Susana A González-Chávez

Universidad Autónoma de Chihuahua | UACH · Faculty of Medicine, PABIOM

The danger model was proposed by Polly Matzinger as complement to the traditional self-non-self- (SNS-) model to explain the immunoreactivity. The danger model proposes a central role of the tissular cells’ discomfort as an element to prime the immune response processes in opposition to the traditional SNS-model where foreignness is a prerequisite....

Spondyloarthritis comprise a group of inflammatory rheumatic diseases characterized by its association to HLA-B27 and the presence of arthritis and enthesitis. The pathogenesis involves both an inflammatory process and new bone formation, which eventually lead to ankylosis of the spine. To date, the intrinsic mechanisms of the pathogenic process ha...

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease whose pathogenic mechanisms remain to be elucidated. The oxidative stress and antioxidants play an important role in the disease process of RA. The study of oxidants and antioxidants biomarkers in RA patients could improve our understanding of disease pathogenesis; likely determining t...

This study aimed to determine the prevalence of musculoskeletal (MSK) pain and rheumatic diseases in the Raramuri population (also known as Tarahumaras) who are an indigenous group in the northern state of Chihuahua in Mexico. We used the Community-Oriented Program for Control of Rheumatic Diseases (COPCORD) methodology. An analytical cross-section...

Patients with juvenile-onset spondyloarthritis (SpA) may develop ankylosis of the midfoot resembling the spinal changes seen in patients with ankylosing spondylitis (AS). The study of the histopathology of the feet of patients with tarsitis could help us understand the pathogenesis of bone formation in affected structures in the SpA. The objective...

Mammography is the modality of choice for the early detection of breast cancer. Deep learning, using convolutional neural networks (CNNs) specifically, have achieved extraordinary results in the classification of diseases, including breast cancer, on imaging. The images used to train a CNN varies based on several factors, such as imaging technique,...

Purpose: To compare the diversities and abundances of bacterial taxa in the microbiome of patients with HLA B27-positive acute anterior uveitis (AAU) in the active and inactive phases. Methods: An observational descriptive prospective and comparative study was conducted in ten HLAB27-positive AAU patients (44.6 ± 13.4 years). The microbiome of the...

The attitudes toward emerging COVID-19 vaccines have been of great interest worldwide, especially among vulnerable populations such as patients with rheumatic and musculoskeletal diseases (RMDs). The aim of this study was to analyze the relationship between the nationwide number of COVID-19 cases and deaths, and vaccine acceptance or hesitancy of p...

Purpose To analyze the differential transcriptome expression in hypertrophic ligaments flavum (HLF) compared to normal ligaments. Methods A case–control study was conducted that included 15 patients with hypertrophy of LF and 15 controls. Samples of LF were obtained through a lumbar laminectomy and analyzed by DNA microarrays and histology. The dy...

La medicina ha tenido un camino en paralelo con la tecnología durante las últimas décadas. El desarrollo de herramientas para la mejora del diagnóstico, pronóstico y tratamiento oportuno ha evolucionado el concepto de salud, la inteligencia artificial (IA) es ejemplo de ello. En esta revisión se abordan temas como la evolución de la historia de la...

The fibroblast-like synoviocytes (FLS) have a crucial role in the pathogenesis of Rheumatoid Arthritis (RA); however, its precise mechanisms remain partially unknown. The involvement of the fibroblast in activating adjuvant-induced arthritis (AA) has not been previously reported. The objective was to describe the participation of footpads’ fibrobla...

Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) could delay the ongoing pathogenic immune processes and potentially prevent its onset. Physical exercise (PE) benefits RA patients; however, its impact in reducing the risk of developing RA has scarcely been studied. The objective was to describe the effects of low-intensity PE applie...

Background: CrossFit is known as a functional fitness training high-intensity exercise to improve physical performance. The most studied polymorphisms are the ACTN3 R577X gene, known for speed, power, and strength, and ACE I/D, related to endurance and strength. The present investigation analyzed the effects of training on ACTN3 and ACE gene expre...

Se han desarrollados diversos modelos animales para comprender los complejos mecanismos de las espondiloartritis. El modelo de artritis espontánea de la cepa de ratón DBA/1 asemeja el daño inflamatorio en SpA por acción del estrés mecánico y de factores hormonales y de crecimiento causando artritis, sinovitis, dactilitis y entesitis. Estudios indic...

