Valentin Sinitsyn

Lomonosov Moscow State University | MSU · Radiology Chair

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Since computed tomography (CT) is a part of standard diagnostic protocol in pancreatic ductal adenocarcinoma (PDAC), we have evaluated the value of CT for sarcopenia screening in patients with PDAC, intending to expand the diagnostic value of tomographic studies. In our study, we included 177 patients with available CT images. Two groups were forme...

Мы использовали русскоязычный вариант психолингвистического теста Данеман-Карпентер (reading span; Daneman, Carpenter, 1980; Федорова и др., 2018) и фМРТ покоя для изучения корреляций объема вербальной РП при чтении с функциональными связями (ФС) головного мозга. В отличие от более раннего исследования Осаки и коллег (Osaka et al., 2021), мы не дел...

An increase in left ventricular (LV) extracellular volume (ECV) is an important parameter of LV morphology and is considered synonymous with myocardial fibrosis, as well as a reliable marker of myocardial injury and impaired cardiac function. Accurate methods for detecting and assessing myocardial fibrosis are very important for clinical practice....

Detection of myocardial ischemia based on detection and grading of myocardial perfusion is a cornerstone of coronary artery disease (CAD) diagnosis. Coronary CT angiography (CCTA) is a recognized imaging test for exclusion of anatomically significant coronary stenosis in patients with low or moderate probability of CAD, but gives no information on...

This study explores the use of diffuse reflectance spectroscopy (DRS) and multiwavelength fluorescence spectroscopy for real-time kidney stone identification during laser lithotripsy. Traditional methods are not suitable for in situ analysis, so the research focuses on optical techniques that can be integrated with lithotripsy fibers. Experiments w...

Verbal working memory tests used in studies of its functional neuroanatomy typically load short-term memory more than information processing. However, psycholinguistic tests usually address individual differences in the allocation of working memory resources between information storage and processing; these tests (called complex spans) better predi...

The article offers the latest view on possibilities of diagnostic algorithm to identify vaginal cancer (VC), rare tumor of the woman’s reproductive system. The algorithm is described as a consensus of leading expert in imaging diagnostics, as well as oncogynecologysts, investigating diagnostic challenges and vaginal cancer therapies. The article se...

Cardiovascular magnetic resonance is widely used due to its possibilities for noninvasive cardiac tissue characterization. In recent years native myocardial T1- and T2-mapping techniques have been implemented in routine practice. These techniques provide quantitative analysis of myocardium and allow detection and evaluation of myocardial damage wit...

Aim: To investigate the frequency of complications after a tetralogy of Fallot (ToF) repair (rToF) in pediatric patients, as detected through computed tomography (CT). Methods: A retrospective analysis of 613 patients with ToF was carried out from October 2011 to June 2020. A total of 116 patients (69 male and 47 female), with complications after a...

Myocarditis is often a difficult heart condition to diagnose. This article presents a clinical case of a young patient with symptoms of acute coronary syndrome who showed no evidence of coronary artery disease. Myocarditis was suspected due to elevated levels of cardiospecific enzymes and inflammatory markers, pronounced electrocardiography changes...

The "rice bodies" symptom on magnetic resonance imaging (MRI) of the shoulder joint in patients with rheumatoid arthritis (RA) is a rare but specific finding characterised by the presence of multiple small, round, rice-grain-like structures in the synovial fluid of the joint, synovial pouches or sheaths. The etiology of the "rice bodies" is still n...

Backgraund. Unified terminology is a necessary condition for successful interdisciplinary communication in oncology. The variety of anatomical, pathomorphological and clinical terms used in rectal cancer (RC) is often accompanied by their ambiguous interpretation both in domestic and foreign scientific literature. This not only complicates the inte...

