ArticlePDF Available

Abstract

The corn cob is still a significant component of the corn residue. It is estimated that maize cob accounts for 40–50 percent of total corn production. Corn cob is considered an agriculture waste (by‐product of sweet corn). This by‐product causes environmental pollution, which produces health problems. Its phytochemicals and prebiotic potential provide large benefits for humans when it is consumed. Therefore, corn cob has functional properties such as antioxidant, antimicrobial, anticoagulant, anticancer and reduces the blood glucose level. Corn cob may be used as opportunistic raw material in food products and other possible applications. Current review explained the nutritional composition of corn cob and its possible health benefits. In conclusion, corn cobs have the potential for the development of value‐added products, which are gluten free and also contribute to flourish business of food development and nutraceutical manufacturing industries.
Review
Nutritional, functional, and ethno-medical properties of sweet
corn cob: a concurrent review
Fakhar Islam,
1
* Ali Imran,
1
Muhammad Afzaal,
1
Farhan Saeed,
1
Aasma Asghar,
2
Sumaira Shahid,
1
Arooj Shams,
1
Syeda Mahvish Zahra,
3,4
Sunanda Biswas
5
& Muhammad Arslan Aslam
1
1 Department of Food Science, Government College University, Faisalabad, Pakistan
2 Department of Food Science and Nutrition, Government College University, Faisalabad, Pakistan
3 Department of Environmental Design, Health and Nutritional Sciences, Allama Iqbal Open University, Islamabad, Pakistan
4 Institute of Food Science and Nutrition, University of Sargodha, Sargodha, Pakistan
5 Department of Food & Nutrition, Acharya Prafulla Chandra College, Kolkata, India
(Received 20 December 2022; Accepted in revised form 25 January 2023)
Summary The corn cob is still a significant component of the corn residue. It is estimated that maize cob accounts
for 4050 percent of total corn production. Corn cob is considered an agriculture waste (by-product of
sweet corn). This by-product causes environmental pollution, which produces health problems. Its phyto-
chemicals and prebiotic potential provide large benefits for humans when it is consumed. Therefore, corn
cob has functional properties such as antioxidant, antimicrobial, anticoagulant, anticancer and reduces
the blood glucose level. Corn cob may be used as opportunistic raw material in food products and other
possible applications. Current review explained the nutritional composition of corn cob and its possible
health benefits. In conclusion, corn cobs have the potential for the development of value-added products,
which are gluten free and also contribute to flourish business of food development and nutraceutical
manufacturing industries.
Keywords Corn cob, functional properties, nutritional composition, value-added products.
Introduction
Alternative sources of protein and nutrients must be
investigated as the global population grows in order to
solve the food scarcity problem (Lau et al., 2019). Utili-
sation of whole grains and their products, according to
epidemiological research, is helpful in avoiding chronic
diseases such as cardiovascular disease, obesity, Alzhei-
mer’s disease, diabetes type 2, and a few other malignan-
cies (Solfrizzi et al., 2017). This is due to the foods’
distinct phytochemical compositions and the synergistic
effects of these components. Phytochemicals, rather
than nutrients, are bioactive molecules present in plant
originated foods, are split into several types, which
include phenolic, alkaloids, nitrogen-containing-
compounds, carotenoids, flavonoids, and organo sulfur
compounds, and have been shown to have health bene-
fits in humans owing to their ability to neutralise free
radicals. Phospholipids and flavonoids, in especially, are
crucial chemicals for human health (Adom et al., 2005).
Sweet corn is distinguished from other corns by the
presence of a high level of sugar throughout the milky
and early dough phases, and the kernels are wrinkled
and brittle when dried (Geeta et al., 2017). A by-
product of sweet corn manufacturing for human utilisa-
tion, comprises cobs, husk leaves, discarded kernels,
and some stalks and counts for 6070 percent of the
harvest yield (Fritz et al., 2001). There have been a
growing number of papers in the bread sector about the
addition of food by-products to improve the functional
characteristics or nutritional values of products
(Lau, 2018). SCC, a nutrient-dense agricultural left over
from the processing of maize is rich in phytochemicals,
minerals, and dietary fibre, notably ferulic-acid (Lau
et al., 2019). Moreover, persons with dietary sensitivities
and intolerances in addition to increased consumer pref-
erence for wheat gluten-free items (Nachay, 2010).
Gluten-free (GF) foodstuffs are typically prepared with
low-dietary fibre starches or flours (Singh et al., 2016),
and they are commonly of poor colour, crumb, and
small volume (Matos Segura & Rosell, 2011). Muffins
are a renowned snack food among consumers because
of their delicious taste and delicate, springy texture
(Matos et al., 2014). Because of its hypo-allergenicity,
*Correspondent: E-mail: fakhar.ft440@gmail.com;
fakharislam17462@gcuf.edu.pk
International Journal of Food Science and Technology 2023
doi:10.1111/ijfs.16338
Ó2023 Institute of Food, Science and Technology (IFSTTF).
1
low-fat, low salt, excellent digestibility, and bland fla-
vour, rice is one of the best cereals for making gluten-
free items (Marcoa & Rosell, 2008). When rice flour is
being used to make muffins; however, it results in
decreased quantity, a poor crumb structure, colour, and
texture (Matos et al., 2014). Rice flour also has a low
fibre and ferulic acid content 84 mg kg
1
and 0.62 g/
100 g, similarly Wanyo et al.(2009). SCC flour had
306 mg of ferulic acid and 59.5 grams of insoluble die-
tary fibre per 100 grams (Lau et al., 2019); therefore, it
can be utilised to boost the dietary fibre, ferulic acid
amount, and functional characteristics of GF rice flour
muffins by incorporating it into the recipes. This review
article highlights the nutritional composition of sweet
corn cobs, their functional properties, and the applica-
tion of sweet corn cobs in gluten-free bakery products.
Composition of sweet corn cob
The hemicellulose content of corn cobs is 41.4%, the
cellulose content is 40%, the lignin content is 5.8%, the
crude protein content is 2.5%, the starch content is
2.1%, the ask content is 1.8%, the water soluble carbo-
hydrate content is 1.1%, and the crude fat content is
0.7% (Kaliyan & Morey, 2010). Insoluble dietary fibre
made up more than 60% of the SCC, with cellulose
being the main component and hemicelluloses coming
second (Lau, 2018). Additionally, according to inor-
ganic elemental analysis, corn cobs contained silicon
(5.33 g kg
1
), phosphorus (1.11 g kg
1
), potassium
(10.8 g kg
1
), magnesium (0.55 g kg
1
), inorganic sul-
phur (0.14 g kg
1
), aluminium (0.18 g kg
1
), barium
(0.11 g kg
1
), calcium (0.23 g kg
1
), and traces of
strontium and barium (0.11 g kg
1
), (Mullen et al.,
2010). Moreover, corn cobs may contain antioxidant
compounds. The phenolic content of corn cob extract
is related to its ability to total antioxidant (Lau, 2018).
Serine and glutamine were found to make up the
majority of the 18 free amino acids in SCC, which were
also found to contain alanine, glutamic acid, aspartic,
and proline. Despite the absence of measurements for
free arginine, the free amino acid level in SCC made up
0.7 percent of the composition overall. In comparison
to the required amino acids contained in maize grain,
SCC includes fewer vital amino acids reported by
Belyea et al.(2004). However, the levels of non-
essential and essential amino acids in SCC are higher
than those in other cereal products including rye bran,
barley flour, wheat bran, oat bran, and whole grain
rye. These amino acids include lysine, tryptophan, and
histidine (Mustafa et al., 2007). SCC can thus be uti-
lised in combination with other plant protein bases to
improve the mixture’s whole protein value. Magnesium
and potassium amounts are present 9.62 0.21 g kg
1
DW and 1.67 0.10 g kg
1
DW, respectively. Addition-
ally, detected in SCC was calcium, zinc, lead, copper,
manganese, and iron, but smaller sums. There were
more minerals overall compared to in the sweet corn
cobs examined in the current study those already
described by (Anukam et al., 2017).