To analyze the effect of levofloxacin-induced intestinal microbiota modifications on intestinal, joint, and systemic inflammation in the DBA/1 mice with spontaneous arthritis. The study included two groups of mice, one of which received levofloxacin. The composition and structure of the microbiota were determined in the mice's stool using 16S rRNA...

One in eight women is likely to develop breast cancer at some stage in her life, with a 12.5% average risk rate of developing breast cancer. Early detection and treatment are of vital importance to ensure the patient's survival. Currently, mammography is the main diagnostic study to identify breast cancer. However, since mammography requires a huma...

Los polimorfismos de los genes ACTN3 y ACE relacionados al rendimiento deportivo son causa de polémica debido a quienes se inclinan por las diferencias entre el origen étnico y el estado atlético. Sin embargo, aunque lo anterior es objeto de debate a través de la genética se conoce que los beneficios potenciales del alelo R + I recaen en el rendimi...

Gold salts have been used to treat rheumatoid arthritis (RA) since the 1940s, and, with advances in nanotechnology, the use of nanogold provides multiple options for anti-inflammatory therapies. This paper presents the synthesis and characterization of silica-gold nanostructures (SGNs) and their therapeutic effect in collagen-induced arthritis (CIA...

Problem: Antinuclear antibodies (ANA) potentially play a role in the pathogenesis of connective tissue diseases (CTDs); however, they are also detected in healthy individuals. Our understanding of the physiological and pathological origin of ANA is incomplete. Both; female reproductive processes and deficiencies in DNA damage response (DDR) have b...

Introducción: el objetivo de este estudio fue analizar el pronóstico relacionado con las complicaciones en el periodo postquirúrgico de pacientes con apendicitis complicada. Material y métodos: estudio retrospectivo, que incluyó a pacientes pediátricos con apendicitis complicada en un periodo de tres años, a los que se les realizó apendicectomía p...

COVID-19 vaccination is recommended in patients with rheumatic diseases (RDs) to prevent hospitalized COVID-19 and worse outcomes. However, patients’ willingness to receive a SARS-CoV-2 vaccine and the associated factors vary across populations, vaccines, and time. The objective was to identify factors associated with COVID-19 vaccine acceptance (V...

Purpose: To describe the observations of studies that have explored the effects of exercise on inflammation and tissue remodeling in animal models of inflammatory arthropathies including Rheumatoid Arthritis and Spondyloarthritis. Methods: A search was performed at Pubmed, Scopus and Web of Science databases from 2010 to 2021. The selected artic...

Introducción: La detección temprana de pacientes con errores innatos del metabolismo (EIM) puede mejorar su pronóstico. Los signos y síntomas que presentan los pacientes con EIM son de ayuda para su identificación. El presente estudio tuvo como objetivo evaluar la capacidad diagnóstica de la hipotonía e hiperamonemia como indicadores de EIM en reci...

Introduction Complementary and alternative medicine (CAM) is frequently used by patients with rheumatic diseases (RD) to improve their symptoms; however, its diversity and availability have increased notably while scientific support for its effectiveness and adverse effects is still scarce. Objective To describe the prevalence and diversity of CAM...

Background DBA/1 mice arthritis models have contributed to our understanding of human rheumatoid arthritis (RA) and spondyloarthritis (SpA) pathogenesis, as well as the exploration of therapeutic targets for treatment. Quantitative polymerase chain reaction (qPCR) is an indispensable tool in molecular research, which requires reference gene validat...

IntroductionAlthough low back pain (LBP) is a high-impact health condition, its burden has not been examined from the syndemic perspective.Objective To compare and assess clinical, socioeconomic, and geographic factors associated with LBP prevalence in low-income and upper-middle-income countries using syndemic and syndemogenesis frameworks based o...

The aim of the study was to describe the oral health and orofacial function of Mexican patients with rheumatoid arthritis (RA) and their association with clinical and radiological aspects of the disease. Patients with RA received a complete odontological exam, which also included a clinical and radiographic assessment of the temporomandibular joint...