Squamous cell carcinoma of the renal pelvis is a rare neoplasm. The incidence does not exceed 1% of all neoplasms of this localization. In the general population, up to 90% of all neoplasms of the renal pelvis are represented by urothelial carcinoma, while from 0.7% to 7.0% of cases are squamous cell carcinoma. Stones of the renal collecting system...

Aim The study aimed to determine the efficacy of cardiac computed tomography angiography (CCTA) for diagnosing left atrial appendage (LAA) thrombus before catheter ablation with the patient in the left lateral decubitus position and, also, to evaluate the risk factors for thrombus formation.Material and methods This retrospective, cohort study incl...

BACKGROUND: Aortic aneurysms, known as silent killers, are frequently asymptomatic, leading to vessel rupture and death. Annual rates for ruptures, stratifications, and sudden deaths are up to 3.6%, 3.7%, and 10.8%, respectively. Timely diagnosis and early treatment save a patients life. The use of artificial intelligence (AI) technologies helps to...

Prostate cancer (PСa) is one of the leading causes of cancer morbidity in men. The incidence of localized PCa is higher in high-income countries. There are different types of treatment for localized PCa: from active surveillance to focal therapy or radical treatment. Both patients and urologists are interested in minimizing side effects of treatmen...

BACKGROUND: Artificial intelligence technology can help solve the significant problem of missed findings in radiology studies. An important issue is assessing the economic benefits of implementing artificial intelligence. AIM: To evaluate the frequency of missed pathologies detection and the economic potential of artificial intelligence technology...

Background Left ventricular noncompaction (LVNC) cardiomyopathy is a disorder that can be complicated by heart failure, arrhythmias, thromboembolism, and sudden cardiac death. The aim of this study is to clarify the genetic landscape of LVNC in a large cohort of well-phenotyped Russian patients with LVNC, including 48 families (n=214). Methods All...

The purpose of the study . To analyze the possibility of using artificial intelligence as a decision support system for radiologists for pulmonary nodules detection on Chest CT before and during the COVID-19 pandemic on the example of the system Botkin.AI. Materials and methods. Two groups of Chest CT studies were identified: those performed before...

Congenital portosystemic shunts (CPSS) are rare congenital vascular anomalies associated with partial or complete diversion of the portal blood into the systemic circulation. Congenital extrahepatic portosystemic shunts (CEPSS) are termed Abernethy malformation. This pathology is a diagnostic challenge due to its low incidence and variable clinical...

Background: Artificial intelligence (AI) technologies can help solve the significant problem of missed findings in radiology studies. An important issue is assessing the economic benefits of implementing AI. Aim: to evaluate the frequency of missed pathologies detection and the economic potential of AI technology for chest CT, validated by expert r...

The paper presents the results of evaluating the thickness profile of a skull phantom using a two-dimensional ultrasound array consisting of piezoelectric elements with a center frequency of 2.1 MHz. Two pulse-echo ultrasound methods were used in the experiment: the A-mode elementwise measurements and scanning with a focused probing beam created by...

Coronavirus infection is a topic that has not lost its relevance in the medical community to date. Among the heterogeneous clinical manifestations of this disease lesions of cardiac structures often occur. They are mainly of inflammatory nature and can be both acute and delayed. It is well known that the prognosis for patients with cardiac lesions...

The nipple-areolar complex (NAC) is a specific anatomical and histological structure. Normal structure variabilities, pathological processes various and the complexity of diagnostic imaging cause difficulties for radiologists and physicians. Breast magnetic resonance imaging (MRI) is highly sensitive method for structural features, cancer detection...

Russian Society of Cardiology (RSC) With the participation of the Eurasian Association of Therapists, the Russian Scientific Medical Society of Therapists (RNMOT), the Russian Society of Pathologists, the Russian Society of Radiologists and Radiologists (RSR) Approved by the Scientific and Practical Council of the Russian Ministry of Health (30.09....

