Ugnius Mickys

National Centre of Pathology, Vilnius University Santariskiu Clinics Affiliate, Vilnius, LIthuania · Biopsy pathology

Rationale: Aberrant pancreatic tissue in the gastrointestinal tract is a relatively common finding. However, malignant transformation is extremely rare. Herein, we report a case of ectopic pancreatic ductal adenocarcinoma in the stomach wall. Patient concerns: A 38 year old male presented with nausea, bloating, abdominal distention and weight lo...

Background: Malignant melanoma is becoming more common among middle-aged individuals all over the world. Melanoma metastasis can be found in various organs, although metastases to the spleen and stomach are rare. Herein we present a rare metastatic multifocal melanoma, clinically and histologically mimicking lymphoma, with metastases of multiple o...

MiNEN (mixed neuroendocrine-non-neuroendocrine neoplasm) is described in the 5th edition WHO classification of tumors of the digestive system as a mixed neoplasm, composed of neuroendocrine and non-neuroendocrine parts, each accounting for at least 30% of the tumor. Recently this formal criterion has been criticized based on the theory that both of...

Hepatoid adenocarcinoma is an extremely aggressive special subtype of gastric tumors. It can be lethal as no standard treatment options for this type of gastric cancer exist. Here, we describe a very rare case of a young female on her 21st week of pregnancy who was diagnosed with stage IV hepatoid adenocarcinoma of the stomach with elevated α fetop...

Ovarian steroid-cell tumors (SCTs) are a rare subgroup of sex-cord tumors of the ovary, accounting for less than 0.1% of all ovarian tumors. Not otherwise specified (NOS) tumors are the most common subtype. More than half of patients with SCTs-NOS show hyperandro-genic symptoms. The primary treatment for SCTs is surgery, as most cases are early-sta...

Abstract: Perivascular epithelioid cell tumor (PEComa) is a rare entity, characterized as a mesenchymal tumor with coexpression of melanocytic and smooth muscle markers. The involvement of the gastrointestinal tract is described in up to 100 cases in the English literature. Rectal PEComas are even more uncommon, with only 10 previously described ca...

Background: Malignant mesothelioma of the tunica vaginalis is a rare tumour which comprises less than 1% of all mesotheliomas. Case presentation: 69-years old patient with painful hard mass and hydrocele in the right scrotum to whom a right hydrocelectomy was performed. Any history of scrotal trauma or exposure to asbestos was not present. Excis...

The Spectrum of FANCM Protein Truncating Variants in European Breast Cancer Cases

Diffuse pulmonary lymphangiomatosis (DPL) is a rare disease characterized by uncontrolled proliferation of anastomosing lymphatic channels in the lungs, pleura and mediastinum. Several palliative treatment options have been suggested for this condition, such as surgical interventions, radiotherapy and systemic medications. However, the existing tre...

Germline protein truncating variants (PTVs) in the FANCM gene have been associated with a 2–4-fold increased breast cancer risk in case-control studies conducted in different European populations. However, the distribution and the frequency of FANCM PTVs in Europe have never been investigated. In the present study, we collected the data of 114 Euro...

Transient abnormal myelopoiesis (TAM) is a unique entity that usually occurs in children with Down syndrome (DS) or with trisomy 21 mosaicism. The somatic GATA1 mutation is a distinct feature of TAM. At presentation, TAM can resemble congenital leukemia (CL), which unlike TAM has an extremely poor prognosis and requires prompt therapeutic intervent...

Only 1% to 2% of meningiomas have primary extrameningeal location, which is mostly head and neck region. Primary pulmonary meningiomas (PPMs) are even more uncommon with up to 50 cases reported in the literature. Only 5 cases of PPM with confirmed or possible malignancy have been previously described. Three-grade classification of meningiomas with...

Background To evaluate indications for colectomy in T1 polyps and possible risk factors for lymph node metastasis. Methods Between 2004 and 2017, 40 patients underwent colectomy after endoscopic removal of malignant polyps with T1 carcinoma. Resection was done based on at least one of the unfavourable histopathological criteria. We collected and p...

Implications: Mis-segregation of chromosomes is a prominent feature of chromosome instability and intra-tumoral heterogeneity recurrent in metastatic tumors for which the molecular basis is unknown. The present study provides insight into the mechanism by which defects in rootletin, a centrosome linker component causes tetraploid segregation error...

