Umit Yildiko

Kafkas University · Department of Bioengineering

In this study, firstly, bis(thiosemicarbazone) ligand [L: 2,2′-(2-(2-(4-methoxyphenyl)hydrazineylidene)cyclohexane-1,3-diylidene)bis(hydrazine-1-carbothioamide)] was synthesized by the condensation reaction of thiosemicarbazide and ketone compound (2-(2-(4-methoxyphenyl)hydrazone)cyclohexane-1,3-dione). The metal complexes were synthesized by the r...

In this study, a small molecule, 4-(7-(5′-hexyl-[2,2′-bithiophen]-5-yl)benzo[c][1,2,5]selenadiazol-4-yl)-N, N-diphenyl aniline (HST) employing selenium (Se) containing heterocyclic derivative as a central core unit in their molecular skeleton has been synthesized by Suzuki coupling reaction. The NMR, FT-IR, and mass spectroscopy techniques were use...

This reearch focused on the structural characterization of (2Z,5E)-2-(((E)-benziliden) hidraziniliden)-5-(nitro(fenil)metilen)-3-feniltiazolidin-4-on molecule (Thiazolidinone-Bis Schiff Base). Depending on the molecule's stability phase geometry, all analyses have been carried out utilizing the B3PW91 technique with 6-311++G(d,p) and SDD basis sets...

ADME Analysis and molecular doking studies on 6-((4-benzylpiperidin-1-yl) methyl)- N2-(p-tolyl)-1,3,5-triazine-2,4-diamine molecule

Recent studies on 6-((4-benzylpiperidin-1-yl)methyl)-N2-(p-tolyl)-1,3,5-triazine-2,4-diamine[1] (TADx.) have aimed to elucidate its potential as a counter-drug for Alzheimer's disease (AD). To achieve this, a molecular docking analysis was conducted on the proposed structure using proteins sourced from the Protein Data Bank (PDB). Notably, active p...

Herein, the PCL‐PEG‐PCL macro xanthate reversible addition−fragmentation chain‐transfer agent was obtained on the polyethylene glycol (PEG) (600, 1000, and 1500 g/mol) block, after the addition of ɛ‐caprolactone via ring‐opening polymerization. Then, Poly (Styrene‐b‐ԑ‐Caprolactone‐b‐PEG‐b‐ԑ‐Caprolactone‐b‐Styrene) pentablock copolymer was synthesiz...

Using the Gaussian09 software package, N-(6-(2-(dimethylamino)ethoxy)-5-fluoropyridin-3-yl)-2-(4-fluorophenyl)-5-(trifluoromethyl)pyrazolo[1,5 α]pyrimidine-7-amine(DFPA) the theoretically optimal molecular structure, vibration frequencies and related vibrational movements of the molecule were researched. The DFT(B3PW91 and B3LYP) techniques' 6-311G...

Herein, aromatic polyimides (API) synthesis was carried out by polycondensation of the original diamine (new synthesis) and commercial dianhydride. The original diamine and API were characterized by different analysis techniques. In addition, experimental and quantum chemical calculations of the synthesized API were analyzed by density functional t...

In this study, theoretic analyses were executed on the optimized geometric structure of 3-(6-(3-aminophenyl)thiazolo[3,2-b][1.2.4]triazol-2-yl)-2H-chromen-2-one (ATTC). The basis sets for these theoretical research were B3LYP/DGDZVP and B3LYP/6-311G(d,p). To determine the stability and molecular reactiveness of the molecule, energy range, the HOMO-...

Flavonoids are polyphenolic plant secondary metabolites with biological properties including Alzheimer's disease (AD) inhibition activities. Numerous studies have been conducted on naturally occurring flavonoids modified to obtain effective drugs for the management of AD. In this study, DFT/B3PW91, TD-DFT/B3LYP methods of target molecule hispidulin...