Bioactive components
Phenolic compounds
Numerous physiological characteristics of phenolic
compounds have been linked to them, such as antimi-
crobial, antioxidant, cardioprotective, anti-allergenic,
vasodilatory, anti-artherogenic, anti-thrombotic, and
anti-inflammatory properties (Balasundram et al.,
2006). The most prevalent class of phytochemicals in the
plant kingdom is phenolic compounds (Rouf Shah
et al., 2016). SCC contains phenolic compounds in free,
insoluble-bound, and esterified forms. The insoluble-
bound form has the largest concentration of phenolic
chemicals. (5.410.27 g GAE kg
1
of sample) was fol-
lowed by the esterified phenolic fraction (0.430.05 g
GAE kg
1
) and free phenolic fraction (0.90.08 g GAE
kg
1
) (Lau, 2018). Total phenolics are effective free radi-
cal scavengers are plentiful in purple waxy maize. Com-
pared to tray drying, freeze drying retained a greater
antioxidant capacity Senphan (2019).
Ferulic and p-coumaric acid
Ferulic-acid (FA) is a phenolic acid found through-
out nature. Ferulic acid is often present in fruits and
veggies like rice bran, tomatoes, and sweet corn (Sri
Balasubashini et al., 2003) and has a wide variety of
functional actions against illnesses like diabetes, can-
cer, neurological disorders, and heart disease (Sriniva-
san et al., 2007). Ferulic and p-coumaric-acid total
amounts in all three fractions of sweet corn cobs are
3.060.19 and 4.230.25 g kg
1
DW, correspond-
ingly. Ferulic and p-coumaric acids, with 2.96 and
4.08 g kg
1
, respectively, are the most prevalent in the
insoluble-bound phenolic component of sweet corn
cobs. When comparing to the insoluble bound frac-
tion, the esterified and free phenolic fractions showed
considerably reduced (P<0.05) p-coumaric-acid and
ferulic levels (Lau, 2018).
Carotenoid compounds
Three carotenoids, zeaxanthin, b-carotene, and lutein,
were found and measured in SCC. The predominant
carotenoid in SCC was b-carotene, which was followed
by zeaxanthin and lutein. The antioxidant activity of
peaches, nectarines, and plums has no correlation to
their carotenoid content (Gil et al., 2002). Zeaxanthin
(2.16 mg kg
1
), b-carotene (0.68 mg kg
1
), and lutein
were among the carotenoids found in sweet corn
Ó2023 Institute of Food, Science and Technology (IFSTTF).International Journal of Food Science and Technology 2023
Functional properties of sweet corn cob F. Islam et al.2
kernels (5.95 mg kg
1
). Castillo et al.(2021) results
revealed that SCC had more zeaxanthin and b-
carotene than had previously been reported for
sweet-corn kernels. In all three antioxidant capacity
experiments (TEAC, FRAP, and DPPH), the bound
phenolics fraction had the best antioxidant capacity
and included the most ferulic and p-coumaric acid.
The most abundant carotenoids in SCC were zeaxan-
thin, b-carotene, and lutein reported by Lau (2018).
Supercritical fluid SFE was successful in extracting
substantial amounts of compared to traditional extrac-
tion, for carotenoids. There was no connection
between the carotenoid content. b-carotene content
was also three times higher when using SFE extrac-
tion. This might be because of the greater oxidation
sensitivity of beta-carotene compared to lutein and
zeaxanthin (Yuan et al., 2008). Furthermore, the mix-
ture of low viscosity and supercritical fluid with a high
diffusivity can improve the penetration into a solid
substance with pores and results subsequently lead to
a quicker and more efficient extraction (Lang &
Wai, 2001). The supercritical fluid extraction of carot-
enoids is superior to other vegetable byproducts like
persimmon peel concentration in SCC was higher
(Takahashi et al., 2006). Total phytosterol levels were
two times greater in cobs (68.0217.1 mg 100 g
1
DW) than in kernels (43.889.5 mg 100 g
1
DW), with
the greatest values in Sinhwangok kernels and cobs
60 days after pollination reported by Bae et al.(2022).
Functional properties of SCC
Prebiotic activity
Development profiles of ten L. plantarum strains in
SDM enhanced with an xylooligosaccharides (XOS)-
rich fraction derived from maize processing industry
waste. XOS was readily utilised by all of the microor-
ganisms examined as evidenced by the rise in the num-
ber of maize cobs SCFA liberation and the viscosity of
the culture broth All strains’ OD600 increased when cul-
tivated with 0.5 g L
1
XOS after 12 h of fermentation,
it was greater than 0.6, but in the OD600 was never
higher than medium without any carbohydrate 0.1. The
probiotic L. plantarum S
2
was the one whose develop-
ment was most aided by the prebiotic XOS; however,
strains S
56
and S
57
also grew well. Lb
1
was likewise stim-
ulated, leading to the conclusion that XOS was involved
was the favoured material, which corresponds to the
multiple authors’ reports, all of whom saw a definite
benefit the impact of this prebiotic on Lactobacillus
rhamnosus viability tangles (Madhukumar & Muralik-
rishna, 2010). XOS derived from water-extractable poly-
saccharides found in Bengal gram husk and wheat bran
was also found to enhance the development of bacteria
Lactobacilli (Pan et al., 2009). Furthermore, our current
research has revealed that various strains of L. plan-
tarum had varied characteristics growth characteristics,
which was most likely because to the in the hydrolysis of
XOS, there are variances in xylanase activity. In vivo
testing of the effects of xylooligosaccharides and L. plan-
tarum S2 on the gut microbes in a rat model revealed
that XOS coupled with L. plantarum S2 may enhance
the survivable bifidobacteria and lactobacilli while
decreasing the viable Clostridia spp. Enterobacter,and
Enterococcus reported by Yu et al.(2015).
Antioxidant activity
Corn cob xylan has a TAC of 48.5 mg ascorbic acid
equal per gram of xylan. This action was comparable
to sulphated polysaccharides from the palatable red
seaweed Gracilaria caudata, although it was higher
than that of tamarind seed polysaccharide (Choi et al.,
2009). As a result of corn cob xylan was chosen for fur-
ther investigation of its antioxidative effects because of
its greater TAC using a superoxide-radical scavenging
activity assay (SRSAA), a hydroxyl radical scavenging
activity assay (HRSAA), and a hydrogen peroxide
radical scavenging activity assay capacity for iron
chelation and power reduction antioxidants prevent
metal-lipid interactions by forming insoluble metal com-
plexes the formation of steric hindrance or complexes
with ferrous ions. The largest amounts of total flavo-
noids and phenolics were found in ripe corn silk and
corn cob (P<0.05) reported by Yang et al.(2019).
Anti-proliferative activity
In recent years, antiproliferative analyses of antioxidant
substances have been published (Maqbool et al., 2023).
One of the key challenges in the hunt for anticancer
drugs is the discovery of molecules that inhibit or pro-
long tumour cell proliferation while having no effect on
normal cells. In a dose-dependent approach, effective
against HeLa carcinoma cells, with highest antiproli-
ferative activity 50 percent action for about 2 mg/mL.
Furthermore, no action against normal fibroblast cells
was discovered (3T3) reported by Melo-Silveira et al.
(2011). According to Ryu et al.(2009), pure polysaccha-
rides from Salicornia herbacea can suppress cell growth
in human colon cancer accounts for 50% of the total at
1mgmL
1
. Polysaccharides’ anti-proliferative proper-
ties can be linked to the occurrence of charged groups
on the molecule. Gnabre et al.(2010) discovered a link
between the quantity of sulphate groups and
anti-proliferative activity. Polysaccharides derived from
seaweed have an effect. Furthermore, commercial xylo-
glucans derivatives (xyloglucans selenium esters) had an
anti-proliferative effect on tumour cells (HepG2) with a
dose-dependent effect with a dosage of 1 mg mL
1
,
30% of proliferation is inhibited (Cao & Ikeda, 2009).
Ó2023 Institute of Food, Science and Technology (IFSTTF). International Journal of Food Science and Technology 2023
Functional properties of sweet corn cob F. Islam et al. 3
Neutral polysaccharides, which predominantly comprise
xylose produced from Japanese-bamboo, show specific
cytotoxicity versus acute lymphoblastic-leukaemia cells,
with 60 percent anti-proliferative action 200 g mL
1
is
a concentration of 200 grams per millilitre of water
(Ryu et al., 2009). This shows that polysaccharides, such
as xylan, have anti-proliferative properties not just a
result of their charge density, but a combination of
polysaccharide structural characteristics anti-
proliferative activity and antioxidant content were
shown to have no correlation (R
2
=0.398) (P<0.05 or
above) (Ando et al., 2004). MEC (methanolic extract of
corn cobs) recovered SOD and CAT, lowered malon-
dialdehyde actions, and demonstrated excellent Trolox-
Equivalent-Antioxidant Potential in mice administered
with carbon tetrachloride. Moreover, MEC reduced
HeLa viability through apoptosis caused by an enhance-
ment in the Bax/Bcl-2 ratios, which activated caspase-3.
