![Tathagata Mukherjee](https://i1.rgstatic.net/ii/profile.image/11431281235106542-1712646393027_Q128/Tathagata-Mukherjee-4.jpg)
Tathagata MukherjeeNational Institute of Science Education and Research | NISER · School of Biological Sciences
Tathagata Mukherjee
Master of Science
Research Scholar, Cellular Immunology Laboratory, National Institute of Science Education and Research, Bhubaneswar
About
12
Publications
1,501
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
30
Citations
Introduction
I'm a Senior Research Fellow at the National Institute of Science Education and Research (an off-campus center of Homi Bhabha National Institute, Dept. of Atomic Energy, Govt. of India), Bhubaneswar, Odisha, India. Currently, I'm working on the regulation of T cell and macrophage responses associated with experimental immunosuppression.
Publications
Publications (12)
TRPV1 and TRPA1, are known to be functionally expressed in T cells,
where these two channels differentially regulate effector immune
responses. Telmisartan (TM), an anti-hypertension drug, has been
recently repurposed to suppress various inflammatory responses.
However, the possible involvement of TRP channels during TM-driven
suppression of T cell...
There is no approved antiviral for the management of the Chikungunya virus (CHIKV). To develop an antiviral drug that can manage both CHIKV and arthritis induced by it, an ester conjugate of telmisartan (TM) and salicylic acid (SA) was synthesized (DDABT1). It showed higher potency (IC 50 of 14.53 μM) and a good selectivity index [(SI = CC 50 /IC 5...
Background
Transient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiological conditions, including neuronal inflammation, neuropathic pain, and various immunological responses. Heat shock protein 90 (Hsp90), a cytoplasmic molecular chaperone, is well-reported for various cellular and physiologic...
Toll like receptor 4 (TLR4), a pathogen-associated molecular pattern (PAMP) receptor, is known to exert inflammation in various cases of microbial infection, cancer and autoimmune disorders. However, any such involvement of TLR4 in Chikungunya virus (CHIKV) infection is yet to be explored. Accordingly, the role of TLR4 was investigated towards CHIK...
Transient receptor potential (TRP) channels are a superfamily of cation-specific permeable channels primarily conducting Ca²⁺ ions across various membranes of the cell. The perturbation of the Ca²⁺ homeostasis is the hallmark of viral infection. Viruses hijack the host cell Ca²⁺ signaling, employing tailored Ca²⁺ requirements via TRP channels to me...
Correction to: J. Biosci. (2022) 47:42 https://doi.org/10.1007/s12038-022-00279-2 In the Journal of Biosciences article titled ''Elevation of TRPV1 expression on T-cells during experimental immunosuppression'' by P Sanjai Kumar et al. (https://doi.org/10.1007/s12038-022-00279-2; Vol. 47, Art. ID 42), published in July 2022, the affiliation of the a...
The transient receptor potential vanilloid 1 (TRPV1) channel is a thermo-sensitive, polymodal cation channel. An increase in intracellular calcium (Ca2+) is essential for T-cell responses. Similarly, various immunosuppressive agents are also reported to induce Ca2+ influx. However, the possible involvement of TRPV1 during immunosuppression has not...
Chikungunya virus (CHIKV) has re-emerged as a global public health threat. The inflammatory pathways of RAS and PPAR-γ are usually involved in viral infections. Thus, Telmisartan (TM) with known capacity to block AT1 receptor and activate PPAR-γ, was investigated against CHIKV. The anti-CHIKV effect of TM was investigated in vitro (Vero, RAW 264.7...
Chikungunya virus (CHIKV) has re-emerged as a global public health threat. The inflammatory pathways of RAS and PPAR-γ are usually involved in viral infections. Thus, Telmisartan (TM) with known capacity to block AT1 receptor and activate PPAR-γ, was investigated against CHIKV. The anti-CHIKV effect of TM was investigated in vitro (Vero, RAW 264.7...
An intracellular rise in calcium (Ca2+) is an essential requisite underlying T cell activation and its associated pro-inflammatory cytokine production. Transient receptor potential vanilloid channel (TRPV1) is a thermo-sensitive, polymodal gated and permeable to cations such as Ca2+. It has been reported that TRPV1 expression increases during T cel...