The structural characterization of the 5.5",7"-trihydroxy-3,7-dimethoxy-4'-4"-O-biflavone (TDOB) molecule was done in this study. Based on the molecule's stable phase geometry, entire calculations were done by use of the detailed CAM-B3LYP and PBEPBE approach with SDD and LanL2DZ. In addition, a variety of HOMO-LUMO energy ranges, natural bond inte...

In this study, 4-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-yloxy) phthalonitrile (coded as MTPPN) was chosen as the phthalonitrile compound and the quantum chemical and in-silico studies have been done. First, the basis set of the time dependent density functional theory (TD-DFT) method was used and the boundary orbital energies and band gap cal...

The 6-311G(d,p) and SDD basis sets have been used to calculate the vibration frequencies, and the DFT/B3LYP approach was used to optimize the structure. The energy gap of the molecule has been calculated using the lowest unoccupied molecular orbital (LUMO) with the highest occupied molecular orbital (HOMO). The stability and charge delocalization o...

Here, two different novel sulfonated polyimides were produced using different monomer ratios. With 2 different molecules of diamine, 3,3′,4,4′-biphenyl tetracarboxylic dianhydride and perylene-3, 4, 9, 10-tetracarboxylic dianhydride in an inert atmosphere at two-stage high temperature and the presence of sulfonic acid, sulfonated polyimides were ob...

Axially bis-substituted silicon phthalocyanine was synthesized from the reaction of 2-(3,4-dimethoxy phenyl) ethanol and SiPcCl2. The structure of the compound was justified by FT-IR, ¹ H NMR, ¹³ C NMR, UV-Vis, and mass spectra. The conglomeration action of the phthalocyanine compound was determined by UV-visible spectra at different concentrations...

The synthesis of an axial phthalocyanine compound by the reaction of piperonyl alcohol and SiPcCl2 has been reported. Its structure was characterized by compound ¹HNMR,¹³CNMR, Mass, FTIR and UV visible spectroscopy. Photophysical and photochemical properties of the compound were investigated by fluorescence spectroscopy. The photosensitizer perform...

Axially bis-substituted silicon phthalocyanine was synthesized from the reaction of 2-(3,4-dimethoxy phenyl) ethanol and SiPcCl 2 . The structure of the compound was justified by FT-IR, ¹ H NMR, ¹³ C NMR, UV-Vis, and mass spectra. The conglomeration action of the phthalocyanine compound was determined by UV-visible spectra at different concentratio...

The 2-nitrophenol and 4-nitrophthalonitrile reagents were mixed in the presence of potassium carbonate in dimethylformamide (DMF) under N2 at room temperature. Then, by adding thymol(5-methyl-2-isopropylphenol) and continuing the reaction, 4-(2-(2-isopropyl-5-methylphenoxy)phenoxy)phthalonitrile was obtained. Zinc phthalocyanine (4) was formed from...

A new type of sulfonated polyimide was synthesized from a one-step polycondensation reaction with perylene-3,4,9,10-tetracarboxylic dianhydride and 4,4′-diamino-2,2′-stilbenedisulfonic. Pure characterization of sulfonated polyimide (SPI) was performed by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, thermogravimetric a...

ABSTRACT In this study, fluorescent zinc phthalocyanine compound was synthesized using 4-(2-(4-(2-phenylpropan-2-yl) phenoxy) phenoxy) phthalonitrile and zinc metal salt. The structure of compounds was characterized by using 1 H, and 13C NMR, FT-IR, Mass, UV-Vis spectroscopy. The fluorescence emission, excitation and absorption properties of this p...

Since phthalonitrile compounds have become popular lately, the focus has been on the idea that these compounds should be investigated. A unique phthalonitrile compound, 4-(4-(1-(4-hydroxyphenyl)-1-phenylethyl)phenoxy)phthalonitrile (coded as PN) was selected and molecular modeling studies were carried out on this compound to be brought to the liter...