Protein kinase-C activity was also elevated in treated
tumour cells. As a result of our discoveries, corn cobs
have biotechnological significance as a reservoir of com-
pounds having pharmacological action reported by
Melo-Silveira et al.(2014).
Anticoagulant activity
Thromboembolic illnesses, including stroke, myocardial
infarction, and pulmonary embolism, are defined by the
movement and lodging of thrombus as well as the devel-
opment of blood clots inside the veins or arteries in vari-
ous organs. They are an issue for world health. The
anticoagulant medication mammalian-derived heparin,
which is generated from swine intestinal and bovine lung,
both protects and cures thromboembolic illness. Heparin
therapy includes a number of adverse effects, such as
bleeding and thrombocytopenia in contrast to the possi-
bility of infectious organism contamination, which
restricts its use reported by Chen et al.(2022). When
working with polysaccharides, anticoagulant action is
constantly taken into account. Plant polysaccharides, on
the other hand, are rarely tested for anticoagulant action
because they are mainly neutral. To present, no research
has looked into the anticoagulant properties of xylan’s.
Corn cobs were used to make this dish. As a result, it was
chosen to test this compound’s anticoagulant properties.
Corn cob flour was used to make this extract. To this
objective, xylan was put through anticoagulant testing
like these. In the experimental section, you will find a
description on how to do it. The researchers utilised com-
mercial activated partial thromboplastin time (APTT)
kits to see if the anticoagulant activity of xylan may affect
both extrinsic and intrinsic coagulation pathways Cai
et al.(2015). Additionally, at 2 mg mL
1
, xylan showed
strong ferric chelating action (70 percent). In the aPTT
test, Xylan also demonstrated anticoagulant action
reported by Melo-Silveira et al.(2011).
Antimicrobial activity
A significant issue in medicine is germ resistance to
antibiotics. Several bacteria isolates are found to be
resistant to antibiotics often used in clinical therapy
each year (Mehrotra et al., 2011). Every year, millions
of dollars are spent on this worrying issue, which also
endangers human life. Usman (2023) Thus, worldwide
initiatives to comprehend biology and biochemistry,
seek additional chemicals, and antibiotic activity have
advanced in academic and scientific facilities all about
the globe. Plant extracts were utilised to treat a variety
of human illnesses, including microbial infection, for
thousands of years. As a result, researchers have dis-
covered and created novel antibiotic molecules from
plant extracts. Staphylococcus epidermidis growth was
not inhibited by corn cob xylan in this investigation
(ATCC 35984). The polysaccharide, however, was able
to stop one clinical isolate of KPC produces Klebsiella
pneumoniae in about 25% of cases, which leads to the
development of biofilms was cut in the same percent-
age. KPC isolates are resistant to the majority of com-
mon antibiotics use carbapenems in particular to treat
clinical infections. By fractionating or chemically alter-
ing the functional compounds, which use the xylan as
a scaffold molecule, the apparent low of action
towards KPC may be increased even more. According
to Gul et al.(2011), various plant extracts present dis-
tinctive antibacterial activities against numerous differ-
ent bacterial species. The variation in this outcome
could be brought on by the various combinations of
receptors found in each type of bacteria perceive dis-
tinctive polysaccharide patterns, and as a result, the
technique of responding and signalling is special. Inhi-
bition of proteolytic-enzymes (peptidases) and other
connections that cellular-membrane-transferrin,
inactivate-bacterial-adhesins, and non-specific associa-
tions with polysaccharides may be the cause of poly-
phenol cytotoxic effects towards bacteria (Islam et al.,
2022). Phenolic compound extracted from sweet corn-
cob demonstrated bacteriostatic against Staphylococcus
Albus,Bacillus Subtilis, and Escherichia Coli reported
by Wang & Xu (2014). Additionally, xylan variation
reduced the minimum inhibitory concentration (MIC)
levels for QXy, particularly versus Gram-positive
microbes (S. aureus ATCC 25923), from >2.0 (Xy) to
0.25%w/v quaternized xylan’s (QXy). Modified xylan’s
provide improved antibacterial and antioxidant prop-
erties, as well as the ability to be used or included in
novel materials for a variety of uses, including biomed-
ical, biological, packaging, and therapeutics formula-
tions reported by Fr
ohlich et al.(2022). In an
experiment using normal and tumour human cells,
only HeLa tumour cell production was decreased
(P<0.05) in a dose-dependent way by xylan, reaching
saturation at about 2 mg mL
1
, but 3T3 normal cell
Ó2023 Institute of Food, Science and Technology (IFSTTF).International Journal of Food Science and Technology 2023
Functional properties of sweet corn cob F. Islam et al.4
growth was unaffected after 72 h reported by Melo-
Silveira et al.(2011).
Antidiabetic activity
A chronic metabolic condition called diabetes mellitus
presently affects 3% of the glob’s population. Chronic
hyperglycemia, problems with microvascular disease in
the renal glomeruli, retina, and peripheral nerves, as well
as glucose and lipid metabolism are the disease’s distin-
guishing features (Vinik & Vinik, 2003). Natural hypo-
glycemic agents, especially those derived from plants,
have lately gained popularity since they are regarded to
be less toxic and have less side effects than synthetic
sources. There are around 200 pure phytochemicals hav-
ing hypoglycaemic properties, and plant sources are
employed in various traditional diabetic therapies. How-
ever, experimental studies have shown that the over-
whelming amount of them have little to no effect on
glycaemic control. The PCE- or pinitol-treated animals
demonstrated considerable protection of pancreatic cell
destruction and increased insulin content in their pan-
creatic islets shape. The findings of microarray analysis
show that the liver and adipose tissues have protein and
gene expressions related to fatty acid metabolism and
glycolysis reported by Huang et al.(2015). Corn cobs
contain polysaccharides that have a beneficial role in
SCP-80-I and help reduce the blood glucose level in dia-
betic rats. Therefore, corn cob polysaccharides are used
as a medicine in type 2 diabetic condition reported by
Wang et al.(2022). As a result, SCP-80-1 may success-
fully control diabetic rats’ blood glucose levels, increase
glucose tolerance, and repair damaged islet tissue, show-
ing that this polysaccharide is a natural hypoglycemic
drug with potential for use in the treatment of diabetes
mellitus reported by Ma et al.(2020).
Utilisation of SCC in value-added products
There have been more recent articles in the baking
industry on using food waste to improve the nutritional
benefits or functional characteristics of the foods. To
increase the quality of flatbread, utilise tomato-pomace
as an excellent and economical base of hydrocolloids
(Majzoobi et al.2011). Additionally, many authors
reported that when the pomace of carrot was added,
which reduced the cake’s density, hardness, and cohe-
siveness while improving the sensory evaluations. Addi-
tionally, adding orange pomace flour might enhance a
coeliac patient’s intake of all dietary fibre. Furthermore,
Phimolsiripol et al.(2012) used rice bran to augment the
nutritional fibre concentration of gluten-free-bread
made from rice. Most of the gluten-free foodstuffs avail-
able now are of low quality because they lack flavour
and have a bad mouthfeel (Gallagher et al., 2003). Addi-
tionally, foods that are gluten-free are usually composed
of refined starches or flours that are not enriched or for-
tified. Since they are meant to replace products that con-
tain gluten, the amounts of nutrients may not be the
same. Therefore, it is questionable whether or not main-
taining a lifetime gluten-free diet assures celiac patients
a nutritionally balanced diet. Owing to its white-colour,
bland flavour, hypoallergenic qualities, and improved
digestion, rice flour has drawn increased interest as a
wheat flour substitute in the development of gluten-free
foods (Rosell et al., 2007). Most starches or rice-based
gluten-free foodstuffs contain a variety of hydrocolloids.