The ashwin gene, originally identified in Xenopus laevis, was found to be expressed first in the neural plate and later in the embryonic brain, eyes, and spinal cord. Functional studies of ashwin suggest that it participates in cell survival and anteroposterior patterning. Furthermore, ashwin is expressed zygotically in this species, which suggests...

Simple Summary: Ashwin is a gene involved in the morphogenesis of the central nervous system and the early embryonic development of Xenopus laevis. The analysis of its phylogeny in silico has shown that its functions are restricted to vertebrates, but we lack additional information regarding its biological importance in higher vertebrates, such as...

Aims To assess the effect of physical exercise (PE) on the histological and transcriptional characteristics of proteoglycan-induced arthritis (PGIA) in BALB/c mice. Methods Following PGIA, mice were subjected to treadmill PE for ten weeks. The tarsal joints were used for histological and genetic analysis through microarray technology. The genes dif...

Physical exercise (PE) is recommended for Rheumatoid Arthritis (RA), but the molecular and biological mechanisms that impact the inflammatory process and joint destruction in RA remain unknown. The objective of this study was to evaluate the effect of PE on the histological and transcriptional changes in the joints of adjuvant-induced arthritis (AI...

Objective To characterize the orofacial abnormalities in patients with rheumatoid arthritis (RA) and compare them with those in a reference population. Methods The study included 30 RA patients and 30 consecutive patients in an odontology clinic in whom RA was ruled out. Patients underwent a clinical dental examination which included: (1) clinical...

Objective: To characterize the orofacial abnormalities in patients with rheumatoid arthritis (RA) and compare them with those in a reference population. Methods: The study included 30 RA patients and 30 consecutive patients in an odontology clinic in whom RA was ruled out. Patients underwent a clinical dental examination which included: 1) clini...

Systemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the pathogenesis of which is yet to be understood. SLE is considered to be a multifactorial disease, in which genetic factors, immune dysregulation, and environmental factors, such as ultraviolet radiation, are involved. Recently, the description of novel genes confe...

Alterations in tissue oxygen pressure contribute to a number of diseases, including rheumatoid arthritis (RA). Low partial pressure of oxygen, a condition known as hypoxia, is a relevant feature in RA since it is involved in angiogenesis, inflammation, apoptosis, cartilage degradation, energy metabolism, and oxidative damage. Therefore, alterations...

Background: Rheumatic diseases (RDs) represent a global problem for health care systems and patients. Community Oriented Program for Control of Rheumatic Diseases (COPCORD) is a low-cost screening tool for detecting musculoskeletal (MSK) pain and RDs. Objective: The aim of this study was to examine the pattern of MSK pain and RDs in clinic popul...

To the Editor: We thank The Journal for the opportunity to address some details in the editorial by Appel and Sieper1 about our recent paper “Bone Lineage Proteins in the Entheses of the Midfoot in Patients with Spondyloarthritis”2. As Appel and Sieper stated1, we reported the lack of inflammatory lesions in our set of tissue samples2. Yet in co...

Este artículo puede ser consultado en versión completa en: http://www.medigraphic.com/analesmedicos MicroRNAs in breast cancer ABSTRACT Currently the scientific community is researching for breast cancer biomarkers. In genetics, miRNAs have been studied. MiRNAs are non-codifying endogenous nucleotides that exist throughout the DNA code. MicroRNAs h...

Confocal immunofluorescence is a valuable technique for the detection of relevant molecules in the pathogenesis of arthritis in rat models; however, it requires efficient processing of tissues including bone decalcification. The decalcification process must ensure the complete removal of calcium and also a proper preservation of cellular structures...

Multicentric reticulohistiocytosis (MRH) is a rare multisystem, granulomatous debilitating disease. It affects the skin with a nodular diffuse dermatitis and the joints with a severe, potentially deforming, and handicapping arthritis. No standardized therapy exists, it is a disease with heterogeneous severity, and therefore, a diversity of therapeu...

Lactoferrin (LF) is an 80 kDa iron-binding glycoprotein of the transferrin family that is expressed in most biological fluids and is a major component of the mammalian innate immune system. Its protective effects range from direct antimicrobial activities against a large panel of microorganisms, including bacteria, viruses, fungi and parasites, to...