Pyromellitic dianhydride (PMDA) and 4,4′-diamino-2,2′-stilbenedisulfonic acid (DSD) were polymerized by polycondensation in 1:1 Sulfonated Polyimide (SPI) m-Cresol. The SPI was characterized by spectroscopic analyses (Fourier transform infrared (FT-IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR), ultravi...

Daucus carota L. ssp. major (DCM) plant is widely used in traditional medicine to treat some types of cancer and various diseases. Therefore, we evaluated the biological activities of this plant to define its effects against prostate cancer (PCa), Alzheimer’s disease (AD), oxidation, and diabetes mellitus (DM) as well as identified its phenolic com...

A B S T R A C T In this study to be presented, the BAPMB molecule was synthesized and structurally characterized. All calculations were applied using the detailed DFT/B3LYP method with 6-311G (d, p) and SDD depended on the stable phase geometry of the molecule. Also, various HOMO-LUMO energy gaps, inter-orbital intramolecular interactions of the na...

4-(2-(benzo[d] [1,3] dioxol-5-ylmethoxy) phenoxy) phthalonitrile was first prepared as a starting material. Then, this new phthalonitrile derivative was reacted with Zn and Co salts to obtain new phthalocyanine complexes. Phthalocyanine complexes were evaluated by fluorescence emission, extinction, and absorption measurements. Aggregation studies s...

This study presents the successes in polystyrene (PS) synthesis through reversible additional fragmentation chain transfer (RAFT) polymerization. For RAFT polymerization of styrene, diethanolamine (DEA) RAFT agent was used. The PS synthesis has made significant progress in the control of the molecular weight distribution of polymeric products. The...

In this study, firstly, a new phthalonitrile derivative was synthesized from the reaction of caffeic acid with phthalonitrile. Then, metal phthalocyanine complexes were obtained from the reaction of this phthalonitrile derivative with metal salts. Compounds were characterized by UV, NMR, IR and Mass spectroscopy methods. In addition, the fluorescen...

Novel macro-xanthate agents containing azo initiator and polyethylene glycol (PEG) were synthesized to prepare block copolymers via macromolecular design by an interchange of xanthate (MADIX) polymerization. In this system, the multifunctional agents were used as both macromolecular chain transfer agents and free radical sources. Polystyrene–polyet...

In polymer structure design, branching can occur randomly or by reactions designed to target specific architectures. This microstructural property affects many physical properties such as polydispersity, molecular weight and polymer chain size. A new reversible addition-fragmentation chain transfer/macromolecular design through interchange of xanth...

4-(2-(benzo[d] [1, 3] dioxol-5-ylmethoxy) phenoxy) phthalonitrile was first prepared as a starting material. Then, this new phthalonitrile derivative was reacted with Zn and Co salts to obtain new phthalocyanine complexes. Phthalocyanine complexes were evaluated by fluorescence emission, extinction, and absorption measurements. Aggregation studies...

This study was conducted to evaluate the phenolic content, antioxidant potential, and enzyme inhibitiory properties of Rumex nepalensis by in vitro spectrophotometric methods. The experiments demonstrated that glutathione S-transferase (GST), α-glycosidase (α-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes were strongly...

Novel Ru(II) complexes of Shiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone were synthesized. The ligands (1a-e) were confirmed by IR, ¹H NMR, and ¹³C NMR spectra (only 1b and 1c). Structures of the synthesized Ru(II) complexes (2a-e) were illuminated by elemental analysis, IR, ¹H NMR, ¹³C NMR, and mass...

The 4-(2-[3,4-dimethoxyphenoxy] phenoxy) phthalonitrile was synthesized as the starting material of new syntheses. Zinc, copper, and cobalt phthalocyanines were achieved by reaction of starting compound with Zn(CH3COO)2, CuCl2, and CoCl2 metal salts. Basic spectroscopic methods such as nuclear magnetic resonance electronic absorption, mass and infr...