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on Caucasians in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutat...

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on Caucasians in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutat...

Background MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptosis and may serve as prognostic and predictive markers. In this study we aimed to evaluate the role of miRNA-148a and miRNA-625-3p...

57 metų moteriai dėl T1 tiesiosios žarnos vėžio buvo atlikta transanalinė endoskopinė mikrochirurginė (TME) operacija. Galutinio patologinio tyrimo duomenimis, buvo konstatuota T2 invazija (1 pav.). Ligonei buvo pasiūlyta totalinė mezorektinė ekscizija (TME). Operacija buvo pradėta pusiau sulenkto lenktinio peilio padėtyje, atliekant dalį TME per i...

Background Yolk sac tumour diagnosis should be considered for young age patients admitted to the hospital with non-specific complaints of widespread disease. Correct diagnosis and carefully planned treatment is the key to a successful outcome. Methods and materials We present a rare case of a widespread yolk sack tumour of a uterine broad ligament...

Background. KRAS mutation is an important predictive and prognostic factor for patients receiving anti-EGFR therapy. An expanded KRAS, NRAS, BRAF, PIK3CA mutation analysis provides additional prognostic information, but its role in predicting bevacizumab efficacy is unclear. The aim of our study was to evaluate the incidence of KRAS, NRAS, BRAF and...

Purpose. The treatment of early-stage colorectal adenocarcinoma removed endoscopically depends on histopathologic findings. The aim of this retrospective study was to assess the benefit–risk balance to patients who underwent colectomy after endoscopic polypectomy of T1 carcinoma with unfavourable histological factors. Methods. Thirty one patients (...

malities. We report the case of a 59-year-old woman with a composite pro-T lymphoblastic lymphoma (LBL) and inde-terminate dendritic cell tumor infiltrating the lymph nodes, bone marrow and stomach. Genetic analyses revealed that both cell populations bore +21, while a G13D mutation of the NRAS gene and monosomy 18 were detected only in the pro-T L...

AimsPrimary effusion lymphoma (PEL) is a rare form of aggressive B-cell lymphoma, which typically manifests as malignant effusion in the body cavities. However, extracavitary solid variants are also described. The aim of this study was to investigate copy number aberrations in two cases of solid PEL at their first occurrences and relapse by applyin...

Glomus tumor is a rare benign mesenchymal tumor, mostly found in acral skin or superficial soft tissues, but it can occur in other locations. Glomus tumors in different locations share similar histological and immunohistochemical characteristics, although some aberrant features can be identified. We report a case of 41 year-old male with gastric gl...

There is limited knowledge about BRCA1/2 mutational profile in Lithuania. We aimed to define full BRCA1 and BRCA2 mutational spectrum and clinically relevant prevalence in Lithuania. A dataset of 753 unrelated probands, recruited through clinical setting, was used and consisted of 380 female breast cancer cases, 213 epithelial ovarian cancer cases,...

TikslasAnkstyvos stadijos storosios ir tiesiosios žarnos vėžio, pašalinto endoskopiniu būdu, tolesnė gydymo taktika priklauso nuo histologinio ištyrimo radinių. Šio tyrimo tikslas yra įvertinti kolektomijos naudos ir rizikos santykį pacientams, kuriems atliktaendoskopinė polipektomija ir histologinio tyrimo metu rasti nepalankūs histologiniai veiks...

TikslasAnkstyvos stadijos storosios ir tiesiosios žarnos vėžio, pašalinto endoskopiniu būdu, tolesnė gydymo taktika priklauso nuo histologinio ištyrimo radinių. Šio tyrimo tikslas yra įvertinti kolektomijos naudos ir rizikos santykį pacientams, kuriems atliktaendoskopinė polipektomija ir histologinio tyrimo metu rasti nepalankūs histologiniai veiks...

Rhabdoid colonic tumors are very rare lesions with just a few publications describing such neoplasms. Even more unusual for these lesions are their primary rectal locations, with only two brief case reports having been published on that subject to date. We present a case of a composite rhabdoid rectal carcinoma in a 49-year-old male. The tumor beha...

