Valery Kostjuchenko

Burdenko Neurosurgery Institute · Gamma Knife Center

Background External beam radiotherapy for resistant retinoblastoma is now seen as a last resort to saving the eye because of the risk of severe side effects: secondary cancers and cosmetic problems of orbital bone growth retardation. To reduce such complications, treatment modalities have shifted towards new radiation therapy techniques. No informa...

The treatment of mental illnesses that are resistant to conservative therapy poses a serious problem. Surgical methods with proven efficacy have been proposed for only a small group of psychiatric diseases, while in practice non-classical clinical situations are seen rather often. A 36-year-old man with a 18-year history of “schizophrenia with a pr...

Purpose: To assess differences between frame-based and cone beam computed tomography (CBCT)-defined stereotactic space and to identify predictors of the observed findings. Methods and materials: Differences between frame-based and CBCT-defined stereotactic space after image co-registration were reviewed for 529 patients. Treatment planning syste...

We systematically evaluate a Deep Learning model in a 3D medical image segmentation task. With our model, we address the flaws of manual segmentation: high inter-rater contouring variability and time consumption of the contouring process. The main extension over the existing evaluations is the careful and detailed analysis that could be further gen...

Stereotactic radiosurgery (SRS) is practically non-invasive treatment option, and its application for ablative procedures in functional and psychiatric brain disorders seems rather promising. In such cases, gamma knife surgery (GKS) is considered a standard option due to its proved accuracy in targeting and dosimetry. However, modern linear acceler...

Hypothalamic hamartoma (HH) is a dysplastic lesion fused with hypothalamus and followed by epilepsy, precocious puberty and behavioral disorders. Up to 50% of patients become free of seizures after surgery, but various complications occur in 1/4 of cases. Radiofrequency thermocoagulation, laser interstitial thermal therapy and stereotactic radiosur...

We systematically evaluate a Deep Learning (DL) method in a 3D medical image segmentation task. Our segmentation method is integrated into the radiosurgery treatment process and directly impacts the clinical workflow. With our method, we address the relative drawbacks of manual segmentation: high inter-rater contouring variability and high time con...

Due to its excellent soft tissue contrast, magnetic resonance imaging (MRI) is widely used for target delineation in stereotactic radiosurgery. However, because of a number of factors (inhomogeneity of the constant magnetic field, nonlinearity of the gradient fields, etc.), MR images are more susceptible to spatial distortion as opposed to Computed...

The study objective is to assess the outcomes after stereotactic radiosurgical treatment (SRS) in patients with pilocytic astrocytomas after non-radical surgery and after continued tumor growth. Materials and methods. The report includes 56 patients (37 males and 19 females) who have undergone SRS in N. N. Burdenko National Medical Research Center...

Neurofibromatosis 2 is one of the most prevalence disease among phakomatoses characterized by appearance of new central and peripheral nerve system tumors. The main treatment for this patient is a surgery, but in real time we observe the significant changes in treatment and rehabilitation in this patients including radiation therapy and pharmacothe...

External beam radiotherapy (EBR) remained for a long time the only method of treatment in children with recurrent and resistant retinoblastoma (RB). This method often leads to serious complications, including the occurrence of secondary malignant tumors. Currently, EBR is used as second-line (salvage) therapy. There is no data in the literature of...

The prevailing approach for three-dimensional (3D) medical image segmentation is to use convolutional networks. Recently, deep learning methods have achieved human-level performance in several important applied problems, such as volumetry for lung-cancer diagnosis or delineation for radiation therapy planning. However, state-of-the-art architecture...

Radiosurgery for recurrent glioblastoma Abstract Background. Despite the combined treatment in accordance with modern standards, recurrent glioblastoma usually occurs with in several months after resection and causes low relapse-free and overall survival. One of the most effective methods for malignant glioma progression is repeated radiotherapy. I...

Background: Stereotactic radiosurgery (SRS) is the primary modality for treating brain metastases. However, effective radiosurgical control of brain metastases ≥ 2,5 cm in maximum diameter remains challenging. The SRS possibilities in the treatment of such patients are limited by the high risks of developing post-radiation complications. The use of...

Target imbalance affects the performance of recent deep learning methods in many medical image segmentation tasks. It is a twofold problem: class imbalance – positive class (lesion) size compared to negative class (non-lesion) size; lesion size imbalance – large lesions overshadows small ones (in the case of multiple lesions per image). While the f...

Target imbalance affects the performance of recent deep learning methods in many medical image segmentation tasks. It is a twofold problem: class imbalance - positive class (lesion) size compared to negative class (non-lesion) size; lesion size imbalance - large lesions overshadows small ones (in the case of multiple lesions per image). While the f...

Stereotactic radiosurgery is a minimally-invasive treatment option for a large number of patients with intracranial tumors. As part of the therapy treatment, accurate delineation of brain tumors is of great importance. However, slice-by-slice manual segmentation on T1c MRI could be time-consuming (especially for multiple metastases) and subjective....

Cancer pain is one of the main problem in modern medicine. According European Society for Medical Oncology data, cancer pain prevalence is 64% among patient with terminal stage of disease and in 46% standard pain therapy was ineffective. Radiosurgical hypophysectomy is one of the important and perspective method in cancer pain treatment. This metho...

Stereotactic hypofractionated radiation therapy on the Gamma Knife Icon: single-center experience in Russia. Andrey Golanov1, Ivan Osinov2, Valery Kostyuchenko2, Sergey Banov2, Aleksandr Savateev2, Anjelika Artemenkova2, Aleksandra Dalechina2 1Stereotactic Radiotherapy and Radiosurgery, Moscow Center Gamma Knife, Burdenko Neurosurgical Institute, M...