For instance, rice flour combined with more fat powder
yields biscuits of quality equivalent to those made with
wheat flour (Arendt et al., 2006). Nevertheless, these
gluten-free bakery items that use gums to substitute glu-
ten frequently lack fibre and minerals. Consequently,
research into the potential of substitute gluten-free flour
has increased. In sensory testing, the gluten-free biscuits
formed from a blend of brown rice, soya, maize, and
potato starch function similarly to their wheat-based
counterparts (Schober et al., 2008). Additionally, the
use of pseudocereals-minor cereals that are uncommon
and only grown in a few areas of the world in the prepa-
ration of gluten-free baking has been documented. Vari-
eties include chickpea, carob germ, soy flour, amaranth,
buckwheat flour (Alvarez-Jubete et al., 2010), quinoa
white flour (Elgeti et al., 2014), and quinoa flour. Addi-
tionally, it has been noted that cereals and pseudocer-
eals may contain polyphenols that make them a possible
food source (Saturni et al., 2010). One of the top grain
bases of polyphenols, like as ferulic, p-coumaric acid
gallic, and p-hydroxybenzoic, is buckwheat (Gallardo
et al., 2006). When used to make gluten-free crackers,
these compounds have been shown to increase overall
antioxidant and phenolic action when related to crack-
ers made from wheat (Sedej et al., 2011). Mushroom
production is enhanced by the nutrients in corncob.
Corn cob is used as a substrate for Lentinula edodes
(shiitake) cultivation as wood. The innovative substrate
for mushroom (Lentinula edodes) production is become
difficult those days. It also provides a cost-effective and
environmentally friendly method to convert transform-
ing biomass waste into high-quality edible-mushrooms
(Yu et al., 2022). Using 20% SCCF demonstrated a
reduction in the firmness of muffins while increasing the
volume of muffin and also the amount of airy cells in
the crumb. Compared to rice flour muffins, Sweet corn
cobs flour muffins had higher mean overall like scores
reported by Lau et al.(2022). Boosted integration of
corn cob flour in high-fibre bread preparations
increased the fibre concentration while decreasing the
protein amount (P<0.05). It had no effect on the other
chemical components, including ash, moisture, carbohy-
drate, and fat content. Increased corn cob flour inclu-
sion lowered bread volume while increasing bread
stiffness (P<0.05) reported by Hamzah & Lian (2012).
Ó2023 Institute of Food, Science and Technology (IFSTTF). International Journal of Food Science and Technology 2023
Functional properties of sweet corn cob F. Islam et al. 5
Conclusion
SCC is a by-product of sweet corn. This waste product
is discarded in our ecosystem every year. But this agri-
cultural waste contains important nutrient and func-
tional characteristics. This review paper concludes that
phytochemical such as phenols, carotenoids, and p-
coumaric acid and ferulic are present in corn cobs.
Moreover, polysaccharides and xylan have prebiotic
and therapeutic potential such as antioxidant, antimi-
crobial, anticoagulant, anticancer and reduces the
blood glucose level. Corn cobs are used for the devel-
opment of value-added bakery product products, and
this product is safe for gluten allergy persons.
Acknowledgments
The authors acknowledge Government College Uni-
versity, Faisalabad-Pakistan, for providing the facili-
ties used for the study.
Author contributions
Fakhar Islam: Writing original draft (equal). Ali
Imran: Supervision (equal). Muhammad Afzaal: Inves-
tigation (equal). Farhan Saeed: Formal analysis
(equal). Aasma Asghar: Visualization (equal). Sumaira
Shahid: Formal analysis (equal). Arooj Shams: Investi-
gation (equal). Syeda Mahvish Zahra: Validation
(equal). Sunanda Biswas: Data curation (equal).
Muhammad Arslan Aslam: Formal analysis (equal).
Conflict of interest
The authors declare no conflict of interest.
Ethical approval
The study does not involve any human or animal
testing.
Data availability statement
The data that support the findings of this study are
available from the corresponding author, upon
request.
References
Adom, K.K., Sorrells, M.E. & Liu, R.H. (2005). Phytochemicals and
antioxidant activity of milled fractions of different wheat varieties.
Journal of Agricultural and Food Chemistry,53, 22972306.
Alvarez-Jubete, L., Auty, M., Arendt, E.K. & Gallagher, E. (2010).
Baking properties and microstructure of pseudocereal flours in
gluten-free bread formulations. European Food Research and Tech-
nology,230, 437445.
Ando, H., Ohba, H., Sakak, I.T. et al. (2004). Hot-compressed-water
decomposed products from bamboo manifest a selective
cytotoxicity against acute lymphoblastic leukemia cells. Toxicology
In Vitro,18, 765771.
Anukam, A.I., Goso, B.P., Okoh, O.O. & Mamphweli, S.N. (2017).
Studies on characterization of corn cob for application in a gasifica-
tion process for energy production. Journal of Chemistry,2017.
Arendt, E.K. & Moore, M.M. (2006). Gluten-free cereal-based prod-
ucts. Bakery products: Science and technology,2006, 471496.
Bae, H.H., Ha, J.Y., Go, Y.S. et al. (2022). High phytosterol levels
in corn cobs point to their sustainable use as a nutritional source.
Applied Biological Chemistry,65,19.
Balasundram, N., Sundram, K. & Samman, S. (2006). Phenolic com-
pounds in plants and agri-industrial by-products: antioxidant activ-
ity, occurrence, and potential uses. Food Chemistry,99, 191203.
Belyea, R.L., Rausch, K.D. & Tumbleson, M.E. (2004). Composi-
tion of corn and distillers dried grains with solubles from dry grind
ethanol processing. Bioresource Technology,94, 293298.
Cai, W., Chen, Q., Xie, L., Yang, L. & Zhang, R. (2015). Extrac-
tion, sulfonation and anticoagulant activity of xylan from corncob.
European Food Research and Technology,240, 969975.
Cao, Y. & Ikeda, I. (2009). Antioxidant activity and antitumor activ-
ity (in vitro) of xyloglucan seleniousester and surfated xyloglucan.
International Journal of Biological Macromolecules,45, 231235.
Castillo, S., Rodr
ıguez, A., Bautista-Villarreal, M. et al. (2021). Rhe-
ological and nutritional characterization of sweet corn by-product
(cob) to develop a functional ingredient applied in dressings. Fron-
tiers in Nutrition,8, 666654.
The authors, examines the Rheological and Nutritional Characteriza-
tion of Sweet Corn By-Product (Cob). This work was of the great
novelty and explored the nutritional profile of the sweet corn cobs in
detail that’s why added their study.
Chen, G., Zeng, R., Wang, X. et al. (2022). Antithrombotic activity
of heparinoid G2 and its derivatives from the clam Coelomactra
antiquata. Marine Drugs,20, 50.
Choi, J.-I., Kim, J.-K., Srinivasan, P. et al. (2009). Comparison of
gamma ray and electron beam irradiation on extraction yield, mor-
phological and antioxidant properties of polysaccharides from tam-
arind seed. Radiation Physics and Chemistry,78, 605609.
Elgeti, D., Nordlohne, S.D., F
oste, M. et al. (2014). Volume and tex-
ture improvement of gluten-free bread using quinoa white flour.
Journal of Cereal Science,59,4147.
Fritz, V.A., Randall, G.W. & Rosen, C.J. (2001). Characterization
and utilization of nitrogen contained in sweet corn silage waste
contribution of the Minnesota Agric. Exp. Stn. Agronomy Journal,
93, 627633.
Fr
ohlich, A.C., Bazzo, G.C., Stulzer, H.K. & Parize, A.L. (2022). Syn-
thesis and physico-chemical characterization of quaternized and sul-
fated xylan-derivates with enhanced microbiological and antioxidant
properties. Biocatalysis and Agricultural Biotechnology,43, 102416.
Gallagher, E., Kunkel, A., Gormley, T.R. & Arendt, E.K. (2003).
The effect of dairy and rice powder addition on loaf and crumb
characteristics, and on shelf life (intermediate and long-term) of
gluten-free breads stored in a modified atmosphere. European Food
Research and Technology,218,4448.
Gallardo, C., Jim
enez, L. & Garc
ıa-Conesa, M.T. (2006). Hydroxy-
cinnamic acid composition and in vitro antioxidant activity of
selected grain fractions. Food Chemistry,99, 455463.
Geeta, H.P., Palanimuthu, V. & Srinivas, G. (2017). Study of some
physico-chemical properties of sweet corn. International Journal of
Agricultural Science Research,7, 277286.