Introduction : Computed tomography (CT) and CT angiography are standard imaging modalities for suspected acute intracerebral hemorrhage due to ruptured intracranial aneurysms. In this clinical setting, several protocols of computed tomography and CT angiography may be implemented. The standard CT angiography protocol is limited to intracranial vess...

Left ventricular non-compaction (LVNC) is a rare, genetically and phenotypically heterogeneous disease, which is often accompanied by diagnostic difficulties. Aim. To demonstrate several generations of a family with LVNC with various clinical and phenotypic manifestations of the disease (dilated and isolated types of LVNC) with an identified rs3975...

Aim. To demonstrate two generations of a family with a progressive course of left ventricular non-compaction (LVNC) and the presence of a RBM20 gene variant. Material and methods . Based on the multicenter registry of patients with LVNC, a family with LVNC with a dilated phenotype was selected at the National Medical Research Center for Therapy and...

The prospect of continued manned space missions warrants an in-depth understanding of how prolonged microgravity affects the human brain. Functional magnetic resonance imaging (fMRI) can pinpoint changes reflecting adaptive neuroplasticity across time. We acquired resting-state fMRI data of cosmonauts before, shortly after, and eight months after s...

Aim To evaluate clinical efficacy of the proactive anti-inflammatory therapy in patients hospitalized for COVID-19 with pneumonia and a risk of “cytokine storm”. Material and methods The COLORIT study was a comparative study with randomization into 4 groups: colchicine (n=21) 1 mg for the first 3 days followed by 0.5 mg/day through day 12 or discha...

BACKGROUND: In accordance with the requirements of the IAEA basic safety standards and the International Commission on Radiation Protection, comparing the radiation dose for patients undergoing computed tomography (CT) in diagnostic and treatment clinics with national or international DRLs is important for controlling medical radiation doses. The s...

Inherited cardiomyopathies (CMPs) are fairly common causes of morbidity and mortality, particularly, in young individuals. In substantial number of cases, only morphological diagnostic criteria cannot distinguish one CMP from another because of incomplete penetrance, advanced stage of the disease, or overlapping phenotypes. Genetic testing has beco...

Objective : Identification of the quantitative characteristics of changes in the arterial wall according to ultrasound, CT and MRI; development of the roadmap for the use of radiology diagnostic methods. Material and methods : 548 studies of 483 patients with atherosclerosis were analyzed (15 ultrasound studies, 483 – CTA and 50 – MRI). In the comp...

The theory of systemic and dynamic localization of higher mental functions by Lev Vygotsky and Alexander Luria was based on the data obtained via an original method, syndrome analysis of deficits of higher mental functions in patients with local brain injury. When this theory was being constructed, technical methods for brain investigation were onl...

Ascending thoracic aortic aneurysm is a life-threatening disease, which is difficult to detect prior to the occurrence of a catastrophe. Epidemiology patterns of ascending thoracic aortic dilations/aneurysms remain understudied, whereas the risk assessment of it may be improved. The electronic databases PubMed/Medline 1966–2022, Web of Science 1975...

Introduction: Previously, a functional test with intravenous administration of adenosine triphosphate (ATP) was proposed to assess the reactivity of cerebral circulation and the functional significance of internal carotid artery stenoses, with evaluation by brain SPECT (neuroSPECT) with 99mTc-HMPAO. The types of the reaction of the cerebral blood f...

Variants of the MYH7 gene have been associated with a number of primary cardiac conditions, including left ventricular noncompaction cardiomyopathy (LVNC). Most cases of MYH7-related diseases are associated with such variant types as missense substitutions and in-frame indels. Thus, truncating variants in MYH7 (MYH7tv) and associated mechanism of h...

Highlights. Early atherosclerotic changes in the abdominal aortic wall and common iliac arteries in patients without clinical manifestations of critical atherosclerotic stenosis of the lower extremity arteries were studied using contrast enhanced magnetic resonance imaging. A method for quantitative characterization of the accumulation of paramagne...