Yakıt hücreleri alanında kullanılan sülfonlanmış poliimidler ve uygulamaları hakkında birçok teoriksel ve deneysel çalışmalar bilim insanları tarafından yapılmıştır. Çeşitli yöntemlerle sülfonlanmış poliimidlerin farklı varyasyonları bulunmuş ve yakıt hücresi olarak kullanımında düşük maliyette yüksek performans sergilemesi amaçlanarak aşağıda anla...

(4-((1-((2-(bis(2-hydroxypropyl) amino) ethyl) (2-hydroxypropyl) amino) propan-2-yl) oxy) phthalonitrile) (BHHP) was synthesized from reaction N, N, N′, N′- tetrakis (2-hydroxypropyl) ethylene diamine (SM) with 4-nitro phthalonitrile. Zinc, cobalt and copper phthalocyanine complexes were achieved from the reaction of BHHP compound with metal salts....

Medicinal plants have been used traditionally since ancient times as alternative medications to treat various human diseases. In this work, we examined the chemical constituent, antioxidant activity, and enzyme inhibition of an endemic plant Thymus migricus. The plant extracts showed remarkable inhibition effects against the acetylcholinesterase (A...

In this study, the macromolecular design was performed via interchange of xanthates (MADIX) polymerization. The macro RAFT/MADIX agent containing the structure of polytetrahydrofuran (PTHF) (average Mn ~ 1000 g/mol) was synthesized to use in the polymerization. PS-b-PTHF-b-PS triblock copolymer was obtained by styrene-controlled radical polymerizat...

Nuclear magnetic resonance, vibrational, structural and electronic properties for 4-isopropyl-N, N-Bis (4-azidophenyl) aniline (IPAPA) were determined by quantum chemical calculations of the DFT method. The results were compared with experimental 1H-NMR spectral data. Theoretical chemical calculations and experimental values were in harmony. The ba...

Here phthalic acid metal complexes with acid function were synthesized. Fourie transform infrared spectroscopy (FT- IR), X-ray diffraction analysis (XRD), Scanning electron microscopy-Energy Dispersive Spectrometry (SEM+EDS) devices were used for structure analysis. The structural parameters of the copper and zinc complexes of 4,5-dichlorphthalic a...

Citation: Akman, M.; Ata, A. C.; Yildiko, Ü.; Cakmak, İ. Int. J. Chem.ABSTRACT Perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) has been used as industrial pigments for many years. This perspective makes it important to determine the synthesis and physical properties of PTCDA derivatives and their functional properties for application as elect...

In this study, 4-((2R, 3S)-2, 3, 4-trihydroxybutoxy) phthalonitrile was synthesized and characterized as starting material. This new starting material reacts with cobalt and copper metal salts to obtain metallophthalocyanine complexes. The electronic absorption of cobalt and copper phthalocyanine compounds in different concentrations of THF was inv...

The 4-((9-phenyl-9H-xanthene-9-yl) oxy) phthalonitrile compound was synthesized and characterized as starting material. Zinc phthalocyanine was obtained by reaction of 4-((9-phenyl-9H-xanthen-9-yl) oxy) phthalonitrile with Zn(CH3COO)2. Novel compounds were characterized using mass spectra, UV–Vis spectroscopy, 1H-NMR, 13C NMR, and infrared spectros...

A new compound (4-hydroxy-3-ethoxybenzoyl) oxy) silver (HMBOS) was synthesized. Quantum chemical calculations of the molecule were performed by the density functional theory (DFT) and second order MøllerPlesset perturbation theory (MP2). The characterization of the molecular structure by ionic bonding with silver (I) via oxygen was investigated by...

This study reports the synthesis of new zinc and magnesium phthalocyanine compounds with ((ethylenediamine-N,N′,N′-triacetic acid-N-2-ethyl)oxy) (ETAEO) substituted groups. A novel compound, (4-ETAEO) phthalonitrile, for the starting material of these phthalocyanines was synthesized. The exact characterization of the compounds was carried out with...