Gil, M.I., Tom
as-Barber
an, F.A., Hess-Pierce, B. & Kader, A.A.
(2002). Antioxidant capacities, phenolic compounds, carotenoids,
and vitamin C contents of nectarine, peach, and plum cultivars
from California. Journal of Agricultural and Food Chemistry,50,
49764982.
Gnabre, J., Unlu, I., Chang, T.C. et al. (2010). Isolation of lignans
from Schisandra chinensis with anti-proliferative activity in human
colorectal carcinoma: structureactivity relationships. Journal of
Chromatography B,878(28), 26932700.
Ó2023 Institute of Food, Science and Technology (IFSTTF).International Journal of Food Science and Technology 2023
Functional properties of sweet corn cob F. Islam et al.6
Gul, M.Z., Bhakshu, L.M., Ahmad, F., Kondapi, A.K., Qureshi,
I.A. & Ghazi, I.A. (2011). Evaluation of Abelmoschus moschatus
extracts for antioxidant, free radical scavenging, antimicrobial and
antiproliferative activities using in vitro assays. BMC Complemen-
tary and Alternative Medicine,11, 64.
Hamzah, Y. & Lian, W.F. (2012). Physicochemical properties and
acceptance of high fibre bread incorporated with corn cob flour.
Asian Journal of Food and Agro-Industry,5, 547553.
Huang, B., Wang, Z., Park, J.H. et al. (2015). Anti-diabetic effect of
purple corn extract on C57BL/KsJ db/db mice. Nutrition Research
and Practice,9,2229.
Islam, F., Saeed, F., Afzaal, M. et al. (2022). Nutritional and func-
tional properties of Hyphaene thebaica L. flour: a critical treatise
and review. International Journal of Food Properties,25, 1234
1245.
Kaliyan, N. & Morey, R.V. (2010). Densification characteristics of
corn cobs. Fuel Processing Technology,91, 559565.
Lang, Q. & Wai, C.M. (2001). Supercritical fluid extraction in herbal
and natural productstudiesa practical review. Talanta,53(4),
771782.
Lau, T. (2018). Recovery offunctional ingredients from sweet corn (Zea
mays) cobs. (Doctoral dissertation, University of Reading). https://
centaur.reading.ac.uk/85142/12/21027177_Lau_thesis_redacted.pdf
Lau, T., Clayton, T., Harbourne, N., Rodriguez-Garcia, J. & Oruna-
Concha, M.J. (2022). Sweet corn cob as a functional ingredient in
bakery products. Food Chemistry: X,13, 100180.
The authors, examines sweet corn cob as a functional ingredient.
Authors explored the sweet corn cobs uses in the formation of bak-
ery products in details that’s why we have cited their study in our
article.
Lau, T., Harbourne, N. & Oru~
na-Concha, M.J. (2019). Valorisation
of sweet corn (Zea mays) cob by extraction of valuable com-
pounds. International Journal of Food Science & Technology,54,
12401246.
The authors, explored the bioactive profile of sweet corn cobs in
detail. Our article phytochemical section compatible with their study
that’s why we have cited their article in our study.
Ma, Y., Zhang, K., Wang, X., Lu, X. & Lin, C. (2020). Hypoglyce-
mic effect of sweet corn cob polysaccharide on diabetic rats. Shipin
Kexue/Food Science,41, 169173.
Authors, Ma and their colleagues studied the effect of sweet corn
cobs polysaccharides on diabetic rats in detail and their results sug-
gested that sweet corn cobs polysaccharides have hypoglycemic
effect. So our study heads are compatible with their study that’s why
we have cited their study in our article.
Madhukumar, M.S. & Muralikrishna, G. (2010). Structural charac-
terisation and determination of prebiotic activity of purified xylo-
oligosaccharides obtained from Bengal gram husk (Cicer arietinum
L.) and wheat bran (Triticum aestivum). Food Chemistry,118,
215223.
Majzoobi, M., Ghavi, F.S., Farahnaky, A., Jamalian, J. & Mesbahi,
G. (2011). Effect of tomato pomace powder on the physicochemi-
cal properties of flat bread (Barbari bread). Journal of Food Pro-
cessing and Preservation,35(2), 247256.
Maqbool, J., Anwar, H., Rasul, A. et al. (2023). Comparative
evaluation of ethyl acetate and n-Hexane extracts of Cannabis
sativa L. leaves for muscle function restoration after peripheral
nerve lesion. Food Science & Nutrition,19. https://doi.org/10.
1002/fsn3.3255
Marcoa, C. & Rosell, C.M. (2008). Effect of different protein isolates
and transglutaminase on rice flour properties. Journal of Food
Engineering,84, 132139.
Matos Segura, M.E. & Rosell, C.M. (2011). Chemical composition
and starch digestibility of different gluten-free breads. Plant Foods
for Human Nutrition,66, 224230.
Matos, M.E., Sanz, T. & Rosell, C.M. (2014). Establishing
the function of proteins on the rheological and quality properties
of rice based gluten free muffins. Food Hydrocolloids,35, 150158.
Mehrotra, V., Mehrotra, S., Kirar, V. et al. (2011). Antioxidant and
antimicrobial activities of aqueous extract of Withania somnifera
againstmethicillin-resistant Staphylococcus aureus.Journal of
Microbiology and Biotechnology Research,1,4045.
Melo-Silveira, R.F., Fidelis, G.P., Costa, M.S.S.P. et al. (2011). In
vitro antioxidant, anticoagulant and antimicrobial activity and in
inhibition of cancer cell proliferation by xylan extracted from corn
cobs. International Journal of Molecular Sciences,13, 409426.
Melo-Silveira, R.F., Fidelis, G.P., Viana, R.L.S. et al. (2014). Antioxi-
dant and antiproliferative activities of methanolic extract from a
neglected agricultural product: corn cobs. Molecules,19, 53605378.
Mullen, C.A., Boateng, A.A., Goldberg, N.M., Lima, I.M., Laird,
D.A. & Hicks, K.B. (2010). Bio-oil and bio-char production from
corn cobs and Stover by fast pyrolysis. Biomass and Bioenergy,34,
6774.
Mustafa, A.,
Aman, P., Andersson, R. & Kamal-Eldin, A. (2007).
Analysis of free amino acids in cereal products. Food Chemistry,
105, 317324.
Nachay, K. (2010). Gluten-free offerings increase. Food Technology,
64,1314.
Pan, X., Wu, T., Zhang, L., Cai, L. & Song, Z. (2009). Influence of
oligosaccharides on the growth and tolerance capacity of lactoba-
cilli to simulated stress environment. Letters in Applied Microbiol-
ogy,48, 362367.
Phimolsiripol, Y., Mukprasirt, A. & Schoenlechner, R. (2012). Quality
improvement of rice-based gluten-free bread using different dietary
fibre fractions of rice bran. Journal of Cereal Science,56(2), 389395.
Rosell, C.M., Collar, C. & Haros, M. (2007). Assessment of hydro-
colloid effects on the thermo-mechanical properties of wheat using
the Mixolab. Food Hydrocolloids,21, 452462.
Rouf Shah, T., Prasad, K. & Kumar, P. (2016). Maizea potential
source of human nutrition and health: a review. Cogent Food &
Agriculture,2, 1166995.
Ryu, D.S., Kim, S.H. & Lee, D.S. (2009). Anti-proliferative effect of
polysaccharides from Salicornia herbacea on induction of G2/M
arrest and apoptosis in human colon cancer cells. Journal of Micro-
biology and Biotechnology,19, 14821489.
Saturni, L., Ferretti, G. & Bacchetti, T. (2010). The gluten-free diet:
safety and nutritional quality. Nutrients,2, 16.
Schober, T., Bean, S., Boyle, D. & Park, S. (2008). Improved viscoelas-
tic zein-starch doughs for leavened gluten-free breads: Their rheology
and microstructure. Journal of Cereal Science,48, 755767.
Sedej, I., Saka
c, M., Mandi
c, A. et al. (2011). Quality assessment of
gluten-free crackers based on buckwheat flour. LWT-Food Science
and Technology,44, 694699.
Senphan, T. (2019). Comparative studies on chemical composition
and antioxidant activity of corn silk from two varieties of sweet
corn and purple waxy corn as influenced by drying methods. Food
and Applied Bioscience Journal,7,6480.