Elevated ACE expression in tissues (reflected by blood ACE levels) is associated with increased risk of cardiovascular diseases and is also a marker for granulomatous diseases. We developed a new approach for characterization of ACE status in the blood—ACE phenotyping and established normal values of ACE levels 50–150% of control pooled plasma. ACE...

Aim . To assess the changes in cardiology diagnostics scope in the Russian Federation during the coronavirus disease 2019 (COVID-19) pandemic. Material and methods . In an online survey organized by the Division of Human Health of the International Atomic Energy Agency (IAEA), including questions about changes in the workflow of diagnostic laborato...

ErdheimChester disease (ECD) is a rare non-Langerhans histiocytosis with multisystem inflammatory infiltrates consistent of monocytes/macrophages, reactive microenvironment and fibrotic fields. Cardiovascular involvement is one of the most frequent manifestations of ECD that can lead to life threating complications. In this article we are reporting...

Background. The amount of extracellular myocardial matrix is a non-invasive tool for quantitative assessment of myocardial fibrosis. MRI with late gadolinium-enhancement is considered to be the “Gold standard” of non-invasive practice. Dual Energy computed tomography is a new non-invasive approach for detection of myocardial fibrosis and its progno...

Background. Elevated ACE expression in tissues (reflected by blood ACE levels) is associated with increased risk of cardiovascular diseases and is a marker for granulomatous diseases. We developed a new approach for characterization of ACE status in the blood - ACE phenotyping - and established normal values of ACE levels as 50–150% of control pool...

Purpose: to study the contribution of perfusion iodine maps to diagnosis of acute pulmonary embolism (PE) and compare pulmonary perfusion defects with the main imaging biomarkers of PE. Materials and methods. 130 patients with suspected acute pulmonary thromboembolism were studied using pulmonary computed tomographic angiography with perfusion iodi...

High-grade gliomas (HGG) are the most aggressive primary neuroepithelial tumors. In this group of patients, high mortality rates persist, and the median survival rate fluctuates around 24.5 months. In order to clarify the issue of choosing adequate doses of the necessary stereotactic radiosurgery (SRS), as well as to elucidate the factors affecting...

Background The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown. Objectives The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care...

Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments and visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these changes and whether they equally affect crews of different space agencies remain unknown. We used MRI to analyze the alterations occurrin...

This article describes a clinical case of the heart rhabdomyoma in an adult patient diagnosed in early childhood. The result of the continued tumor growth was cardiac arrhythmia in the form of ventricular extrasystole with runs of ventricular tachycardia. Authors also present a literature review on the frequency of occurrence, morphology, clinical...

Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present findings of brain structural changes associated with long...

In recent years, there has been tremendous interest in the use of artificial intelligence (AI) in radiology in order to automate the interpretation. However, uncontrolled and widespread use of AI solutions may have negative consequences. Therefore, before implementing such technologies in healthcare, thorough training of personnel, adaptation of in...

The concept of “contrast-induced acute renal injury” (CI-AKI) is an increase in the level of plasma creatinine, recorded within 48 hours after contrast drug administration. This condition is the third most common cause of chronic renal failure occurring in a hospital. Despite the rather frequent occurrence of this phenomenon, it is not completely c...

Left ventricular noncompaction (LVNC) is a highly heterogeneous primary disorder of the myocardium. Its clinical features and genetic spectrum strongly overlap with other types of primary cardiomyopathies, in particular, hypertrophic cardiomyopathy. Study and the accumulation of genotype–phenotype correlations are the way to improve the precision o...

Introduction. Classical trigeminal neuralgia (TN) is a common disease, largely diagnosed by measuring the anatomical parameters of the trigeminal nerve and the adjacent artery using MRI. For an adequate assessment the significance of the identified changes, it may be necessary to adjust for the individual characteristics of the patient, such as gen...