In this study, poly (lactic acid-b- ε -caprolactone) was synthesized with the ring opening polymerization of ε-caprolactone using of the poly lactic acid with the presence of DBTDL catalyst. In order to achieve that, poly lactic acid was synthesized by the condensation from the polymerization of the lactic acid with the SnCI2 catalyst. Poly (lactic...

In this work controlled radical polymerization (CRP) of methyl methacrylate was carried out in the presence of the Poly(ethylene glycol)(PEG) xanthate reversible addition fragmentation (RAFT) chain transfer agent designated as (CTA1) and (CTA2). Firstly, PEGs having different molecular weights (400 and 600 g/mol) were reacted KOH and CS2 and the...

Polyglycidyl methacrylate was obtained by radical polymerization of vinyl monomer glycidyl methacrylate using AIBN (2,2 Azobisisobutyronitrile) as the azo initiator. Azide-ended polyglycidylmethacrylate (pGA) was obtained using sodium azide (NaN3). Poly (caprolactonegraft-glycidylmethacrylate) graft copolymer synthesis with triazole ring was carrie...

Abstract Macro monomer were synthesized by click reaction (Cu (I) catalyzed azidealicyclic cyclization) of terminal alkynes and azides formed on different monomer. Poly (acryloyl chloride-graft-epichlorohydrin) graft copolymer were synthesized in the polymerization of the obtained vinyl macro monomer using 2,2’-azobisisobutyronitrile (AIBN) as init...

In this study, using macro RAFT agents containing polyethylene glycol (PEG) (400-600 g/mol) polymer block was carried out polymerization of methyl methacrylate. A series of polymerizations was measured quantitative values of the molecules weight increase by following time. The linear increase against time in block copolymer formation was observed t...

The poly [(ε-caprolacton-b-epichlorohydrin-b-ε-caprolactone)]-g-(polystyrene-)[(PCL-b-ECH-b-PCL)]-g-PS block-graft copolymers were prepared via cationic, ring opening (ROP) and atom transfer radical polymerization (ATRP) transformations. With this goal in the first, cationic ring-opening technique was used to polymerize the epichlorohydrin (ECH). T...

In this work, Macro-Reversible addition fragmentation termination (RAFT) agents based on poly(ethylene glycol) (PEG) possessing different molecular weights and bearing benzoyl xanthate moieties were synthesized by the reaction of PEG potassium xanthate salts with benzoyl chloride, 4-methyl benzoyl chloride and 4-chloro benzoyl chloride. Controlled...

The Cu(I)-catalysed azides and alkynes cycloaddition named as “click chemistry” is widely used in polymer synthesis[1]. The synthesis and characterization of a new type triazole containing copolymer using copper catalysed click polycondensation is reported. The reaction was performed under mild condition using 3,6-diazido-9-butyl-9H-carbazol-2-y...

The synthesis of new two phthalonitrile derivatives is described. Using these starting materials, metallophthalocyanines substituted with four 1H-benzoimidazol-2-ylsulfanyl and 2-(1H-benzo[d]imidazol-2-ylthioetoxy) have been synthesized, respectively. The newly synthesized compounds have been characterized by elemental analyses, UV-visible, IR and...

The synthesis of a new phthalonitrile derivative (4-(benzo[d]thiazol-2-ylthio)phthalonitrile), its metal-free phthalocyanine, and metallo-phthalocyanines are described. Phthalocyanines are formed in high yield with template synthesis. These compounds showed considerable solubility in CHCl3, DMF and DMSO, a primary condition for potential applicatio...

The synthesis of new two phthalonitrile derivatives is described. Using these starting materials, metallophthalocyanines Substituted with four 1H-benzoimidazol-2-ylsulfanyl and 2-(1H-benzo[d]imidazol-2-ylthioetoxy) have been synthesized, respectively. The newly synthesized compounds have been characterized by elemental analyses, UV-visible. IR and...