Singh, J.P., Kaur, A. & Singh, N. (2016). Development of eggless
gluten-free rice muffins utilizing black carrot dietary fibre concen-
trate and xanthan gum. Journal of Food Science and Technology,
53, 12691278.
Solfrizzi, V., Custodero, C., Lozupone, M. et al. (2017). Relation-
ships of dietary patterns, foods, and micro-and macronutrients
with Alzheimer’s disease and late-life cognitive disorders: a system-
atic review. Journal of Alzheimer’s Disease,59(3), 815849.
Sri Balasubashini, M., Rukkumani, R. & Menon, V.P. (2003). Pro-
tective effects of ferulic acidon hyperlipidemic diabetic rats. Acta
Diabetologica,40, 118122.
Srinivasan, M., Sudheer, A.R. & Menon, V.P. (2007). Ferulic acid:
therapeutic potential through its antioxidant property. Journal of
Clinical Biochemistry and Nutrition,40,92100.
Takahashi, M., Watanabe, H., Kikkawa, J. et al. (2006). Caroten-
oids extraction from Japanese persimmon (Hachiya-kaki) peels by
supercritical CO2 with ethanol. Analytical Sciences,22, 14411447.
Usman, I., Imran, A., Arshad, M.U. et al. (2023). Valorization of
mustard and sesame oilseed cakes for food application through
Ó2023 Institute of Food, Science and Technology (IFSTTF). International Journal of Food Science and Technology 2023
Functional properties of sweet corn cob F. Islam et al. 7
ecoinnovative technologies. Food Science & Nutrition,18. https://
doi.org/10.1002/fsn3.3214
Vinik, A.I. & Vinik, E. (2003). Prevention of the complications of
diabetes. American Journal of Managed Care,9, S63S80.
Wang, X., Wang, Z., Zhang, K., Ma, Y. & Xiu, W. (2022). Effects
of sweet corncob polysaccharide on pancreatic protein expression
in type 2 diabetic rats. Journal of Functional Foods,88, 104908.
Wang, X. & Xu, L.P. (2014). Ultrasonic-assisted extraction and
antibacterial properties of polyphenols of sweet corncob. In:
Advanced Materials Research. Pp. 374379, Vol. 1028. Trans Tech
Publications Ltd. https://doi.org/10.4028/www.scientific.net/AMR.
1028.374
Wanyo, P., Chomnawang, C. & Siriamornpun, S. (2009). Substitu-
tion of wheat flour with rice flour and rice bran in flake products:
effects on chemical, physical and antioxidant properties. World
Applied Science Journal,7,4956.
Yang, T., Guang Hu, J., Yu, Y. et al. (2019). Comparison of pheno-
lics, flavonoids, and cellular antioxidant activities in ear sections of
sweet corn (Zea mays L. saccharata Sturt). Journal of Food Proces-
sing and Preservation,43, e13855.
Yu, H., Zhang, D., Zhang, L. et al. (2022). Corncob as a substrate
for the cultivation of Lentinula edodes. Waste and Biomass Valori-
zation,13, 929939.
Yu, X., Yin, J., Li, L. et al. (2015). Prebiotic potential of xylooligo-
saccharides derived from corn cobs and their in vitro antioxidant
activity when combined with lactobacillus. Journal of Microbiology
and Biotechnology,25, 10841092.
Yuan, Y., Gao, Y., Zhao, J. & Mao, L. (2008). Characterization
and stability evaluation of b-carotene nanoemulsions prepared by
high pressure homogenization under various emulsifying condi-
tions. Food Research International,41,6168.
Ó2023 Institute of Food, Science and Technology (IFSTTF).International Journal of Food Science and Technology 2023
Functional properties of sweet corn cob F. Islam et al.8
... Notably, the number of UBP genes varies significantly across species. For instance, the Arabidopsis (Arabidopsis thaliana) genome encodes 27 UBP genes [13], 25 genes in rice (Oryza sativa) [14], 48 genes in moso bamboo (Phyllostachys edulis) [15], and 97 in wheat (Triticum aestivum) [16]. The functions of Arabidopsis UBP genes have been extensively studied. ...
... Maize is one of the world's leading crops and is of considerable value to feed, food, pharmaceutical, and other industries [25,26]. However, the UBP gene family in maize has not been extensively studied. ...
... In addition, the expression levels of ZmUBP genes in maize roots and embryos were generally higher than those in other plant parts, indicating that ZmUBP-mediated deubiquitination may be crucial for nutrient uptake and sexual reproduction. Up to now, the only study on maize UBP genes is the identification of three Arabidopsis UBP gene homologs in maize, namely, ZmUBP15, ZmUBP16, and ZmUBP19, which only analyzed their expression patterns in roots, leaves, spikes, and seeds, as well as in the presence of metal, salt, and osmotic stresses [25], but there is no in-depth study of the roles that all members of the maize UBP family play in plant growth and in response to high-temperature, low-temperature, and drought stresses. Therefore, we selected eight ZmUBP genes with high expression levels under abiotic stresses using RT-qPCR to investigate their roles in plant growth and abiotic stress response. ...
Article
Full-text available
Background Ubiquitin-specific proteases (UBPs) are a large family of deubiquitinating enzymes (DUBs). They are widespread in plants and are critical for plant growth, development, and response to external stresses. However, there are few studies on the functional characteristics of the UBP gene family in the important staple crop, maize (Zea mays L.). Results In this study, we performed a bioinformatic analysis of the entire maize genome and identified 45 UBP genes. Phylogenetic analysis indicated that 45 ZmUBP genes can be divided into 15 subfamilies. Analysis of evolutionary patterns and divergence levels indicated that ZmUBP genes were present before the isolation of dicotyledons, were highly conserved and subjected to purifying selection during evolution. Most ZmUBP genes exhibited different expression levels in different tissues and developmental stages. Based on transcriptome data and promoter element analysis, we selected eight ZmUBP genes whose promoters contained a large number of plant hormones and stress response elements and were up-regulated under different abiotic stresses for RT-qPCR analysis, results showed that these genes responded to abiotic stresses and phytohormones to varying degrees, indicating that they play important roles in plant growth and stress response. Conclusions In this study, the structure, location and evolutionary relationship of maize UBP gene family members were analyzed for the first time, and the ZmUBP genes that may be involved in stress response and plant growth were identified by combining promoter element analysis, transcriptome data and RT-qPCR analysis. This study informs research on the involvement of maize deubiquitination in stress response.
... Corn cob is inevitably and massively generated as a by-product of the corn agriculture. Nowadays, corn cob is either burnt as fuel or treated as a waste causing environmental pollution [1,2]. Corn cob can be hydrolyzed into corn cob hydrolysate (CCH) with xylose, arabinose and glucose [1,2]. ...
... Nowadays, corn cob is either burnt as fuel or treated as a waste causing environmental pollution [1,2]. Corn cob can be hydrolyzed into corn cob hydrolysate (CCH) with xylose, arabinose and glucose [1,2]. Numerous efforts have been made to obtain efficient routes for resource utilization of CCH [3][4][5]. ...
Article
Full-text available
Corn cob is a major waste mass-produced in corn agriculture. Corn cob hydrolysate containing xylose, arabinose, and glucose is the hydrolysis product of corn cob. Herein, a recombinant Escherichia coli strain BT-10 was constructed to transform corn cob hydrolysate into 1,2,4-butanetriol, a platform substance with diversified applications. To eliminate catabolite repression and enhance NADPH supply for alcohol dehydrogenase YqhD catalyzed 1,2,4-butanetriol generation, ptsG encoding glucose transporter EIICBGlc and pgi encoding phosphoglucose isomerase were deleted. With four heterologous enzymes including xylose dehydrogenase, xylonolactonase, xylonate dehydratase, α-ketoacid decarboxylase and endogenous YqhD, E. coli BT-10 can produce 36.63 g/L 1,2,4-butanetriol with a productivity of 1.14 g/[L·h] using xylose as substrate. When corn cob hydrolysate was used as the substrate, 43.4 g/L 1,2,4-butanetriol was generated with a productivity of 1.09 g/[L·h] and a yield of 0.9 mol/mol. With its desirable characteristics, E. coli BT-10 is a promising strain for commercial 1,2,4-butanetriol production.