Background Acute post-ablation pericarditis is the most common complication of epicardial ablation of ventricular arrhythmias (VA), while regional pericarditis following an initially uneventful endocardial catheter ablation (CA) procedure is a rare and elusive diagnosis. Case summary We report a case of a 66-years old Russian female who developed...

Russian Society of Cardiology (RSC) With the participation: Eurasian Association of Therapists (EUAT), Society of Specialists in Heart Failure (OSSN), Russian Scientific Medical Society of Therapists (RNMOT), Russian Society of Pathologists, Russian Society of Radiologists and Radiologists (RSR) Endorsed by: Research and Practical Council of the Mi...

Left ventricular non-compaction is a heterogeneous heart disease with various phenotypic and clinical manifestations. The article presents the results of clinical, instrumental and molecular genetic investigations of a family with diagnosed left ventricular non-compaction (LVNC) with different clinical and phenotypic manifestations. As a result of...

This study reviewed the head and neck cancer diagnosis publications using dual-energy computed tomography (DECT). The qualitative and quantitative analysis of the data was DECT obtained using intravenous contrast enhancement for localized tumors, which shows the importance of constructing iodine maps for obtaining additional diagnostic information....

Objectives: to assess the possibility of using ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in patients with carcinoma of unknown primary (CUP); to determine the effectiveness of PET/CT for detecting a primary tumor lesion in patients with a histologically verified diagnosis of CUP and the contribution of PET/CT...

Aim . To assess the diagnostic value of standard and modified ultrasound criteria for left ventricular noncompaction (LVNC). Material and methods . The study included 37 patients. All patients underwent echocardiography and magnetic resonance imaging (MRI). Patients with any of the standard echocardiographic criteria for LVNC (Chin, Jenni, Stollber...

The results of surgical treatment of 59 patients with veno-occlusive erectile dysfunction and follow-up of 8 years are presented. The age of patients is 18-48 years old (average age is 29.3 ± 7.6). Five of them had hemodynamic and clinical signs of arteriovenous erectile dysfunction in the stage of subcompensation, 16 patients underwent simultaneou...

Common diagnostic approach in patients with suspected cardiac amyloidosis includes cardiac magnetic resonance imaging and scintigraphy. We report the first clinical case of false-positive results of scintigraphy in a patient with Danon disease.

Cavernous malformations of the brain have become an increasingly common pathology in recent years, thanks to the advancement of modern methods of neuroimaging. Despite the benign nature of the course in most cases, these formations can cause convulsions and serious neurological disorders. Typically, clinical manifestations are caused by hemorrhages...

BACKGROUND: Several COVID-19 patients are subjected to multiple imaging examinations during hospitalization, the cumulative effect of which can significantly increase the total dose of radiation received. The effective radiation dose can be reduced by lowering the current and voltage of the X-ray tube, but this reduces image quality. One possible s...

Objectives We aimed to explore the impact of the COVID-19 pandemic on cardiac diagnostic testing and practice and to assess its impact in different regions in Europe. Methods The online survey organised by the International Atomic Energy Agency Division of Human Health collected information on changes in cardiac imaging procedural volumes between...

Background . Cardiovascular diseases are one of the main causes of death among women, and current prevention paradigms may not be sufficient in this group. In this context, it has been suggested that the detection of breast vascular calcifications can improve the screening and assessment of the risk of cardiovascular diseases in apparently healthy...

Impact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World

Left ventricular non-compaction cardiomyopathy (LVNC) is a rare heart disease, with or without left ventricular dysfunction, which is characterized by a two-layer structure of the myocardium and an increased number of trabeculae. Studying of familial forms of LVNC is helpful for risk prediction and genetic counseling of relatives. Here, we present...

OBJECTIVES: The aim of this study was to define the variability of maximal wall thickness (MWT) measurements across modalities and predict its impact on care in patients with hypertrophic cardiomyopathy (HCM). BACKGROUND: Left ventricular MWT measured by echocardiography or cardiovascular magnetic resonance (CMR) contributes to the diagnosis of HCM...

