Т.Т. Хамроев

Institute of Chemistry of plant substances named after academician Sobir Yunusovich Yunusov of the Academy of Sciences of the Republic of Uzbekistan · Pharmacology and toxicology

Abstract: Effective doses were selected after studying the activity of a dry extract of the Tribulus terrestris L. plant growing in the territory of the Republic of Uzbekistan, based on screening studies on experimental animals. Its anti hypoxic activity was evaluated using models of normobaric, heme, and cytotoxic hypoxia. According to the results...

Since the prevalence of acute and especially severe chronic liver diseases of various etiologies increases from year to year, this pathology is recognized as the main burden on health worldwide. Currently, it has been established that the use of drugs based on essential phospholipids and plant origin with antioxidant and hepatoprotective activity i...

Ушбу мақолада мамлакаимиз ва Ўрта Осиё ҳудудида кенг тарқалган Adonis turkestanica ўсимлигининг экстракция жараёнида ҳосил бўлган қолдиғини психофармакологик фаоллигини ўрганиш натижалари тақдим этилган. Ўрганилган моддани тажриба ҳайвонларининг ҳаракат ва қидирув ҳамда анксиолитик фаоллиги 0,1; 1,0 ва 10 мг/кг дозаларда оғиз орқали бир маро...

At the Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan, a number of scientists conducted extensive pharmaco-toxicological studies to study the biological activity of vincane hydrochloride and its derivatives. Based on these studies, a number of studies were conducted not only on the special pharmacologi...

Indole alkaloids including sedative activity of pyrazolone iodine methylate and pyrazolone chloride were caused by alcohol sleep and feeling against arousal or fear effects were studied by the Sonberg method. In this study, pyrazoline iodine methylate and pyrazaline chloride reduced sleep time by increasing the sleep time caused by alcohol, in the...

The article presents data on the study of the anxiolytic activity of compounds representing new triazole derivatives – combinations of two privileged structures. At the "Raised Cruciform labyrinth" installation, such indicators of the studied compounds, the time of exit into the open sleeve, the number of exits and the total time spent in it wer...

Resume. In this presented article, it was presented that 5-(p-Aminophenyl)-1,3,4-oxadiazole-2-tion (conditionally D-111) at doses of 10, 30 and 60 mg / kg when administered orally to white mice with various analyzers, including strychnine (1.2 mg / kg subcutaneously), and also orally in doses of 10 and 30 mg/kg. the anticonvulsant activity of the s...

These papers present a study of the synthetic compound potassium salt 5-(o-aminophenyl)-1,3,4-oxadiazol-2-thione (D-361) at doses of 10; 30 and 60 mg/kg by oral administration on motor activity, locomotor action of phenamine, haloperidol catalepsy and M-cholinergic receptors in experimental animals. Based on the results of the experiment, it was...

In these presented works, when studying the biological activity of dried grape seed extract under normal conditions, the motor-research activity, actoprotective and anticonvulsant activity of experimental animals was determined. Based on the results obtained, it was found that the test substance in doses of 30 and 60 mg/kg in the experiment reduce...

The effect of plant proanthocyanidin – yantacin isolated from the camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis in experimental conditions was studied. The studies wer...

In this article, we studied an anticonvulsant model induced by different analyzers of corazole (80 mg/kg s.c.), strychnine (1.2 mg/kg s.c.), isoniazid (300 mg/kg ip) and bicuculin (2.7 mg/kg s.c.) when administered orally to white mice, N-deacetylappaconitin at doses of 0.01; 0.05; 0.1; 0.5; 1.0 and 2.0 mg/kg anticonvulsant effect of the test subst...

Under experimental conditions, the effect of plant proanthocyanidin-yantacin isolated from a camel thorn plant (Alhagi pseudalhagi)-Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis was studied. The studies were...

Annotation. In the present study, experimental models of chronic toxic hepatitis were induced by intragastric, subcutaneous and intraperitoneal administration of a solution of heliotrin. Hematological, biochemical and morphological research methods were used to assess the severity of liver damage. Based on the data obtained, toxic hepatitis was con...

The aim of this study was to study the biological activity and acute toxicity of the effect of dry extract of Gossypium hirsutum L on the central nervous system. He have a central psychostimulating effect, have smaller doses of M-cholinomimetic effect. The dopamine-positive effect of the drug was revealed.

Gossypium hirsutum L. – is a cotton plant of the Malvaceae family. We know that all organs of cotton are valuable raw materials for the industry and can be completely utilized. Through its unique composition, cotton is widely known in traditional and folk medicine as an excellent antiviral, antipyretic, hemostatic and astringent agent that helps...

In this article, N-deacetyllappaconitine in doses of 0.01 was studied on a model of arrhythmia caused by aconitine when administered orally to white rats; 0.05; 0.1; 0.5; 1.0 and 2.0 mg / kg pharmacodynamic parameters of the substance and comparative drugs of allapinin and propafenone. The antifibrillar effect of N-deacetylappaconitine in variou...

The aim of this study was to study a new antiarrhythmic effect of N-deacetylappaconitine on the central nervous system. He have a central sedative effect, have large doses of weak M-anticholinergic action. The dopamine-positive effect of the drug was revealed.

In chronic experiments in laboratory animals, studied toxicological perspective new antiarrhythmic effect of N-deacetyllappaconitine for the treatment of arrhythmic states, an original herbal preparation based on Aconitum leucostonum, Ac.Septentrionale was created. During 2,5 months of intragastric administration in animals exposed to all doses of...

The aim of the present study was to study a new antiarrhythmic effect of N-deacetyllappaconitine on the general pharmacological irritant effect on the skin, when applied to the conjunctival sac of the eye, mucosal hyperemia and lacrimation, cumulative, allergenic and diuretic effects. At the same time, it does not cause changes, which makes it more...

The aim of the present study was to study a new antiarrhythmic effect of N-deacetyllappaconitine on the general pharmacological irritant effect on the skin, when applied to the conjunctival sac of the eye, mucosal hyperemia and lacrimation, cumulative, allergenic and diuretic effects. At the same time, it does not cause changes, which makes it more...

The aim of the study was to study the antiarrhythmic activity of N-deacetylappaconitine when administered orally. The study was conducted on models of arrhythmias caused by intravenous administration of a solution of aconitine, barium chloride, calcium chloride and epinephrine to animals. N-deacetylappaconitine showed a pronounced antiarrhythmic ef...

Study of the antihypoxic activity of liposamal forms of the substance of the adaptogenic drug ecdisten obtained by ultrasound treatment (RCD) on models of cytotoxic, hemic and hypercapnic hypoxia in white mongrel male mice. Cytotoxic hypoxia causing a single subcutaneous injection of sodium nitroprusside at a dose of 20 mg/kg, hemic hypoxia intrape...

Preliminary pharmacological studies of the gum exatract of underground parts of Ferula tajikorum plant (EFT) were conducted. EFT witth LD50 5 g/kg in dose 10 mg/kg p.o. during prolonged administration decreased of spontane locomotors activity fall down to 25% and it was evaluated as sedation. In dose 30 mg/kg sedation was not stable. At a dose of 3...