... Collectively, these nutrients comprised 10-15% of corncob DW. Our findings are in line with those reported in the literature, which emphasize high fiber contents of approximately 90% (comprising cellulose, hemicellulose and lignin), along with comparable levels of ash and protein at 4% in the corncobs of different maize varieties, expressed on dry weight 37,38 . In contrast, we observed high levels of available carbohydrates (ranging from 4 to 11%), which could be attributed to the maturity stage of our samples 39 . ...
Article
Full-text available
The research investigates the potential use of maize cobs (or corncobs) from five genotypes, including the B73 inbred line and four locally cultivated landraces from Northern Italy, as substrate for implementing Solid State fermentation processes with four Medicinal Mushrooms (MMs). The corncobs were characterized based on their proximate composition, lignin, phenolics content (both free and bound), and total antioxidant capacity. Among the MMs tested, Pleurotus ostreatus and Ganoderma annularis demonstrated the most robust performance. Their growth was parametrized using Image Analysis technique, and chemical composition of culture samples was characterized compared to that of corncobs alone. In all culture samples, the growth of MMs led to a significant reduction (averaging 40%) in the total phenolics contents compared to that measured in corncobs alone. However, the high content of free phenolics in the cobs negatively impacted the growth of P. ostreatus. The final MM-corncob matrix exhibited reduced levels of free sugars and starch (≤ 2.2% DW, as a sum) and increased levels of proteins (up to 5.9% DW) and soluble dietary fiber (up to 5.0% DW), with a notable trend toward higher levels of β-glucan compared to corncobs alone. This research paves the way for the use of this matrix as an active ingredient to enhance the nutritional value of food preparations.
... However, they can also harm healthy cells and cause side effects. High doses of chemotherapy can cause longterm complications such as heart problems and kidney damage [8,9]. Chemotherapy drugs circulate throughout the body and can affect both cancerous and healthy tissues [10,11]. ...
Article
Cancer affects millions of people worldwide, and it is projected that there will be 1,958,310 new cancer cases and 609,820 cancer fatalities in the United States in 2023. Epirubicin (EPI) is a prospective anticancer chemotherapeutic agent that has demonstrated efficacy against a variety of malignancies, including breast, ovarian, gastric, lung, and pancreatic cancers, as well as non-Hodgkin lymphomas and acute leukemia, which account for approximately 25% of all cancer cases. Utilizing nanotechnology, novel drug delivery systems (DDS) have been developed to enhance the therapeutic efficacy of EPI and resolve its limitations. This article examines various nanocarriers used for EPI delivery and co-delivery, with dimensions ranging from 1.5 to 876 nm, encapsulation efficiencies between 3.9% and 99.6%, zeta potentials between −31 and + 31 mV, and drug release profiles ranging from 10% to 100% over 40 min to two weeks. Functionalized with targeted ligands such as antibodies, aptamers, folic acid, or transferrin, the nanocarriers can respond to pH, temperature, magnetic fields, or enzymes. In addition, the article discusses the advantages and disadvantages of various nanocarrier types and co-delivery strategies, as well as future prospects and difficulties. This exhaustive analysis provides the most recent data on multiple nanocarriers for EPI delivery and co-delivery, focusing on their design principles, modes of action, and therapeutic effects.
Chapter
Cancer is a widespread burden that represents a devastating ailment that contributes to an increasing global health and economic load. Over the past few decades, a consistent upward trend in the utilization of natural product-based anticancer agents was established. Nutritional supplements and phytochemicals exhibit promising biological properties for preventing the risk of oxidative stress-related diseases. Within the confines of this chapter, we will delve into the chemopreventive and anticancer potential of a range of dietary supplements and nutraceuticals. The utilization of certain bioactive substances and nutraceuticals in preventing or combating cancer holds substantial promise. This chapter aims to keep readers informed about the scientific substantiation concerning various bioactive substances and nutraceuticals in the context of cancer prevention and treatment. In this chapter, our objective is to provide a comprehensive summary of the potential anticancer properties inherent in food supplements and nutraceuticals, offering an overview of their underlying mechanisms of action and their compatibility with other medications, rendering them well-suited for alternative approaches to cancer management.
Article
Full-text available
Abstract Peripheral nerve injuries are one of those complex medical conditions for which a highly effective first‐line treatment is currently missing. The use of natural compound as medicines to treat various disorders has a long history. Our previous research explored that crude Cannabis sativa L. accelerated the recovery of sensorimotor functions following nerve injury. The purpose of the current study was to investigate the effects of n‐Hexane and ethyl acetate extracts of C. sativa L. leaves on the muscle function restoration in a mouse model after sciatic nerve injury. For this purpose, albino mice (n = 18) were equally divided into control and two treatment groups. The control group was fed on a plain diet while treatment groups were given a diet having n‐Hexane (treatment 1) and ethyl acetate (treatment 2) extracts of C. sativa L. (10 mg/kg body weight), respectively. The hot plate test (M = 15.61, SD = 2.61, p = .001), grip strength (M = 68.32, SD = 3.22, p
Article
Full-text available
Agricultural waste valorization is currently getting attention across the world owing to its environmental impact and rich phytochemistry. The mandate of the current investigation was the extraction and characterization of bioactive moieties from the mustard oilseed cake/meal MOC and sesame oilseed cake/meal SOC through ultrasound extraction (UE) techniques due to its higher yield and less burden on the environment as compared to conventional extraction (CE). Purposely, the MOC and SOC were initially subjected to compositional analysis. Thereafter, bioactive moieties were extracted by using different solvents, that is, ethanol and distilled water, and by applying conventional and ultrasonic extraction techniques. The outcomes indicated that among the techniques, ultrasound exhibited the highest results, and in solvents, ethanol performed better. The treatment extracted with ethanol with UE at 10 min showed the best result for total phenolic contents (TPC) as (6.07 ± 0.03 09 g GAE/100 g MOC) and (7.09 ± 0.04 g GAE/100 g SOC), DPPH radical scavenging activity (67.3 ± 1.9 TE/100 g MOC) & (72.68 ± 1.9 TE/100 g SOC), and FRAP was recorded as (2.83 ± 0.02 g TE/100 g MOC) & (3.56 ± 0.03 g TE/100 g SOC). The higher antioxidant potential showed that the mustard and sesame waste holds significant therapeutic potential owing to its rich antioxidant profile and thus should be utilized for the development of functional products against lifestyle‐related disorders. In conclusion, ultrasound is a better technique for maximum as well as accurate extraction, with ethanol exhibiting as a better solvent for this process with more yields as compared to distilled water. Value addition of agriculture waste.
Article
Full-text available
Phytosterols are important structural components of plant cells that affect membrane fluidity, permeability, and membrane-related metabolic regulation. These compounds, which are abundant in vegetable oils and corn kernel oil, are also beneficial for human health. Cultivation of corn ( Zea mays L.) produces huge amounts of cobs as a by-product, but efforts to utilize cobs are still limited. Here, we investigated phytosterol, crude oil, and fatty acid contents in the kernels and cobs of four major corn cultivars in South Korea and explored the potential use of cobs as a source of phytosterols. Total phytosterol levels were two times higher in cobs (68.0–217.1 mg 100 g ⁻¹ DW) than in kernels (43.8–89.5 mg 100 g ⁻¹ DW) and were highest in the kernels and cobs of Sinhwangok at 60 days after pollination. We showed that not only kernels but also cobs can be a rich source of phytosterols. The results also revealed that the amount of phytosterol is depending on a genetic background as well as developmental stages suggesting further investigation would enhance the utilization of corn cobs as a phytosterol source.
Article
Full-text available
The importance of plant secondary metabolites in food and their possible impacts on human health are the subjects of a steadily developing number of studies. Furthermore, as consumers become more conscious of diet-related issues, they desire natural ingredients that are anticipated to be safe and health-promoting; as a result, doum flour might be regarded as an excellent source of functional compounds. Hyphaene thebaica L. is a palm plant species with eatable ovoid fruits and a woody texture that is endemic to upper Egypt. It is one of the world’s most significant and valuable plants. Doum flour is considered to contain higher moisture content, crude fiber, ash content, protein, fat, and vitamins, especially niacin, folic acid, pyridoxine, riboflavin, and thiamin. Previous findings showed that doum flour has high functional and nutritional qualities and may be used for a variety of key applications in the food sector. Doum nuts contain antioxidants as well as metabolites like tannins, saponins, steroids, glycosides, terpenes, and terpenoids. The results of different studies have indicated that doum flour is effective in various health maladies. This review highlights the anti-inflammatory, antioxidant, antibacterial, anticancer, nutritional content, fertility activity, the rheological, and pharmacological ability of Hyphaene thebaica L. flour extracts and their significant phyto-constituents such as polyphenol, essential-oil, and flavonoid components.