Breast vascular calcifications are a manifestation of calcinosis of the medial layer of the artery walls. This type of calcifications is well visualized on mammograms. Mammography is a widespread and affordable screening test for breast cancer. The studies published in recent years demonstrate a relationship of breast vascular calcifications to car...

Objectives This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardi...

Objectives The aim of this study was to define the variability of maximal wall thickness (MWT) measurements across modalities and predict its impact on care in patients with hypertrophic cardiomyopathy (HCM). Background Left ventricular MWT measured by echocardiography or cardiovascular magnetic resonance (CMR) contributes to the diagnosis of HCM,...

The objective is to describe a case of hypofractioned skull base meningioma radiosurgery. Clinical case. For 5 years, female patient S., 55 years old, suffered from headaches. In 2012, magnetic resonance imaging of the brain showed petroclival meningioma on the left actively and homogenously accumulating the contrast agent. The patient refrained fr...

The article presents the results of stenting of the left renal vein in 35 patients with proven hemodynamically significant compression of the vein in “aorto-mesenteric tweezers”. Clinical manifestations of lesions of the left renal vein are very diverse, and pathogenetic mechanisms remain not fully understood. Therefore, the determination of indica...

The article presents the examination of three generations of a family with diagnosed left ventricular noncompaction (LVNC) and various phenotypic manifestations of the disease (isolated, hypertrophic and dilated type of LVNC). As a result of a molecular genetics tests, a previously undescribed single nucleotide deletion in the PRDM16 gene was revea...

Speech disfluencies are a notable component of natural discourse production and comprehension that may play a role of signals that control the flow of communication. Using task-based functional MRI, we examined how brain functional connectivity changes when listeners encounter a disfluency. Participants listened to fragments of audio recordings of...

Aim. To analyze and demonstrate various phenotypes in patients with familial left ventricular noncompaction (LVNC). Materials and methods. In 2013 was created a multicenter registry of LVNC patients. On its basis 30 families with a familial LVNC were selected. Results. 30 LVNC families were selected from the register. From a total of 115 people (...

Aim. To analyze diagnostic performance of cardiovascular magnetic resonance (CMR) in patients, presented with myocardial infarction with nonobstructed coronary arteries (MINOCA). Materials ant methods. 46 consecutives patients presented with myocardial infarction without evidence of obstructive coronary disease on angiography between January, 1 20...

About ~50% of patients with arrhythmogenic cardiomyopathy (ACM) carry a pathogenic or likely pathogenic mutation in the desmosomal genes. However, there is a significant number of patients without positive familial anamnesis. Therefore, the molecular reasons for ACM in these patients is frequently unknown and a genetic contribution might be underes...

Cavernous malformations of the brain are currently a fairly common vascular pathology, the number of detected cases has increased dramatically in recent years. This is due to the introduction into clinical practice and widespread dissemination of modern neuroimaging methods, such as computed tomography and magnetic resonance imaging. Before the adv...

Actuality The course of the novel coronavirus disease (COVID-19) is unpredictable. It manifests in some cases as increasing inflammation to even the onset of a cytokine storm and irreversible progression of acute respiratory syndrome, which is associated with the risk of death in patients. Thus, proactive anti-inflammatory therapy remains an open s...

Aim. To assess the impact of the first wave of coronavirus disease 2019 (COVID-19) pandemic on the diagnosis of heart disease in the Russian Federation.Material and methods. Fifteen Russian medical centers from 5 cities took part in an online survey organized by the Division of Human Health of the International Atomic Energy Agency (IAEA), containi...

Although working memory (WM) is crucial for intellectual abilities, not much is known about its brain underpinnings, especially the structural connectivity. We used diffusion tensor imaging (DTI) to look across the whole brain for the white matter integrity correlates of the individual differences in the reading span (verbal WM capacity during read...