone marrow...

Multiple myeloma (MM) is the second most common malignant neoplasm of the hematopoietic system. Survival rate has improved significantly in patients over the past decade with the use of new therapeutic strategies. The absence of adverse factors at the time of diagnosis does not always determine a positive course of the disease. Therefore, the searc...

2 В настоящей инструкции по применению (далее-инструкция) изложен метод количественного определения микробиоты раневого отделяемого и оценки её этиологической значимости. Метод включает оценку клинического состояния раны на основании предложенных критериев, описание процедуры взятия и посева раневого отделяемого и алгоритмы интерпретации результато...

Objective To study clinical parameters of multiple myeloma progression in residents of the Gomel region of Belarus Methodology The study included 159 MM patients who were examined at the State Institution “Republican Research Center for Radiation Medicine and Human Ecology”, Gomel from 2018 to 2021. The average age was 62. Female patients prevaile...

Despite significant progress in the understanding of the pathogenesis of paraproteinemic hemoblastoses, these diseases remain incurable. In their development, they go through the stage of paraproteinemias, benign diseases, characterized by the detection of monoclonal paraprotein in the blood serum and / or urine, presence of clonal plasma cells in...

Objective: to study the clinical laboratory features of the course of solitary plasmacytoma (SP) and extramedullary multiple myeloma (EMM). Material and methods. The study included 42 people (22 patients newly diagnosed with EMM and 20 patients diagnosed with SP of various localization). The results were evaluated after 3 years of the study. The me...

Introduction. One of the main problems in transplantology is the detection of simple, reliable and non-invasive markers that could predict adverse immune reactions and adjust immune suppressive therapy in allograft recipients in a timely manner. Objective. To determine the immunological criteria for the prediction of a graft dysfunction. Material a...

Objective: to determine a complex of the most significant prognostic factors in chronic lymphocytic leukemia (CLL) for the purpose of evaluation of the probability of the disease progression. Material and methods. The study included 127 CLL patients whose clinical and laboratory parameters (sizes of the lymph nodes, liver and spleen, general and bi...

Multiple myeloma is an incurable malignancy of hematopoietic tissue characterized by lesions of the bone marrow, presence of multiple destructive processes within bone tissue, kidney damage, and infectious complications. Up to 60 % cases of newly diagnosed multiple myeloma debut from monoclonal gammopathy. Monoclonal gammopathies are a large group...

Objective: to identify the interconnection of laboratory parameters with different courses of chronic lymphocytic leukemia (CLL) and to develop a comprehensive model for the assessment of the risk of the disease progression. Material and methods. The study included 127 patients with CLL whose laboratory parameters were evaluated (general and bioche...

Aim: to study the relation of angiotensin-converting enzyme ACE (I/D) in genetic susceptibility of diabetic nephropathy (DN). Methods. I/D polymorphism of ACE gene was studied in 58 patients with diabetes type 2. Results. There are no reliable differences in detection of DD genotype and D allele in patients with DN and without DN (40,9 and 52,3 %,...

The article presents the molecular genetic analysis of the prevalence of somatic mutations in FLT3, NPM1, CEBPA, and p53 genes in a group consisting of 23 patients with myelodysplastic syndrome MDS (option - refractory anemia with excess blasts, RAEB) and 97 patients with acute nonlymphoblastic leukemia (ANLL). It was ascertained that FLT3-ITD muta...

The comparative analysis of the methylation status of promoter regions of eleven different suppressor genes has been carried out in the groups of patients with benign prostatic hyperplasia, prostate cancer and in patients without pathology with the use of methylation-specific polymerase chain reaction. The group without pathology revealed no methyl...

The molecular-genetic analysis of DNA samples extracted from the blood and marrow of 14 patients with myelodysplastic syndrome (refractory anemia with excess blasts) and 52 patients with acute non-lymphoblastic leukemia has been performed. It did not reveal any clinically unfavourable mutations of FLT3 gene in the group of the patients with myelody...

The work that has been carried out describes for the first time the hereditary caused breast cancer cases in Gomel region of Belarus, having defined a spectrum and frequencies of the most significant genetic factors underlying the given pathology. After the molecular-genetic testing of 667 primary breast cancer cases it was shown that out of eight...