Article
Full-text available
Clam heparinoid G2 (60.25 kDa) and its depolymerized derivatives DG1 (24.48 kDa) and DG2 (6.75 kDa) prepared from Coelomactra antiquata have been documented to have excellent fibrinolytic and anticoagulant activity. In this study, to further explore the antithrombotic activity of G2, DG1 and DG2, azure A, sheep plasma, and clot lytic rate assays were used to determine their anticoagulant and thrombolytic activity in vitro. The results indicated that the anticoagulant titer of G2 was approximately 70% that of heparin and the thrombolytic activity of DG2 was greater than G2, DG1, and heparin activities. Moreover, in a carrageenan-induced venous thrombosis model, oral administration of G2 and DG1 each at 20 mg/kg and 40 mg/kg for 7 days significantly reduced blacktail thrombus formation, increased tissue-type plasminogen activator, fibrin degradation products, and D-dimer levels, decreased von Willebrand factor and thromboxane B2 levels, and restored phylum and genus abundance changes of intestinal bacteria. DG2 had no antithrombotic effect. At 20 mg/kg, G2, DG1, and heparin had comparable antithrombotic activities, and DG1 at 40 mg/kg had more muscular antithrombotic activity than G2. Thus, DG1 could be an antithrombotic oral agent owing to its more robust antithrombotic activity and lower molecular weight.
Article
Full-text available
The cobs of sweet corn, also known as vegetable corn, are a nutritionally rich agricultural by-product. Sweet corncob polysaccharide (SCP-80-I) is a bioactive macromolecule extracted from the sweet corncob. Previous studies have shown that SCP-80-I has beneficial biological activities, including anti-oxidative and hypoglycemic properties. Previously, we showed that SCP-80-I had hypoglycemic effects, but the overall molecular changes associated with SCP-80-I have not yet been clarified in vivo. In this study, we investigated the hypoglycemic effects of SCP-80-I in diabetic rats with insulin resistance and analyzed the hypoglycemic mechanisms of SCP-80-I using tandem mass tag (TMT) -labeled quantitative proteomics. Using gene onotology (GO) annotations and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis, the biological process, cell composition, and molecular function terms associated with the differentially expressed proteins were identified, as were the associated signaling pathways. In total, 4780 proteins exhibited a fold-change greater than 1.5. Six differentially expressed proteins related to the development and treatment of diabetes were selected, encoded by the genes Pik3r5, Ndufb3, Pygl, Cbl, Prkcd, and Stat1. SCP-80-I induced hypoglycemia mainly through the PI3K-Akt and JAK-STAT signaling pathways. SCP-80-I also ameliorated diabetes by regulating the expression of the Pik3r5, Ndufb3, Pygl, Cbl, Prkcd, and Stat1 genes. This study provided a theoretical basis for the treatment of diabetes and the development of hypoglycemic drugs. Our results suggested that SCP-80-I plays a beneficial role in reducing blood glucose in diabetic mice, which helps to clarify the molecular mechanisms by which sweet corncob polysaccharide reduces blood glucose.
Article
Full-text available
Gluten free (GF) products are often inferior in quality attributes, nutritional content and consumer acceptability. The use of GF by-products is a novel strategy to improve the structure and nutritional profile of these products. Sweet corn cob (SCC) is a by-product of sweet corn processing containing a considerable amount of fibre and ferulic acid. The effect of baking on ferulic acid content, colour, texture and physical characteristics on muffins incorporated with SCC flour (SCCF) as a value-added food ingredient was investigated using a GF model system. The freeze-dried SCCF, containing ferulic acid (6.02 mg g⁻¹) was used to replace the rice flour at varying levels of 10, 20, and 30%. In general, SCCF increased dietary fibre and free ferulic acid content of muffins. Inclusion of 20% SCCF showed an increase in terms of the height of the muffin and number of air cells in the crumb, along with a decrease in the hardness of muffins. Muffins with SCCF showed higher mean overall liking scores than rice flour muffin.
Article
Full-text available
Corncob contains nutrients for the growth of mushrooms. Since wood, the original substrate for mushroom production, is becoming difficult to obtain these days, the study aims to evaluate the effect of using corncob as a substrate for Lentinula edodes (shiitake) cultivation, and to provide an economic and eco-friendly approach to transform waste biomass into high quality edible mushrooms. Six formulas containing gradient proportions of corncob were assessed (100 cultivation bed-log per group) together with an oak sawdust control. Chemical profile analysis suggested corncob substitution reduced the substrate’s carbon level and increased nitrogen level. Formulas containing 18–58% corncob obtained higher yield comparing to the sawdust control, indicating a strong boosting effect of corncob. The formula composing of 50% corncob, 28% oak sawdust, 20% wheat bran, and 2% gypsum showed the best performance with the fastest mycelia growth, better log browning, the highest yield (722.08 g/log) and summit biological efficiency (80.23%). The determined carbon/nitrogen in this substrate was 67.21. The size (pileus diameter) of fruit bodies were not much affected by the change in formulas. Addition of corncob had an influence on nutritional composition of mushrooms. The highest polysaccharide content in fruit bodies (4.51 g/100 g) was found when the substrate contains 40% corncob. Corncob is a major agricultural waste in the world. These results revealed an excellent potential of corncob when used as a main substrate ingredient for L. edodes cultivation. Graphic Abstract
Article
We have previously prepared a polysaccharide from sweet corn cobs named SCP-80-1 and have demonstrated it to have a good hypoglycemic effect in vitro. In this study, we evaluated the hypoglycemic effect of SCP-80-1 on streptozotocin (STZ)-induced diabetic rats. The diabetic animals were administered intragastrically with SCP at doses of 100, 200 and 400 mg/kg mb or metformin at 200 mg/kg mb for 28 days. The fasting blood glucose, glucose tolerance, insulin content, blood lipids, visceral organ indices and pancreatic tissue sections were measured. The results showed that SCP-80-1 could decrease the fasting blood glucose level and postmeal blood glucose level, and improve the glucose tolerance of diabetic rats. It was also found that SCP-80-1 could improve blood lipid levels by reducing the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol and increasing the level of high-density lipoprotein cholesterol. In addition, SCP-80-1 could reduce organ swelling to a certain extent, repair the damaged islet tissue, and increase the number of islet B cells. Therefore, SCP-80-1 can effectively regulate the blood glucose level of diabetic rats, improve glucose tolerance and repair the injured islet tissue, indicating that this polysaccharide is a natural hypoglycemic agent that is promising for application in the treatment of diabetes mellitus.
Article
Natural polysaccharides such as xylans have attracted attention in recent years as promising substances due to their characteristics and because they are renewable sources. However, to increase their potential for application, it is important to improve some properties, achieved through modification of their structure. The purpose of this work was to synthesize, characterize and study the properties of quaternized (QXy) and sulfated xylan (SXy), produced from xylan (Xy) extracted from corn cobs. Xy presented two populations of different molecular weights and high Reducing Sugar content. Fourier Transform Infrared Spectroscopy (FTIR), Mass Spectrometry (MS), Nuclear Magnetic Resonance (¹H NMR and ¹³C NMR) and Elementary Analysis (CHNOS) confirmed the intended synthesis modifications as new characteristics, arising from the groups introduced, were observed. Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and X-Ray Diffraction (XRD) showed changes in characteristics, which were induced by the modifications. Xylan modification led to an increase in its DPPH radical-scavenging activity for all concentrations tested, especially for QXy, reaching a maximum of 93.5%. Xylan modification also decreased the minimum inhibitory concentration (MIC) values for QXy, especially against Gram-positive bacteria (Staphylococcus aureus ATCC 25923), from >2.0 (Xy) to 0.25%w/v (QXy). Modified xylans present enhanced antioxidant and antimicrobial activities and the potential to be applied or incorporated in new materials for different purposes, such as biological, biomedical, packing and drug delivery formulations.