The occurrence of ectopic decidua has been observed mostly in the ovaries, uterus and cervix. Ectopic gastrointestinal deciduosis is a physiological condition. Only several cases of ectopic decidua, causing complications have been presented in literature. To the best of our knowledge, sigmoid or any other bowel perforation, caused by deciduosis, ha...

A 14-year-old boy presented with asymptomatic right hydronephrosis detected on routine yearly ultrasound examination. Previously, he had at least two normal renal ultrasonograms, 4 years after remission of acute myeloblastic leukemia, treated by AML-BFM-93 protocol. A function of the right kidney and no damage on the left was confirmed by a DMSA sc...

Germline TP53 gene mutations are associated with complex cancer predisposition syndrome, the Li--Fraumeni syndrome, and are not as rare as were previously thought. Currently, the identification of Li--Fraumeni syndrome is mostly based on a conformance to descriptive criteria, which recently were amended to include wider spectrum of malignancies. Th...

Key words: lymphangioleiomyomatosis, tuberous sclerosis, treatment of lymphangioleiomyomatosis. Lymphangioleiomyomatosis (LAM) is a rare women's disease that is characterized by unusual lymphatic smooth muscle cell proliferation. First disease onset occurs between the second and fourth decades of women's life. Usually primary site of this desease p...

Systemic mastocytosis is an uncommon condition characterized by abnormal proliferation of mast cells in one or more organ. The specific D816V KIT mutation is present in most cases. Gastrointestinal symptoms occur commonly but histologic characterization of gastrointestinal involvement is incomplete. The purpose of this study was (1) to describe the...

A 46-year-old woman was admitted to the hospital with complaints of chronic diarrhoea, vomiting and severe muscle weakness. Clinical examination showed a lethargic, malnourished, dehydrated patient with ascites and bilateral leg oedema. Laboratory evaluation revealed mild normochromic normocytic anaemia and severe hypoproteinaemia with hypoalbumina...

Objective To review GIST cases diagnosed in 2003–2004 at the Lithuanian State Centre of Pathology, to evaluate the histological findings and to correlate histological features with the risk of malignant biological behavior. Materials and methods To evaluate the patiens’ age and sex distribution, localization, metastases, GIST relapses and multiple...

Mindaugas Plečkaitis1, Ugnius Mickys2, Darius Dasevičius2 1 Vilniaus greitosios pagalbos universitetinė ligoninė, Šiltnamių g. 29 LT-04130, Vilnius 2 Valstybinis patologijos centras, Baublio g. 5, LT-08406 Vilnius El. paštas: mindaugaspleckaitis@yahoo.com; ugnius.mickys@vpc.lt Tikslas Išanalizuoti GIST atvejus, diagnozuotus Valstybiniame patologi...

This article contains histological review of prostate biopsies techniques from the digitally guided prostate biopsies to modern extended-core prostate biopsy protocols. The technique of transrectal ultrasonography (TRUS) guided biopsy of the prostate has evolved considerably since the original description by K. K. Hodge and colleagues. A better und...

Traditionally, spindle cell tumors of the gastrointestinal tract have been classified as leiomyoma or leiomyosarcoma because of a close morphologic resemblance to smooth muscle tumors. Tumors with epithelioid cells were designated as leiomyoblastoma and later as epithelioid leiomyoma or leiomyosarcoma. The term “gastrointestinal stromal tumor” incl...

Mindaugas Plečkaitis1, Ugnius Mickys1, Arvydas Rimkevičius2 1 Valstybinis patologijos centras Baublio g. 5, LT-08406 Vilnius 2 Vilniaus universiteto Eksperimentinės ir klinikinės medicinos institutas, Žygimantų g. 9, LT-01102 Vilnius El paštas: mindaugas.pleckaitis@vpc.lt; ugnius.mickys@vpc.lt Tradiciškai gastrointestininio trakto šeivinių ląsteli...

Algimantas Sruogis1, Ugnius Mickys2, Tadas Petraitis1, Edita Kaubrienė3, Feliksas Jankevičius1 1 Vilniaus universiteto Onkologijos instituto Urologijos skyrius, Santariškių g. 1, LT-08661 Vilnius El paštas: sruogis@loc.lt 2 Lietuvos nacionalinis patologijos centras 3 Vilniaus universiteto Onkologijos instituto Intervencinės echoskopijos ir ultragar...