Stereotactic radiosurgery is a minimally-invasive treatment option for a large number of patients with intracranial tumors. As part of the therapy treatment, accurate delineation of brain tumors is of great importance. However, slice-by-slice manual segmentation on T1c MRI could be time-consuming (especially for multiple metastases) and subjective...

Classification-based image retrieval systems are built by training convolutional neural networks (CNNs) on a relevant classification problem and using the distance in the resulting feature space as a similarity metric. However, in practical applications, it is often desirable to have representations which take into account several aspects of the da...

Deep learning methods are actively used for brain lesion segmentation. One of the most popular models is DeepMedic, which was developed for segmentation of relatively large lesions like glioma and ischemic stroke. In our work, we consider segmentation of brain tumors appropriate to stereotactic radiosurgery which limits typical lesion sizes. These...

Deep learning methods are actively used for brain lesion segmentation. One of the most popular models is DeepMedic, which was developed for segmentation of relatively large lesions like glioma and ischemic stroke. In our work, we consider segmentation of brain tumors appropriate to stereotactic radiosurgery which limits typical lesion sizes. These...

Brain metastases are often detected in melanoma patients. Central nervous system (CNS) involvement is usually associated with poor prognosis. We describe a case of a female patient with multiple melanoma brain metastases who survived for 49 months after detection of CNS involvement and the first radiosurgery. She underwent several courses of irradi...

Introduction: Preoperative stereotactic radiosurgery (pre-SRS) is a recent advancement in the strategy for brain metastasis (BM) management, and available data demonstrate the advantages of pre-SRS before postoperative radiation treatment, including lower rates of local toxicity, leptomeningeal progression, and a high percentage of local control. T...

Pilocytic astrocytomas are the most common gliomas (World Health Organization (WHO) grade 1) in children. According to many authors, stereotactic irradiation (radiotherapy and radiosurgery) is an effective method that provides a prolonged, recurrence-free survival in patients who have had partial tumor removal or in patients with an unresectable tu...

Objective: To study the overall survival and intracranial relapse in patients with brain metastases (BM) after radiosurgical treatment (SRS) on the machine Gamma Knife. Material and Methods: The analysis of treatment results in 416 patients with BM (178 men and 238 women) was conducted. Patients with radiosensitive tumors: breast cancer (n = 113; 2...

Piloid astrocytoma (PA) is a glioma that is most frequently encountered in children (WHO grade I). According to most authors, stereotactic radiation (radiotherapy and radiosurgery) is an effective method to control tumor growth in patients with incomplete removal of PA and its recurrence. The authors describe a clinical case of a female patient wit...

Unlabelled: The study purpose was to evaluate the impact of gamma knife radiosurgery (GKRS) alone on the overall survival and rate of intracranial recurrences in brain metastasis patients. Material and methods: Treatment outcomes in 502 patients (211 males and 291 females with 2782 brain metastases (BMs)) were retrospectively reviewed. Most pati...

The development of chemotherapy led to significant advances in cancer treatment, but its efficacy in treatment of brain metastases is insufficient. Fractionated whole brain irradiation has been the standard treatment for brain metastases, but provides limited local control and as a result, poor clinical results. Radiosurgery using "Gamma Knife" and...

Piloid astrocytoma (PA) is a low-grade (WHO grade I) glial tumor that is more common in pediatric patients. According to the data of many authors, stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) promote long-term remission or delayed tumor progression in patients with inoperable tumors after incomplete removal of a tumor and wit...

Unlabelled: Arterio-venous malformation (AVM) of the brain are congenital malformations of cerebral vessels in the embryonic period. Standards in AVM treatment is currently applying the endovascular technique, microneurosurgical removal and stereotactic radiation. Materials and methods: In the period from 2005 to 2011, in 139 patients with arter...

Gamma-Knife radiosurgery treatment for intracranial metastases of renal-cell cancer results are presented. Treatments were made in 3 Eastern European Centers: in Prague, Moscow and St. Petersburg from 2000 to 2011. 312 patients were treated. Median survival was 8 months (1-91 months). Follow up data were collected for 210 patients. Neurologic state...

Pilocytic astrocytoma (PA) is a low-grade glial tumor (WHO grade I) with predominant occurrence in pediatric patients. According to many authors, stereotactic radiosurgery (SRS) and radiotherapy (SRT) promote long-term remission or retardation of tumor progression in patients with in inoperable lesions after incomplete resection or recurrence. Ther...

Treatment of intracerebral metastases is one of the key problems in neurooncology. Modern methods of combined treatment do not significantly affect terms of survival. Quality of life during the whole period of treatment depends on selected tactics. We summarized our experience of treatment of 119 patients with cerebral metastases of extracranial tu...

Hypothalamic hamartoma (HH) is malformation of the brain manifesting by paroxysmal disorders (gelastic seizures) and endocrine disorders (mostly precocious sexual development). Surgical resection of HH is associated with the risk of severe neurological and neuroendocrine complications. Alternative ways of treatment are being investigasted. Stereota...

Stereotactic radiosurgery (SRS) becomes more widely used in treatment of patients with intracranial tumors. In spite of low invasiveness this method produces risk of development of radiation-induced complications including symptomatic focal necrosis. Authors report a case of radiation-induced necrosis occurred in a patient treated for benign glioma...

A Gamma-Knife unit that is currently the gold standard in radiosurgery was first used in clinical practice in 1968. The essence of the radiosurgical treatment is to apply the stereotactic technique to high-precision irradiation of small intracranial targets by narrow beams of ionizing radiation from external sources. Three hundred and six patients...